Associations of Circulating Lymphocyte Subpopulations with Type 2 Diabetes: Cross-Sectional Results from the Multi-Ethnic Study of Atherosclerosis (MESA). by Nels C Olson, Margaret F Doyle, Ian H de Boer, Sally A Huber, Nancy Swords Jenny, Richard A Kronmal, Bruce M Psaty, Russell P Tracy

“…<h4>Objective</h4>Distinct lymphocyte subpopulations have been implicated in the regulation of glucose homeostasis and obesity-associated inflammation in mouse models of insulin resistance. …”
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Alterations in gamma-aminobutyric acid and glutamate neurotransmission linked to intermittent theta-burst stimulation in depression: a sham-controlled study by Linda Steinholtz, Robert Bodén, Anders Wall, Mark Lubberink, David Fällmar, Jonas Persson

“…Abstract Gamma-aminobutyric acid (GABA) and glutamate are implicated in the antidepressant effects of repetitive transcranial magnetic stimulation (rTMS), though findings from magnetic resonance spectroscopy (MRS) are inconsistent. …”
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Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study by Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran

“…Pyroptosis, an inflammatory form of programmed cell death, is implicated in periodontitis and diabetes. The activation of gasdermin D (GSDMD), a key mediator of pyroptosis, promotes cytokine release and perpetuates tissue destruction in both. …”
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The effects of the form of sugar (solid vs. beverage) on body weight and fMRI activation: A randomized controlled pilot study. by John W Apolzan, Owen T Carmichael, Krystal M Kirby, Sreekrishna R Ramakrishnapillai, Robbie A Beyl, Corby K Martin

“…Differences in fMRI signals between views of low-fat (LF (<30%)) high sugar (HS (>30%)) food, and non-food images were calculated in brain regions implicated in energy homeostasis, taste, and reward.…”
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Association study between genetic variations in gene and lung cancer risk in North Indian population: A multiple interaction analysis by Charu Bahl, Siddharth Sharma, Navneet Singh, Digamber Behera

“…Wnt pathway has been implicated in the process of human carcinogenesis. Axis inhibition protein2 ( Axin2 ), a major scaffold protein is an antagonist of Wnt pathway and is potent to act as a tumor suppressor gene in various human cancers. …”
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Mechanistic Studies on the Role of IL-17/NLRP3 in Arsenic-Induced Activation of Hepatic Stellate Cells Through Hepatocyte Proptosis by Ting Hu, Mei Chen, Sai Tian, Peng Luo, Jiangping Zhang

“…Long-term exposure to arsenic, a prevalent environmental contaminant, has been implicated in the pathogenesis of various hepatic conditions. …”
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Intraabdominal fat-free volume, but not fat volume, predicts the development of peritonitis in patients on peritoneal dialysis: a retrospective cohort study by Ryunosuke Mitsuno, Kohkichi Morimoto, Kenji Kaneko, Daiki Kojima, Toshifumi Nakamura, Takashin Nakayama, Eriko Yoshida Hama, Shun Tonomura, Yoshitake Yamada, Masahiro Jinzaki, Kiyotaka Uchiyama, Naoki Washida, Takeshi Kanda, Tatsuhiko Azegami, Tadashi Yoshida, Jun Yoshino, Kaori Hayashi

“…However, the clinical implication of IAFV in patients on peritoneal dialysis (PD) is unclear. …”
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Comparison of lateral tail vein and retro-orbital venous sinus as routes of inoculation to study Group B streptococcal systemic infection by Jéssica da Conceição Mendonça, Stephen Lumsdaine, Lindsey R. Burcham

“…In summary, these findings suggest that both tail vein injection and retro-orbital venous sinus injection are viable models to study Group B streptococcal systemic infection and result in largely similar disease outcomes within our tested parameters.IMPORTANCEStreptococcus agalactiae or Group B Streptococcus (GBS) is the leading cause of invasive disease in neonates and immunocompromised adults and is implicated in severe cases of sepsis, pneumonia, and meningitis. …”
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Citrobacter and Acinetobacter are respectively involved in feeding intolerance in preterm infants of different gestational ages: a prospective case-control study by Chunyan Fu, Jinglin Xu, He Wang, Dongmei Chen, Zhiyong Liu

