Non-antibiotic therapies for multidrug-resistant gastrointestinal infections: an overview of the use of probiotics, natural compounds, and bacteriophages by Manuela Oliveira, Manuela Oliveira, Áurea Madureira-Carvalho, Áurea Madureira-Carvalho, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Ricardo Jorge Dinis-Oliveira, Diana Dias da Silva, Diana Dias da Silva, Diana Dias da Silva, Diana Dias da Silva

“…One of these alternatives is probiotics, harmless bacteria that compete with pathogenic species, which have been considered beneficial due to their therapeutic potential since they strengthen the mucosal barrier and modulate the host immune response. …”
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Multiomics comparative analysis of feces AMRGs of Duroc pigs and Tibetan and the effect of fecal microbiota transplantation on AMRGs upon antibiotic exposure by Tao Wang, Yuheng Luo, Xiangfeng Kong, Ling Fang, Liping Zhu, Bing Yu, Ping Zheng, Zhiqing Huang, Xiangbing Mao, Yu Jie, Junqiu Luo, Hui Yan, Jun He

“…Our study explored the diversity, abundance, transcriptional activity, and bacterial hosts of AMRGs in Tibetan and Duroc pig feces using metagenomic and metatranscriptomic sequencing technologies. …”
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Hyodeoxycholic acid modulates gut microbiota and bile acid metabolism to enhance intestinal barrier function in piglets by Jie Chong, Jie Chong, Yongming Zhou, Zhi Li, Xiaokai Li, Jinwei Zhang, Jinwei Zhang, Haoran Cao, Jideng Ma, Liangpeng Ge, Liangpeng Ge, Hang Zhong, Hang Zhong, Jing Sun, Jing Sun

“…Concurrently, HDCA enhanced intestinal barrier integrity by upregulating tight junction proteins (ZO-1, Claudin, Occludin) and suppressing pro-inflammatory cytokines (TNF-α, IL-1β). …”
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Global changes in gene expression of mRNA and miRNA in liver tissues of Micropterus salmoides after infection with Aeromonas hydrophila by Zhi Lei Yao, Ming Yu, Xiao Wang, Hong Ju Chen, Xiang Shan Ji, Yan Zhao

“…Aeromonas hydrophila is a common pathogenic bacterium in cultivated Largemouth bass (Micropterus salmoides), but its pathogenicity to Largemouth bass and the molecular mechanism of host anti-A. hydrophila infection remains uncertain. …”
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The protein kinases family in fungi: adaptability, virulence and conservation between species by Emanoelle La Santrer, Cláudia Barbosa Assunção, Thiago Miguelito Navarro de Camargo, Izabella Rodrigues, Sabrina Sidney Campolina, Edgar Lacerda de Aguiar, Thiago de Souza Rodrigues, Rachel Basques Caligiorne

“…In Cryptococcus neoformans, GCN2 emerges as the sole kinase responsible for eIF2α phosphorylation, a unique role in modulating translational responses to environmental and host-induced stressors. Previous studies have shown that the absence of GCN2 disrupts eIF2α phosphorylation, impairing stress responses and reducing pathogenicity, therefore being an important target for development of new generation antifungals. …”
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Microbiome profiling reveals gut bacterial species associated with rapid lung function decline in people with HIV by Xiangning Bai, Xiangning Bai, Xiangning Bai, Sajan C. Raju, Sajan C. Raju, Andreas Dehlbæk Knudsen, Rebekka Faber Thudium, Nicoline Stender Arentoft, Marco Gelpi, Marco Gelpi, Safura-Luise Heidari, Ken M. Kunisaki, Ken M. Kunisaki, Karsten Kristiansen, Karsten Kristiansen, Johannes Roksund Hov, Johannes Roksund Hov, Susanne Dam Nielsen, Susanne Dam Nielsen, Susanne Dam Nielsen, Marius Trøseid, Marius Trøseid, Marius Trøseid

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Disease-Resistance Functional Analysis and Screening of Interacting Proteins of ZmCpn60-3, a Chaperonin 60 Protein from Maize by Bo Su, Lixue Mao, Huiping Wu, Xinru Yu, Chongyu Bian, Shanshan Xie, Temoor Ahmed, Hubiao Jiang, Ting Ding

