Increased Serum Levels of Tumor Necrosis Factor-Alpha, Resistin, and Visfatin in the Children with Autism Spectrum Disorders: A Case-Control Study by Mohammad Ali Ghaffari, Elham Mousavinejad, Forough Riahi, Masoumeh Mousavinejad, Mohammad Reza Afsharmanesh

“…There is, however, limited knowledge on variations of adipokines in ASD. The present study aimed to analyze the serum levels of resistin, visfatin, and tumor necrosis factor-alpha (TNF-α) in children with ASD in relation to body weight, gender, and ASD severity level. …”
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Identification of Diabetic Retinopathy Genes through a Genome-Wide Association Study among Mexican-Americans from Starr County, Texas by Yi-Ping Fu, D. Michael Hallman, Victor H. Gonzalez, Barbara E. K. Klein, Ronald Klein, M. Geoffrey Hayes, Nancy J. Cox, Graeme I. Bell, Craig L. Hanis

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Design, Synthesis and Biological Activity Study of γ-Aminobutyric Acid (GABA) Derivatives Containing Bridged Bicyclic Skeletons as BCAT1 Inhibitors by Wen Luo, Zilu Pan, Xinyuan Zhu, Yan Li, Yong Li, Yudi Zhang, Jiamin Pan, Jian Ding, Hua Xie, Guilong Zhao

“…Branched-chain amino acid aminotransferases (BCATs), existing as the two isoforms BCAT1 and BCAT2, are responsible for the catabolism of branched-chain amino acids (BCAAs) and are highly upregulated and implicated in a diverse range of cancers. BCAT1 inhibitors represent a potential class of therapeutic agents for cancers; however, none have yet progressed to clinical development. …”
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Efficacy of cognitive behavioral therapy for insomnia and lemborexant medication for different subtypes of chronic insomnia: study protocol for a randomized controlled trial by Si-Jing Chen, Hans Ivers, Thien Thanh Dang-Vu, Colin M. Shapiro, Colleen E. Carney, Rébecca Robillard, Charles M. Morin

“…Sleep reactivity and arousal level will be evaluated as potential mediators of treatment-related changes in CBT-I and pharmacotherapy. Discussion This study will contribute to the development of personalized medicine for managing different insomnia phenotypes and will have implication for knowledge mobilization of sleep research. …”
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Cross–Species Transmission at the Wildlife–Livestock Interface: A Case Study of Epidemiological Inference From Mule Deer GPS Collar Data by Jennifer L. Malmberg, Jeremy Alder, Halcyon Killion, Danielle Buttke, Kim M. Pepin, George Wittemyer

“…GPS collar data demonstrated spatial overlap with dairy cattle in the 50 days prior to death, implicating potential spillover from cattle as the transmission pathway. …”
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Genome-wide association study of common bean (Phaseolus vulgaris L.) unveils novel loci governing root-to-seed zinc allocation by Muhammad Tanveer Altaf, Muhammad Azhar Nadeem, Sefa Ayten, Emre Aksoy, Sheikh Mansoor, E. M. B. M. Karunathilake, Yong Suk Chung, Faheem Shehzad Baloch

“…Abstract Micronutrient malnutrition is a global health concern, highlighting the importance of essential micronutrients like zinc in human diet, and enhancing zinc concentration in staple crops like common beans is a promising strategy. In this study, we performed genome-wide association studies to identify genetic loci associated with Zn accumulation in a diverse panel of 177 Turkish common bean landraces and six commercial varieties. …”
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Effects of Benzo[a]Pyrene Exposure on Lung Cancer: A Mechanistic Study of Epigenetic m6A Levels and YTHDF1 by Siyi Xu, Jie Li, Sheng Yang, Panpan Yang, Yiru Niu, Yiling Ge, Geyu Liang

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Genome-Wide Association Studies Provide Molecular Insights into the Genetic Determination of the Fruit Shape-Related Traits of <i>Actinidia eriantha</i> by Lu Chen, Dongfeng Jia, Yansong Liu, Huan Gao, Jipeng Mao, Xiaobiao Xu

“…Wild germplasm resources typically exhibit greater genetic diversity in fruit morphology compared to cultivated varieties. The study analyzed fruit shape-related traits of 216 <i>Actinidia eriantha</i> plants from a wild population in Jiangxi Province, China, and identified significant associated single nucleotide polymorphisms (SNPs) and candidate genes for the target traits using genome-wide association analysis (GWAS). …”
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The rs243865 Polymorphism in Matrix Metalloproteinase-2 and its Association With Target Organ Damage in Patients With Resistant Hypertension: Cross-Sectional Study by An Tuan Huynh, Hoang Anh Vu, Ho Quoc Chuong, Tien Hoang Anh, An Viet Tran

“…Particular attention recently has focused on the role of matrix metalloproteinase-2 (MMP-2) gene polymorphisms, implicated in hypertensive target organ damage (TOD). …”
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RETRACTED ARTICLE: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies by Changyoun Kim, Armine Hovakimyan, Karen Zagorski, Tatevik Antonyan, Irina Petrushina, Hayk Davtyan, Gor Chailyan, Jonathan Hasselmann, Michiyo Iba, Anthony Adame, Edward Rockenstein, Marcell Szabo, Mathew Blurton-Jones, David H. Cribbs, Anahit Ghochikyan, Eliezer Masliah, Michael G. Agadjanyan