“…Methods We undertook a prospective case-control study in which we enrolled 80 preterm infants at a gestational age < 34 weeks. …”
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Reduced Field-of-View Diffusion-Weighted Imaging of the Lumbosacral Enlargement: A Pilot In Vivo Study of the Healthy Spinal Cord at 3T. by Marios C Yiannakas, Francesco Grussu, Polymnia Louka, Ferran Prados, Rebecca S Samson, Marco Battiston, Daniel R Altmann, Sebastien Ourselin, David H Miller, Claudia A M Gandini Wheeler-Kingshott

“…The DTI acquisition and analysis protocol presented here is clinically feasible and may be used in future investigations of neurological conditions implicating the lower SC.…”
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X-chromosomal maternal and fetal SNPs and the risk of spontaneous preterm delivery in a Danish/Norwegian genome-wide association study. by Solveig Myking, Heather A Boyd, Ronny Myhre, Bjarke Feenstra, Astanand Jugessur, Aase S Devold Pay, Ingrid H G Ostensen, Nils-Halvdan Morken, Tamara Busch, Kelli K Ryckman, Frank Geller, Per Magnus, Håkon K Gjessing, Mads Melbye, Bo Jacobsson, Jeffrey C Murray

“…<h4>Background</h4>Recent epidemiological studies suggest that the maternal genome is an important contributor to spontaneous preterm delivery (PTD). …”
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Occupational injuries, mental workload and coping strategies among the nursing workforce in the Eastern Region of Ghana: a multi-centre study by Collins Atta Poku, Abital Ayergo Ahulu, Janet Otomo, Doris Hagan, Catherine Kroamah Dwumfour, Joseph Shahadu Issifu, Veronica Dzomeku

“…Methods A multi-centre cross-sectional study was conducted in selected hospitals in the Eastern Region of Ghana. …”
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Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. by Brendan J Keating, Sam Tischfield, Sarah S Murray, Tushar Bhangale, Thomas S Price, Joseph T Glessner, Luana Galver, Jeffrey C Barrett, Struan F A Grant, Deborah N Farlow, Hareesh R Chandrupatla, Mark Hansen, Saad Ajmal, George J Papanicolaou, Yiran Guo, Mingyao Li, Stephanie Derohannessian, Paul I W de Bakker, Swneke D Bailey, Alexandre Montpetit, Andrew C Edmondson, Kent Taylor, Xiaowu Gai, Susanna S Wang, Myriam Fornage, Tamim Shaikh, Leif Groop, Michael Boehnke, Alistair S Hall, Andrew T Hattersley, Edward Frackelton, Nick Patterson, Charleston W K Chiang, Cecelia E Kim, Richard R Fabsitz, Willem Ouwehand, Alkes L Price, Patricia Munroe, Mark Caulfield, Thomas Drake, Eric Boerwinkle, David Reich, A Stephen Whitehead, Thomas P Cappola, Nilesh J Samani, A Jake Lusis, Eric Schadt, James G Wilson, Wolfgang Koenig, Mark I McCarthy, Sekar Kathiresan, Stacey B Gabriel, Hakon Hakonarson, Sonia S Anand, Muredach Reilly, James C Engert, Deborah A Nickerson, Daniel J Rader, Joel N Hirschhorn, Garret A Fitzgerald

“…A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust meta-analyses. …”
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Biological subphenotypes in patients hospitalized with suspected infection in Thailand: a secondary analysis of a prospective observational studyResearch in context by Prapassorn Poolchanuan, Taylor D. Coston, Viriya Hantrakun, Parinya Chamnan, Gumphol Wongsuvan, Pavan K. Bhatraju, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West, Shelton W. Wright

