Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases by Pierre M Jean Beltran, Joel D Federspiel, Xinlei Sheng, Ileana M Cristea

“…The understanding of these host–pathogen interactions is crucial for the development of treatments and preventive measures against infectious diseases. …”
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Unraveling ScAPD1-mediated resistance mechanism to Verticillium dahliae through integrated host-pathogen transcriptomics by Qilin Yang, Ruirui Yang, Huan Zhang, Fangliu Yin, Leyi Wang, Daoyuan Zhang, Xiaoshuang Li

“…This study investigates the role of ScAPD1, a Soloist transcription factor from the extremophilic moss Syntrichia caninervis, in conferring resistance to V. dahliae when overexpressed in the model plant Arabidopsis thaliana. We employed an integrated host-pathogen transcriptomics approach (dual RNA-seq), alongside physiological and biochemical experiments. …”
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A host-pathogen metabolic synchrony that facilitates disease tolerance by Ying-Tsun Chen, Gaurav Kumar Lohia, Samantha Chen, Zihua Liu, Tania Wong Fok Lung, Chu Wang, Sebastián A. Riquelme

“…Here we show, in a Pseudomonas aeruginosa pneumonia mouse model, that disease tolerance depends on the mitochondrial metabolite itaconate, which mediates cooperative host-pathogen interactions. In P. aeruginosa, itaconate modifies key cysteine residues in TCA cycle enzymes critical for succinate metabolism, inducing bioenergetic stress and promoting the formation biofilms that are less immunostimulatory and allow the bacteria to integrate into the local microbiome. …”
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mSphere of Influence: The integral art of resolving host-virus interactions by Elliott D. SoRelle

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Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration by Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose

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Understanding Host–Pathogen Interactions in Congenital Chagas Disease Through Transcriptomic Approaches by Tatiana M. Cáceres, Luz Helena Patiño, Juan David Ramírez

“…This review synthesizes findings from three RNA-seq studies that explore the molecular underpinnings of congenital Chagas disease, emphasizing differentially expressed genes (DEGs) implicated in host–pathogen interactions. The DAVID tool analysis highlighted the overexpression of genes associated with the innate immune response, including pro-inflammatory cytokines that drive chemotaxis and neutrophil activation. …”
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Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. by Joshua A F Sutton, Oliver T Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F Gibson, Eric J G Pollitt, Simone C Tazoll, William Turnbull, Natalia H Hajdamowicz, Bartłomiej Salamaga, Grace R Pidwill, Alison M Condliffe, Stephen A Renshaw, Waldemar Vollmer, Simon J Foster

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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES

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Exploration of drug repurposing for Mpox outbreaks targeting gene signatures and host-pathogen interactions by Saber Imani, Sargol Aminnezhad, Moslem Alikarami, Zahra Abedi, Iman Samei Mosleh, Mazaher Maghsoudloo, Zahra Taheri

“…Subtype-specific host-pathogen protein-protein interaction networks were constructed, and key modules from the HPI and WGCNA were integrated to identify significant host proteins. …”
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A Comprehensive Multi-Omics Study of Serum Alterations in Red Deer Infected by the Liver Fluke <i>Fascioloides magna</i> by Josipa Kuleš, Miljenko Bujanić, Ivana Rubić, Karol Šimonji, Dean Konjević

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Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions by Aarash Bordbar, Nathan E Lewis, Jan Schellenberger, Bernhard Ø Palsson, Neema Jamshidi

“…To date, integrative analysis of host–pathogen interactions using in silico mass‐balanced, genome‐scale models has not been performed. …”
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Outbreak reconstruction with a slowly evolving multi-host pathogen: A comparative study of three existing methods on Mycobacterium bovis outbreaks by Hélène Duault, Benoit Durand, Laetitia Canini

“…Mycobacterium bovis is a slowly evolving multi-host pathogen and previous studies on outbreaks involving both cattle and wildlife have identified observation biases. …”
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Dual RNA-seq reveals the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus by Qiyuan Jin, Yaxuan Zhai, Rui Qiang, Xin Ma, Chenhao Zhao, Jinqi Zhong, Jijie Li, Qi Chen, Mingxiao Han, Hong Du, Qifei Cong, Haifang Zhang

“…ABSTRACT This study aimed to elucidate the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus infection. …”
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In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae by Yalin Zhang, Lifang Cui, Ruibing Liu, Zili Feng, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Feng Wei, Heqin Zhu

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Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination by Haoran Zhong, Zhiqiang Fu, Jinming Liu, Yamei Jin

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Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania by Zhi Ming Xu, Michaela Zwyer, Hellen Hiza, Sarah Schmidiger, Mohamed Sasamalo, Miriam Reinhard, Anna Doetsch, Sonia Borrell, Olivier Naret, Sina Rüeger, Dylan Lawless, Simon Tang, Faima Isihaka, Hosiana Temba, Thomas Maroa, Rastard Naftari, Christian Beisel, Jerry Hella, Klaus Reither, Daniela Brites, Damien Portevin, Sebastien Gagneux, Jacques Fellay

“…While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to uncover host–pathogen interactions. …”
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Brucella infection induces chromatin restructuring in host cells to activate immune responses by Dejian Xie, Heling Xu, Changwei Su, Jingjing Lu, Wenlong Shen, Ping Li, Bingyu Ye, Jiabao Hou, Junwei Deng, Yan Zhang, Shanhu Li, Zhihu Zhao

“…While their molecular mechanisms are well-characterized, how Brucella induces chromatin restructuring in host cells remains poorly understood, representing a critical gap in host-pathogen interaction research.MethodsUsing an established in vitro infection model of Brucella-infected RAW264.7 murine macrophages, we integrated Hi-C, ATAC-seq, and RNA-seq to generate multi-omics datasets. …”
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Dual RNA-seq study of the dynamics of coding and non-coding RNA expression during Clostridioides difficile infection in a mouse model by Victor Kreis, Claire Toffano-Nioche, Cécile Denève-Larrazet, Jean-Christophe Marvaud, Julian R. Garneau, Florent Dumont, Erwin L. van Dijk, Yan Jaszczyszyn, Anaïs Boutserin, Francesca D'Angelo, Daniel Gautheret, Imad Kansau, Claire Janoir, Olga Soutourina

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Dual single-cell and bulk RNA sequencing reveal transcriptional profiles underlying heterogenous host-parasite interactions in human peripheral blood mononuclear cells by Praveena Chandrasegaran, Bekir Faydaci, Barbara Shih, Barbara Shih, Musa A. Hassan

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TIMP1 secretion induced by Toxoplasma effector GRA24 via p38 MAPK signaling promotes non-disruptive parasite translocation across polarized brain endothelial monolayers by Elena Afanaseva, Antonio Barragan

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