Molecular Mechanisms of Pathogenic Fungal Virulence Regulation by Cell Membrane Phospholipids by Yitong Li, Hongchen Wang, Hengxiu Wang, Tianming Wang, Daqiang Wu, Wenfan Wei

“…Recent research has increasingly highlighted the role of phospholipid components in fungal cell membranes, which are not only vital for maintaining cellular integrity but also significantly influence fungal pathogenicity. …”
Get full text

Reverse transcriptase inhibitors diminish systemic proinflammatory responses to bacterial pathogens by Karthik Hullahalli, Katherine G. Dailey, Ryan Acbay, Masataka Suzuki, George I. Balazs, Matthew K. Waldor

“…ABSTRACT Bacterial infections can induce exuberant immune responses that can damage host tissues. Previously, we demonstrated that systemic Escherichia coli infection in mice causes tissue damage in the liver. …”
Get full text

Algorithms for Effector Prediction in Plant Pathogens and Pests: Achievements and Current Challenges by César De los Santos-Briones, Karla Gisel Carreón-Anguiano, Sara E. Vila-Luna, Jewel Nicole Anna Todd, Ignacio Islas-Flores, Luis Sáenz-Carbonell, Pablo Alejandro Gamas-Trujillo, Blondy Canto-Canché

“…Among the organisms’ commonalities, certain bacteria, fungi, phytoplasmas, and nematodes may cause similar symptoms, and some of their effectors may target the same proteins or biological processes in the plant hosts. The integration of effector analyses of organisms of different living kingdoms, through the identification of common short linear motifs, domains, and three-dimensional structures, may aid in the development of novel algorithms for effectoromics. …”
Get full text

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. by Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James

Get full text

The intensity of the transcriptional response varies across infection with distinct viral strains in an insect host by Allyson M. Ray, Anja Tehel, Jason L. Rasgon, Robert J. Paxton, Christina M. Grozinger

“…Overall, this study provides the first evidence for strain-specific immune responses to DWV infection, and integrates these findings into the broader domain of insect immunity and host-pathogen dynamics.…”
Get full text

Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi by Kamila Kulig, Maria Rapala-Kozik, Justyna Karkowska-Kuleta

“…Extracellular vesicles (EVs) are integral components of the multifaceted landscape of host-pathogen interactions, with their abundant production by all contributors involved in these complex and dynamic relations. …”
Get full text

ENaC is a host susceptibility factor to bacterial infections in cystic fibrosis context by Hamadoun Touré, Nicolas Durand, Mickael Orgeur, Lee Ann Galindo, Fabienne Girard-Misguich, Isabelle Guénal, Jean-Louis Herrmann, Sébastien Szuplewski

Get full text

Galectin-3: a novel antimicrobial host factor identified in goat nasal mucus by Yichao Ma, Xinming Qin, Jiachen Liu, Shiqi Liu, Ruoyang Lin, Baoyan Meng, Xiaojing Cui, Qian Yang

Get full text

Knockdown of annexin A2 enhances the host cell apoptosis induced by Eimeria tenella by Jixia Wang, Mingxiao Wang, Yuting Wang, Mengbo Xu, Yang Liu, Mingxue Zheng, Rui Zhao, Rui Bai, Yanping Zhao, Li Zhang, Xiaoling Lv, Yu Yang, Wenchao Guan, Xiaozhen Cui

“…Annexin A2 (ANXA2) is a multifunctional protein involved in host-pathogen interactions during viral and parasitic infections. …”
Get full text

The rules in co-infection of multiple viruses across diverse lineages in a fungal host by Jie Duan, Yuduo Yao, Jialing Xu, Anmeng Zhang, Xiaojing Kong, Yang Lin, Jiatao Xie, Jiasen Cheng, Yanping Fu, Tao Chen, Bo Li, Xiao Yu, Xueliang Lyu, Xueqiong Xiao, Amir Sharon, Naomi Kagan Trushina, Ioly Kotta-Loizou, Daohong Jiang

“…Emerging evidence indicates that multiple viruses can infect a single host, and viral co-infection can exert a profound influence on host physiology. …”
Get full text

Multiomics analysis uncovers host-microbiota interactions regulate hybrid vigor traits in geese by Hongyu Ni, Yuwei Yang, Chengwen Wang, Zongdi Li, Wuyang Liu, Yuxin Han, Hao Jiang, Hao Sun, Yumei Li, Yonghong Zhang

“…Additionally, there was a depletion of the pathogenic genus Desulfovibrio. Integrated multi-omics analyses demonstrated that host genes and microbiota interact closely, synergistically governing hybrid vigor traits. …”
Get full text