“…Summary: Background: Subphenotypes of infected patients have been reported in Europe and North America, but few studies have investigated populations in Southeast Asia. …”
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Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. by Tamra E Meyer, Germaine C Verwoert, Shih-Jen Hwang, Nicole L Glazer, Albert V Smith, Frank J A van Rooij, Georg B Ehret, Eric Boerwinkle, Janine F Felix, Tennille S Leak, Tamara B Harris, Qiong Yang, Abbas Dehghan, Thor Aspelund, Ronit Katz, Georg Homuth, Thomas Kocher, Rainer Rettig, Janina S Ried, Christian Gieger, Hanna Prucha, Arne Pfeufer, Thomas Meitinger, Josef Coresh, Albert Hofman, Mark J Sarnak, Yii-Der Ida Chen, André G Uitterlinden, Aravinda Chakravarti, Bruce M Psaty, Cornelia M van Duijn, W H Linda Kao, Jacqueline C M Witteman, Vilmundur Gudnason, David S Siscovick, Caroline S Fox, Anna Köttgen, Genetic Factors for Osteoporosis Consortium, Meta Analysis of Glucose and Insulin Related Traits Consortium

“…We observed no associations with serum sodium or potassium levels exceeding p<4 x 10(-7). Follow-up studies of newly implicated genomic loci may provide additional insights into the regulation and homeostasis of human serum magnesium levels.…”
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Insights into correlations between H. pylori infection and chronic hepatitis C disease progression: A Comparative study in the Egyptian population by Ahmed Ragab, Asmaa M Elbrolosy, Naglaa S Elabd, Ayman Elgamal, Mahmoud Rizk, Ali Nada, Marwa M Omar, Sama S Eleowa, Sanaa S Hamam, Amira S Elmaghraby

“… Background: Accumulating evidence implicated H. pylori infection in the disease progression of patients with chronic liver. …”
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Genome-wide association study identifies GPC5 as a novel genetic locus protective against sudden cardiac arrest. by Dan E Arking, Kyndaron Reinier, Wendy Post, Jonathan Jui, Gina Hilton, Ashley O'Connor, Ronald J Prineas, Eric Boerwinkle, Bruce M Psaty, Gordon F Tomaselli, Thomas Rea, Nona Sotoodehnia, David S Siscovick, Gregory L Burke, Eduardo Marban, Peter M Spooner, Aravinda Chakravarti, Sumeet S Chugh

“…<h4>Background</h4>Existing studies indicate a significant genetic component for sudden cardiac arrest (SCA) and genome-wide association studies (GWAS) provide an unbiased approach for identification of novel genes. …”
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Projecting direct medical costs and productivity benefits of improving access to advanced therapy for rheumatoid arthritis: a projection modelling study by Chee Yoong Foo, Nurul Azwani Nadia Mansor, Shereen Suyin Ch’ng, Mollyza Mohd Zain

“…ABSTRACTIntroduction: To ensure the sustainability of the AT access improvement, it is important that health system stakeholders have timely, analyzed information accessible for reference and decision-making support. In this study, we projected the direct costs required as well as the expected direct medical cost-offset and productivity benefits resulting from improving the disease control. …”
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Machine learning-based predictive modeling of angina pectoris in an elderly community-dwelling population: Results from the PoCOsteo study. by Shahrokh Mousavi, Zahrasadat Jalalian, Sima Afrashteh, Akram Farhadi, Iraj Nabipour, Bagher Larijani

“…<h4>Methods</h4>Medical records of 2000 participants in the PoCOsteo study between 2018 and 2021 were analyzed. The Rose Angina Questionnaire was used to indicate angina pectoris. …”
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Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study by Weian Mao, Guiquan Wang, Xiao Wang, Yan Shen, Shuai Yuan, Lin Wang, Haiyan Yang, Yan Li, Kai Chen, Jun Liu, Xi Dong, Yue Zhao, Liangshan Mu

“…PheWAS found that targeting GCKR may improve renal function and glucose homeostasis but cause dyslipidemia and uric acid abnormalities. Conclusions This study provided novel evidence that circulating GCKR levels are causally implicated in GDM and related complications, suggesting that it may be a promising target for treatment.…”
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