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Bikaverin as a molecular weapon: enhancing Fusarium oxysporum pathogenicity in bananas via rhizosphere microbiome manipulation
Published 2025-04-01“…Secondary metabolites are critical tools employed by pathogens to interact with their environment and modulate host–pathogen dynamics. …”
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Disarming <i>Staphylococcus aureus</i>: Review of Strategies Combating This Resilient Pathogen by Targeting Its Virulence
Published 2025-04-01“…While promising, challenges such as strain variability, biofilm resilience, pharmacokinetic limitations, and resistance evolution underscore the need for combination therapies and advanced formulations. Integrating anti-virulence strategies with traditional antibiotics and host-directed therapies offers a sustainable solution to combat multidrug-resistant <i>S. aureus</i>, particularly methicillin-resistant strains (MRSA), and mitigate the global public health crisis.…”
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Temporal dynamics of the bat wing transcriptome: Insight into gene-expression changes that enable protection against pathogen
Published 2023-12-01“…Additionally, we found that the genes involved in cytokine or chemokine activity were up-regulated in late-hibernation compared to early-hibernation and that FOSB regulation of immune cell activation was differentially expressed in bats infected with Pd during late-hibernation, implying that the host’s innate immune function was enhanced during late-hibernation so as to resist pathogenic infection. …”
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Control of Opportunistic Oral Cavity Infections Using Postbiotics Secreted by Aerobic Oral Flora, with Minimal Impact on Host Cells
Published 2024-09-01“…These compounds hold promise for managing oral infections, particularly in vulnerable populations, by restoring microbial balance, directly inhibiting pathogen growth, and promoting a healthy mucosal immune response. …”
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Platelets in infection: intrinsic roles and functional outcomes
Published 2025-07-01“…Platelets have long been acknowledged for their essential roles in hemostasis and thrombosis; however, recent insights highlight their broader involvement as key participants in host responses during infection. Beyond their classical functions, platelets exhibit diverse anti-infective capabilities, such as direct pathogen internalization, receptor-mediated pathogen recognition, the release of antimicrobial peptides, cytokines, and chemokines, and the generation of immunomodulatory extracellular vesicles. …”
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Microorganisms in wild European reptiles: bridging gaps in neglected conditions to inform disease ecology research
Published 2025-08-01“…Molecular diagnostics have increasingly supplanted traditional microscopy, yet crucial tools such as culture-based methods and serology remain underutilised, limiting certain aspects of microorganism and disease characterisation.Bipartite host-microorganism network analysis revealed a specialised, modular structure promoted by specific microbial communities within particular hosts, themselves influenced by potential co-evolutionary dynamics or uneven sampling efforts.These findings underline the importance of integrating reptile disease ecology into wildlife conservation and public health frameworks, emphasising the urgent need to expand surveillance, particularly in underrepresented taxa and regions, to effectively address emerging disease threats under a One Health approach.…”
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Serological and molecular insights into tick-borne pathogens in wild donkeys from an unexplored Mediterranean nature reserve
Published 2025-01-01“…Its climate provides a favorable environment for a wide variety of flora and fauna, including ticks and tick-borne pathogens (TBPs) of medical and veterinary importance. …”
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Comparative genomic analysis of Mycoplasma agalactiae strain GM139 highlights unique surface architecture and pathogenic determinants
Published 2025-05-01“…Additionally, features such as a larger spma locus, an intact gsmA known to encode a phase-variable glucan affecting serum resistance, and the presence of integrative and conjugative element (ICE) and transposases might have also influenced the pathogenicity and host range of these strains, segregating them into two well-separated phylogenetic clusters on the basis of a newly developed cgMLST scheme. …”
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Genome Sequence Resources from Three Isolates of the Apple Canker Pathogen Neonectria ditissima Infecting Forest Trees
Published 2025-03-01“…Thus, knowledge about the N. ditissima isolates infecting different host species is essential for designing integrated pest management strategies. …”
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Unraveling key transposable elements in pathogen-induced bovine mastitis through comparative in vivo and in vitro transcriptomic analysis
Published 2025-07-01“…Extensive studies have indicated that TEs contribute to transcriptional changes in the host during pathogen invasion. However, despite their potential significance, the key functional TEs associated with bovine mastitis remain unclear, highlighting the need to explore the critical roles of TEs in the immune processes of this disease. …”
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Longitudinal profiling of host response and oropharyngeal respiratory microbiome reveals dynamic alterations during recovery from community-acquired pneumonia
Published 2025-06-01“…CAP increased the relative abundance of Streptococcus, Veillonella, and Peptostreptococcus, while decreasing that of Haemophilus, Neisseria, and Porphyromonas. Integrated analysis of host response and oropharyngeal microbiome revealed that the relative abundance of Haemophilus, Neisseria, Porphyromonas, and Stomatobaculum were positively related to mitochondrial structure and function pathways, whereas the relative abundance of Prevotella declined over time in patients and positively correlated with anti-pathogen and interferon signaling pathways. …”
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Exploring the host response in infected lung organoids using NanoString technology: A statistical analysis of gene expression data.
Published 2024-01-01“…Additionally, the identification of shared and unique genes unveiled host-specific responses to specific pathogens. IAV exerted a sustained impact on genes from the initial 24 hours, while PIV3 displayed a delayed yet substantial genomic response, suggestive of a gradual and nuanced strategy.…”
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Integrated evaluation of lung disease in single animals.
Published 2021-01-01“…Intervention strategies require characterization of the host-pathogen interaction by accurately assessing all of the above-mentioned disease parameters. …”
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Animal Wellness: The Power of Multiomics and Integrative Strategies
Published 2024-01-01“…Furthermore, the interaction between hosts and pathogens, as observed through the assessment of host gut microbiota, plays a crucial role in shaping animal health and, consequently, their performance. …”
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