The critical role of Toxoplasma gondii GRA1 in nutrient salvage by Bolin Fan, Biyun Qin, Mingjun Li, Yuchao Zhu, Fuqiang Fan, Hao Xu, Lilan Xue, Yukun Chen, Ming Pan, Bang Shen

“…GRA1 disruption impaired the structure of IVN and abolished the targeting of other GRA proteins to their destinations, which compromised the parasite’s ability to import nutrients from the hosts. These findings reveal the functional mode of GRA1 in T. gondii and highlight its potential as a target for developing new interventions against toxoplasmosis.…”
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Helicobacter pylori-targeted AI-driven vaccines: a paradigm shift in gastric cancer prevention by Zhiwei Tu, Youtao Wang, Junze Liang, Jinping Liu

“…Helicobacter pylori (H. pylori), a globally prevalent pathogen Group I carcinogen, presents a formidable challenge in gastric cancer prevention due to its increasing antimicrobial resistance and strain diversity. …”
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Pentamidine inhibition of streptopain attenuates Streptococcus pyogenes virulence by Keya Trivedi, Christopher N. LaRock

“…This study examines how targeting a specific, highly conserved virulence factor of the secreted cysteine protease streptopain can sensitize a serious pathogen to killing by the immune system. Manipulating the host-pathogen interaction, rather than attempting to directly kill a microbe, is a promising therapeutic strategy. …”
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Insights into periodontal disease: comparative analysis of animal models by Binapani Barik, Saurabh Chawla, Saurabh Chawla, Bhabani Sankar Satapathy, Swadesh Kumar Pattanik, J. Aravind Kumar, Saleh Al-Farraj, Gurudutta Pattnaik, Mika Sillanpää, Mika Sillanpää

“…While human cell cultures provide insights into cellular mechanisms, animal models play a crucial role in understanding the complex host-pathogen interactions and developing therapeutic interventions. …”
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Microbial metabolites and immune modulation by Hassan Ghasemi

“…Microbial metabolites serve as molecular mediators, orchestrating immune homeostasis and modulating responses to pathogens, inflammation, and diseases.1,2 Understanding these interactions has opened new avenues for therapeutic interventions targeting immune-related disorders. …”
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Quantifying transmission and immunity dynamics of multiple SARS-CoV-2 variants using models and epidemic data from a highly populated area. by Monica S Shah, Jiyoung Lee, Laura W Pomeroy

“…Gaining a better understanding of population-level transmission and immune dynamics following the emergence of a novel pathogen can inform future public health interventions including vaccine schedules.…”
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Epidemiology of Acinetobacter baumannii: analysis of hazard factors associated with positivity cases in Guizhou province, China from 2015 to 2023 by Zhongzhi Liang, Di Tian, Yanlan Huang, Shanjiang Dou, Anxin Yang, Zuyi Chen

“…IntroductionThe widely prevalent Acinetobacter baumannii is a gram-negative opportunistic pathogen, with the enormous potential to trigger multiple concurrent diseases. …”
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Comparative Genomic Analysis of <i>Campylobacter</i> Plasmids Identified in Food Isolates by Yiping He, Gretchen Elizabeth Dykes, Siddhartha Kanrar, Yanhong Liu, Nereus W. Gunther, Katrina L. Counihan, Joe Lee, Joseph A. Capobianco

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Analysis of Streptococcus dysgalactiae subspecies equisimilis gene transcripts during experimental primate necrotizing myositis by Jesus M. Eraso, Randall J. Olsen, S. Wesley Long, Ahmad Faili, Samer Kayal, James M. Musser

“…Collectively, our data provide new insights into the SDSE genes transcribed in vivo, thereby enhancing our understanding of the molecular basis of pathogen and primate host interactions. The SDSE genes identified in this study offer promising targets for future studies on molecular pathogenesis and therapeutic interventions.IMPORTANCEStreptococcus dysgalactiae subspecies equisimilis (SDSE) has emerged as an increasingly important bacterial pathogen causing serious invasive infections in humans worldwide. …”
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The Establishment of 3D Polarity-Reversed Organoids From Human Endometrial Tissue as a Model for Infection-Induced Endometritis by Xin Zhang, Li Zhang, Linyuan Fan, Zhaohui Liu

