Psychological factors and obesity, not thyroid biomarkers, predict thyroid-dependent quality of life in treated hypothyroidism: a cross-sectional study by Bence Bakos, Tibor Solymosi, Balázs Szili, Ágnes Vincze, Szilvia Mészáros, Márk Stempler, Richárd Ármós, András Kiss, Anna Bakos, Nikolette Szücs, Péter Reismann, Judit Tőke, Péter Pusztai, Péter Lakatos, István Takács

“…Individual variations in thyroxine conversion, autoimmune inflammation, and psychological factors have all been implicated as a potential cause. Methods In this cross-sectional study we have examined the association of numerous demographic, disease-specific, and laboratory parameters as well as three patient reported outcome measures with thyroid-dependent QoL as measured by the Underactive Thyroid-Dependent Quality of Life Questionnaire. …”
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The Correlations of the Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio with Bone Mineral Density in Postmenopausal Women: A Cross-Sectional Study by Pierpaolo Panebianco, Gianluca Testa, Giulia Barbagallo, Luciano Costarella, Alessia Caldaci, Sveva Condorelli, Marco Sapienza, Vito Pavone

“…Chronic inflammation is implicated in osteoporosis pathogenesis, with inflammatory mediators promoting bone resorption. …”
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Niemann–Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study by Ryuk Jun Kwon, Ho Jun Kim, Young-Shin Lee, Hye Sun Lee, Sang Yeoup Lee, Eun-Ju Park, Youngin Lee, Sae Rom Lee, Jung-In Choi, Soo Min Son, Jeong Gyu Lee, Yu Hyeon Yi, Young Jin Tak, Seung-Hun Lee, Gyu Lee Kim, Young Jin Ra, Young Hye Cho

“…Niemann–Pick C1-Like 1 (NPC1L1) plays a crucial role in cholesterol absorption and has been implicated in cancer progression across various cancers. …”
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Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. by Elizabeth G Holliday, Albert V Smith, Belinda K Cornes, Gabriëlle H S Buitendijk, Richard A Jensen, Xueling Sim, Thor Aspelund, Tin Aung, Paul N Baird, Eric Boerwinkle, Ching Yu Cheng, Cornelia M van Duijn, Gudny Eiriksdottir, Vilmundur Gudnason, Tamara Harris, Alex W Hewitt, Michael Inouye, Fridbert Jonasson, Barbara E K Klein, Lenore Launer, Xiaohui Li, Gerald Liew, Thomas Lumley, Patrick McElduff, Barbara McKnight, Paul Mitchell, Bruce M Psaty, Elena Rochtchina, Jerome I Rotter, Rodney J Scott, Wanting Tay, Kent Taylor, Yik Ying Teo, André G Uitterlinden, Ananth Viswanathan, Sophia Xie, Wellcome Trust Case Control Consortium 2, Johannes R Vingerling, Caroline C W Klaver, E Shyong Tai, David Siscovick, Ronald Klein, Mary Frances Cotch, Tien Y Wong, John Attia, Jie Jin Wang

“…While genome-wide association studies (GWAS) for late AMD implicate genes in complement, inflammatory and lipid pathways, the genetic architecture of early AMD has been relatively under studied. …”
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Genetic insights into causal effects of lipids and lipid-modifying targets on calcific aortic valve stenosis: a Mendelian randomized study by Chengrong Wu, Qian Pu, Yalin Zou, Juan Jin, Yu Lei, Yaxin Hu, Zhuo Chen, Lei Yu

“…Abstract Calcific aortic valve stenosis (CAVS) is steadily rising worldwide with no effective pharmacological agents available. Observational studies implicated dyslipidaemia as a risk factor for CAVS. …”
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Overweight and glucose/lipid metabolism abnormality associated with SSRIs: a pharmacovigilance study based on the FDA adverse event reporting system by Jinming Cao, Zhicong Chen, Yan Wang, Yunpeng Ma, Zhen Yang, Jian Cai, Zhijun Xiao, Feng Xu

