Exploring the impact of the host defense peptide Pap12-6 on immune response and epithelial integrity in chicken-derived ileal explant cultures by Rege Anna Márton, Patrik Tráj, Máté Mackei, Csilla Sebők, Júlia Vörösházi, Ágnes Kemény, Evelin Kámán-Tóth, Dávid Géza Horváth, Viviána Molnár-Nagy, Zsuzsanna Neogrády, Gábor Mátis

“…In poultry farming, animals are constantly exposed to enteral pathogens and are simultaneously required to maintain high production performance, making it challenging to preserve enteral homeostasis. …”
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Researchers’ perspectives on the integration of molecular and genomic data into malaria elimination programmes in Africa: a qualitative study by Paulina Tindana, Daniel Enos Sekwo, Leonard Baatiema, Abdoulaye Djimde, the Pathogen Genomics Diversity Network, Africa (PDNA)

“…Results The study revealed that majority of malaria genomics researchers focused on understanding the genetic composition and adaptation of the malaria parasite, its vector, and human host. Their investigations delved into areas such as drug and insecticide resistance, parasite evolution, host interactions, human host susceptibility to malaria, diversity of vaccine candidates, and molecular surveillance of malaria. …”
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Phosphatase UBLCP1 is required for the growth, virulence and mitochondrial integrity of Toxoplasma gondii by Kaiyin Sheng, Kaiyue Song, Yimin Yang, Haiyan Wu, Zhendong Du, Xueqiu Chen, Yi Yang, Guangxu Ma, Aifang Du

“…Conclusions UBLCP1 is required for the mitochondrial integrity and essential in the lytic cycle (e.g., host cell invasion and parasite replication) in vitro and the pathogenicity of this parasite in vivo. …”
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Autophagy in aquatic animals: mechanisms, implications, and future directions by Md. Abu Kawsar, Md. Abu Kawsar, Md. Abu Kawsar, Md. Abu Kawsar, Diponkor Adikari, Yang Zhang, Yang Zhang

“…This review synthesizes current knowledge on the regulation and function of autophagy in aquatic species, emphasizing key molecular pathways, environmental triggers such as temperature, salinity, hypoxia, and pollutants, and host responses to pathogenic infections. We explore model systems, particularly zebrafish, that have advanced our mechanistic understanding of autophagy, while also identifying gaps in research concerning economically important aquaculture species. …”
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Dynamic proteomic changes and ultrastructural insights into Pochonia chlamydosporia’s parasitism of Parascaris equorum eggs by Luyao Hao, Luyao Hao, Fengmiao Zhao, Hongyou Liu, Hongyou Liu, Chengyu Ma, Chengyu Ma, Xiaoqing Jia, Xiaoqing Jia, Lili Jiang, Zhaobin Fan, Rui Wang, Rui Wang

“…Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis identified key pathways including signal transduction, cell wall biosynthesis, energy metabolism, and host-pathogen interactions. qPCR validation further supported the molecular basis of parasitic behavior. …”
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Breaking Barriers: Candidalysin Disrupts Epithelial Integrity and Induces Inflammation in a Gut-on-Chip Model by Moran Morelli, Karla Queiroz

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Lactobacillus lysates protect oral epithelial cells from pathogen-associated damage, increase secretion of pro-inflammatory cytokines and enhance barrier integrity by Steven D. Mercer, Christopher Doherty, Gurdeep Singh, Thomas Willmott, Tanaporn Cheesapcharoen, Rawee Teanpaisan, Catherine O’Neill, Ruth G. Ledder, Andrew J. McBain

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Candidalysin biology and activation of host cells by Léa Lortal, Claire M. Lyon, Jakob L. Sprague, Johannes Sonnberger, Olivia K. A. Paulin, Don N. Wickramasinghe, Jonathan P. Richardson, Bernhard Hube, Julian R. Naglik

“…Secreted by C. albicans hyphae and encoded by the ECE1 gene, this 31-amino acid peptide integrates into and permeabilizes host cell membranes, causing damage across diverse cell types. …”
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Pathogenicity and virulence of Borrelia burgdorferi by Martin Strnad, Natalie Rudenko, Ryan O.M. Rego

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Integrated Transcriptome Analysis Reveals the Lung miRNA–mRNA Regulatory Network Associated with Avian Pathogenic <i>E. coli</i> Infection by Huan Li, Jishuang Tan, Xiaoyi Li, Susan J. Lamont, Hongyan Sun

