IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers by Sunita Mathur, John Muscedere, David M Maslove, Miranda Hunt, John Gordon Boyd, Stephanie Sibley, Tracy Boyd, Michelle Tryon, Natasha Arianne Jawa, Michaela Hanley, Robin Westphal, Afolasade Fakolade

“…Our secondary objective is to explore the perspectives of survivors of critical illness and their families about the intervention and their participation in the study. Tertiary outcomes will be a battery of cognitive, physical functioning and psychiatric outcomes.Implications Survivorship from critical illness extends beyond surviving an ICU stay. …”
Get full text

Shared genetic architecture between eating disorders, mental health conditions, and cardiometabolic diseases: a comprehensive population-wide study across two countries by Joeri Meijsen, Kejia Hu, Dang Wei, Stefana Aicoboaie, Helena L. Davies, Ruyue Zhang, Mischa Lundberg, Richard Zetterberg, Joëlle Pasman, Weimin Ye, Thomas Werge, Cynthia M. Bulik, Fang Fang, Alfonso Buil, Nadia Micali

“…This research enhances our understanding of comorbidity patterns and has important implications for developing integrated treatment approaches.…”
Get full text

Needs and Preferences of Swedish Young Adults for a Digital App Promoting Mental Health Literacy, Occupational Balance, and Peer Support: Qualitative Interview Study by Martin Karaba Bäckström, Sonya Girdler, Ben Milbourn, Annika Lexén

“…ObjectiveThe overarching aim of this study was to conduct a needs assessment as part of coproducing a digital mental health app for Swedish young adults. …”
Get full text

Engaging adolescents and young adults in decisions about return of genomic research results: study protocol for a mixed-methods longitudinal clinical trial protocol by Amy A. Blumling, Michelle L. McGowan, Cynthia A. Prows, Kristin Childers-Buschle, Lisa J. Martin, John A. Lynch, Kevin R. Dufendach, Ellen A. Lipstein, Melinda Butsch Kovacic, William B. Brinkman, Melanie F. Myers

“…Qualitative interviews with a subset of participants explore decisional stability, adolescent/young adult engagement with parents in decision-making, and the impact of learning pathogenic/likely pathogenic and autosomal recessive carrier results. Discussion This study explores decision making and decision stability between adolescents and parents (where applicable), as well as the ethical implications and impact of return of clinical-grade genetic research results to adolescents and young adults. …”
Get full text

Identifying Potential Urban Greenways by Considering Green Space Exposure Levels and Maximizing Recreational Flows: A Case Study in Beijing’s Built-Up Areas by Tao Liu, Le Yu, Xin Chen, Yunmiao Chen, Xiaomeng Li, Xinyi Liu, Yue Cao, Fan Zhang, Chenggang Zhang, Peng Gong

“…In this study, we introduce a user behavior-driven assessment framework for planning multifunctional urban greenways that connect parks with high green space exposure and maximize recreational mobility. …”
Get full text

Factors associated with functional health literacy and the quality of life of riverside residents served by the primary care network in the Brazilian amazon: a cross-sectional stud... by Ana Kedma Correa Pinheiro, Carlos Eduardo Raymundo, Eliene do Socorro da Silva Santos, Marcio Yrochy Saldanha dos Santos, Adriana de Oliveira Sarefino, Maria Helena do Nascimento Souza, Ingrid Bentes Lima, Raquel Gomes da Silva, Laura Maria Vidal Nogueira

“…Methods a cross-sectional study with 312 users of a riverside Family Health Team, using the Health Literacy Test, classified as adequate, limited, and inadequate, and the Study Short Form 12 Health Survey questionnaire, analyzing the physical and mental components in isolation. …”
Get full text

INvestigational Study Into Transplantation of the Uterus (INSITU): a cross-sectional survey among women with uterine factor infertility in the UK assessing background, motivations... by Srdjan Saso, Timothy Bracewell-Milnes, Benjamin P Jones, James Richard Smith, Joseph Yazbek, Meen-Yau Thum, Lorraine S Kasaven, Saaliha Vali, Ifigenia Mantrali, James Nicopoullos, Cesar Diaz-Garcia, Isabel Quiroga

“…Responses were assessed against the study selection criteria.Participants Women with AUFI.Results 210 women completed the questionnaire. …”
Get full text

Evaluation of the Genotoxicity and Cytotoxicity of Bioceramic Endodontic Sealers in HepG2 and V79 Cell Lines: An In Vitro Study Using the Comet and Micronucleus Assays by Antonija Tadin, Marija Badrov, Danijela Juric Kacunic, Nada Galic, Matea Macan, Ivan Kovacic, Davor Zeljezic

“…These results support the use of calcium silicate-based sealers in clinical practice, highlighting the need for further studies to evaluate their performance in vivo and their implications for patient safety.…”
Get full text

Association between prehospital advanced life support by emergency medical services personnel and neurological outcomes among adult out‐of‐hospital cardiac arrest patients treated... by Tetsuya Yumoto, Takashi Hongo, Toru Hifumi, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda, Takashi Yorifuji, Atsunori Nakao, Hiromichi Naito, SAVE‐J II study group

“…Conclusion Prehospital ALS was associated with worse neurological outcomes at hospital discharge in patients treated with ECPR for OHCA. Further prospective studies are required to determine the clinical implications of these findings.…”
Get full text

Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study by Andres M Lozano, Wendy Lou, Peter Giacobbe, Sidney H Kennedy, Michelle Wu, Vanessa K Tassone, Venkat Bhat, Fatemeh Gholamali Nezhad, Yuelee Khoo, Qiaowei Lin, Ilya Demchenko, Reinhard Janssen-Aguilar, Amanda K Ceniti, Sakina J Rizvi, Mary Pat McAndrews

