PROGRESSION OF POLYCYTHEMIA VERA TO ACUTE MYELOID LEUKEMIA FOLLOWING LONG-TERM HYDROXYUREA THERAPY: A CASE STUDY by Bengisu Ece Duman, Melis Selin Kadıoğlu, Halil İbrahim Yüksel, Birol Güvenç

Get full text

Study of seasonal variation in groundwater geochemistry for beneficial use of drinking and irrigation in Aundha Nagnath tehsil of Maharashtra, India by Vaishnavi Raut, Vasant Wagh, Kartik Tadse, Shankar Karuppannan

“…Abstract The study aims to understand the seasonal variation in groundwater geochemistry for drinking and irrigation uses in Aundha Nagnath tehsil of Maharashtra, India. …”
Get full text

An open-label study evaluating the safety and efficacy of AMO-01 for the treatment of seizures in Phelan-McDermid syndrome by Tess Levy, J. Lloyd Holder, Jr., Joseph P. Horrigan, Michael F. Snape, Alison McMorn, Christina Layton, Hailey Silver, Kate Friedman, Hannah Grosman, Slayton Underwood, Danielle Halpern, Jessica Zweifach, Paige M. Siper, Alexander Kolevzon

“…Future placebo-controlled studies with larger sample sizes and repeated dosing are warranted.…”
Get full text

Shared neural signatures of photophobia in migraine and post-traumatic headache: a task-based fMRI study by Rune Häckert Christensen, Haidar Muhsen Al-Khazali, Anna Gudrun Melchior, Messoud Ashina, Håkan Ashina

“…Methods This cross-sectional functional magnetic resonance imaging (fMRI) study included 80 adults with persistent PTH, 261 with migraine, and 143 healthy controls (HCs). …”
Get full text

Selective serotonin reuptake inhibitor use is associated with right ventricular structure and function: the MESA-right ventricle study. by Corey E Ventetuolo, R Graham Barr, David A Bluemke, Aditya Jain, Joseph A C Delaney, W Gregory Hundley, Joao A C Lima, Steven M Kawut

“…<h4>Purpose</h4>Serotonin and the serotonin transporter have been implicated in the development of pulmonary hypertension (PH). …”
Get full text

An exploratory study of implementing a breakthrough series collaborative in early childhood education and care centers in the United States by Tamara Halle, Anne Douglass, Jennifer Cleveland, Tiffany Bamdad, Hallie Garrison, Kerensa Nagle, Kathryn Tout, Jennifer Agosti, Stephanie Doyle, Diana Gal-Szabo

“…Abstract This study evaluates a professional development (PD) initiative that used an innovative quality improvement methodology, the Breakthrough Series Collaborative (BSC), in early childhood education and care (ECEC) settings in the United States. …”
Get full text

Mechanistic insights into Alpha-Synuclein binding to P2RX7: A molecular dynamic and docking study. by Mukesh Kumar, Kanchan Singh, Jayant Joshi, Shreya Sharma, Amit Kumar, Karuna Irungbam, Manish Mahawar, Mohini Saini

“…Activation of P2RX7 by αSyn is implicated in neuronal degeneration, potentially causing pore dilation and increased inflammation. …”
Get full text

Molecular Identification of Gastroenteritis Pathogens among Adults and Children in Al-Ahsa, Saudi Arabia: A Retrospective Study by Ahmed K. Alqurayn, Hisham M. Yousef, Hameed H. Al Jawad, Abdullatif S. Al Rashed, Obeid E. Obeid, Khaled R. Alkharsah

“…Objectives: To determine the viral, bacterial, and parasitic pathogens implicated in infectious diarrhea among children and adults and describe their seasonality in Al-Ahsa, Saudi Arabia. …”
Get full text

Two Different Transgenes to Study Gene Silencing and Re-Expression During Zebrafish Caudal Fin and Retinal Regeneration by Ryan Thummel, Christopher T. Burket, David R. Hyde

“…First, we demonstrated that the transgene is highly methylated in adult zebrafish caudal fin tissue, but not during fin regeneration, implicating methylation as a potential means of transgene silencing in this line. …”
Get full text

Association of modifiable risk factors and telomere length with five neuroendocrine neoplasms: a bidirectional Mendelian randomization study by Xujia Li, Lingli Huang, Yue Yan, Yuming Rong, Xuxian Chen, Mengge Gao, Jinsheng Huang

“…The outcomes of reverse MR suggested a bidirectional causal relationship between telomere length and gastric neuroendocrine neoplasms. Conclusion This study provided genetic evidence for the causal relationships between potentially modifiable risk factors and the risk of five neuroendocrine neoplasms. …”
Get full text