“…Based on these preclinical data, we selected the PV-1950D vaccine for future IND enabling preclinical studies and clinical development.…”
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A bibliometric study on the impact of gut microbiota on the efficacy of immune checkpoint inhibitors in cancer patients: analysis of the top 100 cited articles by Ziqi Zhao, Kun Xu, Boqian Hu, Yizhuo Jiang, Xisheng Xu, Yuliang Liu

“…The article by Routy et al. (2018) was the most frequently cited.ConclusionsThis study highlights the significant role of the gut microbiota in ICI development and efficacy, emphasizing the necessity for international and interdisciplinary collaboration. …”
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Infection of porcine enteroids and 2D differentiated intestinal epithelial cells with rotavirus A to study cell tropism and polarized immune response by Miaomiao Yan, Ang Su, Suvarin Pavasutthipaisit, Rebecca Spriewald, Guntram A. Graßl, Andreas Beineke, Doris Hoeltig, Georg Herrler, Paul Becher

“…Therefore, apical-out enteroids and 2D intestinal epithelial cells provide useful primary cell culture models that can be extended to analyze invasion and replication strategies of agents implicated in enteric diseases or to study immune and inflammatory responses of the host induced by enteric pathogens.…”
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Relationship between serum mature brain-derived neurotrophic factor level and coronary slow flow phenomenon: a cross-sectional study by Hongshan Zhang, Alan Frederick Geater, Virasakdi Chongsuvivatwong, Guofu Zhu, Yong Meng, Wenxiang Duan, Lijin Pu

“…Abstract Brain-derived neurotrophic factor (BDNF) has been implicated in cardiovascular disease. However, the role of BDNF in coronary slow flow phenomenon (CSFP) remains unclear. …”
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Common variants in IL-1RN, IL-1β and TNF-α and the risk of ovarian cancer: a case control study by Amira Ben Ahmed, Sabrina Zidi, Ikram Sghaier, Ezzeddine Ghazouani, Amel Mezlini, Wassim Almawi, Besma Yacoubi Loueslati

“…Aim of the study: Several studies implicated altered inflammatory response in the susceptibility to ovarian cancer, and polymorphisms in inflammatory cytokines were shown to play an important role in the development of malignancies, including ovarian cancer (OC). …”
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Accelerated risk of renal disease progression in pre-ESRD patients with proton pump inhibitors use: a nationwide population-based study by Chien-Huei Huang, Chih-Jung Tsai, Chien-Chou Su, Chi-Tai Yen, Ju-Ling Chen, Ching-Lan Cheng

“…Specifically, omeprazole (adjusted HR, 1.784; 95% CI: 1.079–2.951) and esomeprazole (adjusted HR, 1.847; 95% CI: 1.332–2.561) were associated with a notably higher risk of ESRD and AKI. Conclusions The study highlights the significance of the accelerated renal risk, especially for moderate to advanced CKD patients, when prescribing PPIs and to implicate the clinicians prescribed PPIs and H2B in pre-ESRD patients.…”
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Associations of accelerated biological ageing with incident dementia, cognitive functions and brain structure: a prospective cohort study based on UK Biobank by Xiao Ren, Xiaowei Zheng, Yonghong Zhang, Zhengbao Zhu, Mengyao Shi, Pinni Yang, Lulu Sun, Ruirui Wang, Yiqun Li, Wenyang Han, Minglan Jiang, Yiming Jia

“…Background Several small-sample studies have suggested that biological processes of ageing are implicated with dementia and cognitive function. …”
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Higher C-reactive protein to high-density lipoprotein cholesterol ratio is associated with hyperuricemia in diabetes and prediabetes: a cross-sectional study by Dongni Huang, Dongni Huang, Jing Ma, Yan Zhao, Yan Zhao, Qi Pan, Guogang Xu, Lixin Guo, Lixin Guo

“…BackgroundThe ratio of C-reactive protein to high-density lipoprotein cholesterol (CRP/HDL-c) reflects systemic inflammation and lipid status, both of which are implicated in uric acid metabolism. This study aimed to investigate the association between CRP/HDL-c and the prevalence of hyperuricemia (HUA) among adults with diabetes or prediabetes.MethodsThis cross-sectional study included 10915 adults with diabetes or prediabetes from the Health Management Institute of the PLA General Hospital. …”
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Blood biochemical landscape and new insights into clinical decision-making for polycystic ovary syndrome in Chinese women: a prospective cohort study by Yutong Li, Yutong Li, Xiufeng Lin, Ke Zou, Jing Du, Qingni Li, Linkun Zhong, Shan Jiang

“…Bidirectional Mendelian randomization (MR) was employed to assess genetic associations and causal relationships between PCOS and SHBG. Molecular docking studies evaluated cryptotanshinone’s binding affinity to key proteins (COL1A1, COL4A2, COL6A2) in the PI3K/Akt pathway. …”
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Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies by Anna Wawruszak, Jarogniew Luszczki, Damian Bartuzi, Joanna Kalafut, Estera Okon, Arkadiusz Czerwonka, Andrzej Stepulak

“…Accumulative evidence suggests that each sirtuin possesses individual character, implicating its role in the regulation of multifaceted biological functions leading to BC initiation, progression and metastasis. …”
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Maternal phthalate exposure, gestational length, and preterm birth risk: a prospective cohort study nested within a randomised trial by Karen P Best, Lisa N Yelland, Liu Ge, Zumin Shi, Shalem Leemaqz, Robert Gibson, Maria Makrides, Philippa Middleton

“…Methods This prospective cohort study was nested within the Omega-3 to Reduce the Incidence of Prematurity (ORIP) trial. …”
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