Microbiota-Accessible Borates as Novel and Emerging Prebiotics for Healthy Longevity: Current Research Trends and Perspectives by Andrei Biţă, Ion Romulus Scorei, Marvin A. Soriano-Ursúa, George Dan Mogoşanu, Ionela Belu, Maria Viorica Ciocîlteu, Cristina Elena Biţă, Gabriela Rău, Cătălina Gabriela Pisoschi, Maria-Victoria Racu, Iurie Pinzaru, Alejandra Contreras-Ramos, Roxana Kostici, Johny Neamţu, Viorel Biciuşcă, Dan Ionuţ Gheonea

“…Microbiota-accessible borate (MAB) complexes, such as boron (B)–pectins (rhamnogalacturonan–borate) and borate–phenolic esters (diester chlorogenoborate), have a significant impact on healthy host–microbiota symbiosis (HMS). The mechanism of action of MABs involves the biosynthesis of the autoinducer-2–borate (AI-2B) signaling molecule, B fortification of the mucus gel layer by the MABs diet, inhibition of pathogenic microbes, and reversal of GM DYS, strengthening the gut barrier structure, enhancing immunity, and promoting overall host health. …”
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In Vitro Adhesion and Invasion Rates of <i>Staphylococcus aureus</i> Isolated from Mastitic Cows Are Modulated by the <i>agr</i> System and <i>MSCRAMM</i> Genes by Erika Carolina Romão Bonsaglia, Bruna Fernanda Rossi, Fabio Sossai Possebon, Nathalia Cristina Cirone Silva, Juliano Leonel Gonçalves, Ivana Giovannetti Castilho, Ary Fernandes Junior, Marcos Veiga dos Santos, Vera Lúcia Mores Rall

“…These findings contribute to the understanding of the pathogen–host dynamics in bovine mastitis and highlight the importance of both MSCRAMMs and the <i>agr</i> system in modulating disease severity. …”
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Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in T... by Mahmoud Bayoumi, Ramya S. Barre, Ruby A. Escobedo, Vinay Shivanna, Nathanial Jackson, Chengjin Ye, Adolfo García-Sastre, Ahmed Mostafa, Luis Martinez-Sobrido

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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…Therefore, there is an urgent need for more research on the pathogenesis of N. fowleri and the identification of novel targets for intervention. With the advances in genomic and proteomic technologies, new opportunities have emerged to explore the molecular biology of N. fowleri and its host response. …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…We identified genes that are thus far unique to S. molnari, which reveal their evolutionary novelty and likely role as adaptations to specific host niches. In addition, we describe the pathogenicity-associated genetic toolbox of S. molnari and discuss the implications of our discoveries for disease control by shedding light on specific targets for potential intervention strategies.…”
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Community involvement and engagement in designing a social-media based educational intervention for oral and sexual health promotion in transgender women in Malaysia: a narrative s... by Lahari A. Telang, Hezreen Shaik Daud, Zariq Rosita-Hanif, Betty Nizam, Aoife G. Cotter, Abdul Rashid

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Comprehending toll-like receptors: pivotal element in the pathogenesis of sepsis and its complications by Wei Wang, Shengtian Mu, Dongli Yan, Huan Qin, Zhen Zheng

“…This review delineates the intricate roles of Toll-like receptors (TLRs), essential components of the innate immune system, in mediating host responses during sepsis. TLRs recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), thereby initiating signaling cascades that lead to the synthesis of pro-inflammatory cytokines and chemokines. …”
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From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Con... by Xianfu Mu, Kongjun Liu, Jinghan Yang, Juan Liu, Fengpei Du, Gefei Hao, Peiyi Wang

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New Insights on the Carbapenem-resistant Gram Negative-associated-Infections: Challenges and Opportunities by Samar S. Mabrouk, Ghada R. Abdellatif, Ahmed S. Abu Zaid, Khaled M. Aboshanab

