Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data fro... by Simon Gilbody, Dean McMillan, Bob Phillips, Kym I E Snell, Richard D Riley, David A Richards, Jaime Delgadillo, Shehzad Ali, Chris Salisbury, Lewis W Paton, Lucinda Archer, Peter A Coventry, Stephen Pilling, Andrew S Moriarty, Joshua E J Buckman, Nick Meader, Carolyn A Chew Graham

“…Relationship status warrants further research to explore its role as a prognostic factor for relapse.Clinical implications Until we can accurately stratify patients according to risk of relapse, a universal approach to relapse prevention may be most beneficial, either during acute-phase treatment or post remission. …”
Get full text

Potential of Urinary Mutation and Methylation Biomarkers in Selecting Candidates for Repeat Transurethral Resection of Bladder Tumor in Non–muscle-invasive Bladder Cancer: A Prospe... by Xiao Yang, Lingkai Cai, Yaqun Xin, Xinfeng Chen, Bing Zheng, Jie Han, Lin Yuan, Xuejian Yang, Pengchao Li, Juntao Zhuang, Peikun Liu, Ruixi Yu, Rongjie Bai, Yiyang Liu, Tonghui Ma, Qiang Cao, Qiang Lu

“…Conclusions and clinical implications: The OncoUrine test may identify patients who can avoid unnecessary re-TURBT, especially for intermediate-risk NMIBC cases and high-risk NMIBC cases with DM in the initial TURBT specimen. …”
Get full text

Agreeing a set of biopsychosocial variables for collection across the UK Eating Disorders Clinical Research Network: a consensus study using adapted nominal group technique by Lu Qi, Sarah Byford, Agnes Ayton, Sabine Landau, Gerome Breen, Dasha Nicholls, Ulrike Schmidt, Daniel Munblit, Tom Jewell, James Downs, Stephen Anderson, Anna Carnegie, Sheryllin McNeil, Clare Llewellyn, Moritz Herle, Jessica Griffiths, Suzanne Baker, Iona Smith, Saakshi Kakar, Laura Meldrum, Una Foye, Chelsea M Malouf, Hope Virgo, Marilyn Okoro, Karina L Allen

Get full text

The Influence of Fashion Involvement, Hedonic Consumption, and Shopping Lifestyle on Generation Z Consumer Preferences Through Hedonic Shopping Motivation (A Study on Inzia Scarf H... by Nadhiva Auliya Fatmala, Nurul Azizah

“…The variable that most significantly affects Consumer Preferences is Hedonic Shopping Motivation, followed by Shopping Lifestyle, then Fashion Involvement and Hedonic Consumption. This study provides theoretical implications by enriching the understanding of consumer behavior and market segmentation, as well as practical implications for companies in enhancing marketing strategies, product development, and shopping experiences following Generation Z preferences. …”
Get full text

Pain Relief as a Primary Treatment Goal: at What Point does Functioning and Well-Being Become more Important? a Case Study of an Adolescent with Debilitating Chronic Pain by Andrew S Tseng, Karen Weiss, Tracy Harrison, Dan Hansen, Barbara Bruce

Get full text

Leveraging clustering techniques to drive sustainable economic innovation in the India–Gulf interchange by Ibrahim Rashid Al-Shamsi, Boumedyen Shannaq

“…The findings advocate for strategic collaborations and offer a model methodology for sustainable development, with broader policy implications. The study reveals that Current Saudi Arabia’s progress is linked to strategies akin to India’s, suggesting India as a model for Gulf countries.…”
Get full text

Improving Quality of Care Through Detection of Complexity Among Community‐Dwelling Older People Receiving District‐Nurse Support: ImPaCt Study Randomised Controlled Trial by Jennifer Boak, Tshepo Rasekaba, Irene Blackberry

“…Future studies should explore clients' perspectives, the PCI's effect on and implications for hospital (re)admissions and longevity at home. …”
Get full text

Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors. by Martijn van de Bunt, Jocelyn E Manning Fox, Xiaoqing Dai, Amy Barrett, Caleb Grey, Lei Li, Amanda J Bennett, Paul R Johnson, Raymond V Rajotte, Kyle J Gaulton, Emmanouil T Dermitzakis, Patrick E MacDonald, Mark I McCarthy, Anna L Gloyn

Get full text

A Theoretical Study on the Efficacy and Mechanism of Combined YAP-1 and PARP-1 Inhibitors in the Treatment of Glioblastoma Multiforme Using Peruvian Maca <i>Lepidium meyenii</i> by Albert Gabriel Turpo-Peqqueña, Sebastian Luna-Prado, Renato Javier Valencia-Arce, Fabio Leonardo Del-Carpio-Carrazco, Badhin Gómez

“…The proteins YAP-1 (Yes-associated protein 1) and PARP-1 (Poly-(ADP-ribose)–polymerase-1) have been implicated in this resistance, playing crucial roles in cell proliferation and DNA repair mechanisms, respectively. …”
Get full text

Enterovirus Detection Trends Based on Respiratory Specimens from a Single Tertiary Hospital in Korea (2018–2024): A Retrospective Study Using Multiplex PCR Data by Jeong Su Han, Sung Hun Jang, Jae-Sik Jeon, Jae Kyung Kim

“…Certain serotypes have been implicated in respiratory infections; however, epidemiological studies analyzing EV circulation based on clinical respiratory specimens are limited in Korea. …”
Get full text

Genetic profiling of rat gliomas and cardiac schwannomas from life-time radiofrequency radiation exposure study using a targeted next-generation sequencing gene panel. by Ashley M Brooks, Andrea Vornoli, Ramesh C Kovi, Thai Vu T Ton, Miaofei Xu, Ahmed Mashal, Eva Tibaldi, Federica Gnudi, Jian-Liang Li, Robert C Sills, John R Bucher, Daniele Mandrioli, Fiorella Belpoggi, Arun R Pandiri

Get full text

Macrophage Migration Inhibitory Factor and Malondialdehyde as Potential Predictors of Vascular Risk Complications in Type 2 Diabetes Mellitus: Cross-Sectional Case Control Study in... by Heba Kamal Morsi, Manar Mohammad Ismail, Hassan Abdelaziz Hassan Gaber, Amani Abdelhamid Elbasmy

Get full text

A comparative study of the antioxidant activities of three series of first- and second-generation PPI dendrimers (G1 and G2) functionalized by2- hydroxy-P-naphthoquinone by El Hadji Gorgui DIOUF, Talibouya NDIOR, Lahad NIANG, Mamadou Kébé, Mamadou Latyr Ndour, Adama Faye, Ibrahima BA, Nicolas Cyrille AYESSOU, Moussoukoye DIOP

“…Oxidative stress is caused by an imbalance between the pro-oxidant and antioxidant systems, with the former benefiting. It is implicated in numerous pathologies, either as a cause or a consequence. …”
Get full text

Indonesian language policy and perspectives on its implementation in promoting Bahasa Indonesia as an international language by Gatut Susanto, David Pickus, DeAndree Espree-Conaway, Suparmi, Awaludin Rusiandi, Hany Noviya

“…Bahasa Indonesia is currently studied by many foreign students and taught internationally. …”
Get full text

The Novel Action of miR-193b-3p/CDK1 Signaling in HCC Proliferation and Migration: A Study Based on Bioinformatic Analysis and Experimental Investigation by Xue Pang, Wei Wan, Xingxing Wu, Yu Shen

“…Functional analysis results implicated that DEGs are significantly associated with “cell cycle,” “cell division,” and “proliferation.” …”
Get full text

Clinicians’ experience with infographic summaries from the BMJ Rapid Recommendations: a qualitative user-testing study among residents and interns at a large teaching hospital in S... by Thomas Agoritsas, Per Vandvik, Tiffany Hirschel

