Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms by Laura Ryder, Frederic Schrøder Arendrup, José Francisco Martínez, Goda Snieckute, Chiara Pecorari, Riyaz Ahmad Shah, Anders H. Lund, Melanie Blasius, Simon Bekker-Jensen

“…In addition, NO production is associated with ZNF598-mediated ubiquitination of the ribosomal protein RPS10 and GCN2-mediated activation of the integrated stress response, which are well-described responses to the collision of ribosomes. In sum, our work implicates a novel role of NO as an inducer of ribosome collision and activation of ribosomal surveillance mechanisms in human cells.…”
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CardioGenAI: a machine learning-based framework for re-engineering drugs for reduced hERG liability by Gregory W. Kyro, Matthew T. Martin, Eric D. Watt, Victor S. Batista

“…Scientific contribution This work introduces CardioGenAI, an open-source machine learning-based framework designed to re-engineer drugs for reduced hERG liability while preserving their pharmacological activity. …”
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