Systems Biology-Driven Discovery of Host-Targeted Therapeutics for Oropouche Virus: Integrating Network Pharmacology, Molecular Docking, and Drug Repurposing by Pranab Dev Sharma, Abdulrahman Mohammed Alhudhaibi, Abdullah Al Noman, Emad M. Abdallah, Tarek H. Taha, Himanshu Sharma

“…<b>Results:</b> The PPI network analysis highlighted immune-mediated pathways such as Fc-gamma receptor signaling, cytokine control, and T-cell receptor signaling as critical intervention points. Molecular docking revealed strong binding affinities between the selected compounds and the prioritized targets, suggesting their potential efficacy as host-targeting antiviral candidates. …”
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Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers by Yaohui Sun, Zhiming Gan, Xiaojin Wang, Jian Liu, Wei Zhong, Zhiyan Zhang, Jiebin Zuo, Hang Zhong, Xiuting Huang, Zhixiang Yan, Qingdong Cao

“…Patients with ES-LUAD exhibited local microbial dysbiosis, suggesting the potential pathogenicity of certain microbial species. Through multi-omics correlations, intricate local crosstalk between the host and local microbial communities was observed. …”
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EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. by Ruyang Tan, Yuling Zhang, Mengqian Huang, Honghua Chen, Zixiang Liu, Zining Wang, Xiaoyan Li, Tao Wang, Zhiyun Wang

“…Our findings offer new insights into how EV-D68 manipulates host translation and highlight the potential of targeting LARP1 and PABPC1 for antiviral interventions.…”
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A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses. by Hugh D Mitchell, Amie J Eisfeld, Amy C Sims, Jason E McDermott, Melissa M Matzke, Bobbi-Jo M Webb-Robertson, Susan C Tilton, Nicolas Tchitchek, Laurence Josset, Chengjun Li, Amy L Ellis, Jean H Chang, Robert A Heegel, Maria L Luna, Athena A Schepmoes, Anil K Shukla, Thomas O Metz, Gabriele Neumann, Arndt G Benecke, Richard D Smith, Ralph S Baric, Yoshihiro Kawaoka, Michael G Katze, Katrina M Waters

“…Here we implement an integrated network interrogation approach, in which proteome and transcriptome datasets from infection of both viruses in human lung epithelial cells are utilized to predict regulatory genes involved in the host response. We take advantage of a novel "crowd-based" approach to identify and combine ranking metrics that isolate genes/proteins likely related to the pathogenicity of SARS-CoV and influenza virus. …”
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High-risk clonal groups of avian pathogenic Escherichia coli (APEC) demonstrate heterogeneous phenotypic characteristics in vitro and in vivo by James R. G. Adams, Huijun Long, Charlotte A. Birdsall, Kamran Qureshi, Emma King, Sara Perez, Keith Warner, Shahriar Behboudi, Roberto M. La Ragione, Jai W. Mehat

“…These results highlight the need for intervention strategies that can simultaneously target a broad range of pathogenic lineages.…”
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Enhancing bloodstream infection diagnostics: a novel filtration and targeted next-generation sequencing approach for precise pathogen identification by Ting-Syuan Lin, Ting-Syuan Lin, Ting-Syuan Lin, ZiHao Zhu, ZiHao Zhu, ZiHao Zhu, XiaoHong Lin, Hsi-Yuan Huang, Hsi-Yuan Huang, Hsi-Yuan Huang, Li-Ping Li, Li-Ping Li, Li-Ping Li, Jing Li, Jing Li, Jing Li, Jie Ni, Jie Ni, Jie Ni, PeiZhi Li, LanChun Chen, WeiXin Tang, HuiXin Liu, XiaoLong Se, MingFei Xie, Canling Long, Chih-Min Chiu, Szu-Han Fang, JiaMing Zhao, Yang-Chi-Dung Lin, Yang-Chi-Dung Lin, Yang-Chi-Dung Lin, XueTao Yu, Hsien-Da Huang, Hsien-Da Huang, Hsien-Da Huang, Hsien-Da Huang

“…The filtration membrane, designed with surface charge properties to be electrostatically attractive to leukocytes for the selective capture of specific cells, demonstrated high efficiency in removing host cells and nucleic acids, achieving over a 98% reduction in host DNA and thereby minimizing background interference in pathogen detection. …”
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Advances in sepsis research: Insights into signaling pathways, organ failure, and emerging intervention strategies by Yehua Li, Siying Ren, Shen’ao Zhou

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Biological Control of Mosquito-Borne Diseases: The Potential of Wolbachia-Based Interventions in an IVM Framework by El Hadji Amadou Niang, Hubert Bassene, Florence Fenollar, Oleg Mediannikov

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High throughput screening for human disease associated-pathogens and antimicrobial resistance genes in migratory birds at ten habitat sites in China by Lan Wang, Ru Jia, Rufei Ma, Jie Li, Shanrui Wu, Yeshun Fan, Dan Zhao, Dianfeng Chu, Yihua Wang, Guogang Zhang, Jie Liu

