Role of structure-based drug design (SBDD) in the repurposing and discovery of anti-viral leads against Monkeypox virus disease by Jihane Touhtouh, Fettouma Chraa, Doha EL Meskini, Taoufiq Benali, Abdelhakim Bouyahya, Long Chiau Ming, Said Moshawih, Khalil Hammani, Tarik Aanniz

“…Nowadays, the SBDD approach facilitates the systematic analysis of biochemical and interaction processes relevant to pharmaceuticals at the molecular scale. …”
Get full text

Global antibiotic hotspots and risks: A One Health assessment by Bingshuang Yan, Fuyang Huang, Jiaolong Ying, Dafang Zhou, Samira Norouzi, Xianming Zhang, Bin Wang, Fei Liu

“…Therefore, addressing this emergent issue necessitates a One Health framework that integrates these interconnected dimensions. …”
Get full text

YOLOv11-RDTNet: A Lightweight Model for Citrus Pest and Disease Identification Based on an Improved YOLOv11n by Qiufang Dai, Shiyao Liang, Zhen Li, Shilei Lyu, Xiuyun Xue, Shuran Song, Ying Huang, Shaoyu Zhang, Jiaheng Fu

“…However, existing object detection models face limitations in complex backgrounds, target occlusion, and small target recognition, and they struggle to be efficiently deployed on resource-constrained devices. To address these issues, this study proposes a lightweight pest and disease detection model, YOLOv11-RDTNet, based on the improved YOLOv11n. …”
Get full text

Aromatase reduces sperm motility by down-regulating the expression of proteins related to ATP synthesis in seminal plasma extracellular vesicles by Xuliang Luo, Yan Guo, Xuelian Li, Zi Mei, Haobo Zhou, Ping Qiu, Haoxin Wang, Yan Chen, Yanzhang Gong

“…Currently it is still unclear whether SPEV are involved in the process of that aromatase affects the quality semen in chicken. …”
Get full text

Stable Gastric Pentadecapeptide BPC 157 as a Therapy and Safety Key: A Special Beneficial Pleiotropic Effect Controlling and Modulating Angiogenesis and the NO-System by Predrag Sikiric, Sven Seiwerth, Anita Skrtic, Mario Staresinic, Sanja Strbe, Antonia Vuksic, Suncana Sikiric, Dinko Bekic, Dragan Soldo, Boris Grizelj, Luka Novosel, Lidija Beketic Oreskovic, Ivana Oreskovic, Mirjana Stupnisek, Alenka Boban Blagaic, Ivan Dobric

“…Although approached through many concepts, the pleiotropic healing issue, specifically, maintaining/reestablishing tissue integrity, remains a central challenge in pharmacology, particularly when the process is misdirected or not properly controlled. …”
Get full text

Lightweight coal miners and manned vehicles detection model based on deep learning and model compression techniques: A case study of coal mines in Guizhou region by Beijing XIE, Heng LI, Zheng LUAN, Zhen LEI, Xiaoxu LI, Zhuo LI

“…Furthermore, the WIOU boundary regression loss function is employed to increase the model's focus on common quality samples, addressing issues such as regression errors caused by imbalanced training samples. …”
Get full text

ANN-SVM-IP: An Innovative Method for Rapidly and Efficiently Detecting and Classifying of External Defects of Apple Fruits by Nashaat M. Hussain Hassan, Mohamed M. Hassan Mahmoud, Mohamed A. Ismeil, M. Mourad Mabrook, A. A. Donkol, A. M. Mabrouk

“…This paper attempts to address these issues by offering a novel method (ANN-SVM-IP) that integrates image processing (IP)-based segmentation and ML algorithms (ANN-SVM) for extracting and classifying exterior defects in apple fruits. …”
Get full text

Comprehensive assessment of fatty acid profiles of meat products to develop action plan strategies for healthier products by Sakineh Yazdanparast, Fatemeh Mohammadi-Nasrabadi, Ali Hashmati, Roghayeh Rezazadeh, Mehdi Taheri, Barbod Alhouei, Fatemeh Esfarjani

“…Abstract The global consumption of processed meat products has increased over the last few years. …”
Get full text

One health agriculture: Heat stress mitigation dilemma in agriculture by Edit Mikó, Gideon Adu Donyina, Wissem Baccouri, Violetta Tóth, Kovács Flórián, Ingrid Melinda Gyalai, Gizem Yüksel, Dávid Köteles, Vineet Srivastava, George Wanjala

“…In our opinion, the efficacy of the One Health Approach in reducing Agri-heat stress depends on the process of conceptualization. This process includes recognizing the issue or hypothesis, as well as incorporating cooperating teams in the creation of environmentally friendly approaches. …”
Get full text

MLAR-Net: A Multilevel Attention-Based ResNet Module for the Automated Recognition of Emotions Using Single-Channel EEG Signals by M. Maithri, U. Raghavendra, Anjan Gudigar, Samir Kumar Praharaj, Karthikeyan Sriram, Massimo Salvi, Chai Hong Yeong, Filippo Molinari, U. Rajendra Acharya

“…However, not all channel information is important for emotion recognition. Another issue with the existing dataset is the availability of a small quantity of samples. …”
Get full text

