Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair by Lei Qi, Jing Wang, Jinge Yan, Weidong Jiang, Weiwen Ge, Xin Fang, Xudong Wang, Steve GF Shen, Lu Liu, Lei Zhang

“…To address these issues, engineered extracellular vesicles (EV) with sequential stem cell recruitment and osteogenic functions were developed. …”
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Development of a vocational rehabilitation intervention to support return-to-work and well-being following major trauma: a person-based approach by Roshan das Nair, Trevor Jones, Richard Morriss, Marilyn James, Denise Kendrick, Stephen Timmons, Blerina Kellezi, Priya Patel, Jain Holmes, Jade Kettlewell, Kate Radford, Kay Bridger, Rebecca Lindley, Hereward Tresidder, Isobel Andrews, Blanca De Dios Perez, Abigail Statham, Tadeusz Jones, Karen Hoffman

“…This paper describes development of a vocational rehabilitation intervention (the ROWTATE intervention) to support RTW following traumatic injury.Design Sequential and iterative person-based approach in four stages—Stage 1: review of evidence about the efficacy and mechanisms of RTW interventions; Stage 2: interviews (n=38) and focus groups (n=25) with trauma survivors and service providers in five UK MTCs to identify the issues, and challenges faced postinjury; Stage 3: codesign workshops (n=43) with trauma stakeholders in MTCs to conceptually test and identify intervention delivery barriers/enablers; Stage 4: meetings (n=7) with intervention development working group (IDWG) to: (1) generate guiding principles, (2) identify key intervention features (process, components, mechanisms) to address unmet rehabilitation needs; (3) generate a logic model and programme theory to illustrate how the intervention works; and (4) develop a training package to support delivery.Results Trauma survivors described unmet needs relating to early advice about RTW; psychological support; pain management; hidden disabilities (eg, fatigue); estimating recovery; and community, amputee and musculoskeletal rehabilitation. …”
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The transcriptional repressor Ctbp2 as a metabolite sensor regulating cardiomyocytes proliferation and heart regeneration by Yanting Meng, Jianwen Ding, Yanping Wang, Jing Wang, Wei Huang, Wenkang Jiang, Jiayi Li, Xiujuan Lang, Sifan Zhang, Yumei Liu, Xijun Liu, Hulun Li, Bo Sun

“…Abstract Background C-terminal binding protein-2 (Ctbp2) is an evolutionarily conserved transcriptional repressor that regulates fundamental processes such as cell proliferation and apoptosis. …”
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Centering equity, diversity, and inclusion in youth digital mental health: findings from a research, policy, and practice knowledge exchange workshop by Medard Adu, Bilikis Banire, Bilikis Banire, Mya Dockrill, Alzena Ilie, Elizabeth Lappin, Patrick McGrath, Patrick McGrath, Samantha Munro, Kady Myers, Gloria Obuobi-Donkor, Rita Orji, Rebecca Pillai Riddell, Lori Wozney, Lori Wozney, Lori Wozney, Victor Yisa

“…Nine action recommendations focused on diversifying research and development funding, policy and standards, youth and community led promotion, long-term trust-building and collaboration, and needing to callout and advocate against unsafe digital services and processes.ConclusionKey policy, training and practice implications are discussed.…”
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Correction of TRMM 3B43 Monthly Precipitation Data Using Quantile Regression Model in the Urmia Lake Basin by Sima Kazempour Choursi, Mahdi Erfanian, Hirad Abghari, Mirhassan Miryaghoobzadeh, khadijeh Javan

“…The process led to almost all points aligning closely with the ideal line of 1:1 after using quantile regression. …”
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Developing and validation of religious education curriculum in preschool by Zeinab Ashrafi Soltan-Ahmadi, Sadegh Maleki Avarsin, Javad Keyhan, jahangir yari

“…Shamshiri & Nowzari (2018) in presenting the local model of religious education for preschool children emphasized and necessitated the method of grounding by providing practical learning activities for the active participation of children in the process of religious education.…”
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Mixed Land use Pattern in Deteriorated and Inefficient Neighborhoods of Region Eighteen of Tehran and its Role in Sustainable Neighborhood Regeneration by Mojtaba Roustaei, Ahmad Pour Ahmad, Nafiseh Marsousi, esmaeil ali akbari

“…Urban development based on the mixed land use is a new approach not only to regulate and make optimal use of physical space but also achieve sustainability, especially in the process of regenerating deteriorated and inefficient urban area of neighborhoods. …”
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Addressing Shortcomings in Contingency Standards of Care by Alexander Quan

“…To mitigate these ethical issues, I offer recommendations for reimagining resource allocation during contingency standards of care. …”
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Effect of Elevated Storage Temperatures on the Physicochemical and Sensory Properties of Apple Puree by Andrey I. Sergeev, Irina G. Kalinina, Natalia G. Shilkina, Irina I. Barashkova, Margaret A. Gradova, Mikhail V. Motyakin, Victor B. Ivanov

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Methyl jasmonate promotes postharvest ripening and softening of mango and regulates the expression of key genes by ZHANG Shasha, WANG Xin, GUO Pan, ZHANG Jing, MA Dexin, SHAO Yuanzhi, LI Wen

“…Ethephon (ETH) induces the generation of endogenous ethylene, thereby achieving the effect of rapidly initiating the ripening process. This process is non-adjustable and irreversible, resulting in excessive over-ripening, softening, and rotting of a large number of fruits. …”
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Research on Model Reconstruction Methods for Partial Point Cloud Information Loss by Zhengping CHANG, Guoshuai YUAN, Jiuhua LI, Yang ZHAO, Zhongqi WANG

