Mycobacterium tuberculosis protein Rv2652c enhances intracellular survival by inhibiting host immune responses by Jihong Li, Yafeng Dou

“…Abstract Backgrounds Mycobacterium tuberculosis (Mtb), the pathogen responsible for tuberculosis, secretes a multitude of proteins that modulate the host's immune response to ensure its own persistence. …”
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Comparative transcriptomes reveal insights into different host responses associated with Fusarium head blight resistance in wheat by Hao Wang, Xiaoying Yang, Tingting Li, Zuchun Li, Jianing Zhao, Zi Wang, Zhenyu Wang, Tingdong Li, Chunhuan Chen, Jixin Zhao, Changyou Wang, Xinlun Liu, Pingchuan Deng, Wanquan Ji

“…Some of these genes have previously been reported to participate in physiological processes related to wheat FHB resistance, including Pm3-like resistance proteins, lactoylglutathione lyase, serine/threonine protein phosphatases, NBS-LRR resistance proteins, glutathione S-transferase (GST), and RPM1 resistance proteins. Additionally, we integrated FHB-responsive genes and lncRNAs with previously reported FHB QTLs, and constructed an interaction regulatory network between pathogen and host through a co-expression network. …”
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Role of infectious agents in cancer pathogenesis and therapy by Ezichi F. Ofoezie, Chinwendu A. Ogbonna, Sandra C. Olisakwe, Chioma J. Anunobi, Ezinne T. George, Simeon Babarinde, Chidera G. Chukwuemeka, Uzochukwu E. Ogbonna, Chibuzo C. Amafili, Chibuzo V. Alisigwe, Onyinyechi J. Omaba, Henry N. Ogbonna

“…This review delves into the complex mechanisms pathogens drive oncogenesis, emphasizing chronic inflammation, immune evasion, genetic integration, and epigenetic alterations. …”
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Interaction of the SXT/R391 element ICEPmiJpn1 with its natural host Proteus mirabilis by Douglas Lyra de Holanda Fonseca, Gaby Soares Scheunemann, Bruna Nakanishi Fortes, Kelly Ishida, Rodrigo S. Galhardo

“…Furthermore, the findings support the notion that ICE transfer between bacteria is influenced not only by element-specific regulators but also by strain-specific factors.IMPORTANCEMobile genetic elements play a key role in the spread of antimicrobial resistance, raising concerns about multidrug-resistant bacteria, yet their interactions with bacterial hosts are not well characterized. This study explores the relationship between ICEPmiJpn1, a globally distributed SXT/R391 integrative and conjugative element (ICE), and its natural host Proteus mirabilis, revealing minimal effects on bacterial fitness and pathogenicity. …”
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Host–Microbiota–Parasite Interactions in Grass Carp: Insights from <i>Ichthyophthirius multifiliis</i> Infection by Fangxiang Li, Dongdong Jiang, Qing Wang, Ouqin Chang, Jiyuan Yin, Meiling Yu, Houjun Pan

“…This study integrated analyses of host pathological indices, immune response and skin/gill/gut microbiota shifts after <i>I. multifiliis</i> infection. …”
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Vers une approche individu-centrée pour modéliser et simuler l’expression spatiale d’une maladie transmissible : la peste à Madagascar by Dominique Badariotti, Arnaud Banos, Vincent Laperrière

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Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy. by John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes

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Targeting epigenetic regulators to overcome drug resistance in the emerging human fungal pathogen Candida auris by Yuping Zhang, Lingbing Zeng, Xinhua Huang, Yuanyuan Wang, Guangsheng Chen, Munika Moses, Yun Zou, Sichu Xiong, Wenwen Xue, Yanmei Dong, Yueru Tian, Ming Guan, Lingfei Hu, Zhe Yin, Dongsheng Zhou, Xiaotian Huang, Changbin Chen

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The small and large subunits of carbamoyl-phosphate synthase exhibit diverse contributions to pathogenicity in Xanthomonas citri subsp. citri by Jing GUO, Xue SONG, Li-fang ZOU, Hua-song ZOU, Gong-you CHEN

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PUFA-PLs biosynthesis enzymes contribute to pathogenic development of rice blast fungus Magnaporthe oryzae by Qiao Liu, Ruhui Long, Cailing Zhi, Zhibin Liang, Yi Zhen Deng