The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions. by Michal Letek, Patricia González, Iain Macarthur, Héctor Rodríguez, Tom C Freeman, Ana Valero-Rello, Mónica Blanco, Tom Buckley, Inna Cherevach, Ruth Fahey, Alexia Hapeshi, Jolyon Holdstock, Desmond Leadon, Jesús Navas, Alain Ocampo, Michael A Quail, Mandy Sanders, Mariela M Scortti, John F Prescott, Ursula Fogarty, Wim G Meijer, Julian Parkhill, Stephen D Bentley, José A Vázquez-Boland

“…We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. …”
Get full text

A temperature-induced metabolic shift in the emerging human pathogen Photorhabdus asymbiotica by Elena Lucy Carter, Nicholas R. Waterfield, Chrystala Constantinidou, Mohammad Tauqeer Alam

“…We have reconstructed an extensively manually curated genome-scale metabolic model of P. asymbiotica (iEC1073, BioModels ID MODEL2309110001), validated through in silico gene knockout and nutrient utilization experiments with an excellent agreement between experimental data and model predictions. Integration of iEC1073 with transcriptomics data obtained for P. asymbiotica at temperatures of 28°C and 37°C allowed the development of temperature-specific reconstructions representing metabolic adaptations the pathogen undergoes when shifting to a higher temperature in a mammalian compared to insect host. …”
Get full text

SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis by Fuxiang Li, Ximeng Zhang, Jinjin Xu, Yue Zhang, Guo Li, Xirui Yang, Guofang Deng, Youchao Dai, Baohua Liu, Christian Kosan, Xinchun Chen, Yi Cai

“…ABSTRACT Phagocytosis of Mycobacterium tuberculosis (Mtb) followed by its integration into the matured lysosome is critical in the host defense against tuberculosis. …”
Get full text

Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions. by Jenny M Tam, Carlos E Castro, Robert J W Heath, Michael L Cardenas, Ramnik J Xavier, Matthew J Lang, Jatin M Vyas

“…Some preliminary observations challenge long-held beliefs about immune responses to microorganisms; however, the lack of spatial and temporal control between the phagocytic cell and microbe has rendered focused observations into the initial interactions of host response to pathogens difficult. This paper outlines a method that advances live cell imaging by integrating a spinning disk confocal microscope with an optical trap, also known as an optical tweezer, in order to provide exquisite spatial and temporal control of pathogenic organisms and place them in proximity to host cells, as determined by the operator. …”
Get full text

Cell wall remodeling in a fungal pathogen is required for hyphal growth into microspaces by Hinata Miki, Melani Mariscal Gomez, Ayaka Itani, Daisuke Yamanaka, Yoshikatsu Sato, Antonio Di Pietro, Norio Takeshita

“…The ability of fungal hyphae to traverse narrow plant tissue spaces, such as apoplastic gaps and plasmodesmata, is essential for successful host colonization. The research demonstrates that the Mpk1 mitogen-activated protein kinase (MAPK) pathway, responsible for cell wall integrity, is crucial for hyphal growth through microspaces, while other MAPK pathways are not. …”
Get full text

TPO1-based polyamines transport contributes to pathogenicity of sugarcane smut fungus by Kai Yin, Zhijian Hu, Chuyan Chen, Zhibin Liang, Guobing Cui, Yi Zhen Deng

Get full text

Fungal Melanin in Plant Pathogens: Complex Biosynthesis Pathways and Diverse Biological Functions by Hui Jia, Ning Liu, Lu Zhang, Pan Li, Yanan Meng, Wei Yuan, Haixiao Li, Dezeng Tantai, Qing Qu, Zhiyan Cao, Jingao Dong

“…Melanin modulates fungal virulence by influencing appressorial integrity and turgor pressure formation, thereby participating in the host infection process and the formation of overwintering sclerotia. …”
Get full text

A framework to predict zoonotic hosts under data uncertainty: A case study on betacoronaviruses by Andrea Tonelli, Marcus S. C. Blagrove, Maya Wardeh, Moreno Di Marco

“…Abstract Modelling approaches aimed at identifying unknown hosts of zoonotic pathogens have the potential to make high‐impact contributions to global strategies for zoonotic risk surveillance. …”
Get full text

The use of volatile organic compounds in preventing and managing invasive plant pests and pathogens by Riccardo Favaro, Miroslav Berka, Martin Pettersson, Gunda Thöming, Carla C. M. Arce, Maria L. Inácio, Ted C. J. Turlings, Jorge M. S. Faria, Jorge M. S. Faria, Thomas Jung, Damien Bazin, Alberto Pozzebon, Sergio Angeli, Luca Cappellin

“…It underscores the importance of early detection and rapid response as integral components of effective invasive pest management, and it discusses the limitations of current control measures and the increasing globalization that facilitates the spread of pests and pathogens. …”
Get full text