Global spillover of land-derived microbes to Ocean hosts: Sources, transmission pathways, and one health threats by Hai-Chao Song, Hany Elsheikha, Tao Yang, Wei Cong

“…Pathogens originating on land can spread, adapt, and persist in marine environments, infecting a wide range of hosts and potentially re-entering terrestrial environments. …”
Get full text

Editorial: Opportunistic pathogens: pathogenesis and multi-drug resistance mechanisms by Shicheng Chen, Lisheng Liao, Mingxi Wang

Get full text

A Comprehensive Multi-Omics Study of Serum Alterations in Red Deer Infected by the Liver Fluke <i>Fascioloides magna</i> by Josipa Kuleš, Miljenko Bujanić, Ivana Rubić, Karol Šimonji, Dean Konjević

Get full text

Outbreak reconstruction with a slowly evolving multi-host pathogen: A comparative study of three existing methods on Mycobacterium bovis outbreaks by Hélène Duault, Benoit Durand, Laetitia Canini

“…However, the majority of these methods remain untested on realistic simulated multi-host data. Mycobacterium bovis is a slowly evolving multi-host pathogen and previous studies on outbreaks involving both cattle and wildlife have identified observation biases. …”
Get full text

The wheat receptor-like cytoplasmic kinase TaRLCK1B is required for host immune response to the necrotrophic pathogen Rhizoctonia cerealis by Tian-ci WU, Xiu-liang ZHU, Liang-jie LÜ, Xi-yong CHEN, Gang-biao XU, Zeng-yan ZHANG

Get full text

In the coevolution of cotton and pathogenic fungi, resistant cotton varieties lead to an escalation in the virulence of Verticillium dahliae by Yalin Zhang, Lifang Cui, Ruibing Liu, Zili Feng, Hongjie Feng, Jinglong Zhou, Lihong Zhao, Feng Wei, Heqin Zhu

Get full text

Comparative proteomics of Listeria monocytogenes strains of food and clinical origin reveals strain-specific adaptation mechanisms by Ivanka Krasteva, Maria Schirone, Chiara Di Pancrazio, Francesco Manocchia, Federica D'Onofrio, Marta Maggetti, Fabrizia Perletta, Francesco Pomilio, Gianfranco Bruno, Marina Torresi, Gabriella Centorotola, Antonello Paparella, Flavio Sacchini, Nicola D'Alterio, Mirella Luciani, Mirella Luciani

“…Listeria monocytogenes is a foodborne pathogen capable of surviving in diverse environments, including food-processing settings and the human host. …”
Get full text

Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions by Aarash Bordbar, Nathan E Lewis, Jan Schellenberger, Bernhard Ø Palsson, Neema Jamshidi

“…To date, integrative analysis of host–pathogen interactions using in silico mass‐balanced, genome‐scale models has not been performed. …”
Get full text

Simultaneous profiling of sexually transmitted bacterial pathogens, microbiome, and concordant host response in cervical samples using whole transcriptome sequencing analysis by Catherine M. O’Connell, Hayden Brochu, Jenna Girardi, Erin Harrell, Aiden Jones, Toni Darville, Arlene C. Seña, Xinxia Peng

“…Together, our study suggests that total RNA profiling will advance understanding of the interplay of pathogen, host and microbiota during natural infection and may reveal novel, outcome-relevant biomarkers.…”
Get full text

Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions by Tielong Xu, Ziqi Lin, Yicheng Yu, Muhammad Irfan, Munir Ahmed, Maya Septriana, Twinky Zebrina Cysta Sumantri, Anindini Winda Amalia, Bin Zheng

Get full text

Machine learning based on pangenome-wide association studies reveals the impact of host source on the zoonotic potential of closely related bacterial pathogens by Cheng Han, Shiying Lu, Pan Hu, Jiang Chang, Deying Zou, Feng Li, Yansong Li, Qiang Lu, Honglin Ren

“…Abstract Variations in host species significantly impact bacterial growth traits and antibiotic resistance, making it essential to consider host origin when evaluating the zoonotic potential of pathogens. …”
Get full text

Dual RNA-seq reveals the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus by Qiyuan Jin, Yaxuan Zhai, Rui Qiang, Xin Ma, Chenhao Zhao, Jinqi Zhong, Jijie Li, Qi Chen, Mingxiao Han, Hong Du, Qifei Cong, Haifang Zhang

“…ABSTRACT This study aimed to elucidate the complement protein C3-mediated host-pathogen interaction in the brain abscess caused by Staphylococcus aureus infection. …”
Get full text

Bacterial extracellular vesicles for gut microbiome–host communication and drug development by Dingfei Qian, Peijun Xu, Xinwei Wang, Chong Du, Xiao Zhao, Jiaqi Xu

Get full text

Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle. by Qisheng Li, Yong-Yuan Zhang, Stephan Chiu, Zongyi Hu, Keng-Hsin Lan, Helen Cha, Catherine Sodroski, Fang Zhang, Ching-Sheng Hsu, Emmanuel Thomas, T Jake Liang

Get full text

Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. by Irena Zurnic, Sylvia Hütter, Ute Rzeha, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V Hamann, Tobias Kern, Gesche K Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N Engelman, Peter Cherepanov, Dirk Lindemann

Get full text

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles by Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu

Get full text

Integrating respiratory microbiome and host immune response through machine learning for respiratory tract infection diagnosis by Hongbin Chen, Tianqi Qi, Siyu Guo, Xiaoyang Zhang, Minghua Zhan, Si Liu, Yuyao Yin, Yifan Guo, Yawei Zhang, Chunjiang Zhao, Xiaojuan Wang, Hui Wang

“…This study suggests that the model integrating LRTM and host transcriptome data can be an effective tool for LRTIs diagnosis.…”
Get full text

Correction: Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. by Irena Zurnic, Sylvia Hütter, Ute Rzeha, Roger Helbig, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V Hamann, Tobias Kern, Gesche K Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N Engelman, Peter Cherepanov, Dirk Lindemann

Get full text

Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection. by Krishna P Kota, Brett Eaton, Douglas Lane, Melanie Ulrich, Ricky Ulrich, Brian D Peyser, Camenzind G Robinson, James G Jaissle, Gianluca Pegoraro, Sina Bavari, Rekha G Panchal

Get full text

Integrative Analysis of Shared Pathogenic Genes and Potential Mechanisms in Gardnerella vaginalis and Persistent HPV16 Infection by Ye Li, Yue Wang, Xianhua Liu, Huifeng Xue, Liying Wang, Maotong Zhang, Pengming Sun

“…Bacterial vaginosis, often accompanied by Gardnerella vaginalis (GV) overgrowth, is associated with persistent high-risk human papillomavirus (HR-HPV) infection, particularly HPV16. This study integrated transcriptomic data from in vitro GV infection experiments and a GEO dataset (GSE75132) of HPV16 persistence to elucidate shared pathogenic mechanisms. …”
Get full text