“…Therefore, the adverse reactions of patients after SSRI administration became a public and clinical concern. In this study, we conducted a pharmacovigilance study using the Adverse Event Reporting System (FAERS) database of the US Food and Drug Administration. …”
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Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. by Alexandra Zhernakova, Eli A Stahl, Gosia Trynka, Soumya Raychaudhuri, Eleanora A Festen, Lude Franke, Harm-Jan Westra, Rudolf S N Fehrmann, Fina A S Kurreeman, Brian Thomson, Namrata Gupta, Jihane Romanos, Ross McManus, Anthony W Ryan, Graham Turner, Elisabeth Brouwer, Marcel D Posthumus, Elaine F Remmers, Francesca Tucci, Rene Toes, Elvira Grandone, Maria Cristina Mazzilli, Anna Rybak, Bozena Cukrowska, Marieke J H Coenen, Timothy R D J Radstake, Piet L C M van Riel, Yonghong Li, Paul I W de Bakker, Peter K Gregersen, Jane Worthington, Katherine A Siminovitch, Lars Klareskog, Tom W J Huizinga, Cisca Wijmenga, Robert M Plenge

“…Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. …”
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Potential inappropriate medications and drug–drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database by Huaqiao Jiang, Yanhua Lin, Weifang Ren, Lina Lu, Xiaofang Tan, Xiaoqun Lv, Ning Zhang

“…IntroductionPotential inappropriate medications (PIMs) and potential drug–drug interactions (pDDIs) are important factors leading to adverse drug reactions (ADRs) in the elderly. This study aimed to evaluate the incidence and pattern of PIMs and pDDIs in the elderly based on a real-world pharmacovigilance database and identify the variables associated with them.MethodsThis retrospective study evaluated PIMs and pDDIs by updated Beers criteria and Lexi-Interact online, respectively, using ADRs reported for those aged ≥65 years submitted between 2011 and 2023 from a real-world database of a tertiary care teaching hospital. …”
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The effect of prednisolone ingestion and acute exercise on lipocalin-2 and its variants in young men: a pilot randomised crossover study by Carlie Bauer, Rhiannon K. Patten, Qiyang Sun, Haoyun Li, Daniels Konja, Mary Woessner, Xuzhu Lin, Andrew Garnham, David L. Hare, Peter R. Ebeling, Marc Sim, Joshua R. Lewis, Yu Wang, Lewan Parker, Itamar Levinger

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High Plasma Polyamine Levels Are Associated With an Increased Risk of Poststroke Cognitive Impairment: A Multicenter Prospective Study From CATIS by Yu He, Yiming Jia, Yi Liu, Xinyue Chang, Pinni Yang, Mengyao Shi, Daoxia Guo, Yanbo Peng, Jing Chen, Aili Wang, Tan Xu, Jiang He, Yonghong Zhang, Zhengbao Zhu

“…We aimed to prospectively investigate the associations of plasma putrescine, spermidine, and spermine with PSCI among patients with ischemic stroke in a multicenter cohort study. Methods and Results We measured plasma polyamine levels at baseline among 619 patients with ischemic stroke from a preplanned ancillary study of CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). …”
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Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study by Chen HB, Li L, Sun YK, Liu Y, Chen W, Liu P, Liao YH, Xie A

“…At 2-month follow-up, decreased FC implicated in emotion regulation, executive function, and memory; increased FC in semantics, attention, and auditory-visual processing. …”
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The role of the MicroBiome in PANCreatic cancer and its precursors— the study protocol of the MiBiPanc systematic review and meta-analysis by My-Lan Pianka, Alexander Werba, Samuel Zimmermann, Johannes A. Vey, Eva Kalkum, Solveig Tenckoff, Andrew Tony-Odigie, Christoph W. Michalski, Frank Pianka

“…Although the human microbiota contributes to health by supporting nutritional and hormonal homeostasis, modulating inflammation, detoxifying harmful compounds, and producing beneficial metabolites, several studies have implicated its crucial modulatory role in numerous diseases, including cancer. …”
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ELEVATED CIRCULATING ENDOTHELIN-1 AND OXIDATIVE STRESS AS POTENTIAL BIOMARKERS FOR PREECLAMPSIA IN WOMEN FROM TAMILNADU: A CASE CONTROL STUDY. by Dr. P. Bagavathiammal, Dr. P. M. Sasikala, Dr. R. Menaha, Dr. Revathi. A, Panneerselvam Periasamy, Dr. Sasikala Gunasekaran

