A network medicine approach to investigating ME/CFS pathogenesis in severely ill patients: a pilot study by Li-Yuan Hung, Chan-Shuo Wu, Chia-Jung Chang, Peng Li, Kimberly Hicks, Joshua J. Dibble, Braxton Morrison, Chimere L. Smith, Ronald W. Davis, Wenzhong Xiao

“…This pilot study harnessed the power of network medicine to unravel the complex pathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). …”
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Clinicians’ attitudes to oncology clinical practice guidelines and the barriers and facilitators to adherence: a mixed methods study protocol by Frances Rapport, Jeffrey Braithwaite, Yvonne Tran, Mia Bierbaum, Gaston Arnolda, Bróna Nic Giolla Easpaig, Geoffrey P Delaney, Winston Liauw, Richard Kefford

“…The objectives of this study are to assess clinicians’ attitudes to CPGs for cancer treatment and the perceived barriers to and facilitators of CPG adherence in order to inform the implementation of cancer treatment CPGs.Methods and analysis A mixed methods study will be conducted using a three-phase, sequential design, with each phase informing the next. …”
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Quality of Experience Under Huge Load for WebRTC Applications: A Case Study of Three Media Servers by Ivan Chicano-Capelo, Francisco Gortazar, Micael Gallego

“…From our extensive analysis of the data collected, we provide detailed implications for practitioners when using WebRTC applications.…”
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Framing of disaster impact in online news media: a case study from Malawi on flood risk management by Hannah Bailon, Kees Boersma, Claudia Orellana-Rodriguez, Marc Van Den Homberg, Marc Van Den Homberg

“…However, each news media outlet frames disasters differently, especially since disasters diffuse in time and space. This study addresses these challenges by interrogating the implications of varying depictions of disasters in media reporting and their added value for impact databases. …”
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In situ heat treatment in laser beam welding: a study on high-temperature processing of low-carbon steels by Milton Sergio Fernandes de Lima, Rafael Humberto Mota de Siqueira, Antonio Jorge Abdalla, Raquel Alvim de Figueiredo Mansur, Caroline Cristine de Andrade Ferreira, Vagner Braga, Isabela Atílio Ligabo, Sheila Medeiros de Carvalho, Stephen Liu Chuen, Daolun Chen

“…Nevertheless, the implications of heating and cooling routines during LBW are still not fully understood, and studying them is important for industrial applications. …”
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Functional group influence on uranyl ion adsorption by L-cysteine-grafted graphene oxide: A theoretical study by Bo Liu, Hongjuan Sun, Xu Tang, XinTing Su

“…Notably, L-Cys-GO materials prepared via nucleophilic substitution display superior adsorption performance compared to those synthesized through amide reactions. This study provides a theoretical foundation for the design of effective uranyl ion adsorption materials and holds significant implications for nuclear waste management and environmental pollution remediation.…”
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The Economic and societal burden associated with drug-resistant epilepsy in the Netherlands: an AIM@EPILEPSY burden-of-disease study protocol by Ruud Houben, Ghislaine A P G van Mastrigt, Albert Colon, Silvia Evers, Olaf E M G Schijns, Marian H J M Majoie, Darin Elabbasy, Laura M’Rabet, Vivianne H J M van Kranen-Mastenbroek, Daniëlle B P Eekers, Marc Hendriks

“…These challenges include the physical and mental implications of epilepsy on both caregivers and patients with epilepsy. …”
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The importance of quality of health campaign information for outcome evaluation. A case study from Guinea-Bissau and Bangladesh by Sebastian Nielsen, Sören Möller, Christine Stabell Benn, Peter Aaby

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Operationalizing postmortem pathology-MRI association studies in Alzheimer’s disease and related disorders with MRI-guided histology sampling by Chinmayee Athalye, Alejandra Bahena, Pulkit Khandelwal, Sheina Emrani, Winifred Trotman, Lisa M. Levorse, Zahra Khodakarami, Daniel T. Ohm, Eric Teunissen-Bermeo, Noah Capp, Shokufeh Sadaghiani, Sanaz Arezoumandan, Sydney A. Lim, Karthik Prabhakaran, Ranjit Ittyerah, John L. Robinson, Theresa Schuck, Edward B. Lee, M. Dylan Tisdall, Sandhitsu R. Das, David A. Wolk, David J. Irwin, Paul A. Yushkevich

“…The innovations presented here provide a scalable and reproducible approach to studying postmortem brain pathology, with implications for advancing diagnostic and therapeutic strategies for Alzheimer’s disease and related disorders.…”
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The health experience of children, adolescents and their families during the COVID-19 pandemic: an exploratory qualitative study in pediatric homecare by Clélia Zahnd, Sandra Zoni, Marie-Aline Gonthuey, Julie Bucher Andary, Véronique de Goumoëns

“…To the best of our knowledge, no study has explored the health experience of the entire family during the COVID-19 pandemic by giving them a voice. …”
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Genotype Distribution and Migration Patterns of Hepatitis C Virus in Shandong Province, China: Molecular Epidemiology and Phylogenetic Study by Lin Lin, Guoyong Wang, Lianzheng Hao, Tingbin Yan