“…Notably, the enhanced resistance phenotype against Pseudomonas syringae pv. tomato DC3000 (<i>Pst</i> DC3000) in <i>ZmCpn60-3</i>-overexpressing transgenic lines was specifically abolished by pretreatment with ABT, a salicylic acid (SA) biosynthetic inhibitor. Our integrated findings reveal that this chaperonin protein orchestrates plant immune responses through a dual mechanism: triggering a reactive oxygen species (ROS) burst while simultaneously activating SA-mediated signaling cascades, thereby synergistically enhancing host disease resistance. …”
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Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…We also carried out additional validations including colocalization, linkage disequilibrium check and host–pathogen interactome predictions. We integrated MR findings with clinical trial evidence from several drug gene related databases to identify drugs with repurposing potential. …”
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Transcriptomic insights into the interplay between polyketide biosynthesis and other secondary metabolite biosynthetic clusters and biological pathways in entomopathogen Beauveria... by Wachiraporn Toopaang, Wachiraporn Toopaang, Wachiraporn Toopaang, Wachiraporn Toopaang, Thippawan Yoocha, Thippawan Yoocha, Chaiwat Naktang, Chaiwat Naktang, Nuchnudda Wichienchote, Phornsiri Pechsrichuang, Sithichoke Tangphatsornruang, Sithichoke Tangphatsornruang, Morakot Tanticharoen, Yu-Liang Yang, Yu-Liang Yang, Alongkorn Amnuaykanjanasin

“…Our findings indicate that pks15 plays an important role in fungal development and pathogenicity. Within the pks15 cluster, the UDP-glucosyl transferase gene Bbugt1 was consistently upregulated 3-fold in the WT in vivo compared to the WT in vitro armyworm group 48–96 h post-inoculation. …”
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Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination by A. Marín-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue, D. Martin

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Diversity of anopheline species and malaria transmission dynamics in high-altitude areas of western Cameroon by Belinda Claire Kiam, Aline Gaelle Bouopda-Tuedom, Jean Arthur Mbida Mbida, Ibrahima Ibrahima, Samuel J. White, Pacome V. K. Tchuenkam, Zachary R. Popkin-Hall, Mariama Mbouh, Charlène Tina Nanssong V., Luc Abate, Clément Janvier Onguene, Brigitte Tumamo Fotso, Jacob M. Sadler, Jonathan B. Parr, Jessica T. Lin, Jonathan J. Juliano, Innocent Mbulli Ali, Rhoel R. Dinglasan, Sandrine Eveline Nsango

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Thlaspi arvense suppresses gut microbiota related TNF inflammatory pathway to alleviates ulcerative colitis by Wenkai Wang, Yiyang Zhao, Ziwei Wang, Chaowei Wang, Ling Bi, Yan Wang, Yan Wang

“…These findings establish TA’s multi-target pharmacology spanning host-microbe interactions and intracellular signaling, while providing a rationale for standardizing TA-based formulations and advancing isovitexin as a precision therapeutic agent for inflammatory bowel diseases.…”
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Bacterial extracellular biomolecules-derived multimodal manganese nanoparticles control watermelon Fusarium wilt by dysregulating fusaric acid biosynthesis pathway and precise tuni... by Muhammad Noman, Temoor Ahmed, Mohammad Shafiqul Islam, Jing Wang, Yingying Cai, Shuang Liang, Zhongna Hao, Hayssam M. Ali, Haiping Qiu, Zhen Zhang, Rongyao Chai, Yanli Wang, Bin Li, Jiaoyu Wang

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The role of gut microbiota in traditional Chinese medicine processing: A general review by Rui-Rui Qiao, Ya-Long Chen, Ya-Ya Bai, An-Dong Dong, Rui Tian, Ya-Jun Shi, Chong-Bo Zhao, Peng Zhao, Jing Sun, Qiao Zhang, Yu-Ping Tang

