Deep brain stimulation of the anterior cingulate cortex reduces opioid addiction in preclinical studies by Mahdi Fatemizadeh, Esmail Riahi, Gholamreza Hassanzadeh, Anahita Torkaman-Boutorabi, Forough Radfar, Maryam Farahmandfar

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Relationship between Hand Eczema Severity and Occupational Stress: A Cross-Sectional Study by Meriam Hafsia, Imene Kacem, Olfa El Maalel, Maher Maoua, Aicha Brahem, Haifa Aroui, Sana El Guedri, Houda Kalboussi, Souhail Chatti, Najib Mrizek

“…Stress has been recently implicated as a contributing factor of hand eczema (HE) severity. …”
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Ethnobotanical Study of Rattans on Suku Anak Dalam Community in Bukit Duabelas Nasional Park by Dwi Mairida, Muhadiono Muhadiono, Iwan Hilwan

“…</p><p><strong>How to Cite</strong></p><p>Mairida, D., Muhadiono, M., &amp; Hilwan, I. (2016). Etnobotanical Study of Rattans on Suku Anak Dalam Community in Bukit Duabelas Nasional Park. …”
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Preliminary Study to Understand the Role of Gut Microbiota in Coronary Slow Flow Phenomenon (CSFP) by Tayfun Gurol, Tayyip Karaman, Yesim Gurol, Osman Ugur Sezerman, Sinem Oktem Okullu

“…Given the emerging role of gut microbiome in cardiovascular diseases, this study investigates the microbial composition associated with CSFP. …”
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Phthalate exposure is associated with subclinical coronary atherosclerosis: The Aragon Workers' Health Study (AWHS) by Diana María Mérida, Carolina Torrijo-Belanche, Belén Moreno-Franco, Martín Laclaustra, Jimena Rey-García, Sofía Gimeno-Ruiz, Ana Bayán-Bravo, Pilar Guallar-Castillón

“…This study aimed to evaluate the association between phthalate exposure and subclinical coronary atherosclerosis (SCA). …”
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Expression study of Wnt/β-catenin signaling pathway associated lncRNAs in schizophrenia by Fatemeh Manafzadeh, Behzad Baradaran, Seyed Gholamreza Noor Azar, Kamran Javidi Aghdam, Reza Dabbaghipour, Asghar Shayannia, Soudeh Ghafouri-Fard

“…The mechanism and etiology of schizophrenia are extremely complex and multiple signaling pathways recruit genes implicated in the etiology of this disease. While the role of Wnt/β-catenin signaling in this disorder has been verified, the impact of long noncoding RNAs (lncRNAs) associated with this pathway has not been studied in schizophrenia. …”
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Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries by Alexander S. Hatoum, Aaron J. Gorelik, Lauren Blaydon, Spencer B. Huggett, Tingying Chi, David A. A. Baranger, Alex P. Miller, Emma C. Johnson, Arpana Agrawal, Ryan Bogdan

“…Psychiatric genome-wide association studies (GWAS) have identified hundreds of genome-wide significant (GWS) loci that have rapidly advanced our understanding of disease etiology. …”
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TASTY trial: protocol for a study on the triad of nutrition, intestinal microbiota and rheumatoid arthritis by Sofia Charneca, Ana Hernando, Inês Almada-Correia, Joaquim Polido-Pereira, Adriana Vieira, Joana Sousa, Ana Santos Almeida, Carla Motta, Gonçalo Barreto, Kari K. Eklund, Ana Alonso-Pérez, Rodolfo Gómez, Francesco Cicci, Daniele Mauro, Salomé S. Pinho, João Eurico Fonseca, Patrícia Costa-Reis, Catarina Sousa Guerreiro

“…Abstract Background The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). …”
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Gut microbiota composition and phylogenetic analysis in autism spectrum disorder: a comparative study by Fangtao Xiang, Mei Zhang, Xin Wei, Jiali Chang

“…BackgroundAutism spectrum disorder (ASD) is frequently associated with gastrointestinal (GI) disturbances, implicating the gut microbiota and its metabolites, short-chain fatty acids (SCFAs), in disease pathology via the gut-brain axis. …”
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Causal roles of immune cells and metabolites in chronic pancreatitis: a mendelian randomization study by Chao Zhang, Tao Yang, Yuan Yu, Qian Jia, Wan-Meng Xiao, Sha Liu, Ze-Hui Yu, Cheng-Li Wen, Yan Wei, Hao Li, Mu-Han Lü

“…Methods This study utilized publicly available genome-wide association study (GWAS) databases and conducted a two-sample Mendelian randomization (MR) analysis to examine the causal relationships (CRs) among 731 immune cells, 1,400 metabolites, and CP. …”
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Prognostic and immunological landscape of DDX17 in pan-cancer analysis: a comprehensive study by Yu Lei, Xin He, Peng Chen, Yiping Qin, Bin Ge, Yan Liu, Pu Li, Xing Wei

