A Comprehensive Description of the Roadmap to Identify and Validate a Myelin Biomarker by Giovanna Capodivento, Davide Visigalli, Andrea Armirotti, Chiara Demichelis, Marinella Carpo, Roberto Fancellu, Erika Schirinzi, Daniele Severi, Diego Franciotta, Fiore Manganelli, Gabriele Siciliano, Alessandro Beronio, Elisabetta Capello, Paola Lanteri, Eduardo Nobile-Orazio, Angelo Schenone, Luana Benedetti, Lucilla Nobbio

“…Background: Demyelination and remyelination are major issues for scientists dealing with myelin disorders in both clinical and research fields. …”
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Quantitative fluorescence techniques and their applications in shale oil reservoir research: a case study of Permian Fengcheng Formation in Mahu Sag, Junggar Basin by Chengzhou JIANG, Guiwen WANG, Lianteng SONG, Liliang HUANG, Song WANG, Yilin ZHANG, Yuyue HUANG, Xuqiang FAN

“…The shale oil reservoirs of the Permian Fengcheng Formation in the Mahu Sag of the Junggar Basin are characterized by a source and reservoir integration. Their formation process is affected by various factors, including sedimentation, diagenesis, and organic matter evolution, resulting in highly complex source rock properties and reservoir characteristics. …”
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The illusion of success: Test set disproportion causes inflated accuracy in remote sensing mapping research by Yuanjun Xiao, Zhen Zhao, Jingfeng Huang, Ran Huang, Wei Weng, Gerui Liang, Chang Zhou, Qi Shao, Qiyu Tian

“…A rigorous approach for accuracy assessment was suggested, and an example of tea plantations mapping is used to demonstrate the process and analyse potential issues in traditional approaches. …”
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Enhancing Black Soil Fertility and Microbial Community Structure via Microbial Agents to Reduce Chemical Fertilizer Dependency: A Strategy to Boost Maize Yield by Fenglin Zhang, Nan Wang, Chenyu Zhao, Luze Yang, Xingmin Zhao, Hongjun Gao, Fugui Zhang, Hongbin Wang, Ning Huang

“…Replacing a portion of chemical fertilizers with microbial agents can effectively solve these issues. In this study, we conducted a field plot experiment comparing eight different treatment combinations to investigate the effects of combining microbial agents with varying amounts of chemical fertilizers on black soil nutrients, soil ecology, and maize yield. …”
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Advances in bone tissue engineering using biomaterial based scaffolds, purine crosslinking and Wnt signaling by Celine J. Agnes, Bettina M. Willie, Aldo R. Boccaccini, Maryam Tabrizian

“…Additionally, we will highlight recent work on the design of chitosan-based scaffolds modified with purine crosslinking, to overcome cytotoxicity issues associated with other chemical crosslinkers. …”
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Cap2Seg: leveraging caption generation for enhanced segmentation of COVID-19 medical images by Wanlong Zhao, Wanlong Zhao, Fan Li, Fan Li, Yueqin Diao, Yueqin Diao, Puyin Fan, Puyin Fan, Zhu Chen, Zhu Chen

“…Cap2Seg not only segments lesion areas but also generates related medical text descriptions, guiding the segmentation process. This design enables the model to perform optimal segmentation without requiring text input during inference. …”
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An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation by Sebastian Benjamin, GW McElfresh, Maanasa Kaza, Gregory J. Boggy, Benjamin Varco-Merth, Benjamin Varco-Merth, Sohita Ojha, Shana Feltham, William Goodwin, William Goodwin, Candice Nkoy, Candice Nkoy, Derick Duell, Derick Duell, Andrea Selseth, Tyler Bennett, Aaron Barber-Axthelm, Nicole N. Haese, Nicole N. Haese, Helen Wu, Courtney Waytashek, Carla Boyle, Jeremy V. Smedley, Jeremy V. Smedley, Caralyn S. Labriola, Caralyn S. Labriola, Michael K. Axthelm, Michael K. Axthelm, R. Keith Reeves, R. Keith Reeves, Daniel N. Streblow, Daniel N. Streblow, Jonah B. Sacha, Jonah B. Sacha, Afam A. Okoye, Afam A. Okoye, Scott G. Hansen, Scott G. Hansen, Louis J. Picker, Louis J. Picker, Benjamin N. Bimber, Benjamin N. Bimber