“…Introduction: Traditional Chinese Medicine Processing (TCMP) is an integral component of Chinese medicine culture, playing a crucial role in altering the pharmacological properties of herbs, increasing their efficacy and mitigating their toxicity and adverse reactions, in order to optimize their therapeutic efficacy. …”
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EasyMetagenome: A user‐friendly and flexible pipeline for shotgun metagenomic analysis in microbiome research by Defeng Bai, Tong Chen, Jiani Xun, Chuang Ma, Hao Luo, Haifei Yang, Chen Cao, Xiaofeng Cao, Jianzhou Cui, Yuan‐Ping Deng, Zhaochao Deng, Wenxin Dong, Wenxue Dong, Juan Du, Qunkai Fang, Wei Fang, Yue Fang, Fangtian Fu, Min Fu, Yi‐Tian Fu, He Gao, Jingping Ge, Qinglong Gong, Lunda Gu, Peng Guo, Yuhao Guo, Tang Hai, Hao Liu, Jieqiang He, Zi‐Yang He, Huiyu Hou, Can Huang, Shuai Ji, ChangHai Jiang, Gui‐Lai Jiang, Lingjuan Jiang, Ling N. Jin, Yuhe Kan, Da Kang, Jin Kou, Ka‐Lung Lam, Changchao Li, Chong Li, Fuyi Li, Liwei Li, Miao Li, Xin Li, Ye Li, Zheng‐Tao Li, Jing Liang, Yongxin Lin, Changzhen Liu, Danni Liu, Fengqin Liu, Jia Liu, Tianrui Liu, Tingting Liu, Xinyuan Liu, Yaqun Liu, Bangyan Liu, Minghao Liu, Wenbo Lou, Yaning Luan, Yuanyuan Luo, Hujie Lv, Tengfei Ma, Zongjiong Mai, Jiayuan Mo, Dongze Niu, Zhuo Pan, Heyuan Qi, Zhanyao Shi, Chunjiao Song, Fuxiang Sun, Yan Sun, Sihui Tian, Xiulin Wan, Guoliang Wang, Hongyang Wang, Hongyu Wang, Huanhuan Wang, Jing Wang, Jun Wang, Kang Wang, Leli Wang, Shao‐kun Wang, Xinlong Wang, Yao Wang, Zufei Xiao, Huichun Xing, Yifan Xu, Shu‐yan Yan, Li Yang, Song Yang, Yuanming Yang, Xiaofang Yao, Salsabeel Yousuf, Hao Yu, Yu Lei, Zhengrong Yuan, Meiyin Zeng, Chunfang Zhang, Chunge Zhang, Huimin Zhang, Jing Zhang, Na Zhang, Tianyuan Zhang, Yi‐Bo Zhang, Yupeng Zhang, Zheng Zhang, Mingda Zhou, Yuanping Zhou, Chengshuai Zhu, Lin Zhu, Yue Zhu, Zhihao Zhu, Hongqin Zou, Anna Zuo, Wenxuan Dong, Tao Wen, Shifu Chen, Guoliang Li, Yunyun Gao, Yong‐Xin Liu

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The complete mitochondrial genomes of Macrostylophora euteles and Citellophilus tesquorum sungaris and the phylogenetics of known Siphonaptera mitogenomes by Mingna Duan, Yafang Liu, Jun Wu, Shuang Liu, Shaobo Tang, Dandan Jiang, Quanfu Zhang, Wei Gu, Wei Gu, Xing Yang

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Leveraging Electron Beam (eBeam) Technology for Advancing the Development of Inactivated Vaccines by Ruvindu Perera, Suresh D. Pillai, Adnan Alrubaye, Palmy Jesudhasan

