Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system by Xuelian Wu, Fan Liu, Tao Li, Danfeng Li, Yanru Shen, Xiaoai Zhang, Shuo Liu, Qi Jiang, Chenyan Zhao, Jianhui Nie, Youchun Wang, Baomin Feng, Wei Liu, Weijin Huang

“…However, the mechanisms underlying the pathogenicity and transmission of DEHV remain poorly understood. …”
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Targeting cytokine signaling in mice infected with bunyaviruses provides protection from severe disease and death by Dr Joseph Golden, Dr. Xiankun Zeng, LTC Curtis Cline, Dr. Charles Shoemaker, Dr. Jun Liu, Mr. Collin Fitzpatrick, Dr Christopher Stefan, Dr. Aura Garrison, Dr. Brian Carey

“…This work highlights the host inflammatory pathway induced by viral infection as a component of the pathological process and should be consider important targets for medical intervention. …”
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Unraveling the role of UilS, a urea-induced acyl-homoserine lactonase that enhances Serratia marcescens fitness, interbacterial competition, and urinary tract infection by Marisel R. Tuttobene, Brayan S. Arango Gil, Gisela Di Venanzio, Javier F. Mariscotti, Rodrigo Sieira, Mario F. Feldman, María Soledad Ramirez, Eleonora García Véscovi

“…Clinical isolates often exhibit resistance to multiple antibiotics, posing challenges for successful treatment. Understanding its pathogenic mechanisms is crucial for elucidating new potential targets to develop effective therapeutic interventions and manage S. marcescens infections. …”
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Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis by Khushboo Borah, Tom A Mendum, Nathaniel D Hawkins, Jane L Ward, Michael H Beale, Gerald Larrouy‐Maumus, Apoorva Bhatt, Martine Moulin, Michael Haertlein, Gernot Strohmeier, Harald Pichler, V Trevor Forsyth, Stephan Noack, Celia W Goulding, Johnjoe McFadden, Dany J V Beste

“…However, the metabolic plasticity of this pathogen and the complexity of the metabolic networks present a major obstacle in identifying those nodes most amenable to therapeutic interventions. …”
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398 Phage Wars: Uncovering the resistance strategies of Escherichia coli O157:H7 by Edwin Rivera-Lope, Rivera-Lopez Edwin Omar, Moriniere Lucas, Kazakov Alexey, Deutschbauer Adam, Arkin Adam, Mutalik Vivek, Dudley G. Edward

“…The discovery of novel antiviral mechanisms offers promising targets for phage-based interventions, potentially enhancing strategies for controlling this dangerous pathogen.…”
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Genes linked to schistosome resistance identified in a genome-wide association study of African snail vectors by Tom Pennance, Jacob A. Tennessen, Johannie M. Spaan, Tammie J. McQuistan, George Ogara, Fredrick Rawago, Kennedy Andiego, Boaz Mulonga, Meredith Odhiambo, Martin W. Mutuku, Gerald M. Mkoji, Eric S. Loker, Maurice R. Odiere, Michelle L. Steinauer

“…SudRes1 includes receptor-like protein tyrosine phosphatases while SudRes2 includes a class of leucine-rich repeat-containing G-protein coupled receptors, both comprising diverse extracellular binding domains suggestive of host-pathogen interaction. Resistant and susceptible haplotypes show numerous coding differences including presence/absence of entire genes. …”
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Macrophage Dysfunction in Tuberculosis–Diabetes Mellitus Comorbidity: A Scoping Review of Immune Dysregulation and Disease Progression by Simone E. Barry, Alice Sawka, Antonietta Maldari, Joseph Inauen, Sam LaBroome, James B. Geake

“…Among these dysfunctions, macrophages—the primary immune cells responsible for pathogen recognition, phagocytosis, and bacterial clearance—exhibit profound alterations in TB-DM. …”
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Factors associated with ovine footrot lesions in Uruguayan flocks: a cross-sectional study by Waldemir Santiago Neto, Ana Crescionini, Ludmila Slimovich, Caroline da Silva Silveira, Sofía Salada, Martín Fraga, Sergio Fierro

“…Ovine footrot has Dichelobacter nodosus as the primary pathogen, and it is characterized by its infectious and multifactorial nature, such as environmental conditions, management practices, and host susceptibility, leading to variable prevalence and economic impacts across regions. …”
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Roles of the lipopolysaccharide biosynthesis-related gene HP0858 in the fitness of Helicobacter pylori and its virulence in Galleria mellonella by Tram Thi Hong Nguyen, Pei-Chun Chen, Po-Chuan Wang, Wen-Han Wang, Chung-Yu Lan, Steffen Backert, Mou-Chieh Kao

“…Helicobacter pylori is a pathogenic bacterium associated with the development of gastric cancer and other gastric disorders. …”
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Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization by Campylobacter jejuni by Brandon Ruddell, Alan Hassall, Orhan Sahin, Paul J. Plummer, Qijing Zhang, Amanda J. Kreuder

