Microbiome-Based Interventions for Food Safety and Environmental Health by Blessing Oteta Simon, Nnabueze Darlington Nnaji, Christian Kosisochukwu Anumudu, Job Chinagorom Aleke, Chiemerie Theresa Ekwueme, Chijioke Christopher Uhegwu, Francis Chukwuebuka Ihenetu, Promiselynda Obioha, Onyinye Victoria Ifedinezi, Precious Somtochukwu Ezechukwu, Helen Onyeaka

“…This study explored emerging methodologies, such as long-read sequencing, culturomics, synthetic biology, machine learning, and AI-driven diagnostics, that are transforming the field of microbiome–host interactions. Unlike traditional broad-spectrum approaches, these tools enable precise interventions, such as detecting foodborne pathogens and remediating polluted soils for safer agriculture. …”
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A Global Comparative Genomic Analysis of Major Bacterial Pathogens in Bovine Mastitis and Lameness by Szilvia Kusza, Zoltán Bagi

“…Our findings provide crucial insights into pathogen adaptation and host–microbe interactions, suggesting the need for region-specific intervention strategies. …”
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Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy by Su Zhang, Yang Meng, Lian Zhou, Lei Qiu, Heping Wang, Dan Su, Bo Zhang, Kui‐Ming Chan, Junhong Han

“…Abstract Emerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host tissues defending against external invasive pathogens or internal tissue injury. …”
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Lipid Bodies: Inflammatory Organelles Implicated in Host-Trypanosoma cruzi Interplay during Innate Immune Responses by Heloisa D'Avila, Daniel A. M. Toledo, Rossana C. N. Melo

“…The increased knowledge of lipid bodies in pathogenic mechanisms of infections may not only contribute to the understanding of pathogen-host interactions but may also identify new targets for intervention.…”
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Heat stress in chickens induces temporal changes in the cecal microbiome concomitant with host enteric serotonin responses by Joshua M. Lyte, Xinglin Jia, Valentina Caputi, Danyang Zhang, Karrie M. Daniels, Gregory J. Phillips, Mark Lyte

“…As these findings demonstrate that heat stress can alter serotonin concentrations in the chicken intestinal tract, with distinct outcomes depending on duration of the stressor, serotonergic signaling may serve as potential leverageable point of intervention in host-microbe interactions including foodborne pathogen colonization in the chicken gut. …”
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Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction by Cun Li, Yifei Yu, Zhixin Wan, Man Chun Chiu, Jingjing Huang, Shuxin Zhang, Xiaoxin Zhu, Qiaoshuai Lan, Yanlin Deng, Ying Zhou, Wei Xue, Ming Yue, Jian-Piao Cai, Cyril Chik-Yan Yip, Kenneth Kak-Yuen Wong, Xiaojuan Liu, Yang Yu, Lin Huang, Hin Chu, Jasper Fuk-Woo Chan, Hans Clevers, Kwok Yung Yuen, Jie Zhou

“…Abstract The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. …”
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Age-based host response to turkey arthritis reovirus in commercial turkeys in the presence of maternally derived antibodies by Saroj Khatiwada, John Ngunjiri, Patricia A. Boley, Kush K. Yadav, Amir Ghorbani, Michael Abundo, Carolyn M. Lee, Jelmer W. Poelstra, Chang-Won Lee, Saad Gharaibeh, Gireesh Rajashekara, Scott P. Kenney

“…This study investigated age-related host and gut microbiota responses to TARV infection in commercial turkeys derived from vaccinated breeder hens. …”
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A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity. by Vanina Guernier, Cyrille Goarant, Jackie Benschop, Colleen L Lau

“…Epidemiological surveys with appropriate sampling design, pathogen typing and data analysis are needed to improve our understanding of transmission patterns and to develop effective intervention strategies.…”
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Viral Pathogenic Spectrum and Epidemiological Characteristics of Febrile Rash Illness in China From 2009 to 2021 by Zhen Zhu, Naiying Mao, Xujing Chi, Pengbo Yu, Fangcai Li, Jianxing Wang, Binzhi Ren, Yingying Liu, Min Mu, Runan Zhu, Bing Zhao, Zhenguo Gao, Kongxin Hu, Aili Cui, Yan Zhang

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Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by Neisseria meningitidis. by Sarah G Earle, Mariya Lobanovska, Hayley Lavender, Changyan Tang, Rachel M Exley, Elisa Ramos-Sevillano, Douglas F Browning, Vasiliki Kostiou, Odile B Harrison, Holly B Bratcher, Gabriele Varani, Christoph M Tang, Daniel J Wilson, Martin C J Maiden

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A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis. by Erika Kroll, Carlos Bayon, Jason Rudd, Victoria J Armer, Anjana Magaji-Umashankar, Ryan Ames, Martin Urban, Neil A Brown, Kim Hammond-Kosack

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Disarming <i>Staphylococcus aureus</i>: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence by Abdelaziz Touati, Nasir Adam Ibrahim, Takfarinas Idres

“…<i>Staphylococcus aureus</i> is a formidable pathogen notorious for its antibiotic resistance and diverse virulence mechanisms, including toxin production, biofilm formation, and immune evasion. …”
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Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. by Gareth McVicker, Tomasz K Prajsnar, Alexander Williams, Nelly L Wagner, Michael Boots, Stephen A Renshaw, Simon J Foster

“…We subsequently elucidated the effect of antibiotic intervention within the host using mixed inocula of resistant and sensitive bacteria. …”
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Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection. by Zhihao Chen, Qiyuan Jin, Jinqi Zhong, Zonggang Xie, Qi Chen, Liubing Li, Jijie Li, Chenhao Zhao, Junfeng Wang, Xiaoying Tang, Mingxiao Han, Ru Li, Ziyuan Li, Zelei Tong, Min Wang, Hong Du, Haifang Zhang

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Temporal Variation and Human Host Predominance in <i>Aedes aegypti</i> from Coastal and Western Kenya: Insights from Pooled Blood Meal Metagenomics by Kavinya Mwendwa, Francis Mutuku, Sammy Wambua, Makenzi Nzaro, Bryson A. Ndenga, Kennedy Agoi, Angelle D. LaBeaud, Carren Bosire

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Unraveling microbial pathogenesis through omics technologies for better therapeutic interventions by Ankita Sharma, Alka Rana, Binoy Kumar, Poonam Kumari, Kanika Choudhary, Sunil Kumar, Dixit Sharma

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The Effects of Vitamins and Micronutrients on Helicobacter pylori Pathogenicity, Survival, and Eradication: A Crosstalk between Micronutrients and Immune System by Ali Nabavi-Rad, Mahsa Azizi, Shaghayegh Jamshidizadeh, Amir Sadeghi, Hamid Asadzadeh Aghdaei, Abbas Yadegar, Mohammad Reza Zali

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Complex-mediated evasion: modeling defense against antimicrobial peptides with application to human-pathogenic fungus Candida albicans by Yann Bachelot, Anastasia Solomatina, Marc Thilo Figge

“…Abstract Understanding the complex interplay between host and pathogen during infection is critical for developing diagnostics and improving therapeutic interventions. …”
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Emerging highly pathogenic H5N1 influenza triggers fibrotic remodeling in human airway organoids by Hussin Rothan, Ahmed Mostafa, Mahmoud Bayoumi, Chengjin Ye, Ramya S. Barre, Anna Allué-Guardia, Aitor Nogales, Jordi B. Torrelles, Luis Martinez-Sobrido

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Highly pathogenic avian influenza H5N1 in the United States: recent incursions and spillover to cattle by Ahmed Mostafa, Aitor Nogales, Luis Martinez-Sobrido

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