The Potential of Artificial Intelligence in Pharmaceutical Innovation: From Drug Discovery to Clinical Trials by Vera Malheiro, Beatriz Santos, Ana Figueiras, Filipa Mascarenhas-Melo

“…AI has revolutionized drug discovery and development by enabling rapid and effective analysis of vast volumes of biological and chemical data during the identification of new therapeutic compounds. The algorithms developed can predict the efficacy, toxicity, and possible adverse effects of new drugs, optimize the steps involved in clinical trials, reduce associated time and costs, and facilitate the implementation of innovative drugs in the market, making it easier to develop precise therapies tailored to the individual genetic profile of patients. …”
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Innovative approach for gauge-based QPE in arid climates: comparing neural networks and traditional methods by Bayan Banimfreg, Ernesto Damiani, Vesta Afzali Gorooh, Duncan Axisa, Luca Delle Monache, Youssef Wehbe

“…The superior performance of the neural network approach suggests significant potential for improving water resource management practices, optimizing cloud seeding interventions, and informing policy decisions. …”
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Automated segmentation of brain metastases in T1-weighted contrast-enhanced MR images pre and post stereotactic radiosurgery by Hemalatha Kanakarajan, Wouter De Baene, Patrick Hanssens, Margriet Sitskoorn

“…Abstract Background and purpose Accurate segmentation of brain metastases on Magnetic Resonance Imaging (MRI) is tedious and time-consuming for radiologists that could be optimized with deep learning (DL). Previous studies assessed several DL algorithms focusing only on training and testing the models on the planning MRI only. …”
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Heterogeneous Graph Attention Networks for Scheduling in Cloud Manufacturing and Logistics by Dmitrii Fomin, Ilya Makarov, Mariia Voronina, Anna Strimovskaya, Vitaliy Pozdnyakov

“…Our model minimizes both manufacturing and logistics costs, achieving significant performance improvements over greedy algorithms and comparable results to strong genetic algorithms in large-scale scenarios with up to 20 locations. …”
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The potential role of next-generation sequencing in identifying MET amplification and disclosing resistance mechanisms in NSCLC patients with osimertinib resistance by Xiao Xiao, Xiao Xiao, Ren Xu, Ren Xu, Jun Lu, Beibei Xin, Chenyang Wang, Kexin Zhu, Hao Zhang, Xinyu Chen

“…With FISH results as gold standard, enumeration algorithm was applied to establish the optimal model for identifying MET amplification using gene copy number (GCN) data.ResultsThe optimal model for identifying MET amplification was constructed based on the GCN of MET, BRAF, CDK6 and CYP3A4, which achieved a 74.0% overall agreement with FISH and performed well in identifying MET amplification except polysomy with a sensitivity of 85.7% and a specificity of 93.9%. …”
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Integrating Machine Learning and Material Feeding Systems for Competitive Advantage in Manufacturing by Müge Sinem Çağlayan, Aslı Aksoy

“…Material feeding systems are of pivotal importance in the optimization of productivity, with attendant improvements in quality, reduction of costs, and minimization of delivery times. …”
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Machine Learning-Driven Prediction of One-Year Readmission in HFrEF Patients: The Key Role of Inflammation by Ma F, Hu Y, Han P, Qiu Y, Liu Y, Ren J

“…Predicting one-year readmission risk is crucial for optimizing treatment and reducing costs.Methods: We conducted a single-center retrospective study on adult HFrEF patients admitted to the Cardiovascular Department of the First Affiliated Hospital, Zhejiang University School of Medicine on January 2020 and March 2023. …”
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Application of artificial intelligence in electrochemical diagnostics for human health by Koushlesh Ranjan, Basanti Barar, Minakshi Prasad, Gaya Prasad

“…AI also assists in optimizing sensor design, manages large datasets, and improves the performance and reliability of electrochemical diagnostics (ED) devices. …”
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Electricity nowcasting and forecasting efficiency in blockchain-integrated energy trading platforms by Ameni Boumaiza

“…Our methodology integrates real-time nowcasting algorithms and machine learning-based forecasting models to optimize electricity distribution, battery storage utilization, and cost efficiency within the marketplace. …”
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Predicting Subcontractor Performance Using Web-Based Evolutionary Fuzzy Neural Networks by Chien-Ho Ko

“…The use of inappropriate subcontractors may result in individual work delays, cost overruns, and quality defects throughout the project. …”
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Electrophysiological changes in the acute phase after deep brain stimulation surgery by Lucia K. Feldmann, Diogo Coutinho Soriano, Jeroen Habets, Valentina D'Onofrio, Jonathan Kaplan, Varvara Mathiopoulou, Katharina Faust, Gerd-Helge Schneider, Doreen Gruber, Georg Ebersbach, Hayriye Cagnan, Andrea A. Kühn