“…These findings have implications for public health policy, resource allocation, and targeted treatment strategies. …”
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Clinical and pharmacogenomic predictors of survival in tamoxifen treated breast cancer female patients: a real-world study by Abdullah R. Al-Matrafi, Khaled F. Bedair, Sundararajan Srinivasan, Colin Palmer, Archie Campbell, Caroline Hayward, Ewan R. Pearson, Russell D. Petty

“…A large real-world pharmacogenomic study with long-term follow-up is warranted to determine the impact of CYP2D6 genotyping and its implications for clinical decision making.…”
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Impact of dexmedetomidine as an adjuvant to peribulbar anesthesia on the retinal vasculature in glaucoma patients: an optical coherence tomography angiography study by Mohamed A Awwad, Mona A Elhadad, Mohamed Masoud

“…This effect holds significant implications for glaucoma patients.…”
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Investigating mortality trends and disparities in tricuspid valve disorder: a U.S. nationwide study from 1999 to 2023 by Yusra Ansari, Adarsh Raja, Sandesh Raja, Sheikh Muhammad Ebtehaj Ali, Farman Ali, Isma Noor, Amber Siddique, Saad Shakil, Abdullah, Mahnoor Asghar Keen, Bayan Zafar, Maheera Farooqi, Nabeeha Essam, Muhammad Sami Khan, Muhammad Hamza Shuja, Biruk Demisse Ayalew

“…Further research is required to fully understand the factors driving these trends and their public health implications.…”
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Psychiatric Manifestations of Systemic Lupus Erythematosus Patients in a Tertiary Care Hospital: A Cross-sectional Study by Subhajit Mondal, Sourav Pradhan, Sayanti Ghosh, Arijit Sinha

“…Clinical significance: This study showed positive implications of implementing psychiatric rating scales as a screening tool in SLE patients for early diagnosis of psychiatric manifestations and use as corroborative measures of disease severity.…”
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Bidirectional association between grip strength and cognitive function in Chinese older adults: a nationwide cohort study by Jinfu Wang, Quanming Cui, Xue Xu, Guan Yang

“…Methods This study is based on the China Health and Retirement Longitudinal Study (CHARLS), which included 4,442 eligible individuals aged 60 and above, spanning from 2011 to 2015. …”
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Patients’ accounts of living with and managing inflammatory bowel disease in rural Southern New Zealand: a qualitative study by Tim Stokes, Trudy Sullivan, Fiona Doolan-Noble, Lauralie Richard, Sarah Derrett, Geoff Noller, Andrew McCombie, Michael Schultz, Christine Ho

“…Rural living also had financial implications—cost of time and cost of mobilising resources for long travels to the urban centre for treatments.Conclusions Findings from this study provide a rich understanding of the complex health journeys of people living with IBD and the challenges of managing the condition rurally.…”
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Effect of COVID-19 Lockdown on Alcohol Consumption Among the Youths in Kampala, Uganda. A Cross-Sectional Study by Namiiro AM, Audo R, Nannungi CD, Pitua I, Kiberu D, Talemwa P, Mujuni E, Lwesabula A, Ageimo P, Khaukha AZ, Kuol MJ, Egaru L, Koire M, Ssewante N

“…Alcohol predisposes to a number of health concerns including mental health disorders, cardiovascular diseases among others. This study assessed the impact of the COVID-19 lockdown on alcohol consumption among youths in Kampala, Uganda.Methods: A quantitative cross-sectional study among randomly selected youth aged 18– 35 years living in the five divisions of Kampala. …”
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Premenstrual disorders and risk of sick leave and unemployment: a prospective cohort study of 15 857 women in Sweden by Sara Hägg, Alicia Nevriana, Donghao Lu, Hang Yu, Unnur Anna Valdimarsdottir, Yihui Yang, Elgeta Hysaj, Elizabeth Bertone-Johnson

“…Risk elevations were pronounced for sick leave≥90 days (IRR 1.69, 95% CI 1.50 to 1.91) and depression-related sick leave (IRR 1.41, 95% CI 1.27 to 1.56).Discussion Women with PMDs are at increased risk of sick leave and unemployment, suggesting significant long-term socioeconomic burden associated with PMDs.Clinical implications This study underscores the need for greater awareness of PMDs in clinical practice. …”
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Understanding school frontline workers’ early implementation behavior: insights from the generation healthy kids study in Denmark by Jonas Vestergaard Nielsen, Sofie Koch, Tine Hyldahl Henriksen, Rikke Fredenslund Krølner, Line Lund, Louise Ayoe Sparvath Brautsch, Line Kattai Ulrikkeholm, Camilla Trab Damsgaard, Malte Nejst Larsen, Thomas Skovgaard

“…IntroductionChildhood obesity is a growing global public health issue, with significant implications for children’s physical and psychological well-being. …”
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