Study Protocol: Comparison of Clinical Pregnancy Outcomes of Intracytoplasmic Sperm Injection (ICSI) Using Testicular and Ejaculated Spermatozoa in Male Patients with High DNA Frag... by Juhi Barai, Akash More, Namrata Choudhary

“…Expected Results: Standardization of the SDF test, in which the best SDF test will be adopted, and a precise threshold will be used to determine the sperm DNA damage which may enhance the ICSI outcome, along with the difference between the ICSI outcome of both the testicular and ejaculated spermatozoa with high SDF. Study Implication: It helps in assessing the ICSI outcome in testicular and ejaculated spermatozoa in patients with high DNA fragmentation.…”
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Genetic Insights Into Type 2 Diabetes Mellitus Susceptibility: A Case-Control Study of the ADIPOQ rs1501299 Polymorphism in the Population of Noakhali Region of Bangladesh by Md. Anamul Haque, Md. Sad Salabi Sawrav, Shipan Das Gupta, Shuvo Chandra Das, Dhirendra Nath Barman, Mohammed Mafizul Islam, Md. Murad Hossain

“…The study, involving 152 T2DM patients and 118 healthy controls, explores the genetic underpinnings of T2DM, considering the rising prevalence in Bangladesh. …”
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Statistical Modeling to Improve Time Series Forecasting Using Machine Learning, Time Series, and Hybrid Models: A Case Study of Bitcoin Price Forecasting by Moiz Qureshi, Hasnain Iftikhar, Paulo Canas Rodrigues, Mohd Ziaur Rehman, S. A. Atif Salar

“…The practical implication of this study is that financial analysts have a tool (the proposed model) that can yield insightful information about potential investments.…”
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Improving the safety of pindang, a traditional fish product from Indonesia: case study from Palabuhanratu, Sukabumi District, West Java Province, Indonesia by Novalia Rachmawati, Radestya Triwibowo, Tom Ross, Shane Powell, Mark Tamplin

“…Due to uncertainty or limited availability of fresh fish, many pindang producers use frozen fish as an alternative raw material. Reports implicate pindang as a major causative agent of HFP outbreaks in Indonesia. …”
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Exploring the Contribution of Single Nucleotide Polymorphisms in FSHR, LHR, PPAR-γ, and INSR Genes to the Pathogenesis of Polycystic Ovary Syndrome: A Case-control Study by Mohd Noorjahan Begum, A Lalithamma, Vandali Jyothi, Madhan Krishnan

“…Materials and Methods: This case-control study conducted in Malla Reddy Institute of Medical Sciences (MRIMS), Telangana, India. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Purpose: Anaplastic lymphoma kinase (ALK) dysregulation is implicated in numerous cancers. Tyrosine kinase inhibitors (TKIs) targeting ALK have improved disease outcomes, but resistance mechanisms are common. …”
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An association between poor oral health, oral microbiota, and pain identified in New Zealand women with central sensitisation disorders: a prospective clinical study by Sharon Erdrich, Ingrid C. Gelissen, Momchilo Vuyisich, Ryan Toma, Joanna E. Harnett

“…Oral pathogens are implicated in the aetiology of several chronic conditions. …”
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The use of combined cognitive training and non-invasive brain stimulation to modulate impulsivity in adult populations: a systematic review and meta-analysis of existing studies by Najat R. Khalifa, Yousef Alabdulhadi, Pilar Vazquez, Charlotte Wun, Peng Zhang

“…IntroductionImpulsivity, a tendency to act rashly and without forethought, is a core feature of many mental disorders that has been implicated in suicidality and offending behaviours. …”
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Union makes strength: a worldwide collaborative genetic and clinical study to provide a comprehensive survey of RD3 mutations and delineate the associated phenotype. by Isabelle Perrault, Alejandro Estrada-Cuzcano, Irma Lopez, Susanne Kohl, Shiqiang Li, Francesco Testa, Renate Zekveld-Vroon, Xia Wang, Esther Pomares, Jean Andorf, Nisrine Aboussair, Sandro Banfi, Nathalie Delphin, Anneke I den Hollander, Catherine Edelson, Ralph Florijn, Marc Jean-Pierre, Corinne Leowski, Andre Megarbane, Cristina Villanueva, Blanca Flores, Arnold Munnich, Huanan Ren, Ditta Zobor, Arthur Bergen, Rui Chen, Frans P M Cremers, Roser Gonzalez-Duarte, Robert K Koenekoop, Francesca Simonelli, Edwin Stone, Bernd Wissinger, Qingjiong Zhang, Josseline Kaplan, Jean-Michel Rozet

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Development of a three-species gut microbiome diagnostic model for acute pancreatitis and its association with systemic inflammation: a prospective cross-sectional study by Yuanyuan Gou, Long Yao, Wenli Yang, Qian Chen, Yuetao Wen, Jie Cao

“…While gut microbiome dysbiosis has been implicated in AP pathogenesis, prior studies have predominantly focused on descriptive compositional changes rather than linking specific microbial signatures to clinical inflammatory markers. …”
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A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. by Timothy R Braun, Latonya F Been, Akhil Singhal, Jacob Worsham, Sarju Ralhan, Gurpreet S Wander, John C Chambers, Jaspal S Kooner, Christopher E Aston, Dharambir K Sanghera

