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Recombinant Sendai Virus Vectors as Novel Vaccine Candidates Against Animal Viruses
Published 2025-05-01“…Recombinant SeV vectors (rSeVv) possess several key features that make them highly suitable for developing vaccination strategies: (1) SeV has exclusively cytoplasmic replication cycle, therefore incapable of transforming host cells by integrating into the cellular genome, (2) rSeVv can accommodate large foreign gene/s inserts (~5 kb) with strong but adjustable transgene expression, (3) can be propagated to high titers in both embryonated chicken eggs and mammalian cell lines, (4) exhibits potent infectivity across a broad range of mammalian cells from different animals species, (5) undergo transient replication in the upper and lower respiratory tracts of non-natural hosts, (6) has not been associated with disease in pigs, non-humans primates, and small ruminants, ensuring a favorable safety profile, and (7) induce a robust innate and cellular immune responses. …”
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582
A Stable and Dependable Visual Technique for On-Site Nipah Virus Nucleic Acids Detection
Published 2025-02-01“…Abstract The Nipah Virus (NiV) is a zoonotic pathogen with the mortality rate of up to 75%, recurring in Asia over the past two decades. …”
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Exposure to pesticides is correlated with gut microbiota alterations in a farmland raptor
Published 2025-05-01“…The gut microbiota is crucial for host health and can be impacted by various environmental disruptions, yet the effects of multiple pesticide exposures on farmland organisms’ microbiomes remain largely unexplored. …”
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585
Hyphal penetration is the major pathway of translocation of Candida albicans across the blood-cerebrospinal fluid barrier
Published 2025-04-01“…Candida albicans is one of the leading pathogens in this setting, and may affect the central nervous system (CNS), which is an extremely severe form of the infection. …”
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586
Dysbiosis and extraintestinal cancers
Published 2025-02-01“…Despite recent advances in the remarkable correlation between dysbiosis and extraintestinal cancers, the underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their metabolites, can undermine the integrity of the gut barrier through inflammatory or metabolic pathways, leading to increased permeability and the translocation of pathogens. …”
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587
Grain-sized moxibustion activates dendritic cells to enhance the antitumor immunity of cancer vaccines
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588
Whole Genome Analysis of <i>Pediococcus acidilactici</i> XJ-24 and Its Role in Preventing <i>Listeria monocytogenes</i> ATCC<sup>®</sup> 19115<sup>TM</sup> Infection in C57BL/6 Mic...
Published 2025-03-01“…<b>Background/Objectives:</b> As probiotics gain prominence in the prevention and treatment of intestinal diseases, their protective effects against pathogens and influence on host health have drawn significant attention. …”
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589
Screening of Rice Genotypes for Resistance Against Bacterial Blight Disease
Published 2023-11-01“…Farm, Mandya, Karnataka, India during 2020 to screen the genotypes against BLB under natural field conditions. Host Plant resistance is an important component of an integrated management program for this disease. …”
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NprR, a moonlighting quorum sensor shifting from a phosphatase activity to a transcriptional activator
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593
Characterization of antibiotic resistance genes and virulence factors in organic managed tea plantation soils in southwestern China by metagenomics
Published 2025-05-01“…Overall, these findings provide a basis for integrating ARGs, VFs and pathogen hosts to assess the ecological and health risks in long-term organic managed soils, and increased efforts need to be done in reducing ARGs, VFs and bacterial pathogens in fertilizers for organic managements on agriculture.…”
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594
Alterations and resilience of intestinal microbiota to increased water temperature are accompanied by the recovery of immune function in Nile tilapia
Published 2025-02-01“…After prolonged coevolution, the intestinal microbiota has become an integral part of fish and plays a pivotal role in immunity and metabolism. …”
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Evaluating the Role of Canada Goose Populations in Transmission Dynamics During Peak HPAI Incidence in Iowa, February 2022–December 2023
Published 2025-06-01“…Since its emergence in the United States in February 2022, Highly Pathogenic Avian Influenza (HPAI) H5N1 has caused significant losses for poultry operations, particularly in Iowa between February 2022 and December 2023. …”
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599
Spatial ecology of the Neisseriaceae family in the human oral cavity
Published 2025-05-01“…The Neisseriaceae family, which includes human oral species in the genera Neisseria, Eikenella, Kingella, and Simonsiella, plays a significant role in both commensal and pathogenic relationships. In this study, we investigate the distribution and functional adaptations of Neisseriaceae species across oral habitats, focusing on their site tropisms and ecological roles. …”
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Identification of core gene-gut microbiome associations in diverticulitis patients through a two-sample mendelian randomization and bioinformatics-based investigation
Published 2025-09-01“…Through SNP annotation, we identified 23 host genes associated with pathogenic gut microflora in diverticulosis and diverticulitis, and retrieved 213 diverticulitis-related genes from GeneCards. …”
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