Nebivolol effect on oxidative biomarkers in Tamoxifen-Induced Hepatotoxicity in Female White Albino Rats: In Vivo Study by Noor Ahmed Hammadi, Yassir Mustafa Kamal almullahummadi, Huda Jaber Waheed

“…Unfortunately, Epidemiological studies have identified that Long-term tamoxifen treatment has been associated with the development of hepatotoxicity so it was used in this study to induce liver damage. …”
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Plasma Multiplatform Metabolomics Towards Evaluation of Gender Differences in Pulmonary Arterial Hypertension—A Pilot Study by Renata Wawrzyniak, Tamara Gaillard, Margot Biesemans, Bożena Zięba, Ewa Lewicka, Michał Markuszewski, Alicja Dąbrowska-Kugacka

“…Women are more susceptible to PAH yet have higher survival rates than men, a phenomenon called the “estrogen paradox”. This study aims to investigate the sex-based differences in PAH using plasma untargeted metabolomics. …”
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Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study by Yohanes Tandoro, Hui-Fang Chiu, Chei-Ling Tan, Ming-Hong Hsieh, Yi-Wen Huang, Jianhua Yu, Li-Shu Wang, Chi-Ho Chan, Chin-Kun Wang

“…H. pylori infection and overweight have been implicated in AD via the gut-brain axis (GBA). This study aimed to determine whether supplementation of BRBs has a meaningful effect on H. pylori infection, overweight, and AD development in a clinical trial setting. …”
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Spontaneous Coronary Artery Dissection and a Family History of Aortic Dissection: A Genetic Association Study by Lucy McGrath‐Cadell, Stephanie Hesselson, Ingrid Tarr, Emma M. Rath, Michael Troup, Yunkai Gao, Keerat Junday, Monique Bax, Siiri E. Iismaa, Nicholas Collins, David W. M. Muller, Jason C. Kovacic, Eleni Giannoulatou, Robert M. Graham

“…Polygenic risk scores for SCAD were significantly associated with increased odds of SCAD in probands versus controls (odds ratio, 1.79 [95% CI, 1.08–2.99]; P=0.024). Conclusions Our study supports a complex genetic landscape underlying SCAD, implicating rare monogenic pathogenic variants and polygenic risk. …”
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Long-term risk of allergic disorders following Kawasaki disease: a population-based cohort study by Jae-Hee Seol, Lucy Youngmin Eun, Ji-Ho Lee

“…This study aims to investigate the association between KD and allergic diseases in Korea. …”
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Risk factors of non-typhoidal Salmonella gastroenteritis in hospitalised young children: a case–control study by Pei Yee Woh, May Pui Shan Yeung, E Anthony S Nelson, William Bernard III Goggins

“…Objective To explore risk factors associated with non-typhoidal Salmonella gastroenteritis in young children in Hong Kong.Design A case–control study.Setting Paediatrics wards at three public hospitals in Hong Kong.Participants Cases were children aged above 30 days to below 5 years hospitalised for gastroenteritis at three public hospitals in Hong Kong with culture confirmed non-typhoidal Salmonella infection. …”
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Correlation between selenium levels and selenoproteins expression in idiopathic generalized epilepsy: a study from Karachi by Hareem Nisar, Rafat Amin, Sadaf Khan, Tehseen Fatima, Qamar-Un-Nisa, Jawwad-Us-Salam

“…Abstract Background Oxidative damage has been implicated in multiple neurodegenerative diseases, including epilepsy. …”
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Potential drug–drug interactions among hospitalised cardiac patients in Nepal: a prospective observational study by Sunil Shrestha, Binod Kumar Sah, Arun Kumar Karna, Sangam Subedi, Ranjit Kumar Sah, Nim Bahadur Dangi