“…Background: With the introduction of sensing-enabled deep brain stimulation devices, characterization of long-term biomarker dynamics is of growing importance for treatment optimization. The microlesion effect is a well-known phenomenon of transient clinical improvement in the acute post-operative phase. …”
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A variable threshold ring signature scheme for privacy protection in smart city blockchain applications by Guo Hongzhi, Qin Haowen

“…We further introduce an optimized batch-verification algorithm that cuts the number of expensive pairing checks per signature from O(n) to $$O(1) + n$$ O ( 1 ) + n , dramatically improving throughput. …”
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Machine learning to predict virological failure among HIV patients on antiretroviral therapy in the University of Gondar Comprehensive and Specialized Hospital, in Amhara Region, E... by Daniel Niguse Mamo, Tesfahun Melese Yilma, Makda Fekadie Tewelgne, Yakub Sebastian, Tilahun Bizuayehu, Mequannent Sharew Melaku, Agmasie Damtew Walle

“…Thus, Machine learning predictive algorithms have the potential to improve the quality of care and predict the needs of HIV patients by analyzing huge amounts of data, and enhancing prediction capabilities. …”
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Early Warning of Axillary Lymph Node Metastasis in Breast Cancer Patients Using Multi-Omics Signature: A Machine Learning-Based Retrospective Study by Ke Z, Shen L, Shao J

“…The AUC of GLRM was 0.818 (95% CI: 0.757~0.879), significantly lower than that of RFM’s AUC 0.893 (95% CI: 0.836~0.950).Conclusion: The prediction models based on machine learning (ML) algorithms and multiomics have shown good performance in predicting ALN metastasis, and RFM shows greater advantages compared to traditional GLRM. …”
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Histopathological Image Analysis Using Machine Learning to Evaluate Cisplatin and Exosome Effects on Ovarian Tissue in Cancer Patients by Tuğba Şentürk, Fatma Latifoğlu, Çiğdem Gülüzar Altıntop, Arzu Yay, Zeynep Burçin Gönen, Gözde Özge Önder, Özge Cengiz Mat, Yusuf Özkul

“…Further research is warranted to validate these findings and optimize treatment protocols.…”
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Research on High Arch Dam Deformation Monitoring Model with Deep Capturing Related Features in Factor-time Dimensions by XUE Jianghan, ZHANG Pengtao, TIAN Jichen, LU Xiang, CHEN Jiankang, Guo Yinju

“…However, at the present stage, the dam prediction model based on machine learning mostly adopts the means of data preprocessing, using optimization algorithm, and using the model's characteristics to stack multiple models, lacking in in-depth consideration of the physical mechanism of dam deformation. …”
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Federated Learning-Based Credit Card Fraud Detection: A Comparative Analysis of Advanced Machine Learning Models by Zheng Han

“…However, system heterogeneity, communication costs, and data imbalance remain critical. Oversampling techniques, model optimization, and reduced communication rounds were used to mitigate the issues. …”
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The Emergence of AI-Driven Virtual Hospitals: Redefining Patient Care Beyond Physical Boundaries by Ifrah Hameed, Hafiz Muhammad Haseeb Khaliq

“…For example, AI-based support systems offer data-driven insights that improve diagnostic accuracy and patient outcomes thus transforming healthcare delivery 3. …”
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Machine learning for detection of diffusion abnormalities-related respiratory changes among normal, overweight, and obese individuals based on BMI and pulmonary ventilation paramet... by Xin-Yue Song, Xin-Peng Xie, Wen-Jing Xu, Yu-Jia Cao, Bin-Miao Liang

“…We evaluated the effectiveness of various supervised ML algorithms and identified the optimal configurations for these applications. …”
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HOW I TREAT PH+ ACUTE LYMPHOBLASTIC LEUKEMIA by Robin Foà

“…I have been asked to cover ‘How I Treat Ph+ALL’, which more appropriately should be ‘How Should I Treat Ph+ LL’ Based on the 25-year experience gathered through the GIMEMA trials, the optimal algorithm should be: i) Identify the presence of the BCR/ABL gene lesion within one week from diagnosis; ii) During this time treat patients with steroids; iii) Start induction with dasatinib or ponatinib plus steroids, with no systemic chemotherapy; iv) CNS prophylaxis should be carried out; v) MRD should be monitored molecularly at given timepoints; vi) After induction, all patients should be consolidated with multiple cycles of blinatumomab (up to 5 in our protocols); vii) TKI should not be stopped. …”
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