Determinants for the development of visceral leishmaniasis disease. by Laura-Isobel McCall, Wen-Wei Zhang, Greg Matlashewski

“…In this review, we discuss the vector, host, and pathogen factors that mediate the development of visceral leishmaniasis. …”
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The meaning of death: evolution and ecology of apoptosis in protozoan parasites. by Sarah E Reece, Laura C Pollitt, Nick Colegrave, Andy Gardner

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Understanding the interaction between cytomegalovirus and tuberculosis in children: The way forward. by Laura Olbrich, Lisa Stockdale, Robindra Basu Roy, Rinn Song, Luka Cicin-Sain, Elizabeth Whittaker, Andrew J Prendergast, Helen Fletcher, James A Seddon

“…It is also unclear how potential interventions might affect disease progression and outcome for TB or CMV. …”
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Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. by Philip M Elks, Sabrina Brizee, Michiel van der Vaart, Sarah R Walmsley, Fredericus J van Eeden, Stephen A Renshaw, Annemarie H Meijer

“…Our findings indicate that induction of leukocyte iNOS by stabilizing Hif-1α, or reducing Hif-2α, aids the host during early stages of Mm infection. Stabilization of Hif-1α therefore represents a potential target for therapeutic intervention against tuberculosis.…”
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Rice ragged stunt virus Pns10 induces mitochondrial-mediated apoptosis to promote viral infection in Nilaparvata lugens through disrupting the NlNDUFS1-NlPHB2 interaction. by Lianshun Zheng, Shuai Fu, Ming Zeng, Liyan Li, Dan Wang, Shibo Gao, Yunge Zhang, Cui Zhang, Shifang Fei, Xuan Ye, Lele Chen, Qianhui Chen, Yaqin Wang, Xueping Zhou, Yan Xie, Boli Hu, Jianxiang Wu

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APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps. by Dong Liu, Dat Mai, Ana N Jahn, Tara A Murray, John D Aitchison, Benjamin H Gern, Kevin B Urdahl, Alan Aderem, Alan H Diercks, Elizabeth S Gold

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Dengue virus reduces AGPAT1 expression to alter phospholipids and enhance infection in Aedes aegypti. by Thomas Vial, Wei-Lian Tan, Benjamin Wong Wei Xiang, Dorothée Missé, Eric Deharo, Guillaume Marti, Julien Pompon

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Is "pre-sepsis" the new sepsis? A narrative review. by Rémy Gerard, Antoine Dewitte, Fridolin Gross, Thomas Pradeu, Maël Lemoine, Julien Goret, Maria Mamani-Matsuda

“…The latest Sepsis-3 definition describes sepsis as life-threatening organ dysfunction due to a dysregulated host response. However, this clinical characterization may be too late for effective intervention. …”
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Eating the brain - A multidisciplinary study provides new insights into the mechanisms underlying the cytopathogenicity of Naegleria fowleri. by Ronald Malych, Filipe Folgosa, Jana Pilátová, Libor Mikeš, Vít Dohnálek, Jan Mach, Magdaléna Matějková, Vladimír Kopecký, Pavel Doležal, Robert Sutak

“…The aim of this study was to investigate the interactions between N. fowleri and host cells in order to elucidate the mechanisms underlying the pathogenicity of this amoeba. …”
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Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility. by David S Donaldson, Anuj Sehgal, Daniel Rios, Ifor R Williams, Neil A Mabbott

“…Determining the route by which prions establish host infection will identify the important factors that influence oral prion disease susceptibility and to which intervention strategies can be developed. …”
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CMPK2 restricts Zika virus replication by inhibiting viral translation. by Joanna B Pawlak, Jack Chun-Chieh Hsu, Hongjie Xia, Patrick Han, Hee-Won Suh, Tyler L Grove, Juliet Morrison, Pei-Yong Shi, Peter Cresswell, Maudry Laurent-Rolle

“…Therefore, there is a pressing need to identify host and viral factors that can be targeted for effective therapeutic intervention. …”
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The contribution of social behaviour to the transmission of influenza A in a human population. by Adam J Kucharski, Kin O Kwok, Vivian W I Wei, Benjamin J Cowling, Jonathan M Read, Justin Lessler, Derek A Cummings, Steven Riley

“…Variability in the risk of transmission for respiratory pathogens can result from several factors, including the intrinsic properties of the pathogen, the immune state of the host and the host's behaviour. …”
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Mathematical models of drug-resistant tuberculosis lack bacterial heterogeneity: A systematic review. by Naomi M Fuller, Christopher F McQuaid, Martin J Harker, Chathika K Weerasuriya, Timothy D McHugh, Gwenan M Knight

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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies. by Melanie Rissmann, Danny Noack, Thomas M Spliethof, Vincent P Vaes, Rianne Stam, Peter van Run, Jordan J Clark, Georges M G M Verjans, Bart L Haagmans, Florian Krammer, Marion P G Koopmans, Judith M A van den Brand, Barry Rockx

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Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule. by Tingting Wang, Huaizhi Yang, Qiushuang Sheng, Ying Ding, Jian Zhang, Feng Chen, Jianfeng Wang, Lei Song, Xuming Deng

“…Hypervirulent Klebsiella pneumoniae (hvKP) poses an alarming threat in clinical settings and global public health owing to its high pathogenicity, epidemic success and rapid development of drug resistance, especially the emergence of carbapenem-resistant lineages (CR-hvKP). …”
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Myeloid infection links epithelial and B cell tropisms of Murid Herpesvirus-4. by Bruno Frederico, Ricardo Milho, Janet S May, Laurent Gillet, Philip G Stevenson

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Dissecting the molecular diversity and commonality of bovine and human treponemes identifies key survival and adhesion mechanisms. by Gareth J Staton, Simon R Clegg, Stuart Ainsworth, Stuart Armstrong, Stuart D Carter, Alan D Radford, Alistair Darby, Jonathan Wastling, Neil Hall, Nicholas J Evans

“…This work has shed light on treponeme host adaptation and has identified candidate molecules for future diagnostics, vaccination and therapeutic intervention.…”
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Lymph node colonization dynamics after oral Salmonella Typhimurium infection in mice. by Patrick Kaiser, Emma Slack, Andrew J Grant, Wolf-Dietrich Hardt, Roland R Regoes

“…An understanding of how pathogens colonize their hosts is crucial for the rational design of vaccines or therapy. …”
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Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis by Jiaqi Wang, Yan Zhang, Duo Luo, Jing Xu, Xin Nie, Chen Huang, Hailan Zhao, Minzheng Zhu, Xue Guo, Yong Zhang, Wenjing Qiu, Haoming Xu, Yuqiang Nie, Youlian Zhou

“…These findings suggest that both Sg-derived metabolites and host immune signaling may serve as potential targets for CRC intervention. …”
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Determinants of Campylobacter species diversity in infants and association with family members, livestock, and household environments in rural Eastern Ethiopia by Amanda Ojeda, Loïc Deblais, Bahar Mummed, Mussie Brhane, Kedir A. Hassen, Belisa Usmael Ahmedo, Yenenesh Demisie Weldesenbet, Dehao Chen, Xiaolong Li, Cyrus Saleem, Mark J. Manary, Luiz F. W. Roesch, Sarah L. McKune, Arie H. Havelaar, Gireesh Rajashekara, the CAGED Research Team

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