CRISPR-Cas9 editing of TNFAIP3 variants in salivary gland epithelial cells to study Sjögren’s disease pathogenesis by Subhashis Ghosh, Qisheng Tu, Zoe Xiaofang Zhu, Sreelakshmi Panginikkod, Jake Jinkun Chen, Jake Jinkun Chen

“…Genetic polymorphism in the TNFAIP3 gene has been implicated in the pathogenesis of SD. In this study, we aimed to functionally determine the impact of two specific single-nucleotide polymorphisms (SNPs) in TNFAIP3, rs6920220 (G/A) and rs2230926 (T/C/G), on the pathogenesis of SD. …”
Get full text

Utilization of digital technology-based learning on computational thinking ability of elementary school students: A Meta-analysis study by Ary Kiswanto Kenedi, Sujarwo, Fery Muhamad Firdaus, Yoppy Wahyu Purnomo

“…The research methodology used in this study was meta-analysis. To determine the effect size, thirty-three primary research studies that met the specified inclusion criteria were examined. …”
Get full text

Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO) by Awadhesh Kumar Verma, Payal Gulati, GBVS Lakshmi, Anand Mohan, Neeta Raj Sharma, Pratima R. Solanki, Anil Kumar

“…TMAO interacts with serum albumin in human body and thus, a model study of interaction for TMAO-BSA conjugate is presented in support of it. …”
Get full text

Excessive apoptosis, glycolysis, and abnormal levels of gluconeogenase in rheumatoid arthritis involves in the dysregulation of glucose metabolism: an animal model study by Hui Pi, Qiang Fu, Juan Liu, Haotong Zhou, Youlian Wang

“…The previse mechanisms underlying this association remain incompletely elucidated. In this study, we utilized a cohort of fifty Wistar female rats, establishing a type II collagen-induced arthritis (CIA) model (n = 30). …”
Get full text

LDL cholesterolemia as a novel risk factor for radiographic progression of rheumatoid arthritis: a single-center prospective study. by Yune-Jung Park, Chul-Soo Cho, Paul Emery, Wan-Uk Kim

Get full text

Material philology and Syriac excerpting practices: A computational-quantitative study of the digitized catalog of the Syriac manuscripts in the British Library. by Noam Maeir

“…This study explores the literary practice of excerpting in Syriac manuscripts through a computational-quantitative analysis, contributing to the emerging field of Syriac material philology. …”
Get full text

Untargeted metabolomics-based study of extracts from Simarouba glauca plant parts for insecticidal effects against Spodoptera frugiperda by Komala G, Shanthi Mookiah, Murugan Marimuthu, Sujayanand G. K, Vellaikumar Sampathrajan, Preetha Gnanadhas, Kavitha Govindasamy, Prakash Kolanchi

“…Abstract The Fall armyworm (Spodoptera frugiperda) presents a major challenge to global maize production. This study evaluates the insecticidal potential of Simarouba glauca extracts as an eco-friendly alternative to synthetic pesticides. …”
Get full text

Defining Predictive Factors for Permanent Chemotherapy-Induced Alopecia: Trichoscopy, Reflectance Confocal Microscopy and Histopathology Study on 77 Patients by Michela Starace, Victor Desmond Mandel, Marco Ardigo, Miriam Anna Carpanese, Federico Quadrelli, Francesca Pampaloni, Kaleci Shaniko, Aurora Alessandrini, Francesca Bruni, Alfredo Rossi, Maria Caterina Fortuna, Gemma Caro, Norma Cameli, Martina Silvestri, Gabriella Fabbrocini, Maria Carmela Annunziata, Mariateresa Cantelli, Maria Vastarella, Daniela Rubino, Claudio Zamagni, Giovanni Pellacani, Bianca Maria Piraccini

“…Methods This multicentre, prospective, observational study evaluated patients with cancer who were candidates for chemotherapy with a drug implicated in pCIA development. …”
Get full text

Overcoming Clusterin-Induced Chemoresistance in Cancer: A Computational Study Using a Fragment-Based Drug Discovery Approach by Engelo John Gabriel V. Caro, Marineil C. Gomez, Po-Wei Tsai, Lemmuel L. Tayo

“…Clusterin is one of the many known proteins implicated in cancer chemoresistance, which hinders the effectiveness of chemotherapy. …”
Get full text

Association between herpes simplex virus type 1 and the risk of Alzheimer’s disease: a retrospective case–control study by Christine Johnston, Simon P Fletcher, Yunhao Liu, Shahed Iqbal, Nadine Jarousse

“…Patients with HSV-1 who used antiherpetics were less likely to develop AD compared with those who did not use antiherpetics (adjusted HR 0.83, 95% CI 0.74 to 0.92).Conclusions Findings from this large RWD study implicate HSV-1 in the development of AD and highlight antiherpetic therapies as potentially protective for AD and related dementia.…”
Get full text

