Are deprivation-specific cancer survival patterns similar according to individual-based and area-based measures? A cohort study of patients diagnosed with five malignancies in Engl... by Lucy Elliss-Brookes, Aurélien Belot, Matthew Baker, Fiona C Ingleby, Laura M Woods, Iain M Atherton

“…The magnitude of differentials was similar for area-based and individually-derived measures of deprivation, which was unexpected.Conclusion These unique data suggest that the socioeconomic influence of ‘person’ is different to that of ‘place’ with respect to cancer outcomes. This has implications for health policy aimed at reducing inequalities. …”
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High correlation between detection of dengue IgG from dried blood spots and serum using an indirect IgG ELISA assay: A validation study in Fortaleza, Brazil. by Monica Zahreddine, Beatriz Parra, Laura Pierce, Danielle Ferreira de Oliveira, Mabel Carabali, Katia Charland, Kellyanne Abreu, Valéry Ridde, Danielle Malta Lima, Kate Zinszer

“…The validity of using DBS for ELISA to detect prior dengue infection could have important implications for field-based research. A limitation to this study was that the potential for misclassification due to cross-reactivity (e.g., with Zika virus, Yellow Fever vaccine) was not assessed.…”
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Contributions of a community health worker program in improving district health system performance in South Africa, using routine health service variables in a quasi-experimental s... by Leena Susan Thomas, Joyce Jordaan, Yogan Pillay, Eric Buch

“…Methods This study takes place in the Ekurhuleni health district, in urban South Africa. …”
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Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies [version 4; peer review: 1 approved, 2 approved w... by Tolulope Ogunnusi, Oghenerobor Akpor, Peter Olagbemide, Babafemi Laoye

“…The key findings from this review via the selected case studies revealed the socio-economic and environmental dimensions of the issue, providing a contextual understanding of region-specific vulnerabilities and health outcomes. …”
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Association between the triglyceride-glucose index and severe left main and/or three-vessel disease in patients with non-ST-segment elevation myocardial infarction: a dual-centre r... by Shaoyuan Chen, Peiyi Xie, Xueying Han, Yulian Huang, Dongdong Chen, Haigang Zhang, Bihan Huang

“…The TyG could serve as a non-invasive marker for predicting severe CAD and have implications for guiding treatment strategies in patients with NSTEMI.…”
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Was size of healthcare institution a factor affecting changes in healthcare utilisation during the COVID-19 pandemic in Korea? A retrospective study design analysing national healt... by Chris Lane, Hyun-Ji Lee, Young-Taek Park, Jinhyung Lee

“…Objectives Many small-sized healthcare institutions play a critical role in communities by preventing infectious diseases. This study examines how they have been impacted by the global COVID-19 pandemic compared with large hospitals.Design This study adopted a retrospective study design looking back at the healthcare utilisation of medical facilities according to size after the COVID-19 pandemic. …”
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Identification of individual-level clinical factors associated with increased risk of death during heatwaves: a time-stratified case-crossover study using national primary care rec... by Shakoor Hajat, Ross Thompson, Sari Kovats, Emer O’Connell, Helen Macintyre

“…Results presented have important implications for patient medication management during heat events, incorporating heat-risk considerations into other health policies such as suicide prevention plans and highlighted potential differences between clinical vulnerability and patients at risk.…”
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Lessons learned from the participatory development of a framework to actively involve people living with dementia, individuals from their social networks, and healthcare profession... by Mike Rommerskirch-Manietta, Christina Manietta, Anna Louisa Hoffmann-Hoffrichter, Helga Rohra, Lisa Fink, Heidemarie Kelleter, Helga Elisabeth Breimaier, Johanna Möller, Stefanie Oberfeld, Birgit Alpers, Martina Roes

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Complex immunohistochemical and molecular study on 5 cases of ovarian juvenile granulosa cell tumors reveals a consistent alteration in the PI3K/AKT/mTOR signaling pathway by Adam Šafanda, Nikola Hájková, Michaela Kendall Bártů, Marián Švajdler, Radoslav Matěj, Jitka Hausnerová, Tomáš Zima, Pavel Dundr, Kristýna Němejcová