“…Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).Objective This randomised controlled study aims to evaluate the neuropsychological effects of SCG-DBS.Methods 35 participants with TRD received active or sham stimulation over two 3-month periods. …”
Get full text

How do patients, medical assistants and physicians accept and experience tablet-based cognitive testing by medical assistants in general practice? - A qualitative study by Kristin Rolke, Carolin Rosendahl, Klaus Weckbecker, Alexander Hanke, Michael Wagner, Leon Nissen, Lara Marie Reimer, Stephan Jonas, Philipp Schaper, Jochen René Thyrian, Florian Schweizer, Judith Tillmann

“…Methods In this qualitative study, seven GPs, six MAs and eight patients were qualitatively interviewed regarding the acceptance, user experience of the tablet-based procedure and its implications for GP care. …”
Get full text

Association of BMI, Waist-hip Ratio and Skinfold Thickness with Sensory Conduction of the Median Nerve in First-year Medical Students: A Cross-sectional Study by Seema V Kamaraddi, Janhavi R Bhandare, Harpreet Kour

“…These findings suggest that height and WHR may impact specific aspects of nerve conduction, with potential implications for clinical assessments. Conclusion: This study demonstrates that anthropometric variables, including height, weight, and WHR, significantly influence median nerve sensory conduction parameters. …”
Get full text

Impact of healthy pregnancy and lifestyle in mothers on developmental delay in their offspring: a strength-based analysis of a longitudinal study among indigenous children in Austr... by Md Irteja Islam, Thomas Stubbs, Tuguy Esgin, Alexandra Martiniuk

“…These findings have implications for challenging and reframing the deficit discourse surrounding Indigenous Australian health research and policymaking. …”
Get full text

The clinical impact of oral iron treatment for anaemia in pregnancy in accordance with current guidance: a prospective cohort study in a maternity unit in the Midlands of England by David Churchill, Hind Ali, Samaher Sweity, Dianne Bautista, Mahmoud Moussa, Laura Devison, Julie Icke, Simon J. Stanworth

“…The study population consisted of pregnant women diagnosed with anaemia. …”
Get full text

Early development score as a prognostic factor in nonverbal/minimally verbal children with autism spectrum disorder: A matched case-control study in Cyprus by Margarita Kilili-Lesta, Konstantinos Giannakou, Louiza Voniati

“…Methods In this case-control study, 56 children aged 3–12 years, with an ASD diagnosis, participated. …”
Get full text

The Effect of Utilitarian and Social Motives on the Perception of the Quality of the Mobile Phone Application Brand through the Value and Type of Use by Tourists (Snap Food Case St... by Yazdan Shirmohammadi, Neda Sotoudeh

“…The conceptual model of this research was taken from the model of Trang et al. (2022). This study studied the effect of mobile applications on user behavior and finally compared it with Trang's conceptual model. …”
Get full text

Interventional arterial chemotherapy versus sorafenib for advanced hepatocellular carcinoma in China: a health economic evaluation of open-label, randomised, phase 3 study by Ming Zhao, Yue Hu, Song Chen, Ning Lyu, Xiongying Jiang, Qi-Feng Chen

“…Objectives This post hoc study aimed to evaluate the cost-effectiveness of hepatic artery infusion chemotherapy (HAIC) with fluorouracil, leucovorin and oxaliplatin (HAIC-FO) compared with sorafenib in patients with advanced hepatocellular carcinoma (HCC). …”
Get full text

What is multidisciplinary cancer care like in practice? a protocol for a mixed-method study to characterise ambulatory oncology services in the Australian public sector by David C Currow, Jonathan Karnon, Jeffrey Braithwaite, Yvonne Tran, Mia Bierbaum, Johanna Westbrook, Gaston Arnolda, Robyn L Ward, Ian Olver, Bróna Nic Giolla Easpaig, Klay Lamprell, Geoffrey P Delaney, Winston Liauw, Renuka Chittajallu, Teresa Winata

“…As part of the study of supportive care, we will examine the implications of an introduction of patient-reported measures (PRMs) into care, adding surveys to interviews before and after PRMs roll-out. …”
Get full text

Elucidating epigenetic landscape of gastric premalignant lesions through genome‐wide mapping of 5‐hydroxymethylcytosines: A 12‐year median follow‐up study by Zhongguang Luo, Wenshuai Li, Wanwei Zheng, Yixiang Shi, Maolin Ye, Xiangyu Guo, Kaiyi Fu, Changsheng Yan, Bowen Wang, Bin Lv, Shaocong Mo, Hongyang Zhang, Jun Zhang, Chuan He, Feifei Luo, Wei Zhang, Jie Liu

“…Abstract Background Epigenetic modifications are crucial in tumourigenesis, yet the changes in novel epigenetic regulators like 5‐hydroxymethylcytosines (5hmC) during the evolution of gastric premalignant lesions remain poorly understood. This study aims to investigate the implications of 5hmC in the progression from gastric premalignant lesions to gastric adenocarcinoma (GAC). …”
Get full text

Study protocol of a randomised controlled trial of prostate radiotherapy in high-risk and node-positive disease comparing moderate and extreme hypofractionation (PRIME TRIAL) by Vedang Murthy, Indranil Mallick, Abhilash Gavarraju, Shwetabh Sinha, Rahul Krishnatry, Tejshri Telkhade, Arunsingh Moses, Sadhna Kannan, Gagan Prakash, Mahendra Pal, Santosh Menon, Palak Popat, Venkatesh Rangarajan, Archi Agarwal, Sheetal Kulkarni, Ganesh Bakshi

“…Introduction There has been an interest in studying the efficacy of extreme hypofractionation in low and intermediate risk prostate cancer utilising the low alpha/beta ratio of prostate. …”
Get full text