“…Nimble uses a previously developed pseudoaligner to process either bulk- or single-cell RNA-seq data using custom gene spaces. …”
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Anxiety and inhibitory control play a chain mediating role between compassion fatigue and Internet addiction disorder among nursing staff by Xinxin Tan, Zhongzheng Li, Hong Peng, Min Tian, Jiong Zhou, Ping Tian, Jingrui Wen, Shenglin Luo, Yan Li, Ping Li, Yang Liu

“…Subjective data on compassion fatigue, internet addiction, anxiety, and inhibitory control were collected and analyzed. SPSS 26.0 and its PROCESS macro—plugin were used for data analysis. …”
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Valorization of Alkali–Thermal Activated Red Mud for High-Performance Geopolymer: Performance Evaluation and Environmental Effects by Zhiping Li, Haifeng Dong, Yuwen Wang, Jianbing Men, Junqiang Wang, Xiushao Zhao, Sikai Zou

“…This study investigates the influence of SiO₂/Al₂O₃ molar ratios (2.25–3.00) and the replacement of red mud (RM) with GGBS (50–63%) on the performance of RM-based geopolymers to address the environmental issues posed by RM, including its high alkalinity and heavy metal content. …”
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Pediatric medication management barriers faced by providers serving underserved populations and proposed solutions by Tiranun Rungvivatjarus, Tiranun Rungvivatjarus, Maria Z. Huang, Maria Z. Huang, Britanny Winckler, Britanny Winckler, Erin S. Fisher, Erin S. Fisher, Kyung E. Rhee, Kyung E. Rhee

“…Proposed solutions such as improved technology, dedicated educators, and visual aids may help address these issues while potentially decreasing medication errors.…”
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Anomaly Field Extraction Based on Layered-Earth Model and Equivalent Eddy Current Inversion: A Case Study of Borehole zk506 in Baishiquan, Xinjiang by Yi Yang, Jie Zhang, Qingquan Zhi, Yang Ou, Xingchun Wang, Lei Wang, Junjie Wu, Xiaohong Deng

“…To address the aforementioned issues, in this study, we innovatively put forward a method. …”
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An enhanced alpha evolution moss growth optimizer for prognostic prediction in spontaneous intracerebral hemorrhage by Lingxian Hou, Yongsheng Wang, Xiuqi Lin, Chengye Li, Huangrong Guo, Congcong Jin, Yi Chen, Huiling Chen, Jing Ji, Wenzong Zhu

“…Additionally, it uses an adaptive β parameter to dynamically balance the search process. AEMGO is designed to overcome common issues in traditional meta-heuristic algorithms, such as premature convergence and the exploration–exploitation imbalance, thus enabling the effective identification of key prognostic features. …”
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Kinetic and thermodynamic insights into sewage sludge torrefaction: Energetic optimization and safety considerations by Blanca Castells, Roberto Paredes, David León, Isabel Amez

“…This study provides novel insights into torrefied sewage sludge as a solid biofuel by examining both the energetic conversion process and associated safety issues. To do so, torrefaction was carried out at three different temperatures (220 °C, 250 °C, and 300 °C) and two residence times (30 and 60 min), resulting in seven distinct samples. …”
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Learning from the implementation of person-centred care: a meta-synthesis of research related to the Gothenburg framework by Emma Forsgren, Emma Forsgren, Caroline Feldthusen, Caroline Feldthusen, Caroline Feldthusen, Sara Wallström, Sara Wallström, Sara Wallström, Sara Wallström, Ida Björkman, Ida Björkman, Jana Bergholtz, Jana Bergholtz, Febe Friberg, Joakim Öhlén, Joakim Öhlén, Joakim Öhlén

“…By illustrating this complexity and providing examples of handling practical issues, this study contributes to deeper insights on PCC implementation.…”
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Opinions on hypertension care and therapy adherence at the healthcare provider and healthcare system level: a qualitative study in the Hague, Netherlands by Mattijs E Numans, Michiel L Bots, Sytske van Bruggen, Hedwig M M Vos, Rimke C Vos, Guy Rutten, Saskia E van Grondelle, Judith Meijer, Erik van Duin

