Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases by Pierre M Jean Beltran, Joel D Federspiel, Xinlei Sheng, Ileana M Cristea

“…Abstract Organisms are constantly exposed to microbial pathogens in their environments. When a pathogen meets its host, a series of intricate intracellular interactions shape the outcome of the infection. …”
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mSphere of Influence: The integral art of resolving host-virus interactions by Elliott D. SoRelle

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Unraveling ScAPD1-mediated resistance mechanism to Verticillium dahliae through integrated host-pathogen transcriptomics by Qilin Yang, Ruirui Yang, Huan Zhang, Fangliu Yin, Leyi Wang, Daoyuan Zhang, Xiaoshuang Li

“…This study investigates the role of ScAPD1, a Soloist transcription factor from the extremophilic moss Syntrichia caninervis, in conferring resistance to V. dahliae when overexpressed in the model plant Arabidopsis thaliana. We employed an integrated host-pathogen transcriptomics approach (dual RNA-seq), alongside physiological and biochemical experiments. …”
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Cross-feeding between beneficial and pathogenic bacteria to utilize eukaryotic host cell-derived sialic acids and bacteriophages shape the pathogen-host interface milieu by Darab Ghadimi, Regina Fölster-Holst, Sophia Blömer, Michael Ebsen, Christoph Röcken, Jumpei Uchiyama, Shigenobu Matsuzaki, Wilhelm Bockelmann

“…However, the role of phages in triple reciprocal interactions between pathogenic bacteria, beneficial bacteria, and their host cell sialic acids has not been studied so far. …”
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Integrated genome and transcriptome analysis reveals pathogenic mechanisms of Calonectria eucalypti in Eucalyptus leaf blight by QianLi Liu, GuoQing Li, YuHua Liang, Yan Lin, KaiDong Liu, ZhenChi Huang, ShanNi Cao, FeiFei Liu

“…Moreover, most SMGCs were located in transposable element (TE)-rich regions, supporting a “two-speed” genome architecture that may facilitates adaptive evolution and pathogenic innovation. Conclusions This study provides the first integrative genome and infection-stage transcriptome map of C. eucalypti, revealing a coordinated, stage-specific deployment of pathogenicity-related gene clusters. …”
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A host-pathogen metabolic synchrony that facilitates disease tolerance by Ying-Tsun Chen, Gaurav Kumar Lohia, Samantha Chen, Zihua Liu, Tania Wong Fok Lung, Chu Wang, Sebastián A. Riquelme

“…Here we show, in a Pseudomonas aeruginosa pneumonia mouse model, that disease tolerance depends on the mitochondrial metabolite itaconate, which mediates cooperative host-pathogen interactions. In P. aeruginosa, itaconate modifies key cysteine residues in TCA cycle enzymes critical for succinate metabolism, inducing bioenergetic stress and promoting the formation biofilms that are less immunostimulatory and allow the bacteria to integrate into the local microbiome. …”
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Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration by Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose

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Hosts and Commensal Bacteria Synergistically Antagonize Opportunistic Pathogens at the Single‐Cell Resolution by Sheng Zhang, Ziguang Wang, Anqi Liu, Jinshu Li, Jingjing Zhuang, Xiaowen Ji, Paul I. Mulama, Maoye Li, Haiqun Cao, Eng‐King Tan, Wei Liu

“…However, the molecular mechanisms underpinning the regulatory networks of microbes among themselves and with their host are still in infancy. Here, it is reported that Drosophila and the commensal Lactiplantibacillus plantarum form an alliance to compete with the pathogenic Serratia marcescens using the integrated three‐species model system. …”
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Understanding Host–Pathogen Interactions in Congenital Chagas Disease Through Transcriptomic Approaches by Tatiana M. Cáceres, Luz Helena Patiño, Juan David Ramírez

“…These findings underscore the complex interplay between the host and pathogen that facilitates disease progression. …”
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Staphylococcus aureus cell wall structure and dynamics during host-pathogen interaction. by Joshua A F Sutton, Oliver T Carnell, Lucia Lafage, Joe Gray, Jacob Biboy, Josie F Gibson, Eric J G Pollitt, Simone C Tazoll, William Turnbull, Natalia H Hajdamowicz, Bartłomiej Salamaga, Grace R Pidwill, Alison M Condliffe, Stephen A Renshaw, Waldemar Vollmer, Simon J Foster