“…Conclusion The results of our study further support the hypothesis that the pathogenesis of JGCT may be driven by activation of the PIK3/AKT/mTOR pathway. …”
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Implementation of a Social Media Strategy for Public Health Promotion in Black, American Indian or Alaskan Native, and Hispanic or Latino Communities During the COVID-19 Pandemic:... by Maria Mora Pinzon, Ornella Hills, George Levy, Taryn T James, Ashley Benitez, Sacheen Lawrence, Tiffany Ellis, Venus Washington, Lizbeth Solorzano, Patricia Tellez-Giron, Fernando Cano Ospina, Melissa F Metoxen, Carey E Gleason

“…ConclusionsOur project presents a unique and effective model for health messages and highlights the need for tailoring social media messages and approaches for minoritized audiences (eg, age, gender, race, and ethnicity). Further research studies are needed to explore how specific types of information affect the dissemination of information and the implications for health communications.…”
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The complexity of interpersonal physiology during rupture and repair episodes in the treatment of borderline personality disorder: a proof-of-concept multimethod single case study... by Stine S. Høgenhaug, Stine S. Høgenhaug, Sune V. Steffensen, Sune V. Steffensen, Sune V. Steffensen, Sune V. Steffensen, Franco Orsucci, Franco Orsucci, Giovanna Zimatore, Giovanna Zimatore, Guenter Schiepek, Mickey T. Kongerslev, Mickey T. Kongerslev, Anthony Bateman, Gry Kjaersdam Telléus, Gry Kjaersdam Telléus

“…Physiological arousal is found to underlie important alliance processes, including emotion regulation, relatedness, security, empathic responding, sense-making, and validation in correspondence with different therapist verbal and non-verbal markerbs.DiscussionClinical implications and study limitations are discussed. Recommendations are made for future directions in relation to applying multimethod approaches when studying rupture and repair processes in psychotherapy.…”
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Elements of burden among informal caregivers of community-dwelling older adults receiving home care nursing: a cross-sectional study on health status, well-being, and gender differ... by Sirry Sif Sigurlaugardottir, Sigurveig H. Sigurdardottir, Thor Aspelund, Kristin Bjornsdottir, Magnus Jegermalm, Kjartan Olafsson, Ingibjorg Hjaltadottir

“…Conclusions Caregiver burden is a multidimensional construct with significant implications for caregiver well-being. Key predictors of reduced well-being include self-perceived burden, multifaceted strain, and a diminished sense of life satisfaction. …”
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Boswellia carteri Birdw. Resin Extract Induces Phase-I Cytochrome P-450 Enzyme Gene Expressions in Human Hepatocarcinoma (Hep G2) Cells: In vitro and in silico Studies by Alghamdi SS, Albahlal HN, Alajmi RS, Alsharidah A, Almogren A, Suliman R, Alehaideb ZI

“…Sahar S Alghamdi,1– 3 Hussah N Albahlal,1 Raghad Saleh Alajmi,1 Amani Alsharidah,4 Aljawharah Almogren,2 Rasha Suliman,5 Zeyad I Alehaideb1– 3 1King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia; 2King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia; 3Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia; 4King Saud University (KSU), Riyadh, Saudi Arabia; 5Fatima College for Health Sciences, Abu Dhabi, United Arab EmiratesCorrespondence: Sahar S Alghamdi, Email ghamdisa@ksau-hs.edu.saIntroduction: Boswellia carteri (B. carteri) resin is widely recognized for its anti-inflammatory, wound-healing, and immunomodulatory properties. This study examines the ability of its aqueous extracts to modulate the expression of key cytochrome P450 (CYP) enzymes—CYP1A2, CYP2B6, and CYP3A4—in Hep G2 cells, emphasizing pharmacokinetic and toxicological implications.Methods: Aqueous extracts were evaluated for endotoxin contamination and cytotoxicity to ensure suitability for in vitro experimentation. …”
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A Post-Authorisation Safety Study of a Respiratory Syncytial Virus Vaccine in Pregnant Women and Their Offspring in a Real-World Setting: Generic Protocol for a Target Trial Emulat... by Odette de Bruin, Linda Nab, Jungyeon Choi, Oisin Ryan, Hae-Won Uh, Fariba Ahmadizar, Shahar Shmuel, Heather Rubino, Kitty Bloemenkamp, Cynthia de Luise, Miriam Sturkenboom

