THE IMPACT OF IMPLEMENTING THE FARM TO FORK STRATEGY REGARDING THE USE OF FERTILIZERS AND PESTICIDES IN THE EU by Paula STOICEA, Toma Adrian DINU, Valentina Constanța TUDOR, Mihai GÎDEA, Adina Magdalena IORGA, Irina-Adriana CHIURCIU, Elena SOARE

“…This paper analyzes the existing situation in Romania, Germany, France, Poland, Hungary and the United Kingdom, European countries cultivating cereals, technical plants and oleaginous plants, in the period 2010-2019, regarding the quantities of fertilizers and plant protection substances This analysis has responded to the requests from farmers' associations regarding the effect of the FARM TO FORK strategy, as a essential element of the European Green Pact, has serious implications within the agricultural sector. …”
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Functional regulation of the structure-specific endonuclease FEN1 by the human cytomegalovirus protein IE1 suggests a role for the re-initiation of stalled viral replication forks. by Eva-Maria Schilling, Myriam Scherer, Franziska Rothemund, Thomas Stamminger

“…Flap endonuclease 1 (FEN1) is a member of the family of structure-specific endonucleases implicated in regulation of DNA damage response and DNA replication. …”
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Scaling in Free-Swimming Fish and Implications for Measuring Size-at-Time in the Wild. by Franziska Broell, Christopher T Taggart

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Chronic Exposure of Renal Progenitor Cells (HRTPT) to As (III) Implicates Microfibril Associated Protein 5 (MFAP5) in the Activation of Carcinoembryonic Antigen Related Cell Adhesi... by Md Ehsanul Haque, Donald A. Sens, Scott H. Garrett

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DNA replication timing reveals genome-wide features of transcription and fragility by Francisco Berkemeier, Peter R. Cook, Michael A. Boemo

“…Conversely, regions of strong concordance are associated with open chromatin and active promoters, where elevated firing rates facilitate timely fork progression and reduce replication stress. In this work, we provide a valuable framework for exploring the structural interplay between replication timing, transcription, and chromatin organisation, offering insights into the mechanisms underlying replication stress and its implications for genome stability and disease.…”
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Seismic Intelligence Tool: an extensive multipurpose software for seismic signal analysis by Andrea Bono

“…Seismic Intelligence Tool (SIT) emerges as a software fork from one of Caravel's components previously known as PickFX. …”
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Lambda red mediated gap repair utilizes a novel replicative intermediate in Escherichia coli. by Thimma R Reddy, Léna M S Fevat, Sarah E Munson, A Francis Stewart, Shaun M Cowley

“…Consequently, our findings have important implications for the understanding of E. coli replication and Red recombination.…”
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The DNA replication checkpoint targets the kinetochore to reposition DNA structure-induced replication damage to the nuclear periphery by Tyler M. Maclay, Jenna M. Whalen, Matthew J. Johnson, Catherine H. Freudenreich

“…We show that relocation of a (CAG/CTG)130 tract to the NPC is dependent on phosphorylation of Mrc1 (hClaspin) of the fork protection complex and activation of the Mrc1/Rad53 replication checkpoint, implicating an uncoupled fork as the initial damage signal. …”
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A call for aflatoxin control in Asia by Abeera Umar, Hamzah Shahbaz Bhatti, Sabyan Faris Honey

“…Abstract Aflatoxins are secondary metabolites, produced by some fungal species of the genus Aspergillus, posing health and economic implications throughout the world. Developing countries in Asia usually have tropical conditions and grow crops susceptible to aflatoxin proliferation. …”
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Hyper-Acetylation of Histone H3K56 Limits Break-Induced Replication by Inhibiting Extensive Repair Synthesis. by Jun Che, Stephanie Smith, Yoo Jung Kim, Eun Yong Shim, Kyungjae Myung, Sang Eun Lee

“…Break-induced replication (BIR) has been implicated in restoring eroded telomeres and collapsed replication forks via single-ended invasion and extensive DNA synthesis on the recipient chromosome. …”
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Where is the Italian agriculture heading? by Filippo Arfini, Fabio Bartolini, Anna Carbone, Tatiana Castellotti, Silvia Coderoni, Raffaele Cortignani, Raffaele D'Annolfo, Giovanni Dara Guccione, Michele Donati, Francesca Galli, Roberto Henke, Giampiero Mazzocchi, Alessandro Monteleone, Alessandra Pesce, Maria Rosaria Pupo D'Andrea, Benedetto Rocchi, Donato Romano, Roberta Sardone, Franco Sotte, Stefano Targetti, Catia Zumpano, Meri Raggi