“…By preserving epithelial polarity, this approach offers enhanced physiological relevance, improves host–pathogen interaction studies, and provides a robust platform for evaluating potential therapeutic interventions.…”
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Sialic Acids in Health and Disease by Gerardo N. Guerrero-Flores, Fayth M. Butler, Veronica L. Martinez Marignac, Guangyu Zhang, Fabio J. Pacheco, Danilo S. Boskovic

“…Further investigations encompass a variety of applications, including cell–cell interactions, signaling, host–pathogen interactions, and other biological functions associated with nutrition, metabolism, or genetic disorders. …”
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The PE/PPE family proteins of Mycobacterium tuberculosis: evolution, function, and prospects for tuberculosis control by Zhijing Zhang, Zhijing Zhang, Le Dong, Xin Li, Taibing Deng, Qinglan Wang

“…The PE/PPE protein family, unique to mycobacteria, constitutes ~10% of the Mtb genome and plays critical roles in bacterial physiology, immune evasion, and host-pathogen interactions. This review synthesizes advances in understanding the evolutionary expansion, structural diversity, and functional versatility of PE/PPE proteins, emphasizing their co-evolution with type VII secretion systems (T7SS). …”
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Interplay between autophagy and apoptosis in human viral pathogenesis by Qingqing Shao, Tong Liu, Bin Hu, Liuqing Chen

“…These pathways also act as key battlegrounds in host-pathogen interactions during viral infection. …”
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Overexpression of Interleukin-17 Modulates Responses to Marek’s Disease Virus Infection and Tumor Formation in Chickens by Nitish Boodhoo, Katherine Blake, Fatemeh Fazel, Janan Shoja Doost, Shayan Sharif

“…Understanding the role of host cytokines in MDV pathogenesis is crucial for developing effective interventions. …”
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Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases by Eman K. E. Anwer, Muhammad Ajagbe, Moustafa Sherif, Abobaker S. Musaibah, Shuaib Mahmoud, Ali ElBanbi, Anwar Abdelnaser

“…In addition, gut microbial metabolites play crucial roles in infectious disease susceptibility and resilience, mediating immune pathways that impact pathogen resistance. By consolidating recent insights into the gut microbiota’s role in shaping disease and health, this review underscores the therapeutic potential of targeting microbiome-derived metabolites for treating GI cancers and infectious diseases and calls for further research into microbiome-based interventions.…”
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In vitro antiviral activities of thymol and Limonin against influenza a viruses and SARS-CoV-2 by Gomaa Mostafa-Hedeab, Akram Hegazy, Islam Mostafa, Ibrahim H. Eissa, Ahmed M. Metwaly, Hany Abdelfattah Elhady, Abozer Y. Eledrdery, Sager Holyl Alruwaili, Alaa Oqalaa E. Alibrahim, Fawaz O. Alenazy, Muhannad Faleh Alanazi Alruwaili, Thamer Alshami Marghel, Muharib Alruwaili, Alaaeldin Mohamed Saad, Mahmoud Bayoumi, Assem Mohamed El-Shazly, Luis Martinez-Sobrido, Ahmed Mostafa

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Small but mighty: targeted antifungal liposomes of a smaller size are superior in treating cryptococcal meningitis by Tuyetnhu Pham, Peter Zhang, Suresh Ambati, Richard B. Meagher, Xiaorong Lin

“…To improve the effectiveness of AmB-LLs, we previously developed DectiSomes-targeted AmB-LLs decorated with host dectins that recognize fungal polysaccharides. …”
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Integrated evaluation of lung disease in single animals. by Pratyusha Mandal, John D Lyons, Eileen M Burd, Michael Koval, Edward S Mocarski, Craig M Coopersmith

“…Pulmonary failure in SARS-CoV2-infected hospitalized COVID-19 patients is one such prominent example. Intervention strategies require characterization of the host-pathogen interaction by accurately assessing all of the above-mentioned disease parameters. …”
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The Key Role of <i>Porphyromonas gingivalis</i> in the Pathogenesis of Periodontitis Linked with Systemic Diseases by Bianca Maria Messina, Cristina Grippaudo, Alessandro Polizzi, Andrea Blasi, Gaetano Isola

“…In this regard, <i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) is a key pathogen in the oral microbiome and a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. …”
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Differential Regulation of the Immune Response in the Spleen and Liver of Mice Infected with Leishmania donovani by Rashmi Bankoti, Simona Stäger

“…Leishmania donovani evades these host defense mechanisms to survive and persist in the host. …”
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