“…As a growing body of evidence suggests that maintenance of L-met homeostasis appears to be critical for C. jejuni colonization, interventions targeting the AMC could provide a critical control point for therapeutic drug options to combat this zoonotic pathogen. …”
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Genomic insights into the population structure, antimicrobial resistance, and virulence of Brachyspira hyodysenteriae from diverse geographical regions by Maria Hakimi, Fangshu Ye, Anugrah Saxena, Xiao Hu, Huigang Shen, Paarthiphan Elankumaran, Chloe C. Stinman, Nubia Macedo, Orhan Sahin, Eric R. Burrough, Ganwu Li

“…Virulence factor analysis identified genes linked to hemolysin production, iron uptake, and survival in host environments in most isolates, with a subset of genes demonstrating lineage-specific associations that are further linked to pathogenic potential. …”
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The cell autonomous and non-autonomous roles of itaconate in immune response by Chao Chen, Xinjian Li

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Pilaralisib inhibits the replication of enteroviruses by targeting the PI3K/AKT signaling pathway by Jie Zhou, Yanping Wang, Guangyan Zhu, Mingzhe Yan, Zhengnan Li, Lin Li, Jingwen Kuang, Wenyuan Zhang, Chaolin Huang, Fuli Ren, Qingyu Yang

“…Abstract Enterovirus 71 (EV71) is a significant pathogen responsible for hand, foot, and mouth disease (HFMD), which poses a substantial public health concern, particularly in the Asia-Pacific region. …”
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Immunoregulation in Fungal Infections: A Review and Update on the Critical Role of Myeloid-Derived Suppressor Cells by Valéria de Lima Kaminski, Ana Luiza Oliveira Menezes, Kauan Gonçalves de Lima, Stephani Leonelo de Almeida, Diego Vinícius Alves da Silva, Filipe Nogueira Franco, Nycolas Willian Preite, Flávio Vieira Loures

“…Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immune cells that play a central role in regulating host immune responses during fungal infections. Their recruitment is mediated by pathogen recognition receptors, particularly Dectin-1 and CARD9 signaling, which promote the production of reactive oxygen species (ROS) and IL-1β. …”
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Research progress on immunometabolism and gut microbiota in cryptococcal meningitis: mechanisms and therapeutic implications by Sha Wen, Sha Wen, Sha Wen, Sha Wen, Mu Liu, Mu Liu, Mu Liu, Chengyu Pan, Chengyu Pan, Chengyu Pan, Linhai Zhang, Linhai Zhang, Linhai Zhang, Rong Yan, Rong Yan, Rong Yan, Zucai Xu, Zucai Xu, Zucai Xu

“…We propose a combined therapeutic strategy of “immunomodulators + metabolic inhibitors + microbiota intervention,” moving beyond traditional single-factor research paradigms to establish a multi-omics integrated framework for the precise treatment of CM—spanning molecular mechanisms to clinical translation—and propelling the field of neuroinfectious diseases towards a host-pathogen-microenvironment systemic regulation paradigm.…”
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Viruses of parasites: A roadmap toward diagnostic and therapeutic development. by Sarah Temmam, Nolwenn M Dheilly

“…The discovery that parasites host viruses, and that these parasite viruses can contribute to diseases, has triggered a paradigm shift in thought and action, whereby parasite viruses are being assessed as targets for diagnostic, therapeutic and preventive interventions. …”
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Successful Treatment of Lomentospora Prolificans Infection Following Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report and Literature Review by Yang YH, Di C, Zheng H, Luo Y, Zhang AR, Su T, Mo XD, Sun YQ, Wang Y, Lv M

“…Despite the pathogen’s multidrug resistance and the typically poor prognosis associated with invasive infections in immunocompromised hosts, the patient achieved sustained remission and favorable outcome. …”
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Relationship Between Human Microbiome and <em>Helicobacter pylori</em> by Giada La Placa, Marcello Covino, Marcello Candelli, Antonio Gasbarrini, Francesco Franceschi, Giuseppe Merra

“…The human gut has the most abundant and complex microbial community and performs vital roles in food digestion and nutrient uptake, extraction of absorbable vitamins, and inhibition of pathogen colonization. <i>Helicobacter pylori</i> is a highly specialized human gastric pathogen, predominantly colonizing the gastric mucus layer, on or adherent to the underlying gastric epithelial cell surfaces. …”
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Emerging roles of cytoskeletal transport and scaffold systems in human viral propagation by Younghyun Lim, Yong-Bin Cho, Young-Jin Seo

“…Viruses have long been recognized as significant pathogens, contributing to multiple global pandemics throughout human history. …”
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Using mechanistic models to highlight research priorities for tick-borne zoonotic diseases: Improving our understanding of the ecology and maintenance of Kyasanur Forest Disease in... by Richard M J Hassall, Sarah J Burthe, Stefanie M Schäfer, Nienke Hartemink, Bethan V Purse

“…Neglected zoonotic diseases can have significant impacts on poor and marginalised populations in low-resource settings but ultimately receive less attention and funding for research and interventions. As such, effective control measures and interventions are often hindered by a limited ecological evidence base, which results in a limited understanding of epidemiologically relevant hosts or vectors and the processes that contribute to the maintenance of pathogens and spillover to humans. …”
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