The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci. by Louise V Wain, Inti Pedroso, John E Landers, Gerome Breen, Christopher E Shaw, P Nigel Leigh, Robert H Brown, Martin D Tobin, Ammar Al-Chalabi

“…However, of another 15 genes previously reported as exhibiting ALS-specific copy number variation, only four exhibited copy number variation in this study. Potentially interesting novel loci, including EEF1D, a translation elongation factor involved in the delivery of aminoacyl tRNAs to the ribosome (a process which has previously been implicated in genetic studies of spinal muscular atrophy) were identified but must be treated with caution due to concerns surrounding genomic location and platform suitability.…”
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Mitochondrial dysfunction in Gulf War illness revealed by 31Phosphorus Magnetic Resonance Spectroscopy: a case-control study. by Hayley J Koslik, Gavin Hamilton, Beatrice A Golomb

“…<h4>Background</h4>Approximately 1/3 of 1990-1 Gulf War veterans developed chronic multisymptom health problems. Implicated exposures bear mechanisms that adversely affect mitochondria. …”
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General practitioners’ perspectives on targeted breast ultrasound as primary diagnostic test in women with focal breast complaints: An interview study by C.C.N. Siebers, L. Appelman, M. Palm, J.C.M. Van Zelst, R.M. Mann

“…Decentralization of diagnostic evaluation was considered a potential practical implication of ultrasound as primary diagnostic test. …”
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Genetic variation and reproductive timing: African American women from the Population Architecture using Genomics and Epidemiology (PAGE) Study. by Kylee L Spencer, Jennifer Malinowski, Cara L Carty, Nora Franceschini, Lindsay Fernández-Rhodes, Alicia Young, Iona Cheng, Marylyn D Ritchie, Christopher A Haiman, Lynne Wilkens, Chunyuanwu, Tara C Matise, Christopher S Carlson, Kathleen Brennan, Amy Park, Aleksandar Rajkovic, Lucia A Hindorff, Steven Buyske, Dana C Crawford

“…Genome-wide association studies have identified several genetic variants associated with either AM or ANM in populations of largely European or Asian descent women. …”
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Impact of PM2.5 from Waste Incinerators on Cardiovascular Health: Insights from a Taiwanese Cohort Study by Yu-Chia Chiu, Chi-Jung Chung, Chih-Da Wu, Hui-Tsung Hsu

“…This study aimed to investigate the occurrence of CVDs among residents living near MSWIs with varying waste treatment capacities (WTC). …”
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Linking PFOS exposure to chronic kidney disease: A multimodal study integrating epidemiology, network toxicology, and experimental validation by Xulei Zuo, Shiyi Tan, Yuxi Zhang, Cong Zhang, Li Ma, Xiaoyu Hou, Wei Wang, Rongli Sun, Lihong Yin, Yuepu Pu, Juan Zhang

“…Perfluorooctane sulfonate (PFOS), a widely used persistent organic pollutant, has been implicated in multiple toxicities. However, its nephrotoxic mechanisms remain unclear. …”
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Exploring the factors that promote or diminish a psychologically safe environment: a qualitative interview study with critical care staff by Stephen Brett, Eleanor Murray, Clare Leon-Villapalos, Kate Grailey

“…Objectives This study aimed to quantify the presence of psychological safety (defined as an environment ‘safe for interpersonal risk taking’) in critical care staff, exploring the ways in which this manifested.Design Qualitative interview study incorporating a short quantitative survey.Setting Three intensive care units within one National Health Service Trust in London.Participants Thirty participants were recruited from all levels of seniority and roles within the multidisciplinary team. …”
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Causal relationship between chronic kidney disease, renal function, and venous thromboembolism: a bidirectional Mendelian randomization study by Rongping Yang, Shuanglan Xu, Qian Liu, Xifeng Zhang, Huilin He, Yue Xu, Linna Chen, Xiqian Xing, Jiao Yang

“…Background Chronic kidney disease (CKD) and impaired renal function have been implicated in venous thromboembolism (VTE), but their causal relationships remain uncertain. …”
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A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. by Sreekumar G Pillai, Dongliang Ge, Guohua Zhu, Xiangyang Kong, Kevin V Shianna, Anna C Need, Sheng Feng, Craig P Hersh, Per Bakke, Amund Gulsvik, Andreas Ruppert, Karin C Lødrup Carlsen, Allen Roses, Wayne Anderson, Stephen I Rennard, David A Lomas, Edwin K Silverman, David B Goldstein, ICGN Investigators

“…CHRNA3/5 is the same locus that has been implicated in the risk of lung cancer.…”
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Novel Insights into Causal Effects of Lipid and Lipid-Lowering Targets with Autoimmune Thyroid Disease: A Mendelian Randomization Study by Su C, Tian J, He X, Chang X, Wang G, Liu J

“…However, whether circulating lipids and long-term use of lipid-lowering drugs influence the development of autoimmune thyroid disease (AITD) remains unclear. This study aims to evaluate the effects of lipid-lowering drugs on AITD and explore their potential mechanisms.Methods: Two-sample and two-step Mendelian randomization (MR) studies were performed to assess the causal relationships between circulating lipids (LDL-C, TC, TG, and ApoB) and seven lipid-lowering drug targets (ApoB, CETP, HMGCR, LDLR, NPC1L1, PCSK9, and PPARα) with AITD. …”
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The Effect of Isometric Exercise Position on the Effectiveness of Isolated Work of the Thigh Flexor Muscles Based on the Results of the sEMG Study by Joanna Zyznawska, Grzegorz Frankowski, Ewa Wodka-Natkaniec, Joanna Skoczek

