Friedelin induces apoptosis in oral cancer: Insights from in vitro and in silico studies by Ramya Sekar, Monisha Prasad, Manikandan Alagumuthu

“…Background: Oral cancer is a major health issue in the world because of its high morbidity and mortality rates. …”
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N4BP3 Activates TLR4-NF-κB Pathway in Inflammatory Bowel Disease by Promoting K48-Linked IκBα Ubiquitination by Jiang W, Yin J, Han M, He W, Zhao Y, Hu J, Wang M, Wang S, Xu J, Deng C, Li J, Gong X, Shen Y

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Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Trial by Chen Z, Liu YY, Hu Q, Wang JS, Cao RY, Yu ST, Lu F, Zhong ML, Liang WD, Wang L

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Transcriptomic Changes and Pathological Mechanisms in Familial and Sporadic Idiopathic Restless Legs Syndrome: Implications for Inflammation and Cell Adhesion Molecules by He XR, Song JM, Zhao JP, Zhang J, Feng JT, Chen SQ, Zhou ZY, Wang HM, Zhang Y, Feng Y, Wu YC, Zhu XY

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Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway by Xue X, Wang S, Li J, Yuan H, Pan S, Liu X, Yue Z, Liu Y

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A Peptide Encoded by lncRNA HOXB-AS3 Promotes Cigarette Smoke-Induced Inflammation in Bronchial Epithelial Cells via EZH2-Mediated H3K27me3 Modification by Lin M, Zhou X, Yang Y, Xie P, Li Q, He C, Lin Q, Wei X, Ding Y

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Therapeutic Effect of Brucea Javanica Oil Emulsion in Mice with Irinotecan-Induced Delayed Diarrhea by Lai Z, Zhang Y, Hu X, Chen L, Huang W, Wang J, Chen B, Ren M, Yang B, Su Z, Chen J, Xie J, Lai Z, Xie Y

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Hepatoprotective Effects of Gac (Momordica cochinchinensis) Aril Extract in Acetaminophen-Induced Liver Injury: Modulation of Oxidative Stress, Inflammation, and Glucose Metabolism by Lonan P, Ariyabukalakorn V, Yoysungnoen B, Singsai K, Praphasawat R, Sangkham S, Jantarach N, Riyamongkhol P, Somparn N, Munkong N

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Shu-Feng-Jie-Biao Formula Ameliorates Influenza A Virus-Induced Acute Lung Injury by Inhibiting NF-κB and ERK MAPK Signaling Pathways by Lei B, Huang W, Peng W, Mu J, Liu Y, Zhou C, Cheng T, Wei X, Pan L, Zheng Y, Fang B

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The Improvement of Intestinal Mucosal Epithelial Barrier Integrity by 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone in Rat Experimental Colitis by Szandruk-Bender M, Wiatrak B, Merwid-Ląd A, Dzimira S, Szeląg A, Magdalan JM, Szczukowski Ł, Świątek P, Duda-Madej A, Gębarowski T, Nowak B

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An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation by Sebastian Benjamin, GW McElfresh, Maanasa Kaza, Gregory J. Boggy, Benjamin Varco-Merth, Benjamin Varco-Merth, Sohita Ojha, Shana Feltham, William Goodwin, William Goodwin, Candice Nkoy, Candice Nkoy, Derick Duell, Derick Duell, Andrea Selseth, Tyler Bennett, Aaron Barber-Axthelm, Nicole N. Haese, Nicole N. Haese, Helen Wu, Courtney Waytashek, Carla Boyle, Jeremy V. Smedley, Jeremy V. Smedley, Caralyn S. Labriola, Caralyn S. Labriola, Michael K. Axthelm, Michael K. Axthelm, R. Keith Reeves, R. Keith Reeves, Daniel N. Streblow, Daniel N. Streblow, Jonah B. Sacha, Jonah B. Sacha, Afam A. Okoye, Afam A. Okoye, Scott G. Hansen, Scott G. Hansen, Louis J. Picker, Louis J. Picker, Benjamin N. Bimber, Benjamin N. Bimber

“…IntroductionRNA sequencing (RNA-seq) can measure whole transcriptome gene expression from tissues or even individual cells, providing a powerful tool to study the immune response. …”
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Epigenetic Regulation of Neutrophils in ARDS by Jordan E. Williams, Zannatul Mauya, Virginia Walkup, Shaquria Adderley, Colin Evans, Kiesha Wilson

“…It has been identified that neutrophils in ARDS patients exhibit abnormal methylation patterns and are associated with altered gene expression and prolonged neutrophil activation, thereby contributing to sustained inflammation. …”
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The role and mechanism of HMGB1-mediated Notch1/Hes-1 pathway in anxiety and depression-like behaviors in mice with chronic rhinosinusitis by Fangwei Zhou, Yiting Jiang, Yangsong Li, Jianyao Li, Tian Zhang, Guodong Yu

“…Abstract Background Chronic rhinosinusitis (CRS) is a global health issue, with some patients experiencing anxiety and depression-like symptoms. …”
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Allelopathy and underlying mechanism of mango (Mangifera indica) peel extracts on Alexandrium catenella by Yanqun Wang, Yanqun Wang, Yu Zang, Wenxi Zhao, Mengxue Xu, Jie Bai, Li Li

“…Harmful algal blooms (HABs) have always been a worldwide environmental issue. The methods based on the principle of allelopathy provide a novel direction for controlling HABs; however, there are a few studies on the application of allelopathic algaecides to control harmful algae in marine environments. …”
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Activation of cellular immune responses using a dengue tetravalent subunit DNA vaccine candidate with different cytokines as adjuvants by Luciana de Souza Fernandes, Carine Ribeiro Pessoa, Roberto Sousa Dias, Cynthia Canedo da Silva, Sérgio Oliveira de Paula

“…Dengue remains a critical public health issue in endemic areas, with four co-circulating serotypes (DENV-1–4) and no widely accessible vaccine in Brazil. …”
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Understanding Challenges and Emotions of Informal Caregivers of General Older Adults and People With Alzheimer Disease and Related Dementia: Comparative Study by Nova Mengxia Huang, Liang Ze Wong, Shirley S Ho, Bryan Timothy

“…Posts from older adult–related subreddits were more focused on practical caregiving issues and seeking advice and support, whereas posts from Alzheimer disease–related subreddits emphasized health- and medical-related topics and expressing feelings. …”
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Detection of hyperphosphorylated tau protein and α-synuclein in spinal cord of patients with Alzheimer’s disease by Guo Y, Wang L, Zhu M, Zhang H, Hu Y, Han Z, Liu J, Zhao W, Wang D

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Neuropathological responses to chronic NMDA in rats are worsened by dietary n-3 PUFA deprivation but are not ameliorated by fish oil supplementation. by Vasken L Keleshian, Matthew Kellom, Hyung-Wook Kim, Ameer Y Taha, Yewon Cheon, Miki Igarashi, Stanley I Rapoport, Jagadeesh S Rao

“…Chronic NMDA increased brain cPLA2 activity in each of the three groups, but n-3 PUFA deprivation or fish oil did not change cPLA2 activity or protein compared with the adequate group. sPLA2 expression was unchanged in the three conditions, whereas iPLA2 expression was reduced by deprivation but not changed by supplementation. …”
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Exosome Secretion Regulation in Mice with Acute Lung Injury by Jie HH, Lu WH

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Challenges in Thirst Management for Intubated Patients in the ICU: A Qualitative Study of Healthcare Provider and Patient Perspectives by Yuan Y, He LF, Luo Q, Zhang X, Chen F, Hu RJ

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