“…Background Drug–drug interactions (DDIs) are a significant concern for patients on complex therapeutic regimens, especially involving cardiovascular medications, which are frequently implicated in these interactions.Objectives This study used a standardised interaction database to determine the frequency, severity and risk factors associated with potential DDIs (pDDIs) among cardiovascular disease (CVD) in-patients.Methods The prospective cross-sectional study was conducted at a tertiary care hospital in Nepal from April 2024 to October 2024. …”
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Atmospheric carbon monoxide and hospitalization for mental and behavioral disorders: insights from a longitudinal study in Shijiazhuang by Peihua Hu, Wenting Lu, Xian Gao, Yating Li, Yanli Yang, Wanyi Yin, Liang Dong, Ruojia Ren, Xueyi Wang

“…Background and aimCarbon monoxide (CO), a prevalent environmental pollutant, has been implicated in adverse mental health outcomes, but the mechanistic relationship between atmospheric CO levels and hospital admissions for mental and behavioral disorders remains unclear. …”
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A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. by James D McKay, Therese Truong, Valerie Gaborieau, Amelie Chabrier, Shu-Chun Chuang, Graham Byrnes, David Zaridze, Oxana Shangina, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Ivana Holcatova, Vladimir Janout, Lenka Foretova, Pagona Lagiou, Dimitrios Trichopoulos, Simone Benhamou, Christine Bouchardy, Wolfgang Ahrens, Franco Merletti, Lorenzo Richiardi, Renato Talamini, Luigi Barzan, Kristina Kjaerheim, Gary J Macfarlane, Tatiana V Macfarlane, Lorenzo Simonato, Cristina Canova, Antonio Agudo, Xavier Castellsagué, Ray Lowry, David I Conway, Patricia A McKinney, Claire M Healy, Mary E Toner, Ariana Znaor, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf Neto, Leticia Fernández Garrote, Stefania Boccia, Gabriella Cadoni, Dario Arzani, Andrew F Olshan, Mark C Weissler, William K Funkhouser, Jingchun Luo, Jan Lubiński, Joanna Trubicka, Marcin Lener, Dorota Oszutowska, Stephen M Schwartz, Chu Chen, Sherianne Fish, David R Doody, Joshua E Muscat, Philip Lazarus, Carla J Gallagher, Shen-Chih Chang, Zuo-Feng Zhang, Qingyi Wei, Erich M Sturgis, Li-E Wang, Silvia Franceschi, Rolando Herrero, Karl T Kelsey, Michael D McClean, Carmen J Marsit, Heather H Nelson, Marjorie Romkes, Shama Buch, Tomoko Nukui, Shilong Zhong, Martin Lacko, Johannes J Manni, Wilbert H M Peters, Rayjean J Hung, John McLaughlin, Lars Vatten, Inger Njølstad, Gary E Goodman, John K Field, Triantafillos Liloglou, Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A González, J Ramón Quirós, Carmen Martínez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Kay-Tee Khaw, Timothy Key, H Bas Bueno-de-Mesquita, Petra H M Peeters, Antonia Trichopoulou, Jakob Linseisen, Heiner Boeing, Göran Hallmans, Kim Overvad, Anne Tjønneland, Merethe Kumle, Elio Riboli, Kristjan Välk, Tõnu Vooder, Andres Metspalu, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Hélène Blanché, Ivo G Gut, Pilar Galan, Simon Heath, Mia Hashibe, Richard B Hayes, Paolo Boffetta, Mark Lathrop, Paul Brennan

“…Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. …”
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Causal associations between air pollution and breast cancer risk and survival: a Mendelian randomization study by Wenhuan Li, Yonggang Yang, Rong Xie, Xinyu Su, Pengfei Shi, Lin Chen, Bo Hu

“…Abstract Background Air pollution has been implicated in various health conditions, including cancer. …”
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Sleep reduces CSF concentrations of beta-amyloid and tau: a randomized crossover study in healthy adults by Tim Lyckenvik, Martin Olsson, My Forsberg, Pontus Wasling, Henrik Zetterberg, Jan Hedner, Eric Hanse

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Injury Profiling in Male Police Cadets During Initial Training Phase: A Retrospective Cohort Study by Wissem Dhahbi, Helmi Ben Saad, Ismail Dergaa, Marouen Souaifi, Karim Chamari

