Identification of cold tumor induction–related markers in pancreatic cancer and the clinical implication of PCDH7 by Yuki Mochida, Kenoki Ohuchida, Bo Zhang, Yutaka Yamada, Chikanori Tsutsumi, Akihiro Kubo, Koki Oyama, Tomohiko Shinkawa, Chika Iwamoto, Nobuhiro Torata, Toshiya Abe, Noboru Ideno, Naoki Ikenaga, Kohei Nakata, Yoshinao Oda, Masafumi Nakamura

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Influence of Peptide Conjugation Sites on Lunatin–Alumina Nanoparticles: Implications for Membrane Interaction and Antimicrobial Activity by Carolina Silva Ferreira, Lívia Mara Fontes Costa, Lúcio Otávio Nunes, Kelton Rodrigues de Souza, Giovanna Paula Araújo, Evgeniy S. Salnikov, Kelly Cristina Kato, Helen Rodrigues Martins, Adriano Monteiro de Castro Pimenta, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly

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Leveraging digital skills to reduce cognitive strain: Implications for academic self-efficacy in medical education by Shazia Rehman, Abdullah Addas, Erum Rehman, Muhammad Nasir Khan, Muhammad Ali Shahiman, Md Anisur Rahman, Mi Wang

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Patterns of recurrence after curative D2 resection for gastric cancer: Implications for postoperative radiotherapy by Jing Xu, Li Shen, Yongjie Shui, Wei Yu, Qingqu Guo, Risheng Yu, Yulian Wu, Qichun Wei

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Beyond the left cerebral hemisphere: bilateral language lateralization in healthy aging and its clinical implications by David Toloza-Ramirez, David Toloza-Ramirez, Rodrigo Santibañez, Leonardo Arraño-Carrasco, Romina Zunino-Pesce, Teresa Julio-Ramos, David A. Copland, Camilo Quezada, Carolina Mendez-Orellana, Carolina Mendez-Orellana, Carolina Mendez-Orellana

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Theoretical Model, Model Innovation, and Important Implications of DeepSeek Empowering Library Knowledge Services by ZHANG Xingwang, LI Jie, LI Sifan, WANG Xiaopei

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Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes by Virginia Tajadura-Ortega, Wengang Chai, Lauren A. Roberts, Yibing Zhang, Antonio Di Maio, Alexiane C. Decout, Benedita A. Pinheiro, Angelina S. Palma, Gian De Nicola, Lucia Riaposova, Belen Gimeno-Molina, Yun S. Lee, Hongzhi Cao, Vladimir Piskarev, Yukie Akune, Tiago R. D. Costa, Himani Amin, Lynne Sykes, Phillip R. Bennett, Julian R. Marchesi, Ten Feizi, Yan Liu, David A. MacIntyre

“…S. agalactiae binding to chondroitin sulphate C oligosaccharides is inhibited by L. crispatus. This study highlights glycans as mediators of vaginal bacterial binding events involved in reproductive health and disease.…”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

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Effects of chemoradiotherapy on surface PD-L1 expression in esophageal cancer and its implications for immunotherapy by Lovis Hampe, Stefan Küffer, Tim Niemeier, Niklas Christian Scheele, Laetitia Zoe Hampe, Anna Luisa Riedl, Laura Anna Fischer, David Alexander Ziegler, Martin Leu, Leif Hendrik Dröge, Alexander König, Michael Ghadimi, Friederike Braulke, Stefan Rieken, Hanibal Bohnenberger, Rami A. El Shafie

