Integrating Model‐Informed Drug Development With AI: A Synergistic Approach to Accelerating Pharmaceutical Innovation by Karthik Raman, Rukmini Kumar, Cynthia J. Musante, Subha Madhavan

“…By integrating the predictive power of computational models and the data‐driven insights of AI, the synergy between these approaches has the potential to accelerate drug discovery, optimize treatment strategies, and usher in a new era of personalized medicine, benefiting patients, researchers, and the pharmaceutical industry as a whole.…”
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The Use of Machine Learning for Analyzing Real-World Data in Disease Prediction and Management: Systematic Review by Norah Hamad Alhumaidi, Doni Dermawan, Hanin Farhana Kamaruzaman, Nasser Alotaiq

“…A substantial portion of studies (n=38, 67%) focused on improving clinical decision-making, patient stratification, and treatment optimization. …”
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The Role of Immunohistochemistry as a Surrogate Marker in Molecular Subtyping and Classification of Bladder Cancer by Tatiana Cano Barbadilla, Martina Álvarez Pérez, Juan Daniel Prieto Cuadra, Mª Teresa Dawid de Vera, Fernando Alberca-del Arco, Isabel García Muñoz, Rocío Santos-Pérez de la Blanca, Bernardo Herrera-Imbroda, Elisa Matas-Rico, Mª Isabel Hierro Martín

“…Further research is required to determine the optimal combination of markers, establish a consensus diagnostic algorithm, and validate IHC through large-scale trials. …”
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Machine learning-based integration develops relapse related signature for predicting prognosis and indicating immune microenvironment infiltration in breast cancer by Junyi Li, Shixin Li, Dongpo Zhang, Yibing Zhu, Yue Wang, Xiaoxiao Xing, Juefei Mo, Yong Zhang, Daixiang Liao, Jun Li

“…To address these limitations, this study systematically analyzed RNA-seq high-throughput data and combined 10 machine learning algorithms to construct 117 models. The optimal algorithm combination, StepCox[both] and ridge regression, was identified, and an immune-related gene signature (IRGS) composed of 12 genes was developed. …”
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Transforming urinary stone disease management by artificial intelligence-based methods: A comprehensive review by Anastasios Anastasiadis, Antonios Koudonas, Georgios Langas, Stavros Tsiakaras, Dimitrios Memmos, Ioannis Mykoniatis, Evangelos N. Symeonidis, Dimitrios Tsiptsios, Eliophotos Savvides, Ioannis Vakalopoulos, Georgios Dimitriadis, Jean de la Rosette

“…The terms ‘‘endourology’’, ‘‘artificial intelligence’’, ‘‘machine learning’’, and ‘‘urolithiasis'’ were used for searching eligible reports, while review articles, articles referring to automated procedures without AI application, and editorial comments were excluded from the final set of publications. …”
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Stochastic <i>H</i>_∞ Filtering of the Attitude Quaternion by Daniel Choukroun, Lotan Cooper, Nadav Berman

“…Thanks to the bilinear structure of the quaternion state-space model, the algorithm parameters are independent of the state. …”
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CSEPC: a deep learning framework for classifying small-sample multimodal medical image data in Alzheimer’s disease by Jingyuan Liu, Xiaojie Yu, Hidenao Fukuyama, Toshiya Murai, Jinglong Wu, Qi Li, Zhilin Zhang

“…Addressing this obstacle is crucial for improving diagnostic accuracy and optimizing treatment strategies for those affected by AD. …”
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Anorexia-cachexia syndrome in cancer patients: pathogenetic aspects and treatment options by A. V. Snegovoy, V. B. Larionova, I. V. Kononenko

“…Secondly, it will provide an opportunity to develop a diagnostic algorithm to prevent it. Third, the use of the identified criteria for predicting and outcome of complications both on an outpatient basis and in a hospital will be aimed at creating favorable conditions for anticancer therapy and thereby improving long-term treatment results and patients quality of life. …”
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Exploring Machine Learning Models for Vault Safety in ICL Implantation: A Comparative Analysis of Regression and Classification Models by Qing Zhang, Qi Li, Zhilong Yu, Ruibo Yang, Emmanuel Eric Pazo, Yue Huang, Hui Liu, Chen Zhang, Salissou Moutari, Shaozhen Zhao

“…Regression and classification models were developed using gradient boosting, random forest, and CatBoost algorithms. Regression models predicted vault height as a continuous variable, while classification models categorized vault heights into binary and multi-class tasks. …”
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Thyroid nodule classification in ultrasound imaging using deep transfer learning by Yan Xu, Mingmin Xu, Zhe Geng, Jie Liu, Bin Meng