Differential tissue and cellular distribution of chemokine C-C motif ligand 2 in grey/white matters of healthy and simian immunodeficiency virus infected monkey by Xue Shi, Jingdong Zhang, Huangying Zhao, Hongjun Li, Junyi Zhu, Huangui Xiong

“…In conclusion, our study provides valuable insights into the cellular sources and alterations of CCL2 in the monkey brain under normal and SIV-infected conditions, which may promote better understanding of CCL2 in related neurological processes.…”
Get full text

Freedom from infection: enhancing decision-making for malaria elimination by Chris Drakeley, Dyah A S Lesmanawati, Riris Andono Ahmad, Lindsey Wu, Isabel Byrne, Henry Surendra, Luca Nelli, Risalia Reni Arisanti, Iqbal R F Elyazar, Elin Dumont, Jason Matthiopoulos, Gillian Stresman

“…However, we demonstrate that our integrated approach to data comprehensively addresses this issue, effectively detecting ongoing transmission patterns, even when local reports might suggest otherwise.Our integrated framework has far-reaching implications for malaria control but also for infectious disease control in general. …”
Get full text

Enhanced MPP Tracking in Partial Shading Conditions for Solar PV Systems: A Metaheuristic Approach Utilizing Projectile Search Algorithm by Md Tahmid Hussain, Mohammed Shahabuddin, Liang-Yin Huang, Adil Sarwar, Mohammed Asim, Shafiq Ahmad, Hwa-Dong Liu, Mohd Tariq

“…While the insertion of bypass diodes can address this issue, it often results in multiple power peaks on the Power vs Voltage (P-V) curve characteristics, complicating the process of maximum power tracking. …”
Get full text

QUALITY ATTRIBUTES AND SHELF-LIFE EVALUATION OF GOAT MEAT WITH INDIAN CURD EXTRACT, LACTIC ACID, AND NISIN UNDER REFRIGERATED CONDITIONS by Annada Das, Geeta Chauhan, Ravikant Agrawal, P K Nanda, Serlene Tomar, Pranav Chauhan, Kaushik Satyaprakash, Arun K Das

Get full text

Associations of NT-proBNP and hepcidin levels with clinical and laboratory parameters in patients with heart failure with various severity of left ventricular systolic dysfunction by V. I. Podzolkov, N. A. Dragomiretskaya, S. K. Stolbova, I. S. Rusinov

“…There remain a number of issues about the prognostic significance of the N-terminal pro-brain natriuretic peptide (NT-proBNP) in HF with preserved ejection fraction (EF). …”
Get full text

MOTIVATING STUDENTS TO PARTICIPATE IN PROFESSIONALLY ORIENTED EVENTS MANAGEMENT by T. A. Shulgina, N. A. Ketova, K. A. Kholodova, D. A. Severinov

“…Interactive game technologies, anonymous questioning, methods of descriptive and variation statistics were applied at experimental and final (resultant) stages. Processing of the obtained data was conducted by means of the license version of spreadsheet program Microsoft Excel 2010, as well as the Biostatistics 4.03 program.Results and scientific novelty. …”
Get full text

Real-Time, Risk-Based Clinical Trial Quality Management in China: Development of a Digital Monitoring Platform by Min Jiang, Shuhua Zhao, Yun Mei, Zhiying Fu, Yannan Yuan, Jie Ai, Yuan Sheng, Ying Gong, Jingjing Chen

“…Quality findings from the early-stage, interim-stage, and conclusion-stage QC rounds of clinical trials were rated by using 3 severity grades (minor, major, or critical) and classified into 5 categories (with 4 taxonomy levels under each category). QC report text was processed by using an automated natural language processing tool. …”
Get full text

A Multi-Head Attention-Based Transformer Model for Predicting Causes in Aviation Incidents by Aziida Nanyonga, Hassan Wasswa, Keith Joiner, Ugur Turhan, Graham Wild

“…To streamline investigations, scholars advocate for natural language processing (NLP) and topic modelling methodologies, which organize pertinent aviation terms for rapid analysis. …”
Get full text

Modern polymer composite materials for bone surgery: Problems and prospects by P. A. Povernov, L. S. Shibryaeva, L. R. Lusova, A. A. Popov

“…This review summarizes the research works devoted to the creation of materials used for bone implants and issues involved in their practical testing, as well as analyzes and synthesizes data of scientific articles on the following topics: rationale for the use of biodegradable materials in bone surgery; biodegradation and bioreparation bone graft processes; requirements for degradable polymer composite materials (PCMs) for biomedical applications; overview of polymeric materials suitable for use in implant practice; impact of modifications of the PCM on the structure and biological activity of the material in biological media; effect of exhaust and heat treatment on the molecular structure of polyalkanoates.Results. …”
Get full text

ENSURING STATE SOVEREIGNTY AS A GUARANTEE OF THE COUNTRY'S ECONOMIC DEVELOPMENT by Iryna Drobush, Liudmila Kornuta, Mykola Ukrainets

“…A fundamental element of this process pertains to the matter of sovereignty, which is a prerequisite for a state's participation as an equal participant in international relations. …”
Get full text