“…Despite their generally positive experience, several users had limited understanding of key GRADE (Grading of Recommendations Assessment, Development and Evaluation) domains of the quality of evidence and remained uncertain by the implication of weak or conditional recommendations.Conclusion Our study allowed to identify several aspects of guideline formats that improve their understandability and usefulness. …”
Get full text

A phosphoproteomic study uncovers the importance of PP2A-B56α in liver injury precipitated by NLRP3 activation during MC-LR exposure by Haimeng Yin, Haonan Jiang, Rong Zhao, Yanqiao Zhang, Xing Fan, Xuguang Zhai, Xiaolong Yang, Yali Zhang

“…Phosphoproteomic profiling has revealed that perturbation in biological processes, such as cytoskeleton, junction integrity, translation and transcription, and metabolism, play a contributory role in NLRP3 inflammasome-mediated liver injury. In vitro studies have elucidated the roles of phosphorylated proteins in various biological processes: phosphorylated IQGAP2 is associated with the formation of F-actin stress fibers, phosphorylated ZO-1 is implicated in junctional discontinuity, and phosphorylated eIF4B is involved in the enhancement of cap-dependent translation induced by MC-LR. …”
Get full text

The association of genetic polymorphisms in interleukin-1 receptors type 1 and type 2 with sudden sensorineural hearing loss in a Taiwanese population: a case control study by Chen-Yu Chien, Shu-Yu Tai, Kuan-Hui Li, Hua-Ling Yang, Leong-Perng Chan, Edward Hsi, Ling-Feng Wang, Kuen-Yao Ho, Ning-Chia Chang

“…Abstract Background Sudden sensorineural hearing loss (SSNHL) is a disease with an unknown etiology; damage to the auditory nerve from inflammation due to viral infection or vascular incidents has been implicated. According to several studies, cytokines, including interleukins, are associated with SSNHL in terms of serum expression and genetic polymorphisms. …”
Get full text

Polycystic ovary syndrome, androgen excess, and the risk of nonalcoholic fatty liver disease in women: A longitudinal study based on a United Kingdom primary care database. by Balachandran Kumarendran, Michael W O'Reilly, Konstantinos N Manolopoulos, Konstantinos A Toulis, Krishna M Gokhale, Alice J Sitch, Chandrika N Wijeyaratne, Arri Coomarasamy, Wiebke Arlt, Krishnarajah Nirantharakumar

“…<h4>Background</h4>Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), which affects 10% of women and represents a lifelong metabolic disorder, with increased risk of type 2 diabetes, hypertension, and cardiovascular events. Previous studies have suggested an increased risk of nonalcoholic fatty liver disease (NAFLD) in individuals with PCOS and implicated androgen excess as a potential driver.…”
Get full text

Genetic characterization of Plasmodium vivax linked to autochthonous malaria transmission in the US (2023) using Illumina AmpliSeq technology: a genetic epidemiology studyResearch... by Joel L.N. Barratt, David Jacobson, Edwin Pierre-Louis, Marko Bajic, Julia Kelley, Dhruviben S. Patel, Ira Goldman, Zhiyong Zhou, Ya Ping Shi, Alison Ridpath, Kimberly Mace, Christina Carlson, Alice Sutcliffe, Qiana Butler, Andrea Morrison, Danielle Stanek, Kelly Tomson, Carina Blackmore, Andrew Cannons, Susan Rollo, Chun Wang, Rashmi Tuladhar, Brooke Clemons, Susan Madison-Antenucci, Kimberly Mergen, Jennifer White, Mike Antwi, Laura Rothfeldt, Katelyn Lazenby, Stephen Hedges, Jennifer N. Shray, Ashleah Courtney, Bobby Boyanton, Yvonne Qvarnstrom, Molly Freeman, Brian H. Raphael

“…These were the first autochthonous cases since 2003 when a cluster was identified in Florida. The aim of this study was to genetically characterize the implicated P. vivax isolates in order to complement epidemiologic investigations of these cases. …”
Get full text