“…In this study, we investigate the predictive efficacy of distinguishing between benign and malignant thyroid nodules by employing traditional machine learning algorithms and a deep transfer learning model, aiming to advance the diagnostic paradigm in this field. …”
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Integrating data from unmanned aerial vehicles and Sentinel-2 with PROSAIL-5D-driven machine learning for fuel moisture content estimation in agroecosystems by Jinlong Liu, Jia Jin, Jing Huang, Mengjuan Wu, Shaozheng Hao, Haoyi Jia, Tengda Qin, Yuqing Huang, Dan Chen, Nathsuda Pumijumnong

“…To address the challenge of sparse ground observations, a calibrated PROSAIL-5D radiative transfer model was used to simulate diverse spectral responses, augmenting the training dataset. A genetic algorithm-optimized backpropagation neural network was then applied to assess the effectiveness of the fused remote sensing data and PROSAIL-5D simulation in improving FMC retrieval accuracy. …”
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Using proximal sensor data for soil salinity management and mapping by Yan GUO, Yin ZHOU, Lian-qing ZHOU, Ting LIU, Lai-gang WANG, Yong-zheng CHENG, Jia HE, Guo-qing ZHENG

“…We concluded that two management zones are optimal to guide precision management. Zone A had an average salinity level of about 165 mS m−1, in which salt-tolerant crops, such as cotton and barley can grow normally, while crops such as soybean and cowpeas may be planted using leaching and increasing the mulching film methods to reduce the accumulation of salt in surface soil. …”
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Cost-effectiveness of FIT and a FIT-based model to optimise symptomatic diagnosis of colorectal cancer: health economic modelling for the COLOFIT project by Linda Sharp, Sarah Bailey, Colin Rees, Willie Hamilton, Dawn Craig, Joe West, David Humes, Gary Abel, James Turvill, Brian Nicholson, Chloe Thomas, Jim Chilcott, Colin Crooks, Olena Mandrik, John Whelpton

“…However, strategies to improve diagnosis in the under 50s would be necessary to mitigate potential harm. …”
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Saliva-derived transcriptomic signature for gastric cancer detection using machine learning and leveraging publicly available datasets by Catarina Lopes, Andreia Brandão, Manuel R. Teixeira, Mário Dinis-Ribeiro, Carina Pereira

“…Further research is warranted to optimize saliva-derived molecular signatures, increasing their sensitivity and specificity for early cancer detection and advance the use of liquid biopsies in personalized medicine for improved screening, diagnostic and prognostic capabilities.…”
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Double‐row suture‐bridge technique does not yield better clinical and radiological results than single‐row technique in patients older than 55 years at 2 years minimum follow‐up: A... by Vito Gaetano Rinaldi, Sassoli Iacopo, Federico Coliva, Antongiulio Favero, Alberto Bazzocchi, Marco Miceli, Stefano Di Paolo, Stefano Zaffagnini, Giulio Maria Marcheggiani Muccioli

“…Further research, including randomized controlled trials with long‐term follow‐up, is needed to refine treatment algorithms and improve patient outcomes in rotator cuff surgery. …”
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Dynamic Dwell Time Adjustment in Wire Arc-Directed Energy Deposition: A Thermal Feedback Control Approach by Md Munim Rayhan, Abderrachid Hamrani, Fuad Hasan, Tyler Dolmetsch, Arvind Agarwal, Dwayne McDaniel

“…Experimental validation demonstrated improvements in thermal management, with the dynamic control system maintaining an average temperature undershoot of 1.38% while achieving 96.29% optimal temperature window compliance. …”
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Development and validation of a quick screening tool for predicting neck pain patients benefiting from spinal manipulation: a machine learning study by Changxiao Han, Guangyi Yang, Haibao Wen, Minrui Fu, Bochen Peng, Bo Xu, Xunlu Yin, Ping Wang, Liguo Zhu, Minshan Feng

“…Results The combined LASSO and Boruta algorithms identified nine optimal predictors, with the union feature set achieving superior performance. …”
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Deep Residual Transfer Ensemble Model for mRNA Gene-Expression-Based Breast Cancer by Job Prasanth Kumar Chinta Kunta, Vijayalakshmi A. Lepakshi

“…Being consensus-driven solution, it improved reliability of breast cancer prediction results. …”
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AGW-YOLO-Based UAV Remote Sensing Approach for Monitoring Levee Cracks by HU Weibo, ZHOU Shaoliang, ZHAO Erfeng, ZHAO Xueqiang

“…The incorporation of the Adown module, GMA attention mechanism, and WIoUv3 loss function effectively reduced the model's parameters and computational complexity, while significantly improving the accuracy and robustness of levee crack detection. …”
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Automated Recognition of Abnormalities in Gastrointestinal Endoscopic Images – Evaluation of an AI Tool for Identifying Polyps and Other Irregularities by Weronika Jarych, Elżbieta Tokarczyk, Patryk Iglewski, Daria Ziemińska, Karina Motolko, Rafał Burczyk, Konrad Duszyński, Michał Kociński, Jan Reinald Wendt

“…Key advantages of AI integration in endoscopy include improved sensitivity, minimized detection errors, and the potential to optimize clinical workflow efficiency. …”
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