“…Barriers were related to time, interdisciplinary collaboration, technical and financial issues, availability of blood pressure devices and education of people with hypertension.Conclusions This study highlighted a need for better collaboration between primary and secondary care, for more team-based care including pharmacists and social workers, tools to improve interpersonal skills and more time for patient–healthcare provider communication.…”
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Study protocol: A national cross‐sectional study on psychology and behavior investigation of Chinese residents in 2023 by Diyue Liu, Siyuan Fan, Xincheng Huang, Wenjing Gu, Yifan Yin, Ziyi Zhang, Baotong Ma, Ruitong Xia, Yuanwei Lu, Jingwen Liu, Hanjia Xin, Yumeng Cao, Saier Yang, Runqing Li, Han Li, Ji Zhao, Jin Zhang, Zheng Gao, Yaxin Zeng, Yixiao Ding, Zhuolun Ren, Yan Guan, Na Zhang, Jia Li, Yan Ma, Pei Wei, Jingjing Dong, Yajing Zhou, Yong Dong, Yan Qian, Chen Chen, Yujie Zhao, Yimiao Li, Yujia Zheng, Rongyi Chen, Xiaomeng Li, Yuke Han, Yaoyao Xia, Huixin Xu, Zhaolin Wu, Mingyou Wu, Xinrui Wu, Junyi Hou, Yuelai Cai, Xiaofan Dai, Wenbo Li, Ting Nie, Chongzhe Zhang, Xiaoya Wang, Dan Li, Siyao Yan, Zhiheng Yi, Chenxi Liu, Xinyue Zhang, Lei Shi, Haomiao Li, Feng Jiang, Xiaoming Zhou, Xinying Sun, Yibo Wu, Psychology and Behavior Investigation of Chinese Residents project team

“…The questionnaires included basic information about the individual, personal health status, basic information about the family, the social environment in which the individual lives, psychological condition scales, behavioral level scales, other scales, and attitudes towards topical social issues. Supervisors conducted quality control during the distribution process and returned questionnaires, logically checked and cleaned for data analysis. …”
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Voluntary information and price sharing database – a scoping review of the pricing and procurement landscape across eight Commonwealth Member States by Bridget Kebirungi, Phyllis Ocran, Nduta Kamere, Lynette Keneilwe Mabote, Ngozi Osi, Meghna Joshi-von Heyden, Emily Gilmour, Janneth Mghamba, Layne Robinson, Zaheer-Ud-Din Babar, Helena Rosado, Victoria Rutter

“…Background The Commonwealth Health Ministers’ meetings (2021–2023) identified medicines shortages, pricing, and price transparency as critical issues. This led to the establishment of the Voluntary Information and Price Sharing Database (VIPSD) in 2021, aimed at enhancing procurement transparency, reducing costs, and sharing information on health products amongst member states. …”
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Histone lysine crotonylation accelerates ACSL4-mediated ferroptosis of keratinocytes via modulating autophagy in diabetic wound healing by Fengjuan Li, Haowen Ye, Lanlan Li, Qingling Chen, Xianwu Lan, Liangxiu Wu, Bin Li, Lishan Li, Chuxian Guo, Milad Ashrafizadeh, Gautam Sethi, Jun Guo, Liangyan Wu

“…This study clarifies the relationships between acylation modifications, autophagy, and ferroptosis, while also offering mechanistic insights and potential therapeutic targets for issues associated with diabetic wound healing.…”
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Biochemical and Transcriptomic Analyses Reveal Key Salinity and Alkalinity Stress Response and Tolerance Pathways in <i>Salix linearistipularis</i> Inoculated with <i>Trichoderma</... by Zhouqing Han, Lili Chen, Wenyi Wang, Xueting Guan, Junjie Song, Shurong Ma

“…Soil salinization and alkalinization are pervasive environmental issues that severely restrict plant growth and crop yield. …”
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Printability in Multi-material Projection-Based 3-Dimensional Bioprinting by Chao-fan He, Tian-hong Qiao, Xu-chao Ren, Mingjun Xie, Qing Gao, Chao-qi Xie, Peng Wang, Yuan Sun, Huayong Yang, Yong He

“…Building upon this, we established a fundamental framework for multi-material printability research, encompassing its core logic and essential process specifications. Furthermore, we clarified several critical issues, including the cross-linking behavior of multicomponent bioinks, mechanical mismatch and interface strength in soft–hard composite structures, the penetration behavior of viscous bioinks within hydrogel polymer networks, liquid entrapment and adsorption phenomena in porous heterogeneous structures, and error source analysis along with resolution evaluation in multi-material printing. …”
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