“…Gram-negative bacterial (GNB) infections represent a worldwide serious public health challenge, especially with the increased global spread of carbapenem resistance among these pathogens. There are different forms of carbapenem resistance including, intrinsic and acquired mechanisms, the most significant of which is carbapenemase production. …”
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Advances in Donkey Disease Surveillance and Microbiome Characterization in China by Muhammad Zahoor Khan, Yan Li, Mingxia Zhu, Mengmeng Li, Tongtong Wang, Zhenwei Zhang, Wenqiang Liu, Qingshan Ma, Changfa Wang

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Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission by Ahmed Mostafa, Mahmoud M. Naguib, Aitor Nogales, Ramya S. Barre, James P. Stewart, Adolfo García-Sastre, Luis Martinez-Sobrido

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Characterization of the Gut Microbiota in Patients with Psoriasis: A Systematic Review by Yingjun Gao, Yanfeng Lou, Yun Hui, Huan Chen, Hong Sang, Fang Liu

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Impact of Climate Change and Air Pollution on Bronchiolitis: A Narrative Review Bridging Environmental and Clinical Insights by Cecilia Nobili, Matteo Riccò, Giulia Piglia, Paolo Manzoni

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Molecular and Epidemiological Investigation of <i>Cryptosporidium</i> Infection in Goat Population from Bouira Province, Algeria by Samia Bedjaoui, Djamel Baroudi, Karim Tarik Adjou, Bernard Davoust, Younes Laidoudi

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Understanding Mycobacterium tuberculosis through its genomic diversity and evolution. by Mollie I Sweeney, Carson E Carranza, David M Tobin

“…Pathogen evolution and genomic diversity are shaped by specific host immune pressures and therapeutic interventions. …”
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Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies by Jiaqian Song, Wei Zhang, Deqiang Wang

“…Colorectal cancer (CRC), in particular, has emerged as the second leading cause of cancer-related mortality worldwide. Now, Specific pathogenic bacteria, such as Fusobacterium nucleatum (F. nucleatum) and Helicobacter pylori (H. pylori), critically promote tumorigenesis through multiple mechanisms, including the induction of genotoxic damage, host metabolic reprogramming, and remodeling of the tumor immune microenvironment. …”
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Staphylococcus aureus infection dynamics. by Eric J G Pollitt, Piotr T Szkuta, Nicola Burns, Simon J Foster

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Impact of Sanitation on Rodent Pullulation and Plague Status in an Informal Settlement on the Outskirts of Mahajanga (Madagascar) by Soanandrasana Rahelinirina, Zara Nomentsoa Razafiarimanga, Minoarisoa Rajerison, Medard Djedanem, Pascal Handschumacher, Ronan Jambou

“…The plague cycle involves wild and commensal rodents and their fleas; humans are an accidental host. Madagascar is the country where plague burden is the highest. …”
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Progression of Plasmodium berghei through Anopheles stephensi is density-dependent. by Robert E Sinden, Emma J Dawes, Yasmene Alavi, Joanna Waldock, Olivia Finney, Jacqui Mendoza, Geoff A Butcher, Laura Andrews, Adrian V Hill, Sarah C Gilbert, María-Gloria Basáñez

“…It is well documented that the density of Plasmodium in its vertebrate host modulates the physiological response induced; this in turn regulates parasite survival and transmission. …”
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Serosurvey of <i>Rickettsia</i> spp. and <i>Ehrlichia canis</i> in Dogs from Shelters in Sicily (Southern Italy) by Santina Di Bella, Delia Gambino, Davide Pepe, Antonino Gentile, Valeria Blanda, Antonio Valenti, Francesco Santangelo, Antonino Ballatore, Giuseppe Spina, Giuseppe Barbaccia, Vincenza Cannella, Giovanni Cassata, Annalisa Guercio

“…Vector-borne diseases represent a serious threat to human and animal health, especially where environmental conditions favor pathogen-carrying vectors. Dogs serve as natural hosts for two tick-borne pathogens: <i>Ehrlichia canis</i>, which causes canine monocytic ehrlichiosis, and spotted fever group (SFG) <i>Rickettsia</i> spp., a zoonotic threat in the Mediterranean region. …”
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