“…Their distribution demonstrated certain host or region specificity. Anseriformes carried higher rate of pathogens (39.1%, 72/184) than Charadriiformes (23.2%, 33/142, p < 0.05). …”
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Effects of Lactiplantibacillus plantarum HNU082 intervention on fungi and bacteriophages in different intestinal segments of mice by Xinlei Liu, Zhe Han, Wenyao Ma, Weipeng Cui, Dongyu Zhen, Shuaiming Jiang, Jiachao Zhang

“…Abstract Background Gut fungi and bacteriophages, as members of the gut microbiota, can affect the interactions between gut bacteria and the host, participate in host metabolism, and are associated with various diseases. …”
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A mathematical framework for estimating pathogen transmission fitness and inoculum size using data from a competitive mixtures animal model. by James M McCaw, Nimalan Arinaminpathy, Aeron C Hurt, Jodie McVernon, Angela R McLean

“…We present a method to measure the relative transmissibility ("transmission fitness") of one strain of a pathogen compared to another. The model is applied to data from "competitive mixtures" experiments in which animals are co-infected with a mixture of two strains. …”
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Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…CdnP (Rv2837c) functions as a bifunctional oligoribonuclease and 3′(2′)-phosphoadenosine 5′-phosphate-phosphatase that impedes host immune responses by recognizing bacterial cyclic dinucleotides such as c-di-AMP, which serve as pathogen-associated molecular patterns. …”
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Aryl hydrocarbon receptor facilitates HSV-1 lytic infection by enhancing viral gene transcription and receptor expression by Pu Huang, Pu Huang, Xiaohong Pan, Hongli Chen, Hongli Chen, Mengyue Lei, Ying Ma, Xiaomei Guo, Xiaomei Guo, Jiaxin Xie, Jixiong Li, Jixiong Li, Jing Sun, Yunzhang Hu, Jiandong Shi, Jiandong Shi

“…Once HSV-1 enters the host cells, it recruits host factors to facilitate viral life cycle. …”
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Impact of oral hygiene interventions on oral flora in stroke and comatose patients at tertiary hospital, Shendi, Sudan by Awadelkareem M. Ahamed, Omer E. Elhag, Tarig A. Alfadom, Ahmed M. Ali, Waseem S. Kwami, Abdalsamei A. Hamad, Mojahed B. Saeid, Motwakil I. Imam, Alaa H. Yousef, Lamis A. Ahmed, Saeeda T. Algoni, Salah M. Mohamed, Abuobaida Yassin

“…Background: The oral cavity hosts a diverse microbial ecosystem essential for oral health, but critically ill patients often face imbalances due to poor oral hygiene and antibiotic use. …”
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Mechanisms of miR-18a-5p Target NEDD9-Mediated Suppression of H5N1 Influenza Virus in Mammalian and Avian Hosts by Jipu Wang, Yanan Xing, Lin Chen, Shuyi Han, Ye Wang, Zhilei Zhao, Gaojian Li, Wenchao Li, Hongxuan He

“…These molecules play pivotal roles in host–pathogen interactions, particularly in modulating antiviral immune responses. …”
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The Mechanistic Target of Rapamycin Mediates <i>Clostridium perfringens</i>-Induced Chicken Necrotic Enteritis Attenuated by Secondary Bile Acid Deoxycholic Acid by Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

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A virulent phage vB_VpaP_R28Z infecting Vibrio parahaemolyticus with potential for therapeutic application by Huiying Zhong, Wenjie Huang, Kate Ting Lin, Qian Zhang, Yuchan Deng, Rui Zhang, Ruijie Ma

“…Abstract Background Vibrio parahaemolyticus, a major foodborne pathogen, contaminates aquatic products and causes significant economic losses in aquaculture while threatening food security and public health. …”
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Understanding Post-Translational Modifications in Porcine Reproductive and Respiratory Syndrome Virus Infection by Xiaoyong Chen, Jianlong Zhang

“…This review highlights the significance of PTMs in shaping viral pathogenicity and host antiviral mechanisms and provides valuable insights for future research aimed at developing effective interventions against PRRSV infections.…”
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Biofilm tolerance, resistance and infections increasing threat of public health by Shanshan Yang, Xinfei Li, Weihe Cang, Delun Mu, Shuaiqi Ji, Yuejia An, Rina Wu, Junrui Wu

“…The tolerance mechanism and host reaction of biofilm to antibiotics are reviewed, and bacterial biofilm related diseases formed by human pathogens are discussed thoroughly. …”
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Profiling of the tumor-associated microbiome in patients with hepatocellular carcinoma by Christian Schulz, Ramiro Vilchez-Vargas, Elif Öcal, Nadine Koch, Daniel Puhr-Westerheide, Lu Fornés Burnell, Heidrun Hirner-Eppeneder, Julia Benckert, Maciej Pech, Peter Reimer, Chris Verslype, Christiane Kuhl, Albert Tran, Jens Ricke, Peter Malfertheiner, Marianna Alunni-Fabbroni

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