scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria by Collins M. Morang’a, Riley S. Drake, Riley S. Drake, Riley S. Drake, Riley S. Drake, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Nancy K. Nyakoe, Dominic S. Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga-Etego

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In vitro and in vivo activity of sodium houttuyfonate and sodium new houttuyfonate against Candida auris infection by affecting adhesion, aggregation, and biofilm formation abiliti... by Guangyuan Yang, Ruotong Yang, Xiaoxiao Zhu, Qianwen Xu, Xiaojia Niu, Chengui Miao, Wenfan Wei, Changzhong Wang, Tianming Wang, Daqiang Wu

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Therapeutic potential of Litsea cubeba essential oil in modulating inflammation and the gut microbiome by Liqiong Xia, Ran Li, Ran Li, Ting Tao, Ruimin Zhong, Haifang Du, Ziling Liao, Zhanghua Sun, Changqiong Xu, Changqiong Xu

“…Inflammation, a sophisticated and delicately balanced physiological mechanism, is paramount to the host’s immunological defense against pathogens. However, unfettered and excessive inflammation can be instrumental in engendering a plethora of chronic ailments and detrimental health repercussions, notably within the gastrointestinal tract. …”
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Liver Transcriptome Analysis Reveals a Potential Mechanism of Heat Stress Increasing Susceptibility to <i>Salmonella</i> Typhimurium in Chickens by Qi Zhang, Yvqing Zhu, Zixuan Wang, Qinghe Li, Guiping Zhao, Qiao Wang

“…Validation in HD11 cell infection models confirmed the differential expression of these genes under heat stress and <i>Salmonella</i> Typhimurium co-stimulation, indicating their critical roles in host immune regulation. This study elucidates the intrinsic regulatory relationships through which heat stress promotes <i>Salmonella</i> pathogenicity and inflammatory responses, providing important insights for disease-resistant poultry breeding and prevention strategies.…”
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IL-17: Balancing Protective Immunity and Pathogenesis by Lu Sun, Lufei Wang, Bethany B. Moore, Shaoping Zhang, Peng Xiao, Ann M. Decker, Hom-Lay Wang

“…While substantial progress has implicated unrestrained IL-17 in a variety of infectious diseases or autoimmune conditions, IL-17 plays an important role in protecting the host against pathogens and maintaining physiological homeostasis. …”
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Flavivirus and Filovirus EvoPrinters: New alignment tools for the comparative analysis of viral evolution. by Thomas Brody, Amarendra S Yavatkar, Dong Sun Park, Alexander Kuzin, Jermaine Ross, Ward F Odenwald

“…Multi-genome comparative analysis of these evolving pathogens affords a view of their essential, conserved sequence elements as well as progressive evolutionary changes. …”
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Effects of gastrointestinal probiotic dosage on fish-lettuce growth, water quality, and microbial composition in aquaponics systems by Firew Admasu, Tokuma Negisho Bayissa, Soressa Gershe, Ketema Bacha, Mulugeta Wakjira

“…Probiotics are increasingly recognized in aquaculture for enhancing fish immunity, suppressing pathogens, and reducing reliance on antibiotics. However, their optimal dosage and ecological roles in integrated aquaponics systems remain poorly defined. …”
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Hidden diversity of Trypanosomatidae (Protozoa: Kinetoplastea) in bats from an urban park in Brazil. by Mariana Alves Lima, Marcela Elisa Vaz, Jennifer Emanuelle Ferreira, Ana Cristina Vianna Mariano da Rocha Lima, Débora Cristina Capucci, Sônia Aparecida Talamoni, Felipe Dutra-Rêgo, José Dilermando Andrade Filho

“…By expanding knowledge of trypanosomatid diversity in urban bats, this study highlights the ecological and epidemiological relevance of bats as hosts and underscores the need for targeted surveillance to assess their role in pathogen transmission dynamics.…”
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The comprehensive transcriptomic atlas of porcine immune tissues and the peripheral blood mononuclear cell (PBMC) immune dynamics reveal core immune genes by Qingyao Zhao, Jiahao Wang, Fuping Ma, Quanzhen Chen, Huatao Liu, Jinyan Yang, Siqian Chen, Yongjie Tang, Siyuan Mi, Lulu Wang, Xini Wang, Guohong Liu, Kai Xing, Ying Yu, Chuduan Wang

“…With the development of genomics technology, the combination of transcriptome, genetic variation, immune response, and QTL mapping data to illustrate the interactions between pathogen and host immune system, will be an effective tool for identification of disease resistance genes in pigs. …”
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Staphylococcus aureus nt5 gene mutation through CRISPR RNA-guided base editing weakens bacterial virulence and immune evasion by Xinpeng Liu, Lan Huang, Yang Ye, Haiyi Wang, Min Tang, Fuqiang He, Zijing Xia, Shi Deng, Peng Zhang, Ruiwu Dai, Shufang Liang

