Comparative evaluation of multimarker algorithms for early-stage HCC detection in multicenter prospective studies by Jinlin Hou, Thomas Berg, Arndt Vogel, Teerha Piratvisuth, Jörg Trojan, Enrico N. De Toni, Masatoshi Kudo, Katarina Malinowsky, Peter Findeisen, Johannes Kolja Hegel, Wenzel Schöning, Kairat Madin, Konstantin Kroeniger, Henry Lik-Yuen Chan, Ashish Sharma

“…Methods: An algorithm development study (STOP-HCC-ARP) and clinical validation study (STOP-HCC-MCE) were conducted, recruiting adult participants with HCC (confirmed by radiology or pathology) or CLD in an international, multicenter, case-control design. …”
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Barriers to the implementation of psychosocial interventions on acute mental health wards: an ethnographic observational study by Katherine Berry, Katherine Berry, Isobel Johnston, Isobel Johnston, Paul Wilson, Gillian Haddock, Gillian Haddock, Sandra Bucci, Sandra Bucci, Karina Lovell, Owen Price, Adele Beinaraviciute, Adele Beinaraviciute, Gill Gilworth, Sonalia Kaur, Helen Morley, Helen Morley, Georgia Penn, Georgia Penn, Jessica Raphael, Jessica Raphael, Mica Samji, Richard J. Drake, Richard J. Drake, Dawn Edge, Dawn Edge

“…Although the paper is focused on one specific intervention, the findings have implications for the delivery of other psychosocial interventions within acute mental health settings.MethodWe carried out participant observation across 6 case studies wards all participating in the intervention arm of a cluster randomised controlled trial evaluating the TULIPS intervention compared to treatment as usual. …”
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Nationwide multi-centric prospective study for the identification of biomarkers to predict the treatment responses of nivolumab through comprehensive analyses of pretreatment plasm... by Kuniaki Sato, Satoshi Toh, Taku Murakami, Takafumi Nakano, Takahiro Hongo, Mioko Matsuo, Kazuki Hashimoto, Masashi Sugasawa, Keisuke Yamazaki, Yushi Ueki, Torahiko Nakashima, Hideoki Uryu, Takeharu Ono, Hirohito Umeno, Tsutomu Ueda, Satoshi Kano, Kiyoaki Tsukahara, Akihito Watanabe, Ichiro Ota, Nobuya Monden, Shigemichi Iwae, Takashi Maruo, Yukinori Asada, Nobuhiro Hanai, Daisuke Sano, Hiroyuki Ozawa, Takahiro Asakage, Takahito Fukusumi, Muneyuki Masuda

“…This nationwide multi-centric prospective study aimed to identify a plasma exosome (PEX) mRNA signature, which serves as a companion diagnostic of nivolumab and provides a biological clue to develop effective therapies for a majority of non-survivors.MethodsPre-treatment plasmas (N = 104) of RM-HNSCC patients were subjected to comprehensive PEX mRNA analyses for prognostic marker discovery and validation. …”
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Investigating the Relationship Between Thalamic Volumes, Dementia Risk and Sleep in the PREVENT-Dementia Study by Sita Shah, Axel Laurell, Maria-Eleni Dounavi, Paresh Malhotra, Brian Lawlor

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The strategic value of "chaos" in the South African context for the training of communication students by Gideon de Wet

“…Yet, the School of Communication Studies is inextricably part of the larger institution. …”
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The Wagner Group by Habib Badawi, Mohamad Daabul

“…This study includes the mysterious World Wagner, a private military company, which is said to be related to Russian interests around the world. …”
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Morningness and Conscientiousness: A Meta-analysis, Online Survey and Resting fMRI Study by Debore Buzoku, Sahar Esmat, Ray Norbury

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Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study by Beyazyuz M, Kufeciler T, Bulut L, Unsal C, Albayrak Y, Soydas Akyol E, Baykal S, Kuloglu M, Hashimoto K

“…Furthermore, the serum apoptosis levels in the DS group were significantly higher than the levels in the NDS group.Conclusion: This study suggests that increased levels of apoptosis may be implicated in the pathophysiology of DS syndrome. …”
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The importance of long-term studies in children following viral infection of the central nervous system by Ivanildo P. Sousa, Jr., Patrícia C. de Sequeira, Anne Caroline S.B. Marcos, Nathalia A.A. Almeida, Hanalise V. Huff, Tom Solomon, Vanessa S. de Paula