“…It aims to guide researchers in designing studies and should be adapted to specific settings and data availability.…”
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Multiple first-line therapeutic strategies to mitigate artemisinin resistance: cost analysis of a pilot study from a health system perspective in Kaya health district, Burkina Faso by Rosemonde M. Guissou, Jean Moïse T. Kaboré, Issiaka Soulama, Denise Hien, Yacouba Nombré, Alfred B. Tiono, Christian Burri, Sodiomon B. Sirima

“…Methods Microcosting and activity-based costing approaches were used to assess the cost for providers, of the MFT pilot study implemented in Kaya Heath District, from December 2019 to November 2020. …”
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Restorativeness mediates the effect of a brief virtual reality mindfulness exposure with a multi-ethnic group in a natural environment on global identity salience: a pilot study wi... by Claudia Russo, Luciano Romano, Davide Clemente, Alessia Congiu, Roberta Rodelli, Claudia Navarini, Angelo Panno

“…While scholars have highlighted the role of mindfulness and restorativeness in promoting global identity per se, there is a lack of studies hypothesizing their involvement in a unique framework and adopting virtual reality (VR) as a tool. …”
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Implementation and User Satisfaction of a Comprehensive Telemedicine Approach for SARS-CoV-2 Self-Sampling: Monocentric, Prospective, Interventional, Open-Label, Controlled, Two-Ar... by Florian Voit, Johanna Erber, Silvia Egert-Schwender, Michael Hanselmann, Michael Laxy, Victoria Kehl, Dieter Hoffmann, Samuel D Jeske, Thomas Michler, Ulrike Protzer, Florian Kohlmayer, Roland M Schmid, Christoph D Spinner, Simon Weidlich

“…ObjectiveThis feasibility study aimed to examine a comprehensive telemedicine approach for SARS-CoV-2 testing, focusing on the practicality, user satisfaction, and economic implications of self-sampling guided by a telemedicine platform. …”
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Evaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in ch... by Sacha Stelzer-Braid, Michael Doumit, Michael J Coffey, Isabelle R McKay, Sandra Chuang, Susan Adams, Shafagh A Waters, Nadine A Kasparian, Torsten Thomas, Tamarah Katz, Chee Y Ooi

“…Alterations in diet and intestinal and respiratory microbiomes may have important implications for physical and psychosocial health. Diet influences the intestinal microbiome and should be considered when exploring disease-specific alterations. …”
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Timing of singleton births by onset of labour and mode of birth in NHS maternity units in England, 2005-2014: A study of linked birth registration, birth notification, and hospital... by Peter Martin, Mario Cortina-Borja, Mary Newburn, Gill Harper, Rod Gibson, Miranda Dodwell, Nirupa Dattani, Alison Macfarlane

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Relationship Between Muscle Tone and Elasticity: Simultaneous Quantitative Assessment Using Train-of-Four Monitoring and Continuous Shear Wave Elastography During Anesthesia Induct... by Hitoshi Shitara, Tadanao Hiroki, Ren Koda, Tsuyoshi Sasaki, Masataka Kamiyama, Ryosuke Miyamoto, Kurumi Nakase, Fukuhisa Ino, Takuma Kachi, Rie Mieda, Chizu Aso, Yoshiki Yamakoshi, Shigeru Saito, Hirotaka Chikuda

“…These findings have implications for improving intraoperative muscle function assessments and advancing the application of C-SWE in clinical practice.…”
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