“…Abstract Objective DDX17, an ATP-dependent RNA/DNA helicase, is implicated in the regulation of RNA metabolism and has been linked to tumorigenesis and metastasis in various cancers. …”
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The efficiency and safety of tocilizumab in rheumatoid arthritis(intermediate results of a Russian multicenter study) by E L Nasonov, Elena Yuryevna Panasyuk, S G Buldakov, A B Pavlova, L A Knyazeva, R G Kamalova, I B Vinogradova, E A Shikina, T A Raskina, A A Dmitriyeva, R S Saikovsky, A V Elonakov, V N Amirdzhanova, E N Aleksandrova

“…Clinical and laboratory studies were conducted just before and 4 weeks after the first infusion of TCZ. …”
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The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies by Xiuyuan Zhu, Jiangnan Wei, Jingling Li, Shunli Zuo, Jiaxian Wang, Ning Liu

“…Objective This study aimed to evaluate the causal role of Hcy in various diseases by synthesizing evidence from MR studies. …”
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Causal Central Network Remodeling in Diabetic Neuropathy: An Integrated MR-fMRI Study by Li X, Gao L

“…Neuroimaging identified increased ALFF in the left superior frontal gyrus (LSFG) (AUC=0.79, P&lt; 0.05), which correlated positively with disease duration, accompanied by decoupled FC with the lingual gyrus but enhanced FC with the precuneus.Conclusion: This study establishes DPN as a CNS-periphery integrated network disorder: genetic drivers disrupt default mode-visual integration, while compensatory subcortical-cerebellar hyperconnectivity stabilizes motor function via adaptive mechanisms. …”
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Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes by Fei Yan, Jing Tao, Jie Liu, Yongliang Chen, Zongju Huang

“…GeneMANIA network analysis further implicated NFKB1 in NF-κB signaling and ZFYVE28 in vesicle-mediated transport. …”
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Feature selection and aggregation for antibiotic resistance GWAS in Mycobacterium tuberculosis: a comparative study by Kirill Reshetnikov, Daria Bykova, Daria Bykova, Konstantin Kuleshov, Konstantin Kuleshov, Konstantin Chukreev, Egor Guguchkin, Alexey Neverov, Gennady Fedonin

“…Statistical machine learning (ML) methods are used to infer new genes implicated in drug resistance leveraging large collections of isolates with known whole-genome sequences and phenotypic states for different drugs. …”
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Impact of the alkaline volatile trimethylamine on the physiology of Streptomyces venezuelae: an integrated transcriptomic and metabolomics study by Yanping Zhu, Hanlei Zhang, Meng Liu, Xiuhua Pang

“…Notably, TMA exposure restored the normal expression pattern of the DEGs in MU-1, consistent with the ability of TMA to rescue the MU-1 phenotype, including morphology, acidification of the growth medium, glucose uptake, and antibiotic production; these findings indicated a global impact of TMA on S. venezuelae physiology. In conclusion, our study suggests that the alkaline volatile TMA profoundly affects the physiology of S. venezuelae and may promote the growth of S. venezuelae mutants, enabling their survival in complex microbial communities.IMPORTANCEMicrobes produce a wide array of volatile compounds for which diverse biological roles have been implicated in microbial volatiles. …”
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Whole-Body Cryotherapy Reduces Systemic Inflammation in Healthy Adults: Pilot Cohort Study by Elizabeth Chun, Richard Joseph, Rachele Pojednic

“… BackgroundChronically elevated inflammation is implicated in many conditions, including obesity, metabolic syndrome, and cardiovascular disease, and has been associated with increased mortality risk. …”
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Obesity, but Not Overweight, Is Associated with Increased Presepsin Levels in Infection-Free Individuals: An Exploratory Study by Theocharis Koufakis, Dimitrios Kouroupis, Georgios Dimakopoulos, Theofylaktos Georgiadis, Areti Kourti, Panagiotis Doukelis, Ioanna Zografou, Dimitrios Patoulias, Djordje S. Popovic, Athina Pyrpasopoulou, Luca Busetto, Alexander Kokkinos, Vasilios Tsimihodimos, Kalliopi Kotsa, Michael Doumas, Kali Makedou

“…<b>Conclusions</b>: Although the cross-sectional character of the study cannot demonstrate causal relationships, the results could potentially suggest that systemic inflammation is implicated in the pathogenesis of obesity through the disruption of the intestinal barrier. …”
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Maternal metabolic profiling across body mass index groups: An exploratory longitudinal study by Hege Nyhus Skytte, Marie Cecilie Paasche Roland, Jacob Juel Christensen, Kirsten Bjørklund Holven, Tove Lekva, Nina Gunnes, Trond Melbye Michelsen

“…The unfavorable development of fatty acid composition in overweight/obese women, with possible implication for the offspring, should also be studied further in the future.…”
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