“…Methods: The study involved 25 students of the Jagiellonian University Medical College. …”
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Psychological pain tolerance mediates the association between physical pain sensitivity and suicidal ideation: a cross-sectional study by Meng Liang, Huijing Xu, Qian Jiang, Taosheng Liu

“…Abstract Background Previous studies have consistently identified pain as a significant risk factor for suicidal behavior. …”
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The association between dietary energy density and type 2 diabetes in Europe: results from the EPIC-InterAct Study. by InterAct Consortium, Saskia W van den Berg, Daphne L van der A, Annemieke M W Spijkerman, Geertruida J van Woudenbergh, Mariken J Tijhuis, Pilar Amiano, Eva Ardanaz, Joline W J Beulens, Heiner Boeing, Françoise Clavel-Chapelon, Francesca L Crowe, Blandine de Lauzon-Guillain, Guy Fagherazzi, Paul W Franks, Heinz Freisling, Carlos Gonzalez, Sara Grioni, Jytte Halkjaer, José María Huerta, Inge Huybrechts, Rudolf Kaaks, Kay Tee Khaw, Giovanna Masala, Peter M Nilsson, Kim Overvad, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, María-José Sánchez, Matthias B Schulze, Nadia Slimani, Ellen A Struijk, Anne Tjonneland, Rosario Tumino, Stephen J Sharp, Claudia Langenberg, Nita G Forouhi, Edith J M Feskens, Elio Riboli, Nicholas J Wareham

“…<h4>Background</h4>Observational studies implicate higher dietary energy density (DED) as a potential risk factor for weight gain and obesity. …”
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Molecular epidemiology and antimicrobial resistance of Salmonella at the human–macaque–environment interface in Thailand: A One Health surveillance study by Suchawan Pornsukarom, Daraka Tongthainan, Phairot Phromwat, Suwarak Wannaratana, Kulchai Nakbubpa, Sarut Muangsri

“…Phylogenetic analysis revealed genetic heterogeneity, with no clear clustering by source or serovar. Conclusion: This study underscores the circulation of MDR Salmonella within macaques and their surrounding environments, implicating environmental reservoirs in potential zoonotic and reverse zoonotic transmission. …”
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Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust by Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche, Sibel Ertan, Peter Bauer, Arndt Rolfs, Soraya Hezzaz, Jenny Ghelfi, Norbert Brüggemann, Paul Antony, Paul Wilmes, Christine Klein, Anne Grünewald, Emma L. Schymanski

“…Furthermore, various lipids were found altered in serum including different lysophosphatidylethanolamines (LPEs), and lysophosphatidylcholines (LPCs), some with higher levels in the PD+/LRRK2+ group compared to the control group. A cellular study on isogenic neurons generated from a PD+/LRRK2+ patient demonstrated that BPS negatively impacts mitochondrial function, which is implicated in PD pathogenesis. …”
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The relationship between vitamin D levels and Alzheimer’s disease risk: insights from a centenarian study of Chinese women by Yupeng Li, Xujie Wang, Mei Yu, Fei Wang, Dong Song, Musong Liu, Xu Liang, Hongzhou Liu, Jiangbo Liu, Shihui Fu, Shihui Fu, Xuhui Liu

“…This study aimed to examine the association between serum 25-hydroxyvitamin D [25(OH)D] levels and AD risk in Chinese female centenarians.MethodsWe included 514 female participants aged ≥100 years from the China Healthy Longevity Multicenter Study (CHLMS). …”
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Metabolomics and nutrient intake reveal metabolite–nutrient interactions in metabolic syndrome: insights from the Korean Genome and Epidemiology Study by Minyeong Kim, Suyeon Lee, Junguk Hur, Dayeon Shin

“…Abstract Background Despite advances in metabolomics, the complex relationship between metabolites and nutrient intake in metabolic syndrome (MetS) remains poorly understood in the Korean population. Objective This study aimed to characterize the metabolomic profiles and nutrient intake associated with MetS and to examine their relationships in the Ansan-Ansung cohort of the Korean Genome and Epidemiology Study (KoGES). …”
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Association between sphingomyelin levels and gut microbiota abundance in Alzheimer’s disease: a two-sample Mendelian randomization study by Liping Wang, Yuyan Ding, Yu Tang, Mengqi Yang, Zhihui Yang, Xiao Yang, Jiazeng Xia

“…Abstract Background Several previous observational studies have shown that abnormal sphingomyelin metabolism may be implicated in the pathogenesis of Alzheimer’s disease. …”
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Association between dietary vitamin intake and all-cause mortality in ovarian cancer patients: a prospective cohort study by Qin Ling, Linxiang Wu, Huishan Xu, Yang Zhang, Yuying Chen, Tingting Sun, Zuwei Zhang, Huiling Lai, Shasha He, Shuzhong Yao, Weipeng He, Guofen Yang

“…BackgroundWhile various lifestyle factors have been implicated in cancer prognosis, the role of dietary vitamins in ovarian cancer survival is not well understood. …”
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Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study by Rong Ding, Erjing Cheng, Miao Wei, Liya Pan, Lu Ye, Yi Han, Xuan Zhang, Chao Xue, Jiannan Gong, Hui Zhao

“…This study aimed to investigate the association between the TyG index and all-cause mortality in this high-risk population. …”
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