“… In early 2025, the European Union launched a new phase of dialogue on the future of agricultural and food policies, aiming to move beyond the sustainability-centred narratives of the Green Deal and Farm to Fork strategy. The initiative, grounded in the “Strategic Dialogue on the Future of EU Agriculture” and the Commission’s communication “A Vision for Agriculture and Food,” reframes the role of agriculture within a broader geopolitical and socio-economic context. …”
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DNA glycosylase (NEIL3) overexpression associated with low tumor immune infiltration and poor overall patient survival in endometrial cancer by Cristofer Barry, Aashirwad Shahi, Dawit Kidane

“…Previously, we have shown that DNA repair gene (NEIL3) is required for retaining replication fork integrity during replication stress. Here, we examined whether the overexpression of NEIL3 in endometrial cancer associated with altered genomic instability, tumor immunogenicity and anti-tumor immunity in endometrial tumor. …”
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Exploring the nexus between social and environmental sustainability within EU organic agriculture: a systematic literature review by Giulia Magnano, Luca Falasconi, Claudia Giordano

“…The European Union’s Farm-to-Fork Strategy and Green Deal underscore organic farming’s critical role in promoting sustainability and addressing socio-economic issues, including precarious, seasonal, and undeclared labor. …”
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Molecular dependencies and genomic consequences of a global DNA damage tolerance defect by Daniel de Groot, Aldo Spanjaard, Ronak Shah, Maaike Kreft, Ben Morris, Cor Lieftink, Joyce J. I. Catsman, Shirley Ormel, Matilda Ayidah, Bas Pilzecker, Olimpia Alessandra Buoninfante, Paul C. M. van den Berk, Roderick L. Beijersbergen, Heinz Jacobs

“…Abstract Background DNA damage tolerance (DDT) enables replication to continue in the presence of fork stalling lesions. In mammalian cells, DDT is regulated by two independent pathways, controlled by the polymerase REV1 and ubiquitinated PCNA, respectively. …”
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Condensin II interacts with BLM helicase in S phase to maintain genome stability by Brian Rodemoyer, Ganesha Kariyawasam, Veena Subramanian, Kristina Schmidt

“…Condensin II has also been implicated in maintaining genome integrity outside of mitosis, though the underlying mechanisms are unclear. …”
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Prevalence of antimicrobial-resistant Escherichia coli from raw vegetables in Lebanon by Dima Faour-Klingbeil, Victor Kuri, Sukayna Fadlallah, Ghassan M. Matar

“…Introduction: Fresh produce has been implicated in a number of documented outbreaks of foodborne illness caused by bacteria, viruses, and parasites. …”
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Identification of hookworm DAF-16/FOXO response elements and direct gene targets. by Xin Gao, Zhengyuan Wang, John Martin, Sahar Abubucker, Xu Zhang, Makedonka Mitreva, John M Hawdon

“…The transcription factor of A. caninum, Ac-DAF-16, which has a characteristic fork head or "winged helix" DNA binding domain (DBD), has been implicated in the resumption of hookworm development in the host. …”
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Environmental change drives accelerated adaptation through stimulated copy number variation. by Ryan M Hull, Cristina Cruz, Carmen V Jack, Jonathan Houseley

“…Copy number variation (CNV) is rife in eukaryotic genomes and has been implicated in many human disorders, particularly cancer, in which CNV promotes both tumorigenesis and chemotherapy resistance. …”
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MMS exposure promotes increased MtDNA mutagenesis in the presence of replication-defective disease-associated DNA polymerase γ variants. by Jeffrey D Stumpf, William C Copeland

“…Increased mutagenesis could be explained by mutant variants stalling the replication fork, thereby predisposing the template DNA to irreparable damage that is bypassed with poor fidelity. …”
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Integrated Network Analysis Decipher ZNF384‐Related miR‐20b‐5p and miR‐424‐5p in Colon Adenocarcinoma by Bo Zhang, Yoshihisa Matsumoto

“…Gene functional analysis showed enrichment of genes in DNA repair, replication fork, and cell cycle checkpoint signaling pathways. …”
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