“…It is essential to explore key pathogenicity-driven genes/proteins in bacterial infection and antibiotics resistance, which contributes to develop novel therapeutic strategies against S. aureus infections. …”
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The Antifungal Activity and Mechanism of Dehydroabietic Acid Against <i>Alternaria alternata</i> Causing Poplar Leaf Spot by Yun-Ze Chen, Yun-Di Zhang, Cheng Chen, Qiu-Er Sa, Jing Yang, Guo-Cai Zhang

“…The enzyme activity assay showed that treatment with 56.015 mg/L (EC₅₀) DHA significantly reduced the activities of antioxidant enzymes (superoxide dismutase, catalase, peroxidase) and cell-wall-degrading enzymes (endoglucanase, polygalacturonase, pectin lyase) in <i>A. alternata</i> (<i>p</i> < 0.05), resulting in a decrease in the activity of pathogenic fungi, as well as a reduction in the ability of the <i>A. alternata</i> to degrade the cell wall of the host plant, which led to a decrease in the ability of the <i>A. alternata</i> to infest the host plant. …”
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Intestinal Insights: The Gut Microbiome’s Role in Atherosclerotic Disease: A Narrative Review by Luana Alexandrescu, Adrian Paul Suceveanu, Alina Mihaela Stanigut, Doina Ecaterina Tofolean, Ani Docu Axelerad, Ionut Eduard Iordache, Alexandra Herlo, Andreea Nelson Twakor, Alina Doina Nicoara, Cristina Tocia, Andrei Dumitru, Eugen Dumitru, Laura Maria Condur, Cristian Florentin Aftenie, Ioan Tiberiu Tofolean

“…The gut microbiota, consisting of a diverse collection of microorganisms, impacts the host’s metabolism, immune responses, and lipid processing, all of which contribute to atherosclerosis. …”
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Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity by Li Wang, Limeng Zhu, Song Qin

“…The mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intestinal homeostasis through establishment of a mutually beneficial relationship by tolerating to symbiotic microbiota and retaining the ability to exert proinflammatory response towards invasive pathogens. …”
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Effects of bacteriophages on gut microbiome functionality by Elena Kurilovich, Naama Geva-Zatorsky

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Multidrug and Toxic Compound Extrusion Transporters: Ubiquitous Multifaceted Proteins in Microbes, Plants, and Their Interactions by Chiara Pastacaldi, Dario Gaudioso, Stefania Tegli

“…In recent years, membrane transporters have attracted considerable interest regarding their involvement in the molecular dialogue occurring between microbes and their hosts. In particular, the multidrug and toxic compound extrusion (MATE) transporters form a family of integral membrane proteins, mainly involved in the efflux of toxic and xenobiotic compounds. …”
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Probiotics in Poultry: Unlocking Productivity Through Microbiome Modulation and Gut Health by Muhammad Naeem, Dianna Bourassa

“…Probiotics, live microorganisms providing health benefits, improve gut health through the competitive exclusion of pathogens, immune modulation, antimicrobial compound production, and enhancing gut barrier integrity. …”
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Memory B cell proliferation drives differences in neutralising responses between ChAdOx1 and BNT162b2 SARS-CoV-2 vaccines by David Hodgson, Yi Liu, Yi Liu, Louise Carolan, Siddhartha Mahanty, Kanta Subbarao, Kanta Subbarao, Sheena G. Sullivan, Sheena G. Sullivan, Sheena G. Sullivan, Annette Fox, Annette Fox, Adam Kucharski

“…DiscussionReconstructing in-host kinetics in response to vaccination could help optimise vaccine dosing regimens, improve vaccine efficacy in different population groups, and inform the design of future vaccines for enhanced protection against emerging pathogens.…”
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The gut dysbiosis and plasma lipid metabolisms signatures in children with active tuberculosis by Baixu Sun, Xiaoran Yu, Hui Qi, Fang Xu, Weiwei Jiao, Min Fang, Li Duan, Xi Zeng, Xuemei Yang, Xingyun Wang, Yu Zhu, Kaixia Mi, Adong Shen, Lin Sun

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Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer by Maofu Zhang, Jialin Zhong, Yanyun Shen, Zhongyang Song

“…Moreover, gut microbiota modulate host physiological and pathological processes through immune response regulation, metabolic pathway interference, and direct interaction with gastric tumor cells. …”
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Comparative genome analysis of filamentous fungi reveals gene family expansions associated with fungal pathogenesis. by Darren M Soanes, Intikhab Alam, Mike Cornell, Han Min Wong, Cornelia Hedeler, Norman W Paton, Magnus Rattray, Simon J Hubbard, Stephen G Oliver, Nicholas J Talbot

“…We have also characterised the predicted set of secreted proteins encoded by each genome and identified a set of protein families which are significantly over-represented in the secretomes of plant pathogenic fungi, including putative effector proteins that might perturb host cell biology during plant infection. …”
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