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    Immunogenomic characteristics and prognostic implications of terminally exhausted CD8+ T cells in colorectal cancers by Ji-Ae Lee, Ji-Ae Lee, Hye Eun Park, Hye Eun Park, Dae-Won Lee, Sae-Won Han, Tae-You Kim, Seung-Yong Jeong, Kyu Joo Park, Jeong Mo Bae, Jeong Mo Bae, Gyeong Hoon Kang, Gyeong Hoon Kang

    Published 2025-05-01
    “…This study explored the immunogenomic characteristics and prognostic implications of Tpex and Ttex in colorectal cancers (CRCs).MethodsWe performed multiplex immunofluorescence (mIF) using antibodies against CK, CD3, CD8, TCF1, and FOXP3 to assess diverse subsets of tumor-infiltrating lymphocytes (TILs) in 517 patients with stage III or high-risk stage II CRCs. …”
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    The Role of Anti-Interferon-α Autoantibodies in Severe COVID-19: Implications for Vaccination Prioritization by Xin Rong Lim, Shiyu Liu, Hwee Siew Howe, Khai Pang Leong, Elampirai Elangovan, Chiung-Hui Huang, Kok Ooi Kong, Bernard Yu Hor Thong, Shawn Vasoo, Bernard Pui Lam Leung

    Published 2025-07-01
    “…<b>Background/Objectives</b>: Neutralizing autoantibodies against type I interferons, particularly interferon-alpha (IFN-α), have been implicated in severe COVID-19 outcomes. This study investigated the prevalence and functional significance of anti-IFN-α autoantibodies (AAbs) in hospitalized unvaccinated COVID-19 patients and their association with COVID-19 disease severity. …”
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    Adenovirus vectors can infect mouse megakaryocytes – implications for vaccine-induced thrombosis/thrombocytopenia by Simon Collett, Linda Earnest, Melissa A. Edeling, Ashley Huey Yiing Yap, Julio Carrera Montoya, Chantal Attard, Ladina Di Rago, Alison Farley, Ashley P. Ng, Paul Monagle, Joseph Torresi

    Published 2025-05-01
    “…Background: Adenoviruses, adenoviral vector vaccines, and gene delivery systems have been implicated in thrombosis/thrombocytopenia syndrome. …”
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