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Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development by Guige Xu, Jiangrong Zhou, Kuan Liu, Yining Wang, Theano Tsikari, Fang Qin, Francijna van den Hil, Patrick P. C. Boor, Ibrahim Ayada, Annemarie C. de Vries, Jiajing Li, Shijin Jiang, Dewy M. Offermans, Denis E. Kainov, Harry L. A. Janssen, Maikel P. Peppelenbosch, Marcel J. C. Bijvelds, Wenshi Wang, Valeria V. Orlova, Qiuwei Pan, Pengfei Li

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Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus by Jinbin Hao, Yin Guo, Hui Zhou, Haomiao Ouyang, Jinghua Yang, Wenxia Fang, Cheng Jin

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Porcine β-defensin 5 (pBD-5) modulates the inflammatory and metabolic host intestinal response to infection by Arthur Nery Finatto, Christine Yang, Matheus de Oliveira Costa

“…Host transcriptome sequencing revealed a reduction in the number of differentially expressed genes in cells exposed to B. hyodysenteriae following pBD-5 treatment, when compared to the pathogen alone, suggesting an immunomodulatory effect. …”
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Immunization with a heat-killed prm1 deletion strain protects the host from Cryptococcus neoformans infection by Chao Li, Yang Meng, Hailong Li, Wei Du, Xindi Gao, Chenhao Suo, Yiru Gao, Yue Ni, Tianshu Sun, Sheng Yang, Tian Lan, Meiling Xin, Chen Ding

“…Furthermore, prm1Δ cells show deficiencies in the biosynthesis of chitosan and mannoprotein, which in turn result in impairment of cell wall integrity. Treatment of mice with heat-killed prm1Δ cells was found to facilitate the host immunological defence against infection with wild-type C. neoformans. …”
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Lacticaseibacillus rhamnosus P118 enhances host tolerance to Salmonella infection by promoting microbe-derived indole metabolites by Baikui Wang, Xianqi Peng, Xiao Zhou, Xiuyan Jin, Abubakar Siddique, Jiayun Yao, Haiqi Zhang, Weifen Li, Yan Li, Min Yue

“…Gut commensals, such as Lactobacillus species, have been proven to exhibit broad antibacterial activities and protect hosts against pathogenic infections. Here, Lacticaseibacillus rhamnosus strain P118, screened from 290 isolates recovered from fermented yogurts and healthy piglet intestines using traditional and Caenorhabditis elegans-infection screening strategies, exerts great probiotic properties. …”
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Development of a host-signature-based machine learning model to diagnose bacterial and viral infections in febrile children by Fang Bai, Zelong Gong, Dong Cui, Xiaomei Zhang, Wenteng Hong, Yi Gao, Kai Lin, Weijie Chen, Lu Li, Juan Huang, Biying Zheng, Junfa Xu, Na Xiao

“…In this study, through integrative bioinformatics analysis, we aimed to construct artificial neural network (ANN, multilayer perceptron) and random forest (RF) models based on host gene signatures to diagnose bacterial or viral (B/V) infection in febrile children.ResultsTranscriptome data from the whole blood of children were collected from a public database. …”
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A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis. by Erika Kroll, Carlos Bayon, Jason Rudd, Victoria J Armer, Anjana Magaji-Umashankar, Ryan Ames, Martin Urban, Neil A Brown, Kim Hammond-Kosack

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Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. by Tara J Moriarty, M Ursula Norman, Pina Colarusso, Troy Bankhead, Paul Kubes, George Chaconas

“…Stationary adhesions and extravasating spirochetes were most commonly observed at endothelial junctions, and translational motility of spirochetes appeared to play an integral role in transendothelial migration. To our knowledge, this is the first report of high resolution 3D and 4D visualization of dissemination of a bacterial pathogen in a living mammalian host, and provides the first direct insight into spirochete dissemination in vivo.…”
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The transcriptome of HTLV-1-infected primary cells following reactivation reveals changes to host gene expression central to the proviral life cycle. by Aris E N Aristodemou, David S Rueda, Graham P Taylor, Charles R M Bangham

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Evolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex. by Bardya Djahanschiri, Gisela Di Venanzio, Jesus S Distel, Jennifer Breisch, Marius Alfred Dieckmann, Alexander Goesmann, Beate Averhoff, Stephan Göttig, Gottfried Wilharm, Mario F Feldman, Ingo Ebersberger

“…In summary, this study provides a rich and unbiased set of novel testable hypotheses on how pathogenic Acinetobacter interact with and ultimately infect their human host. …”
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