“…Recent genome-wide association scans (GWAS) and meta-analysis studies on European populations have identified many genes previously implicated in lipid regulation. …”
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Prognostic Correlation of Basic Fibroblast Growth Factor and Vascular Endothelial Growth Factor with Radiological Tumor Size in Pediatric Nephroblastoma and Neuroblastoma: A Prospe... by Pujana Kanneganti, Basant Kumar, Priya Mathew, Vikas Agarwal, Rajanikant Yadav, Ankur Mandelia, Vijai Datta Upadhyay

“…Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF); both are potent angiogenic factors implicated with the growth and metastasis of solid tumors mostly in adult studies. …”
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Proteomics‐Based Soluble Urokinase Plasminogen Activator Receptor Levels and Long‐Term Cardiovascular Outcomes in Survivors of Breast Cancer: A UK Biobank Study by Adithya K. Yadalam, Chang Liu, Yan V. Sun, Anant Mandawat, Arshed A. Quyyumi, Salim S. Hayek

“…Background Breast cancer is associated with increased risk for cardiovascular disease. suPAR (soluble urokinase plasminogen activator receptor) is an immune‐derived signaling glycoprotein implicated in the pathogenesis of atherosclerosis, as well as cancer, representing a shared risk factor for these conditions. …”
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5G radio-frequency-electromagnetic-field effects on the human sleep electroencephalogram: A randomized controlled study in CACNA1C genotyped volunteers by Georgia Sousouri, Corinne Eicher, Rachele Maria D’Angelo, Marie Billecocq, Thomas Fussinger, Mirjam Studler, Myles Capstick, Niels Kuster, Peter Achermann, Reto Huber, Hans-Peter Landolt

“…Methods: Thirty-four participants, genotyped for rs7304986 (15 T/C and 19 matched T/T carriers), underwent a double-blind, sham-controlled study with standardized left-hemisphere exposure to two 5G RF-EMF signals (3.6 GHz and 700 MHz) for 30 min before sleep. …”
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Association of Calpain-10 gene polymorphisms with Type 2 diabetes mellitus: a case-control study from a tertiary care hospital in Pakistan by Humaira Farooqi, Nakhshab Choudhry, Muhammad Nabeel Saddique, Samina Qamar, Rehma Dar, Salman Kazmi, Aamir Jamal Gondal, Nighat Yasmin, Hammad Javaid, Ursula Abu Nahla

“…Calpain-10 (CAPN-10), a gene implicated in insulin secretion and glucose homeostasis, has been studied for its potential involvement in T2DM. …”
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Genotype-Based Housing as a Potential Confounder in Studies Using Transgenic Mouse Models—Insight from the A53T Mouse Model of Parkinson’s Disease by Olga Dubljević, Miodrag Dragoj, Milica Potrebić Stefanović, Maja Srbovan, Miloš Stanojlović, Željko Pavković

“…The obtained data suggests that GbH can influence the parameters of interest in preclinical research, implicating the need for the optimization of future study designs.…”
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Impact of weighted blankets on sleep disturbance among children with attention deficit hyperactivity disorders (ADHD): study protocol for a pragmatic randomised controlled trial by Jeanett Friis Rohde, Elisabeth Ginnerup-Nielsen, Sofus Christian Larsen, Camilla Tjott, Robin Christensen, Berit Lilienthal Heitmann, Eva Ejlersen Waehrens, Anne Katrine Pagsberg, Ina Olmer Specht

“…Trial registration The study protocol is registered on ClinicalTrials.gov no. …”
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The synergistic effect of Thymus vulgaris essential oil and carvacrol with imipenem against carbapenem-resistant Acinetobacter baumannii: in vitro, molecular docking, and molecular... by Saoussen Jilani, Mohamed Ferjeni, Kholoud Al-Shammery, Haya Rashid Mohammed AlTamimi, Malek Besbes, Salwa Ahmed Lotfi, Amr Farouk, Walid Ben Selma, Walid Ben Selma

“…Moreover, carvacrol interacts synergistically with imipenem against all bacterial isolates (FICI ˂ 0.5). The docking study demonstrated that carvacrol seemed to have high binding free energies (−8.1 kcal/mol) against D-alanine: D-alanine ligase (2ZDQ), which is implicated in the pathway of peptidoglycan’ biosynthesis. …”
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Polymorphisms CYP2R1 rs10766197 and CYP27B1 rs10877012 in Multiple Sclerosis: A Case-Control Study by A. Martinez-Hernandez, E. E. Perez-Guerrero, M. A. Macias-Islas, C. A. Nava-Valdivia, A. Villagomez-Vega, B. Contreras-Haro, Y. E. Garcia-Ortega, Y. Esparza-Guerrero, S. G. Gallardo-Moya, J. I. Gamez-Nava, L. Gonzalez-Lopez, E. Oliva-Flores, N. A. Rodriguez-Jimenez, F. Cortes-Enriquez, A. M. Saldaña-Cruz

“…Low vitamin D levels have been reported to be a risk factor for MS, and genetic variances could be implicated. The aim of this study was to evaluate the association of MS with rs10766197 polymorphism of CYP2R1 gene and rs10877012 polymorphism of CYP27B1 gene. …”
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PDGFRα promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India by Sameer Ahmad Guru, Rashid Mir, Musadiq Bhat, Imtiyaz Najar, Mariyam Zuberi, Mamta Sumi, Mirza Masroor, Naresh Gupta, Alpana Saxena

“…Platelet-derived growth factor receptor has been implicated in many malignant and non-malignant diseases. …”
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