Factors in Road Traffic Crashes Among Drivers in Buno Bedelle Zone, Southwest Ethiopia: A Case Control Study by Sabit Zenu, Ameyyu Tesfaye, Gebiso Roba, Ebissa Negera

“…This study was conducted to identify the driver determinants in road traffic crashes in Southwest Ethiopia. …”
Get full text

Integrating agent‐based models into the ensemble ecosystem modelling framework: A rewilding case study at the Knepp Estate, UK by Emily Neil, Ernesto Carrella, Richard Bailey

“…Incorporating space and individual‐level dynamics enabled a more nuanced evaluation of the possible impacts of hypothetical European bison or elk reintroductions, and it revealed an emergent behaviour: woodland regenerated more frequently in thorny scrubland when large herbivores were present. Practical implication. While the ABM‐EEM approach comes with disadvantages such as higher computational demands and reduced transparency, it shows promise for conservation planning and decision‐making, particularly for relatively data‐rich case studies that may require a more complex model.…”
Get full text

Efficiency Assessment of Transit-Oriented Development by Data Envelopment Analysis: Case Study on the Den-en Toshi Line in Japan by Jing Guo, Fumihiko Nakamura, Qiang Li, Yuan Zhou

“…This shift can generate additional benefits from a sustainability perspective. This study aims to assess the efficiency of TOD by applying the data envelopment analysis (DEA) method. …”
Get full text

Group B streptococcus neonatal umbilical colonization managed by dry cord care in nurseries: A retrospective cohort study by Keigo Takahashi, Yuka Sato, Kazushige Ikeda

“…Co-colonization with multiple enteric bacterial species implicates vertical transmission of GBS from undetected carrier mothers during passage through the birth canal.…”
Get full text

Spatial and Temporal Patterns of Trace Element Deposition in Urban Thessaloniki: A <i>Syntrichia</i> Moss Biomonitoring Study by Themistoklis Sfetsas, Sopio Ghoghoberidze, Panagiotis Karnoutsos, Vassilis Tziakas, Marios Karagiovanidis, Dimitrios Katsantonis

“…Multivariate analyses further distinguished the contamination patterns, implicating traffic and industrial activities as key contributors. …”
Get full text

Multisystemic resilience and its impact on youth mental health: reflections on co-designing a multi-disciplinary, participatory study by Linda Theron, Matteo Bergamini, Cassey Chambers, Karmel Choi, Olufunmilayo I. Fawole, Fyneface Dumnamene Fyneface, Jan Höltge, Thandi Kapwata, Diane T. Levine, Diane T. Levine, Zainab Mai Bornu, Makananelo Makape, Celeste Matross, Brian McGrath, Olanrewaju Olaniyan, Dov J. Stekel, Dov J. Stekel, Josh Vande Hey, Caradee Y. Wright, Caradee Y. Wright, Ameh Abba Zion, Michael Ungar

“…It reports on the methodology of the Wellcome-funded R-NEET study: a multidisciplinary, multisystemic, mixed method longitudinal study of resilience among African youth whose status as “not in education, employment or training” (NEET) makes them disproportionately vulnerable to depression. …”
Get full text

Medication adherence in kidney transplant recipients: A cross-sectional study from a nursing clinical practice perspective by Roja Shirafkan, Zahra Majd Teimoori, Ehsan Kazemnejad Leyli, Fateme Jafaraghaee

“…Medication non-adherence is implicated as one of the major causes of early and late kidney transplant rejection. …”
Get full text

Synergetic evolution of energy-economy-environment-society system: A case study of Chengdu-Chongqing urban agglomeration, China by Min An, Wei Xu, Xiaoyan Wang, Weijun He, Xue Fang, Mengfei Song, Bei Wang

Get full text

VCAM-1 predicts poor prognosis and modulates immune infiltration in gastric cancer: a TCGA-based bioinformatics study by Cheng Wu, Cheng Wu, Yungeng Liu, Yungeng Liu, Chuanyuan Liu, Chuanyuan Liu, Chuanfa Fang, Chuanfa Fang

“…Vascular cell adhesion molecule (VCAM)-1, an immune cell adhesion mediator, is implicated in tumor progression; however, its prognostic and immunomodulatory roles in GC remain unclear.MethodsIn this study, we analyzed VCAM-1 expression and its clinical relevance in GC using RNA-sequencing data from The Cancer Genome Atlas. …”
Get full text

Vitamin D Deficiency Is Associated with Increased Osteocalcin Levels in Acute Aortic Dissection: A Pilot Study on Elderly Patients by Elena Vianello, Elena Dozio, Alessandra Barassi, Lorenza Tacchini, John Lamont, Santi Trimarchi, Massimiliano M. Marrocco-Trischitta, Massimiliano M. Corsi Romanelli

“…The identification of these molecules as new factors involved in AAD may be helpful to identify individuals at high risk as well to study preventing strategies.…”
Get full text