Regulation of diel locomotor activity and retinal responses of Anopheles stephensi by ingested histamine and serotonin is temperature- and infection-dependent. by Kevin O Ochwedo, Xiaodi Wang, Nora Céspedes, Ronald E Bentil, Ryan Wild, Emily Hernandez, Amy Hernandez, Hannah L Kaylor, Yared Debebe, Jyotishka Datta, Michael A Robert, Jeffrey A Riffell, Edwin E Lewis, Shirley Luckhart

Get full text

Limiting damage during infection: lessons from infection tolerance for novel therapeutics. by Pedro F Vale, Andy Fenton, Sam P Brown

“…While beneficial at the individual host level, the population consequences of these interventions remain unclear. …”
Get full text

Reviewing the ecological evidence base for management of emerging tropical zoonoses: Kyasanur Forest Disease in India as a case study. by Sarah J Burthe, Stefanie M Schäfer, Festus A Asaaga, Natrajan Balakrishnan, Mohammed Mudasssar Chanda, Narayanaswamy Darshan, Subhash L Hoti, Shivani K Kiran, Tanya Seshadri, Prashanth N Srinivas, Abi T Vanak, Bethan V Purse

“…Options may include "ecological interventions" that target vectors or hosts and require good knowledge of underlying transmission processes, which may be more effective, economical, and long lasting than conventional approaches. …”
Get full text

Metabolic modelling uncovers the complex interplay between fungal probiotics, poultry microbiomes, and diet by Montazar Al-Nijir, Christopher J. Chuck, Michael R. Bedford, Daniel A. Henk

“…However, the complexity of the interactions between probiotics, gut microbiome, and the host hinders the development of effective probiotic interventions. …”
Get full text

A live attenuated NS1-deficient vaccine candidate for cattle-origin influenza A (H5N1) clade 2.3.4.4.b viruses by Ahmed Mostafa, Chengjin Ye, Ramya S. Barre, Vinay Shivanna, Reagan Meredith, Roy N. Platt, Ruby A. Escobedo, Mahmoud Bayoumi, Esteban M. Castro, Nathaniel Jackson, Anastasija Cupic, Aitor Nogales, Timothy J. C. Anderson, Adolfo García-Sastre, Luis Martinez-Sobrido

Get full text

Virulence factors and therapeutic methods of Trueperella pyogenes: A review by Xiangfu Wen, Jia Cheng, Mingchao Liu

“…Currently, virulence factor-mediated vaccine development and other therapeutic approaches are widely regarded as the primary interventions for addressing diseases associated with this pathogen. …”
Get full text

Changing Concepts of “Latent Tuberculosis Infection” in Patients Living with HIV Infection by Stephen D. Lawn, Robin Wood, Robert J. Wilkinson

“…However, the nature of the host-pathogen relationship in those with “latent TB infection” and how this is affected by HIV coinfection are poorly understood. …”
Get full text

Precision Diagnosis of Helicobacter pylori Infection and Its Drug Resistance by Bin Tang, Pu Li, Xuhu Mao

“…Its ability to colonize and persist within the host is driven by a complex arsenal of colonization and virulence factors, underscoring the intricate dynamics of host–pathogen interactions. …”
Get full text

Perspectives on Microbiome Therapeutics in Infectious Diseases: A Comprehensive Approach Beyond Immunology and Microbiology by Hoonhee Seo, Sukyung Kim, Samuel Beck, Ho-Yeon Song

“…These findings underscore the potential of microbiome-based interventions to promote physiological function alongside existing strategies aimed at enhancing host immune responses and pathogen destruction. …”
Get full text

Enhanced hierarchical attention networks for predictive interactome analysis of LncRNA and CircRNA in oral herpes virus by Pradeep Kumar Yadalam, Carlos M. Ardila

“…Conclusion: This study provides insights into lncRNA-circRNA interactions in herpes viral infections, enhancing therapeutic development, disease progression monitoring, and understanding host-pathogen interactions, paving the way for targeted interventions and improved outcomes.…”
Get full text

The microbiota, the malarial parasite, and the mice—a three-sided relationship by Shanli He, Yanwei Qi