“…Endothelin-1 (ET-1), a potent vasoconstrictor, has been implicated in the pathogenesis of PE. Objective: This study aimed to evaluate ET-1 and oxidative stress markers as potential biomarkers for preeclampsia in pregnant women from Erode, Tamil Nadu. …”
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Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment by Defeng Yin, Qin Guo, Hao Jiang, Yonglan Hu, Lu Liu, Xiang Li, Chenglin Wang, Shilin Li, Kaiyu Jin, Yingchun Hu

“…Ferroptosis, a novel form of programmed cell death, has been implicated in its pathogenesis, though its mechanisms remain unclear. …”
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Heat Adaptation Benefits for Vulnerable groups In Africa (HABVIA): a study protocol for a controlled clinical heat adaptation trial by Michaela Deglon, Chad Africa, Larske Marit Soepnel, Thandi Kapwata, Ama de-Graft Aikins, Kweku Bedu-Addo, Guy Howard, Estelle Victoria Lambert, Dale Elizabeth Rae, Martha Sibanda, Christopher Gordon, Mark New, Lara Ruth Dugas

“…Methods HABVIA is a 3-year prospective controlled study to identify, implement and assess heat adaptation solutions in four low-income communities in one urban and one rural site in Ghana and South Africa, respectively. …”
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Ethnobotanical study of traditional medicinal plants used by the Sidama people to treat human ailments in the Bensa district of Sidama region, Ethiopia by Tegenu Mekuria, Juhar Zemede, Belay Melese, Guang-Wan Hu

“…The medicinal efficacy of the studied plants raises awareness of the conservation of valuable plants implicated in treating diverse ailments.…”
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Plasma Soluble Progenitor Cell Receptors as Biomarkers for Severe Anemia Among Malaria‐Infected Pediatrics: A Prospective Study in Ghana by Charles Nkansah, Samuel K. Appiah, Felix Osei‐Boakye, Emmanuel Appiah‐Kubi, Gabriel Abbam, Samira Daud, Charles A. Derigubah, Simon B. Bani, Moses Banyeh, Kofi Mensah, Ruby Tater, Jennifer Obeng Mensah, Anne Natornaa, Isaac Adjei, Muniru M. Tanko, Gilbert Amankwaa, Peter K. Selleh, Samuel B. Aboagye, Onwuka K. Chima, Sylvanus M. Kpangkpari, Prince Ottah, Enoch Boadi, Yeduah Quansah, Ejike F. Chukwurah, Boniface N. Ukwah, Victor U. Usanga

“…ABSTRACT Background Soluble forms of progenitor cell receptors may be implicated in the delayed erythropoietic response during severe anemia. …”
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Association of Platelet Indices with Cardiac Enzymes and Left Ventricular Function in Patients with Acute Myocardial Infarction: A Cross-sectional Study by P Kireeti, Rajesh Singh Laishram, Mayanglambam Bijoy, Sunil Kumar Leishangthem, Rajkumar Ajaykumar, Keisham Jaya Chanu, Ningthoukhongjam Reema, Dhanaraj Singh Chongtham

“…Platelet activation has been implicated in its pathogenesis, and platelet indices, which measure platelet hyperactivity, have been suggested as biomarkers of Coronary Artery Disease (CAD). …”
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Ticket sales versus catering challenges for entrepreneurial hospitality workers at international events: A case study of the Melbourne International Comedy Festival by Paul Strickland, Vanessa Ratten

“…Therefore, the workers need to develop entrepreneurial skills in order to succeed in the competitive marketplace. Implications & Recommendations: Investigating the challenges hospitality workers experience at the MICF when ticket sales are continually sold up until the performance is the first attempt at qualitative research in this field of study bridging the gap in event management, festival, and hospitality literature. …”
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Predicting Postcesarean Pain: A Prospective Cohort Study Using a 3-Question Questionnaire, Local Anesthesia Infiltration, and Observer Rating by Unyime S. Ituk, Sapna Ravindranath

“…Implications: This study highlights the potential of a combined preoperative pain rating questionnaire and anesthesiologist’s predictions to improve postcesarean pain management. …”
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