“…The reconstructed differential properties preserved the original meaning of the scalar fields, ensuring that the transformation process maintained the local feature details of the initial surface to the maximum extent. …”
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Краса стихій світобудови – необроблені форми мінералів у ювелірному мистецтві by Sofia T. Trykolenko

“…Barbaric consumption of natural resources is slowly giving way to recovery. Issues such as the educational function of jewelry art are covered. …”
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PLANO ESTADUAL DE EDUCAÇÃO DE MATO GROSSO DO SUL: entre a gestão gerencial e a gestão democrática by Regina Tereza Cestari de Oliveira

“…MATO GROSSO DO SUL STATE EDUCATION PLAN: management and democratic management Abstract  This paper presents research results and analyzes, from the approval of the National Education Plan (PNE) 2014-2024, the materialization process of the State Education Plan of Mato Grosso do Sul (PEE / MS), in force, as public policy, in order to apprehend the objective conditions in which this process materializes, emphasizing the concepts of education management in dispute, as well as the regulation of the democratic management of education. …”
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Epidemiology of Medical Errors and Incidents in Emergency Medicine by Yu. E. Voskanyan

“…Relevance the issues of patient care and quality management have acquired particular relevance in modern healthcare. …”
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Age- and Organ-Specific Differences in Mitochondrial Bioenergetics in Brown Norway Rats by Jignesh D. Pandya, Matthew Valdez, Joyce E. Royland, Robert C. MacPhail, Patrick G. Sullivan, Prasada Rao S. Kodavanti

“…Mitochondria play a central role in energy homeostasis and act as regulatory checkpoints for downstream metabolic responses and cell senescence processes during an entire life span. Acute or chronic environmental toxicant exposures have shown deleterious organ-specific human health issues at various life stages. …”
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Generative AI in construction risk management: a bibliometric analysis of the associated benefits and risks by Mohamed Abdelwahab Hassan Mohamed, M.K.S. Al-Mhdawi, Udechukwu Ojiako, Nicholas Dacre, Abroon Qazi, Farzad Rahimian

“…Practical implications – The categorisation of GenAI risks in CRM provides a foundation for critical risk management processes, such as risk analysis, evaluation and response planning. …”
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Perceived barriers and facilitators of staff recruiting participants to a randomised controlled trial of a community rehabilitation intervention following hip fracture by Kathryn Harvey, Penelope Ralph, Llinos Haf Spencer, Kodchawan Doungsong, Val Morrison, Andrew Lemmey, Miriam Golding-Day, Susanna Dodd, Ben Hardwick, Shanaz Dorkenoo, Sophie Hennessey, Nefyn Williams

“…Research has shown that many other recruitment issues can be anticipated, for example overestimating target population prevalence; however, a range of factors may play a role. …”
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Optimal selection of favorable production areas for low-permeability sandstone gas reservoirs in the Benxi Formation of the Upper Carboniferous in Ordos Basin by Yu Lei, Fei Shixiang, Zhao Changhu, Chen Guowei, Cui Yuehua

“…Evaluation criteria for favorable areas within the Benxi Formation reservoir are established based on the natural gas accumulation process, providing guidance for selecting optimal target areas for production. …”
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Codevelopment of a complex intervention to reduce inequalities in paediatric diabetes secondary care outcomes for children with type 1 diabetes from underserved groups by Ian Litchfield, Timothy Barrett, Sheila Greenfield, Sabi Redwood, S Uday, T Barrett, Aidan Searle, J Wheeler, Julian P H Shield, T Moore, P Sundaram, F Campbell, S Redwood, S Greenfield, P Brocklehurst, K Khunti, J Shield, V Puthi, P Sachdev, R Willemsen, C Austin, M Ford-Adams, P Narendran, N Ives, Jessica R Wheeler, Kerry Leeson-Beevers, R Kandiyali, K Leeson-Beevers, I Litchfield, A Searle, S Tearne

“…In phase 2 (this report), we applied the COM-B framework to identify intervention components; in phase 3 (this report), we evaluated these components, including focus groups with CYPD, their carers’ and healthcare practitioner (HCP) surveys, using the Acceptability, Practicability, Effectiveness, Affordability, Spill-Over Effects, Equity criteria.Setting Secondary care; children, young people and their carers’ were approached from two large paediatric diabetes services in England, both with socioeconomically and ethnically diverse underserved populations; paediatric diabetes HCPs were surveyed across four English regions.Participants N=69 underserved CYPD (aged 5–19 years) and/or family members took part in interviews; N=48 paediatric diabetes HCP survey respondents (survey 1); N=34 paediatric diabetes HCP survey respondents (survey 2); N=3 young people’s advisory group participants; N=17 underserved CYPD/carers focus group participants; N=9 wider stakeholder participants.Results The codevelopment process and integration of COM-B established four elements for an intervention package: (1) an enhanced peer support/mentoring programme; (2) provision of a health and well-being coach to CYPD/families; (3) family/community support to address social and community issues and (4) training for HCPs, including cultural competence, poverty proofing and to emphasise the need for increased sensitivity and better supported communication in work with CYPD from underserved groups.Conclusions The Diversity in Diabetes codevelopment work informed an intervention to improve diabetes care in underserved groups, reflecting sociocultural contexts and plausible support options at the individual, community and clinical levels. …”
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F- transport law in a coal mine goaf filled with gangue and its variations characteristics with Darcy flow velocity by ZHAO Li, JIA Xiangteng, ZHANG Qing, XU Feng, ZHU Kaipeng, KONG Weifang, XING Mingfei, JIN Yi

“…During coal mining， the massive accumulation of coal gangue and its pollution effects on groundwater have become pressing issues in ecological environment management and resource utilization.ObjectivesUsing coal gangue to backfill goafs as a storage space for purified mine water can not only achieve resource utilization of coal gangue but also help remove fluoride from mine water. …”
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