“…Meanwhile, Plasmodium infection induces decreased microbial diversity and functional pathway deviation in murine microbiota, exacerbating host immunometabolic imbalance. These advancements not only elucidate core biological principles governing “microbiota-host-pathogen” interactions but also transcend traditional pathogen-centric perspectives by pioneering precise intervention strategies based on microbiota homeostasis restoration. …”
Get full text

Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model. by Daniel M Foulkes, Keri Mclean, Tarunima Sharma, David G Fernig, Stephen B Kaye

“…Infection models are vital tools in understanding host-pathogen interactions and the development of novel therapies. …”
Get full text

Individual-based multiscale model for foot-and-mouth disease by Blessings Mufoya, Dephney Mathebula, Dephney Mathebula, Winston Garira

“…An important feature of individual-based network multiscale models is that they incorporate heterogeneity in [i.] host susceptibility to infection, [ii.] the ability of hosts to transmit pathogen to other hosts, [iii.] host immune response, and [iv.] host behaviour. …”
Get full text

Microbiota, chronic inflammation, and health: The promise of inflammatome and inflammatomics for precision medicine and health care by Huan Zhang, Bing Jun Yang Lee, Tong Wang, Xuesong Xiang, Yafang Tan, Yanping Han, Yujing Bi, Fachao Zhi, Xin Wang, Fang He, Seppo J. Salminen, Baoli Zhu, Ruifu Yang

Get full text

Virulence factors released by extracellular vesicles from Cryptococcus neoformans by Wenhao Xiao, Huiqiang Lu, Bowei Jiang, Yaqi Zheng, Puwen Chen, Xiaotong Liu, Junyun Huang

“…Cryptococcus neoformans, a prominent opportunistic pathogen, is equipped with unique mechanisms to evade host immune defenses, notably through its capsule and the secretion of extracellular vesicles (EVs). …”
Get full text

Experimental dissection of tuberculosis protective immunity: a human perspective by Sarah Schmidiger, Sarah Schmidiger, Damien Portevin, Damien Portevin

“…Our knowledge gap in protective immunity in TB impedes the development of such new vaccines and host-directed interventions. Mtb is a pathogen highly adapted to humans and primarily infects the lungs. …”
Get full text

Prediction of potential drug targets and key inhibitors (ZINC67974679, ZINC67982856, and ZINC05668040) against Rickettsia felis using integrated computational approaches by Sudais Rahman, Hsien Liu, Mohibuallah Shah, Mashal M. Almutairi, Iram Liaqat, Tetsuya Tanaka, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Chien-Chin Chen, Abdulaziz Alouffi, Abid Ali

“…The rise in antibiotic-resistant strains of this pathogen underscores the urgent need for new therapeutic interventions. …”
Get full text

Comprehensive RNA-Seq Profiling to Evaluate the Sheep Mammary Gland Transcriptome in Response to Experimental Mycoplasma agalactiae Infection. by Rohini Chopra-Dewasthaly, Melanie Korb, René Brunthaler, Reinhard Ertl

“…Knowledge of mechanisms of its pathogenesis and persistence in the mammary gland are still insufficient, especially the host-pathogen interplay that enables it to reside in a chronic subclinical state. …”
Get full text

Tropical infections and the gut microbiome: dysbiosis, recovery, and clinical implications by Biruk Demisse Ayalew, Muhammad Umar, Muhammad Saeed, Ahtisham Ali, Kaleb Assefa Berhane, Temesgen Mamo Sharew, Yonatan Abbawa Zewdie, Eskeatnaf Yosef Getachew, Zemichael Getu Alemayehu, Abate Bane Shewaye

“…The gastrointestinal (GI) microbiome, crucial for host health through its roles in digestion, immunity, and pathogen protection, is significantly disrupted by tropical infections. …”
Get full text

Molecular dissection of laboratory contamination between two schistosome populations by Kathrin S. Jutzeler, Roy N. Platt, Xue LI, Madison Morales, Robbie Diaz, Winka Le Clec’h, Frédéric D. Chevalier, Timothy J. C. Anderson

Get full text