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Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania
Published 2025-06-01“…While previous genomic studies have largely examined human and bacterial genomes separately, we adopted an integrated approach to uncover host–pathogen interactions. …”
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The putative type 4 secretion system effector BspD is involved in maintaining envelope integrity of the pathogen Brucella
Published 2024-11-01“…From our observations, we propose that BspD of B. abortus is critical for preserving the integrity of the bacterial envelope, particularly under stressful conditions, which may enhance Brucella’s ability to survive within host cells.IMPORTANCEBrucellosis, caused by the intracellular pathogen Brucella, poses a significant health threat. …”
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An integrated systems biology approach establishes arginine biosynthesis as a metabolic weakness in Candida albicans during host infection
Published 2025-08-01“…Heightened expression of arginine biosynthesis genes indicated that increased arginine synthesis mainly occurred through proline intermediates during host interaction. Significantly impaired virulence and in vivo pathogenicity of ALT1-deleted CAL highlighted the potential of targeting arginine metabolism as a novel strategy to combat antifungal resistance and underscored the power of integrating systems biology with experimental approaches in identifying new therapeutic targets.…”
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Genome‐wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus
Published 2025-02-01“…Together, our genome‐wide siRNA library screening unveiled a panorama of host cellular networks engaged in the regulation of highly pathogenic H5N1 influenza virus replication, which may provide potential targets and strategies for developing novel antiviral countermeasures.…”
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A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses.
Published 2013-01-01“…Our results demonstrate the utility of integrating diverse 'omic datasets to predict and prioritize regulatory features conserved across multiple pathogen infection models.…”
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Evaluation of anhydrous processing and storage methods of the temperate bacteriophage ɸV10 for integration into foodborne pathogen detection methodologies.
Published 2021-01-01“…Research described here was undertaken to evaluate two methods for their ability to store the bacteriophage ɸV10 at ambient temperature without aqueous storage solutions while limiting loss of viability. ɸV10 is a temperate bacteriophage which solely infects the zero-tolerance food adulterant Escherichia coli O157:H7 and has been genetically modified to generate a detectable phenotype in host cells. In order to integrate this reporter bacteriophage into food-borne pathogen detection methodologies, two methods of processing phage suspensions for long-term, ambient storage were evaluated: printing solutions onto pieces of dissolvable paper and lyophilizing suspensions with sucrose. …”
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Integrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers
Published 2024-07-01“…Patients with ES-LUAD exhibited local microbial dysbiosis, suggesting the potential pathogenicity of certain microbial species. Through multi-omics correlations, intricate local crosstalk between the host and local microbial communities was observed. …”
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A three-way transcriptomic crosstalk interaction in a biocontrol agent (Bacillus velezensis), a fungal pathogen (Colletotrichum gloeosporioides), and a walnut host (Juglans regia L...
Published 2025-05-01“…This study addresses knowledge gaps in the biocontrol-pathogen-host interaction and provides a theoretical foundation for developing environmentally sustainable strategies to control walnut anthracnose.…”
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