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Beware of hitchhiking ticks? Clarifying the variable roles of bird species in tick movement along migratory routes by Lars Burnus, Joe Wynn, Miriam Liedvogel, Robert E. Rollins

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Unique immune and other responses of human nasal epithelial cells infected with H5N1 avian influenza virus compared to seasonal human influenza A and B viruses by Kai Sen Tan, Jing Liu, Anand Kumar Andiappan, Zhe Zhang Ryan Lew, Ting Ting He, Hsiao Hui Ong, Douglas Jie Wen Tay, Zhen Qin Aw, Bowen Yi, Arfah Mohd Fauzi, Thinesshwary Yogarajah, Lee Ching Pei Carmen, Justin Jang Hann Chu, Vincent T. Chow, Mookkan Prabakaran, De-Yun Wang

“…While less adapted to infecting the nasal epithelium, HPAI H5N1 elicited unique host responses unlike seasonal influenza. Interestingly, H5N1 infection of hNECs induced responses indicative of subdued antiviral activity (e.g. reduced expression of IFNβ, and inflammasome mediators, IL-1α and IL-1β); decreased wound healing; suppressed re-epithelialization; compromised epithelial barrier integrity; diminished responses to oxidative stress; and increased transmembrane solute and ion carrier gene expression. …”
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Goblet cell breakdown: transcriptomics reveals Acinetobacter baumannii early and robust inflammatory response in differentiated human bronchial epithelial cells by Daniela Scribano, Claudia Tito, Astri D. Tagueha, Martina Pasqua, Luciana De Angelis, Francesco Fazi, Dolores Limongi, Marta De Angelis, Lucia Nencioni, Anna Teresa Palamara, Cecilia Ambrosi

“…Transcriptomic profiling was performed to characterize host gene expression changes. Results Initial tissue damage began as early as at 4 h post-infection (hpi); at 24 hpi, goblet cell hypertrophy, reduced mucin secretion, and compromised epithelial integrity were highly evident. …”
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An intact S-layer is advantageous to Clostridioides difficile within the host. by Michael J Ormsby, Filipa Vaz, Joseph A Kirk, Anna Barwinska-Sendra, Jennifer C Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R Chaudhuri, Paula S Salgado, Robert P Fagan, Gillian R Douce

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Fungal biocontrol agents in the management of soil-borne pathogens, insect pests, and nematodes: Mechanisms and implications for sustainable agriculture by Eliakira Kisetu Nassary

“…The review identifies and categorizes the primary mechanisms employed by these fungi, including microbial competition, direct parasitism, production of bioactive secondary metabolites, and stimulation of host plant defences. Across studies, Trichoderma species consistently suppressed soil-borne pathogens such as Fusarium and Rhizoctonia through competitive exclusion and metabolite production, with pathogen reductions reported up to 70 %. …”
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Rates of viral evolution are linked to host geography in bat rabies. by Daniel G Streicker, Philippe Lemey, Andres Velasco-Villa, Charles E Rupprecht

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Salmonella infection impacts host proteome thermal stability by Marlène S. Birk, Philipp Walch, Tarik Baykara, Stephanie Sefried, Jan Amelang, Elena Buerova, Ingrid Breuer, Jörg Vervoorts, Athanasios Typas, Mikhail M. Savitski, André Mateus, Joel Selkrig

“…Intracellular bacterial pathogens hijack the protein machinery of infected host cells to evade their defenses and cultivate a favorable intracellular niche. …”
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SARS-CoV-2 Replication Revisited: Molecular Insights and Current and Emerging Antiviral Strategies by Bryan John J. Subong, Imelda L. Forteza

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The Insidious Threat: Assessing the Dangers and Spread of Tomato Leaf Curl New Delhi Virus by Thuy Thi Bich Vo, Marjia Tabassum, Bupi Nattanong, Muhammad Amir Qureshi, Hyo-jin Im, Giuseppe Parrella, Eui-Joon Kil, Sukchan Lee

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Host–Microbiota Interactions in the Pathogenesis of Porcine Fetal Mummification by Mingyu Wang, Lin Zhang, Zhe Liu, Ao Guo, Gongshe Yang, Taiyong Yu

“…The study found that the abundance of Proteobacteria in the sow’s gut increased progressively from the first parity, providing a theoretical basis for pathogen suppression mechanisms. By integrating fecal metabolomics data, we constructed a four-dimensional regulatory network of host gene–gut microbiota–metabolite–host phenotype. …”
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