“…Although the benefit of neoadjuvant chemoradiotherapy (CRT) followed by adjuvant immunotherapy is evident, the effects of CRT on PD-L1 expression in esophageal cancer are not well understood. This study examines the impact of neoadjuvant CRT on PD-L1 surface expression in esophageal cancer both in vitro and in vivo considering its implications for immunotherapy.MethodsPD-L1 expression dynamics were assessed in esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC) cell lines (OE-33, FLO-1, KYSE-180) treated with Carboplatin, Paclitaxel, radiotherapy (RT), and CRT. …”
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A multi-omic approach implicates novel protein dysregulation in post-traumatic stress disorder by Jiawei Wang, Yujing Liu, Hongyu Li, Tuan P. Nguyen, John Lee Soto-Vargas, Rashaun Wilson, Weiwei Wang, TuKiet T. Lam, Chi Zhang, Chen Lin, Traumatic Stress Brain Research Group, David A. Lewis, Jill Glausier, Paul E. Holtzheimer, Matthew J. Friedman, Kenneth R. Williams, Marina R. Picciotto, Angus C. Nairn, John H. Krystal, Ronald S. Duman, Keith A. Young, Hongyu Zhao, Matthew J. Girgenti

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The bile acid metabolome in umbilical cord blood and meconium of healthy newborns: distinct characteristics and implications by Chunxia Lu, Zhiyong Gao, Siqi Zhang, Ke Du, Die Xu, Wenbin Dong, Yujiao Zhang, Xiaoping Lei

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Elevated THOC5 expression in liver cancer and its implications for tumor progression and therapeutic response by Jin-Shu Pang, Jin-Shu Pang, Yu Yang, Yu Yang, Li Liang, Yu-Jia Zhao, Jin-Dan Li, Li-Peng Li, Xue-Xin Wei, Rui-Zhi Gao, Rong Wen, Yun He, Hong Yang, Hong Yang, Hong Yang, Xiu-Mei Bai, Xiu-Mei Bai

“…The THOC5 gene, part of the THO complex, has emerged as a potential regulator in cancer biology. This study investigates THOC5 expression across various cancers, its role in prognosis, and its potential therapeutic implications, particularly in liver hepatocellular carcinoma (LIHC).MethodsWe analyzed THOC5 expression and its prognostic significance across various cancer types using globally available public datasets. …”
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Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic response by Caiyue Li, Zhipin Liang, Gabrielle Vontz, Connor Kent, Wenbo Ma, Lei Liu, Riya Dahal, Jovanny Zabaleta, Guoshuai Cai, Jia Zhou, Huangen Ding, Qiang Shen

“…Although CISD1 has been identified as a prognostic biomarker in specific cancers, its broader implications in tumorigenesis, cancer progression, and immunotherapy remain unclear. …”
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Differences in the pathological, transcriptomic, and prognostic implications of lymphoid structures between primary and metastatic cutaneous melanomas by Jin Xu, Andrew Knight, Jonathan Nguyen, Hong Wang, Walter J Storkus, Cindy Sander, John M Kirkwood, Jiqiang Yao, Xiaofei Song, Jane Messina, James J Mulé, Lilit Karapetyan, Carlos Moran-Segura, Aofei Li, Marion Joy, Sabrina Bruno, Hassan M Abushukair, Danielle Vargas De Stefano, Ayah N Al-Bzour, Caroline Layding

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Comparative analysis of processing speed impairments in TLE, FLE, and GGE: Theoretical insights and clinical Implications by Adam Falah, Gavin P. Winston

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Systematic review of utility values used in the pharmacoeconomic evaluations for schizophrenia: implications on cost-effectiveness results by Junwen Zhou, Aurélie Millier, Clément François, Samuel Aballéa, Mondher Toumi

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The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity by Burak Arslan, Wagner S. Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C. Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L. Benedet, Nicholas J. Ashton

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Biofilm formation by the host microbiota: a protective shield against immunity and its implication in cancer by Elena Montanari, Giancarla Bernardo, Valentino Le Noci, Martina Anselmi, Serenella M. Pupa, Elda Tagliabue, Michele Sommariva, Lucia Sfondrini

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Loving‐Kindness Meditation: Systematic Review of Neuroimaging Correlates in Long‐Term Practitioners and Clinical Implications by Kiren Bashir, Stephen B. Edstrom, Sara J. Barlow, Danielle Gainer, Jeffrey D. Lewis

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A Narrative Review of RAS Mutations in Early-Stage Colorectal Cancer: Mechanisms and Clinical Implications by Hasan Cagri Yildirim, Damla Gunenc, Elvina Almuradova, Osman Sutcuoglu, Suayib Yalcin

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