Low expression of TOX predicts poor prognosis of patients with breast cancer in the real world: A retrospective study by Chunlei Tan, Danping Wu, Xiaotian Yang, Shiyuan Zhang, Shuqiang Liu, Boqian Yu, Xiao Yu, Yuting Xiu, Yuanxi Huang

“…Background: TOX is a transcription factor that is implicated in the regulation of T cell exhaustion in tumors. …”
Get full text

ROS1 Expression Correlates With Inguinal Lymph Node Affection in Vulvar Cancer Patients: A Retrospective Study by Meletios P. Nigdelis, Annick Bitterlich, Mariam Parvanta, Bashar Haj Hamoud, Erich Franz Solomayer, Martin Ertz, Laura Schnöder, Annette Hasenburg, Bernd Holleczek, Mathias Wagner, Gilbert Georg Klamminger

“…Methods In this retrospective study, 48 patients with VSCC undergoing vulvectomy were included. …”
Get full text

Prevalence and predictors of thyroid nodules among adults: analyzing the association with metabolic syndrome in a cross-sectional study by Golbarg Abrishami, Maryam Emadzadeh, Aida Bakhshi, Yasamin Moeinipour, Ghazaleh Taghavi, Solmaz Hasani

“…Metabolic syndrome, characterized by interrelated metabolic abnormalities, has been implicated as a potential risk factor. This study explores the prevalence of thyroid nodules and their association with metabolic syndrome, leveraging data from a large cohort. …”
Get full text

The association of novel inflammatory marker GlycA and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis (MESA). by Sunyoung Jang, Oluseye Ogunmoroti, Di Zhao, Oluwaseun E Fashanu, Martin Tibuakuu, Eve-Marie Benson, Faye Norby, James D Otvos, Susan R Heckbert, Moyses Szklo, Erin D Michos

“…<h4>Background</h4>Emerging evidence has implicated that inflammation contributes to the pathogenesis of atrial fibrillation (AF). …”
Get full text

The Sero-epidemiology of Coxiella burnetii in Humans and Cattle, Western Kenya: Evidence from a Cross-Sectional Study. by Nicola A Wardrop, Lian F Thomas, Elizabeth A J Cook, William A de Glanville, Peter M Atkinson, Claire N Wamae, Eric M Fèvre

Get full text

Decreased naive and increased memory CD4(+) T cells are associated with subclinical atherosclerosis: the multi-ethnic study of atherosclerosis. by Nels C Olson, Margaret F Doyle, Nancy Swords Jenny, Sally A Huber, Bruce M Psaty, Richard A Kronmal, Russell P Tracy

“…<h4>Background</h4>Adaptive immunity has been implicated in atherosclerosis in animal models and small clinical studies. …”
Get full text

Causal Effects Between Blood Pressure Variability and Alzheimer's Disease: A Two‐Sample Mendelian Randomization Study by Pingping Jia, Ziyu Hao, Karen Yiu, Kelvin Tsoi

“…This study aims to explore the causal relationship between BPV and AD by applying Mendelian randomization (MR) to genome‐wide association study (GWAS) summary data. …”
Get full text

Poor sleep quality was associated with increased plasma aldosterone concentration in community dwellers, a cross-sectional study by Xiufang Li, Mulalibieke Heizhati, Mei Li, Ling Yao, Ting Wu, Wenbo Yang, Lin Gan, Hui Wang, Miaomiao Liu, Adalaiti Maitituersun, Mengyue Lin, Jing Hong, Nanfang Li

Get full text

Maternal periconception serum vitamin B12 concentration and risk of preterm birth: a prospective cohort study by Jun Huang, Weili Yan, Yi Zhang, Yalan Dou, Xiaotian Chen, Guoying Huang, Xiaohua Zhang, Xiangfeng Lu, Yuanzhou Peng

“…Background Maternal vitamin B12 levels during pregnancy have been implicated in the risk of preterm birth, but current evidence remains controversial and just focuses on measurements during pregnancy.Objective To assess the association of maternal periconception serum vitamin B12 concentration, including levels before conception and at early gestation, with the risk of preterm birth and its subtypes in a large Chinese population.Design Prospective cohort study.Participants A total of 26 977 women from Shanghai, China, with serum vitamin B12 concentration measured either before conception or at early gestation.Outcome measures Preterm birth was defined as delivery before 37 weeks of gestation and was stratified as preterm birth &lt;32 and &lt;34 weeks. …”
Get full text

Using AlphaFold-Multimer to study novel protein-protein interactions of predation essential hypothetical proteins in Bdellovibrio by Ibukun John Abulude, Isabel Cristina Rodríguez Luna, Alejandro Sánchez Varela, Andrew Camilli, Daniel E. Kadouri, Xianwu Guo

“…Hypothetical proteins with unestablished functions have been implicated in B. bacteriovorus predation by many studies. …”
Get full text