Essential role of hepcidin in host resistance to disseminated candidiasis by Tanmay Arekar, Divya Katikaneni, Sadat Kasem, Dhruv Desai, Thrisha Acharya, Augustina Cole, Nazli Khodayari, Sophie Vaulont, Bernhard Hube, Elizabeta Nemeth, Alexander Drakesmith, Michail S. Lionakis, Borna Mehrad, Yogesh Scindia

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Pathogenicity of commensal gut biofilm in prefrail aging by Guillaume Le Cosquer, Melissa Pannier, Elodie Meunier, Julie Thevenin, Elise Pyhourquet, Sophie Guyonnet, Bruno Vellas, Yohan Santin, Bruno Guiard, Angelo Parini, Louis Buscail, Barbara Bournet, Damien Guillemet, Celine Deraison, Nathalie Vergnolle, Jean-Paul Motta, for the IHU HealthAge INSPIRE/Open Science study group

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Deciphering the Structural and Functional Paradigms of <i>Clostridioides difficile</i> Toxins TcdA and TcdB by Mohammad Qutub, Amol Tatode, Ujban Md Hussain, Tanvi Premchandani, Jayshree Taksande, Milind Umekar, Deepak Thakre

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Tapping into Metabolomics for Understanding Host and Rotavirus Group A Interactome by Phiona Moloi Mametja, Mmei Cheryl Motshudi, Clarissa Marcelle Naidoo, Kebareng Rakau, Luyanda Mapaseka Seheri, Nqobile Monate Mkolo

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Prophages divert Staphylococcus aureus defenses against host lipids by Biyang Zhou, Amit Pathania, Deepak Pant, David Halpern, Philippe Gaudu, Patrick Trieu-Cuot, Andressa Dias-Leao, Charlotte Pagot, Audrey Solgadi, Alexandra Gruss, Karine Gloux

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Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome. by Moon Kyoo Jang, Kui Shen, Alison A McBride

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Physiologically relevant coculture model for oral microbial-host interactions by Zeyang Pang, Nicole M. Cady, Lujia Cen, Thomas M. Schmidt, Xuesong He, Jiahe Li

“…In vitro bacteria-host cell coculture models have enabled fundamental studies to characterize bacterial infection and host responses in a reductionist yet reproducible manner. …”
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Pathoadaptation of the passerine-associated Salmonella enterica serovar Typhimurium lineage to the avian host. by Emiliano Cohen, Shalevet Azriel, Oren Auster, Adiv Gal, Carmel Zitronblat, Svetlana Mikhlin, Felix Scharte, Michael Hensel, Galia Rahav, Ohad Gal-Mor

“…Correspondingly, this strain demonstrates impaired biofilm formation, intolerance to oxidative stress and compromised intracellular replication within non-phagocytic host cells. Moreover, while this strain showed attenuated pathogenicity in the mouse, it was highly virulent and caused an inflammatory disease in an avian host. …”
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Leishmania mexicana pathogenicity requires flagellar assembly but not motility by Tom Beneke, Rachel Neish, Carolina M. C. Catta-Preta, James Smith, Jessica Valli, Ciaran J. McCoy, Andreia Albuquerque-Wendt, Jeremy C. Mottram, Eva Gluenz

“…These results confirm that flagellar motility is not necessary for mammalian infection, but flagellum assembly and the integrity of the BBSome are essential for pathogenicity.…”
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Pathogenicity and virulence of monkeypox at the human-animal-ecology interface by Md. Mazharul Islam, Pronesh Dutta, Rijwana Rashid, Syed Shariq Jaffery, Ariful Islam, Elmoubashar Farag, Susu M Zughaier, Devendra Bansal, Mohammad Mahmudul Hassan

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Campylobacter jejuni permeabilizes the host cell membrane by short chain lysophosphatidylethanolamines by Xuefeng Cao, Chris H.A. van de Lest, Liane Z.X. Huang, Jos P.M. van Putten, Marc M.S.M. Wösten