“…Many viruses have been implicated in neurodevelopmental disorders with long-term consequences that significantly impact families, healthcare systems, economies, and society. …”
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Questioning Strategy That Works to Foster Critical Thinking Skills: A Study In Islamic University by Fathor Rasyid, Nurul Aini, KJ Varghesse

“…This result suggests teachers use questioning strategy to assist students' progress critical thinking. The implication of the study is that teachers should have the HOTS to facilitate and cultivate critical thinking among students and establish a thinking-oriented classroom…”
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Study of root and shoot characteristics in reaction to drought stress in chickpea (Cicer arietinum L.) by mandana Safavi, saeed Malekzadeh Shafaroudi, ali Ganjeali, abodol reza Bagheri

“…In order to evaluate the effect of drought stress on different morpho-physiological characteristics of chickpea, four distinct genotypes were studied in three sampling times (pre-stress, stress and recovery) with three replications. …”
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Study of structural stability of a concrete gravity dam using a reliability approach� by Mohamed Essaddik Kerkar, Mustapha Kamel Mihoubi

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Headache attributed to ischemic stroke – a new scope for management: a case study by Elsayed Abed, Ahmad Farag El-adawey, Mohamed Hamed Rashad, Ahmed Hassan Elsheshiny, Ali Mahmoud Ali, Fathy Mahmoud Mansour, Abdel-Ghaffar Fayed, Mohammad Fathi Abdulsalam, Shaimaa Sayed Khater

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Going around in a Circle: A Norwegian Study of Suicidal Experiences in Old Age by Anne Lise Holm, Anne Lyberg, Ingela Berggren, Sture Åström, Elisabeth Severinsson

“…Depression has repeatedly been found to be a risk factor for completed suicide, particularly when coupled with a pervasive sense of hopelessness. The aim of this study was to evaluate depressed older persons’ suicidal experiences. …”
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A Review Discussing Synthesis and Translational Studies of Medicinal Agents Targeting Sphingolipid Pathways by Sameena Mateen, Jordan Oman, Soha Haniyyah, Kavita Sharma, Ali Aghazadeh-Habashi, Srinath Pashikanti

“…Dysregulation within this network is implicated in the onset and progression of cardiovascular diseases, metabolic disorders, neurodegenerative disorders, autoimmune diseases, and various cancers. …”
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Immunohistochemical Detection of CD147 Expression in Adenocarcinoma of the Prostate: A Case-Control Study by Sara Suliman, Mona Ellaithi

“…CD147, a transmembrane glycoprotein implicated in tumor progression, invasion, and metastasis, has shown potential as a prognostic biomarker in various cancers. …”
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STANCE OF APPROBATION AND GENEROSITY MAXIMS: A CASE STUDY OF A RURAL-BASED COMMUNITY by Farisani Thomas Nephawe

“…Nonetheless, after applying a ‘foot-in-the-door’ technique, most community members cherished these maxims exceptionally.’ The implication of this study promotes observation of approbation and generosity maxims. …”
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Exploring situated expectancy-value theory: A study of gendered higher education choices by Pikić-Jugović Ivana, Doolan Karin, Baranović Branislava

“…The implication of the study is the need to create intervention programmes aimed at deconstructing gender roles and challenging pupils' stereotypes about educational domains and occupations.…”
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Detection of DNA methylation from buccal swabs using nanopore sequencing to study stunting by Alim El-Hakim, Inswasti Cahyani, Muhammad Zulfikar Arief, Gilang Akbariani, Asep Muhamad Ridwanuloh, Syam Budi Iryanto, Ratih Rahayu, Daeng Deni Mardaeni, Vincentius Budhyanto, Yusnita, Wening Sari, Anggi Pn Hidayati, Intan Razari, Silviatun Nihayah, Kinasih Prayuni, Chandra Utomo, Ratih Asmana Ningrum, Susanti Susanti, Ahmad Utomo

“…Interestingly, this locus on chromosome 21 has been implicated in the stunted phenotype of Down syndrome.…”
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Bacterial profiling of colorectal cancer biopsies: a culture-based study in Indian patients by Manish Kushwaha, Manish Kushwaha, Shubham Chaudhary, Akhilesh Kumar Singh, Govind K. Makharia, Anil Kumar

“…A culture-based approach to assessing bacterial diversity offer advantages, enabling the study of individual bacteria to elucidate mechanisms of intestinal carcinogenesis. …”
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