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HOST/PATHOGEN INTERACTIONS AND THE ROLE OF THE BARRIERS: ON THE EDGE BETWEEN HEALTH AND MULTIFACTORIAL/COMPLEX DISEASES

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Exploration of drug repurposing for Mpox outbreaks targeting gene signatures and host-pathogen interactions by Saber Imani, Sargol Aminnezhad, Moslem Alikarami, Zahra Abedi, Iman Samei Mosleh, Mazaher Maghsoudloo, Zahra Taheri

“…Subtype-specific host-pathogen protein-protein interaction networks were constructed, and key modules from the HPI and WGCNA were integrated to identify significant host proteins. …”
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Messages from Powdery Mildew DNA: How the Interplay with a Host Moulds Pathogen Genomes by Spanu Pietro D

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Reassessing Schistosoma worms: the overlooked role in host pathology and disease elimination by Haoran Zhong, Zhiqiang Fu, Jinming Liu, Yamei Jin

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Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. by Matthew T G Holden, Zoe Heather, Romain Paillot, Karen F Steward, Katy Webb, Fern Ainslie, Thibaud Jourdan, Nathalie C Bason, Nancy E Holroyd, Karen Mungall, Michael A Quail, Mandy Sanders, Mark Simmonds, David Willey, Karen Brooks, David M Aanensen, Brian G Spratt, Keith A Jolley, Martin C J Maiden, Michael Kehoe, Neil Chanter, Stephen D Bentley, Carl Robinson, Duncan J Maskell, Julian Parkhill, Andrew S Waller

“…We sequenced and compared the genomes of S. equi 4047 and S. zooepidemicus H70 and screened S. equi and S. zooepidemicus strains from around the world to uncover evidence of the genetic events that have shaped the evolution of the S. equi genome and led to its emergence as a host-restricted pathogen. Our analysis provides evidence of functional loss due to mutation and deletion, coupled with pathogenic specialization through the acquisition of bacteriophage encoding a phospholipase A(2) toxin, and four superantigens, and an integrative conjugative element carrying a novel iron acquisition system with similarity to the high pathogenicity island of Yersinia pestis. …”
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Influence of Host and Landscape‐Associated Factors in the Infection and Transmission of Pathogens: The Case of Directly Transmitted Virus in Mammals by María del Carmen Villalobos‐Segura, Oscar Rico‐Chávez, Gerardo Suzán, Andrea Chaves

“…However, studies show biases toward certain locations, hosts and detected pathogens, with regional variations in similar host–virus associations. …”
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Brucella infection induces chromatin restructuring in host cells to activate immune responses by Dejian Xie, Heling Xu, Changwei Su, Jingjing Lu, Wenlong Shen, Ping Li, Bingyu Ye, Jiabao Hou, Junwei Deng, Yan Zhang, Shanhu Li, Zhihu Zhao

“…While their molecular mechanisms are well-characterized, how Brucella induces chromatin restructuring in host cells remains poorly understood, representing a critical gap in host-pathogen interaction research.MethodsUsing an established in vitro infection model of Brucella-infected RAW264.7 murine macrophages, we integrated Hi-C, ATAC-seq, and RNA-seq to generate multi-omics datasets. …”
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Horizontal and vertical transmission of microsporidia Nosema pyrausta and Nosema bombycis in the predatory bug Podisus maculiventris (Hemiptera: Pentatomidae) by Arina S. Rumiantseva, Anastasia N. Ignatieva, Inna V. Grushevaya, Alsu M. Utkuzova, Nina V. Binitskaya, Anastasia G. Kononchuk, Ekaterina G. Kozlova, Anastasia A. Khodzhash, Yuri S. Tokarev

Subjects: “…parasite-host interactions…”
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The impact of environmental and host factors on wolbachia density and efficacy as a biological tool by John Roberts Padde, Qingyu Lu, Yuang Long, Donghui Zhang, Min Hou, Lu Chen, Zhipeng Xu, Lin Chen, Minjun Ji

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Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans. by Chandrasekaran Komalapriya, Despoina Kaloriti, Anna T Tillmann, Zhikang Yin, Carmen Herrero-de-Dios, Mette D Jacobsen, Rodrigo C Belmonte, Gary Cameron, Ken Haynes, Celso Grebogi, Alessandro P S de Moura, Neil A R Gow, Marco Thiel, Janet Quinn, Alistair J P Brown, M Carmen Romano

“…The major fungal pathogen of humans, Candida albicans, mounts robust responses to oxidative stress that are critical for its virulence. …”
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