“…Lysophospholipids (LPLs) are crucial for regulating epithelial integrity and homeostasis in eukaryotes, however the effects of LPLs produced by bacteria on host cells is largely unknown. …”
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Phytochemicals act holistically to enhance host defenses during poultry coccidiosis by Inkyung Park, Hyoyoun Nam, Sripathy Ravichandran, Emma H. Wall, Hyun S. Lillehoj

“…These results show the advantage of using in vitro screening based on host-mediated responses, and not on direct pathogen killing, when exploring new phytochemicals to mitigate disease response to reduce economic losses due to coccidiosis.…”
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Compromised base excision repair pathway in Mycobacterium tuberculosis imparts superior adaptability in the host. by Saba Naz, Shruti Dabral, Sathya Narayanan Nagarajan, Divya Arora, Lakshya Veer Singh, Pradeep Kumar, Yogendra Singh, Dhiraj Kumar, Umesh Varshney, Vinay Kumar Nandicoori

“…Tuberculosis caused by Mycobacterium tuberculosis (Mtb) is a significant public health concern, exacerbated by the emergence of drug-resistant TB. To combat the host's dynamic environment, Mtb encodes multiple DNA repair enzymes that play a critical role in maintaining genomic integrity. …”
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Spatiotemporal profile of an optimal host response to virus infection in the primate central nervous system. by Olga A Maximova, Sarah L Anzick, Daniel E Sturdevant, Richard S Bennett, Lawrence J Faucette, Marisa St Claire, Stephen S Whitehead, Kishore Kanakabandi, Zong-Mei Sheng, Yongli Xiao, John C Kash, Jeffery K Taubenberger, Craig Martens, Jeffrey I Cohen

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Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens by Sonia Shivcharan, Doulathunnisa Ahamed Younis, Skylar S. Wright, Chengliang Wang, Bharat Behl, Patience Shumba, Kristina N. Delgado, Arshmeet K. Chawla, Neal M. Alto, Noorjahan Panjwani, Sivapriya Kailasan Vanaja, Jianbin Ruan, Zhichao Fan, Vijay A. Rathinam

“…Thus, tethering the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect bacteria that breach the endolysosomal network.…”
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Synergistic pathogenicity of novel duck Orthoreovirus and salmonella typhimurium in ducks by Bing Li, Mingtian Mao, Huihui Li, Xinhong Man, Mian Wu, Chengguang Lu, Meixi Lu, Mengdi Yuan, Zhanbao Guo, Suyun Liang, Zhengkui Zhou, Youxiang Diao, Shuisheng Hou, Yi Tang

“…These findings highlight the critical importance of understanding co-infection dynamics and their impact on host-pathogen interactions. This study provides valuable insights for developing integrated control strategies targeting mixed infections in poultry, promoting improved health and sustainable production in the duck farming industry.…”
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Advancing vaccine technology through the manipulation of pathogenic and commensal bacteria by Khristine Kaith S. Lloren, Amal Senevirathne, John Hwa Lee

“…These bacteria can modulate immune responses, offering a promising avenue for developing effective and personalized vaccines. Integrating the distinctive characteristics of pathogenic and commensal bacteria with advanced bacterial engineering techniques paves the way for innovative vaccine and therapeutic platforms that could address a wide range of infectious diseases and potentially non-infectious conditions. …”
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Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments. by Anubhav Srivastava, Nisha Philip, Katie R Hughes, Konstantina Georgiou, James I MacRae, Michael P Barrett, Darren J Creek, Malcolm J McConville, Andrew P Waters

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Blood flukes exploit Peyer's Patch lymphoid tissue to facilitate transmission from the mammalian host. by Joseph D Turner, Priyanka Narang, Mark C Coles, Adrian P Mountford

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A Fluorescent Reporter Virus Toolkit for Interrogating Enterovirus Biology and Host Interactions by Mireya Martínez-Pérez, Sebastian Velandia-Álvarez, Cristina Vidal-Verdú, Beatriz Álvarez-Rodríguez, Ron Geller

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