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    Proteomic profiling of gliomas unveils immune and metabolism-driven subtypes with implications for anti-nucleotide metabolism therapy by Jinsen Zhang, Rui Sun, Yingying Lyu, Chaxian Liu, Ying Liu, Yuan Feng, Minjie Fu, Peter Jih Cheng Wong, Zunguo Du, Tianming Qiu, Yi Zhang, Dongxiao Zhuang, Zhiyong Qin, Yu Yao, Wei Zhu, Tiannan Guo, Wei Hua, Hui Yang, Ying Mao

    Published 2024-11-01
    “…Despite substantial progress has been made at the genomic and transcriptomic levels, comprehensive proteomic characterization and its implications remain largely unexplored. In this study, we perform proteomic profiling of gliomas using 343 formalin-fixed and paraffin-embedded tumor samples and 53 normal-appearing brain samples from 188 patients, integrating these data with genomic panel information and clinical outcomes. …”
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    Salvadora persica leaves: phytochemical profile and in vitro-inhibitory activity on inflammatory mediators implicated in periodontal disease by Sabine Kobetitsch, Barbara Gierlikowska, Olaf Kunert, Ahmed M.A. Mazen, Pia Raab, Nadine Kretschmer, Carina Donolo, Teresa Pirker, Rudolf Bauer, Anna K. Kiss, Eva-Maria Pferschy-Wenzig

    Published 2024-12-01
    “…Benzylisothiocyanate, which is likely formed from glucotropaeolin during traditional application of S. persica, showed considerable antiproliferative activity (IC50 in HNO97 cells: 10.19 ± 0.72 µM) besides strongly inhibiting IL-8 and TNFα release.Conclusions Glucotropaeolin and benzylisothiocyanate are likely implicated in the oral health-promoting effects of S. persica leaves. …”
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    ALOX15B-based efferocytosis clusters: prognostic implications and immune cell infiltration in breast cancer by Juan Chen, Chang Zheng, Fei Zhang, Shiyao Sun, Guowen Liu, Guo Huang

    Published 2025-06-01
    “…Abstract Objective Efferocytosis, a process of apoptotic cell clearance, is implicated in the initiation and progression of breast cancer. …”
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    In-silico analysis of nsSNPs in BCL-2 family proteins: Implications for colorectal cancer pathogenesis and therapeutics by Amanda Shen-Yee Kong, Yong Chiang Tan, Hin-Yee Thew, Kok-Song Lai, Swee-Hua Erin Lim, Sathiya Maran, Hwei-San Loh

    Published 2025-06-01
    “…The BCL-2 family proteins are implicated in CRC pathogenesis, yet the impacts of genetic variations within these proteins remains elusive. …”
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