“…It is a successful emerging alternative for developing vaccines against bacterial, protozoan, and viral pathogens. This review includes a descriptive account of the mechanism of action of eBeam and how this technology achieves the complete inactivation of pathogens while retaining the integrity of their surface epitopes. …”
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Yellow fever in South America – A plea for action and call for prevention also in travelers from SLAMVI, ESGITM, EVASG, ALEIMC, GEPI-SEIMC, SEMEVI, and CMTZMV-ACIN by Alfonso J. Rodriguez-Morales, Abdulaziz H. Alhazmi, Abraham Katime, Ahneez Abdul Hameed, Alejandra Morales, Alejandro Claudio Lepetic, Alejandro Risquez, Alex Julián Forero-Delgadillo, Alexis Holguin, Álvaro A. Faccini-Martínez, Amanda Guerrero, Ana Ribeiro, Asma Al Balushi, Aysegul Taylan Ozkan, Balram Rathish, Baruch Diaz, Beatriz Elena Porras-Pedroza, Bhanasut Hunsajarupan, Botond Lakatos, Carlos Álvarez-Moreno, Carlos Neftali Torres-Martinez, Caroline Ronnberg, Cecilia Perret, Christian Morberg Wejse, Aayush Adhikari, Corneliu Petru Popescu, Aula Abbara, Cristian Biscayart, D. Katterine Bonilla-Aldana, Daniele Fasan, Danna Calderon, David de Luna, David A. Forero-Peña, Diana Isabela Costescu-Strachinaru, Diogo Mendes Pedro, Edward J.M. Monk, Eirini Iliaki, Emanuele Pontali, Emmanuel O. Ngbede, Ferenc Balázs Farkas, Marta González-Sanz, Florencia Escarrá, Francesca Mariotti, Francesca F. Norman, Francesco Di Gennaro, Francisco Javier Membrillo, German Arrieta, Giacomo Guido, Ángel Viudes Fuster, Gustavo A. Grandez-Castillo, Hakan Leblebicioglu, Hanna K. de Jong, Hernan Vargas, Jung-ah Kim, Jaime A. Cardona-Ospina, Jaime R. Torres, Jara Llenas-García, Isabell Wagenhäuser, José A. Oteo, Jose Francisco Gallegos Braun, Juan Carlos Sepulveda-Arias, Juan Pablo Hernandez, Julián Ruíz Sáenz, Justin Onyebuchi Nwofe, Justyna Kowalska, Kate E. Jackson, Kubra Aykac, Leonardo Francesco Rezzonico, Luis Felipe Reyes, Luisa Frallonardo, Manuel Krone, Marcela Fuquen Malagón, Marco A. Sempere-Alcocer, Marco Tulio Luque, Maria Carlos, Maria del Mar Faraco Oñorbe, Marina Segura Moreno, Marinella Lauriola, Mario Masana, Marisa Fernandez, Marlen Martinez-Gutierrez, Marta Diaz-Menendez, Miguel J. Martinez, Miguel Mauricio Cabada, Miguel Morante-Ruiz, Miriam J. Alvarez-Martinez, Nancy Sandoval-Paiz, Nuria Chávez, Oana Joean, Octavio Arce, Oliver Koch, Olivier Epaulard, Osman Sezer Cirit, Özlem Türkmen Recen, Pasesa Quispe, Patricia Lourdes Guillot Passerini, Petar Velikov, Miguel Hueda-Zavaleta, Petros Ioannou, Poleta Luga, Rama Shankar Rath, René Echavarría, Rhea O'Regan, Riccardo Paggi, Rodrigo N. Angerami, Salam Abbara, Salim Mattar, Salvatore Scarso, Samuele Gaggioli, Sergio Verbanaz, Siti Mardhiah Muhamad Fauzi, Sofia Jordão, Susana Lloveras, Tamara Ursini, Tánia Chaves, Thomas Weitzel, Tomás Orduna, Tommaso Manciulli, Tommy Rampling, Victor Acero, Virgilio Lezcano, Wendy Karely Moncada-Navas, Wilmer Villamil-Gomez, Yasemin Özsürekçi, Yori Roque, Nadia Noreen, Paul Yonga, Pietro Ferrara, Zitta Barrella Harboe

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Genetic and Molecular Relationships Between Chronic Obstructive Pulmonary Disease and Abdominal Aortic Aneurysm: Insights from a Multi-Omics Approach by Jian Wang, Yuemeng Li, Yun Li, Jamol Uzokov, Zhaoxuan Zhang, Xiaoxu Zhang, Deying Jiang, Han Jiang, Azad Hussain, Chen Chen, Jian Zhang, Yanshuo Han

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The Role of Root Endophyte <i>Pseudomonas putida</i> A32 in the Protection of Two Pepper Genotypes from <i>Pseudomonas syringae</i> pv. <i>aptata</i> by Aleksandra Mesaroš, Marija Nedeljković, Iva Atanasković, Marija Anđelković, Dario Danojević, Slaviša Stanković, Jelena Lozo

“…Endophytes, as an integral part of plants, form unique relationships with their hosts that go beyond classical definitions of symbiosis and influence plant development, immunity, and stress responses. …”
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