“…A retrospective cohort study was conducted using prospectively collected injury data on 979 newly recruited male police cadets enrolled in eight batches between 2015 and 2023. …”
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Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics by Zhang J, Xia Z, Dong C, Zhu J, Ni H, Xu Y, Xu Y

“…Although UMI-77 has demonstrated efficacy in mitigating lung injury in sepsis, the molecular mechanisms underlying its action have not yet been fully elucidated.Methods: This study aimed to delineate the mechanism by which UMI-77 counteracts sepsis-induced ALI using comprehensive transcriptomic and metabolomic analyses.Results: UMI-77 significantly ameliorated histopathological changes in the lungs of mice with sepsis-induced ALI Transcriptomic analysis revealed that 124 differentially expressed genes were modulated by UMI-77 and were predominantly implicated in chemokine-mediated signaling pathways, apoptosis regulation, and inflammatory responses. …”
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Assessing correlation between different temporary restorative materials for microleakage following endodontic treatment: an in-vitro study by Qamar Hashem, Mohammed Mustafa, Mohammed A.S. Abuelqomsan, Ahmed Altuwalah, Ahmed A. Almokhatieb, Mohammad Fareed, Mohmed Isaqali Karobari

“…Abstract Background Coronal microleakage, the passage of fluids and bacteria through the interface between the temporary restoration and the tooth structure, can potentially result in endodontic treatment failure. Purpose This study evaluated and compared the sealing efficacy of various temporary restorative materials utilized during endodontic procedures. …”
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Next-generation sequencing reveals viral aetiologies of encephalitis in Ghana: a prospective cross-sectional study by Richmond Yeboah, Richmond Gorman, Philip El-Duah, James Osei-Mensa, Henry Kyeremateng Acheampong, Emmanuella Nyarko-Afriyie, Michael Owusu, Yaw Ampem Amoako, Kwasi Obiri-Danso, Richard Odame Phillips, Victor Max Corman, Christian Drosten, Augustina Angelina Sylverken

“…The survival rate for patients with co-infections was 28.6% (2/7), with HIV-1 and herpesviruses implicated in 85.7% (6/7) of co-infected cases. This study highlights the potential of NGS to expand the diagnostic capabilities for viral encephalitis. …”
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Visualization of FDA Adverse Drug Reaction Reports: Development and Usability Study of the VisDrugs Web Server by Renjun Yang, Nuoya Yin, Yang Zhang, Francesco Faiola

“…About 2,700,000 reports from health care professionals, where only a single drug was implicated, were aggregated and processed using R for statistical analysis and visualization. …”
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Evaluating Non Enzymatic Antioxidants as Potential Biomarkers for Oxidative Stress in Schizophrenia: A Cross-sectional Study by Hemant Sharad Dahake, Yogesh Ramkrishna Pawade, Jayesh Prabhakar Warade

“…Oxidative stress is implicated in various neurological disorders, including schizophrenia. …”
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Does Bilirubin Have a Causal Relationship With Vitiligo? A Mendelian Randomization Study and Bioinformatics Analysis by Xu D, Yin Y, Teng Y, Huang Y, Yu Y, Tao X, Fan Y, Ding X

“…Although bilirubin, a potent endogenous antioxidant, has been implicated in various dermatological conditions, its specific role in vitiligo remains poorly defined. …”
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Incident arrhythmias in relation to ventilatory parameters and pulmonary disease: evidence from two prospective cohort studies by Yun-Jiu Cheng, Li-Ping Qu, Yi-Jian Liao, Si-Long Lu, Mei-Ping Lin, Qian He, Jin-Bo Fu, Jun-Chi Li, Wen-Juan Duan, Li-Juan Liu

“…Methods We analyzed data from 17,684 adults in two prospective cohort studies-the Atherosclerosis Risk in Communities (ARIC; n = 12,929) and Cardiovascular Health Study (CHS; n = 4,755). …”
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