Dual-species proteomics and targeted intervention of animal-pathogen interactions by Yang Sylvia Liu, Chengqian Zhang, Bee Luan Khoo, Piliang Hao, Song Lin Chua

“…Results: Based on our proteomics results, we studied the iron competition between pathogen iron scavenger and host iron uptake protein, where P. aeruginosa upregulated pyoverdine synthesis protein (PvdA) (fold-change of 5.2313) and secreted pyoverdine, and C. elegans expressed ferritin (FTN-2) (fold-change of 3.4057). …”
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Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction by Yuxin Nong, Xuebiao Wei, Danqing Yu

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Caveolin-Mediated Endocytosis: Bacterial Pathogen Exploitation and Host–Pathogen Interaction by Dibyasri Barman, Rishi Drolia

“…Caveolin proteins facilitate the creation of caveolae and have three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. Many bacterial pathogens hijack caveolin machinery to invade host cells. …”
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Pathways of host cell exit by intracellular pathogens by Antje Flieger, Freddy Frischknecht, Georg Häcker, Mathias W. Hornef, Gabriele Pradel

“…Host cell exit is a critical step in the life-cycle of intracellular pathogens, intimately linked to barrier penetration, tissue dissemination, inflammation, and pathogen transmission. …”
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Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions by Tielong Xu, Ziqi Lin, Yicheng Yu, Muhammad Irfan, Munir Ahmed, Maya Septriana, Twinky Zebrina Cysta Sumantri, Anindini Winda Amalia, Bin Zheng

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Decoding the Bite: Sensory cues, host heterogeneity, and pathogen manipulation in mosquito host-seeking behavior by Ran Zhang, Rui Han, Shuairu Jiao, Xiuyun Wang, Guizhi Xu, Fanghang He, Chengsheng Peng, Qilong Wu, Shengqun Deng

“…Understanding these mechanisms (sensory cues, host factors, pathogen manipulation, and plasticity) is vital for developing targeted interventions (personal protection, odor masking, housing modifications, and microbiota management) to reduce bites and disease transmission.…”
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Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts by Liam J. Morrison, Pieter C. Steketee, Mabel D. Tettey, Keith R. Matthews

“…These trypanosomes also infect multiple species of mammalian host, and this complexity of trypanosome and host diversity is reflected in the spectrum of severity of disease in animal trypanosomiasis, ranging from hyperacute infections associated with mortality to long-term chronic infections, and is also a main reason why designing interventions for animal trypanosomiasis is so challenging. …”
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Insights Into Enterovirus D68 Immunology: Unraveling the Mysteries of Host‐Pathogen Interactions by Asif Naeem, Muhammad Bashir Bello, Mohammad Bosaeed

“…ABSTRACT Background Enterovirus D68 (EV‐D68) has emerged as a significant respiratory and neurological pathogen, particularly affecting children with severe respiratory illnesses and acute flaccid myelitis. …”
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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES

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Lactobacilli-host interactions inhibit Staphylococcus aureus and Escherichia coli-induced cell death and invasion in a cellular model of infection by Despoina Eugenia Kiousi, Maria Panopoulou, Aglaia Pappa, Alex Galanis

“…Future studies will focus on elucidating the specific surface components of L125 involved in these events, paving the way for targeted interventions at the host-pathogen interface.…”
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Host-pathogen interaction profiling of nontypeable Haemophilus influenzae and Moraxella catarrhalis coinfection of bronchial epithelial cells by Adonis D’Mello, Timothy F. Murphy, Martina Wade, Charmaine Kirkham, Yong Kong, Hervé Tettelin, Melinda M. Pettigrew

“…We used transcriptomic profiling with RNA-seq and various bioinformatic analyses to disentangle host-pathogen interactions in epithelial cell infection from the perspective of each species. …”
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Immunogenicity, Pathogenesis, and Host’s Immuno-Responses to Marburg Virus Infection by Emmanuel Edwar Siddig, Nicaise Ndembi, Ayman Ahmed, Claude Mambo Muvunyi

“…Understanding these intricate host–pathogen interactions is critical for developing effective therapeutic strategies and vaccines against MARV. …”
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Erythrocyte phospho-signalling is dynamically altered during infection with Plasmodium falciparum by Jack D. Adderley, Christian Doerig

“…It is well established that intracellular pathogens mobilise signalling pathways to manipulate gene expression of their host cell to promote their own survival. …”
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Being a better version of yourself: genetically engineered probiotic bacteria as host defense enhancers in the control of intestinal pathogens by Ewa Carolak, Joanna Czajkowska, Adrianna Stypułkowska, Wiktoria Waszczuk, Agata Dutkiewicz, Krzysztof Grzymajlo

“…By understanding the complex interplay between probiotics, pathogens, and host immunity, innovative strategies can be developed to harness the full therapeutic potential of probiotic interventions in maintaining gut health.…”
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Comparative proteomics of Listeria monocytogenes strains of food and clinical origin reveals strain-specific adaptation mechanisms by Ivanka Krasteva, Maria Schirone, Chiara Di Pancrazio, Francesco Manocchia, Federica D'Onofrio, Marta Maggetti, Fabrizia Perletta, Francesco Pomilio, Gianfranco Bruno, Marina Torresi, Gabriella Centorotola, Antonello Paparella, Flavio Sacchini, Nicola D'Alterio, Mirella Luciani, Mirella Luciani

“…Listeria monocytogenes is a foodborne pathogen capable of surviving in diverse environments, including food-processing settings and the human host. …”
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Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer by Martha R. Vieyra-Lobato, Jorge Vela-Ojeda, Laura Montiel-Cervantes, Rubén López-Santiago, Martha C. Moreno-Lafont

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Host-Driven Ubiquitination Events in Vector-Transmitted RNA Virus Infections as Options for Broad-Spectrum Therapeutic Intervention Strategies by Sanskruthi Sreepangi, Haseebullah Baha, Lorreta Aboagyewa Opoku, Naomi X. Jones, Maame Konadu, Farhang Alem, Michael D. Barrera, Aarthi Narayanan

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Uncovering a new family of conserved virulence factors that promote the production of host‐damaging outer membrane vesicles in Gram‐negative bacteria by Audrey Goman, Bérengère Ize, Katy Jeannot, Camille Pin, Delphine Payros, Cécile Goursat, Léa Ravon‐Katossky, Kazunori Murase, Camille V. Chagneau, Hélène Revillet, Frédéric Taieb, Sophie Bleves, Laure David, Etienne Meunier, Priscilla Branchu, Eric Oswald

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Exploring the Crossroads of Innate and Adaptive Immunity Against Mycobacterium Tuberculosis by Eden Sedarous, Dima Traboulsi, Heeral Dodhia, Katey Kwan, Suky Zheng, Venice Co

“…Further, cytotoxic T lymphocytes eliminate infected cells, while regulatory T cells modulate immunity. Overall, host immune responses must balance between pathogen control and tissue damage. …”
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Discovery of <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> Lytic Phages with Extensive Host Range Across Rapid- and Slow-Growing Pathogenic Mycobacterial Species by Aleen Clare Golla, Jeanne Chaumontet, Rebecca Vande Voorde, Lia Danelishvili

“…Results: Our library contains a diverse collection of phages that have demonstrated robust lytic activity against MAP. The host range of these phages was thoroughly assessed, revealing that several isolates produce clear plaques on a range of MAP strains, as well as other pathogenic non-tuberculous mycobacterial (NTM) species and <i>M. tuberculosis</i> strains. …”
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