Guards and decoys: RIPoptosome and inflammasome pathway regulators of bacterial effector-triggered immunity. by Haleema Sadia Malik, James B Bliska

“…Virulent microbes produce proteins that interact with host cell targets to promote pathogenesis. For example, virulent bacterial pathogens have proteins called effectors that are typically enzymes and are secreted into host cells. …”
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The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infection. by Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K Singh, Gregory J Bedwell, Alan N Engelman, Adarsh Dharan, Edward M Campbell

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A multi-omics approach to Epstein-Barr virus immortalization of B-cells reveals EBNA1 chromatin pioneering activities targeting nucleotide metabolism. by R Jason Lamontagne, Samantha S Soldan, Chenhe Su, Andreas Wiedmer, Kyoung Jae Won, Fang Lu, Aaron R Goldman, Jayamanna Wickramasinghe, Hsin-Yao Tang, David W Speicher, Louise Showe, Andrew V Kossenkov, Paul M Lieberman

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Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses. by Sofia Banchenko, Ferdinand Krupp, Christine Gotthold, Jörg Bürger, Andrea Graziadei, Francis J O'Reilly, Ludwig Sinn, Olga Ruda, Juri Rappsilber, Christian M T Spahn, Thorsten Mielke, Ian A Taylor, David Schwefel

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A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness. by Laura A Mike, Andrew J Stark, Valerie S Forsyth, Jay Vornhagen, Sara N Smith, Michael A Bachman, Harry L T Mobley

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Molecular fossils illuminate the evolution of retroviruses following a macroevolutionary transition from land to water. by Jialu Zheng, Jianhua Wang, Zhen Gong, Guan-Zhu Han

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Recruitment of a SAP18-HDAC1 complex into HIV-1 virions and its requirement for viral replication. by Masha Sorin, Jennifer Cano, Supratik Das, Sheeba Mathew, Xuhong Wu, Kelvin P Davies, Xuanling Shi, S-W Grace Cheng, David Ott, Ganjam V Kalpana

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Red-light is an environmental effector for mutualism between begomovirus and its vector whitefly. by Pingzhi Zhao, Xuan Zhang, Yuqing Gong, Duan Wang, Dongqing Xu, Ning Wang, Yanwei Sun, Lianbo Gao, Shu-Sheng Liu, Xing Wang Deng, Daniel J Kliebenstein, Xueping Zhou, Rong-Xiang Fang, Jian Ye

“…However, whether and how light affects the host defense which further affects insect preference and performance, remains unclear, nor has been demonstrated how pathogens co-adapt light condition to facilitate vector transmission. …”
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Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies. by Olivia A Pilling, João L Reis-Cunha, Cooper A Grace, Alexander S F Berry, Matthew W Mitchell, Jane A Yu, Clara R Malekshahi, Elise Krespan, Christina K Go, Cláudia Lombana, Yun S Song, Camila F Amorim, Alexsandro S Lago, Lucas P Carvalho, Edgar M Carvalho, Dustin Brisson, Phillip Scott, Daniel C Jeffares, Daniel P Beiting

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HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC. by Natasha Wood, Tanmoy Bhattacharya, Brandon F Keele, Elena Giorgi, Michael Liu, Brian Gaschen, Marcus Daniels, Guido Ferrari, Barton F Haynes, Andrew McMichael, George M Shaw, Beatrice H Hahn, Bette Korber, Cathal Seoighe

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Cholesterol metabolism and intrabacterial potassium homeostasis are intrinsically related in Mycobacterium tuberculosis. by Yue Chen, Berge Hagopian, Shumin Tan

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DHX15 inhibits mouse APOBEC3 deamination. by Wenming Zhao, Ayan Modak, Susan R Ross

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TNF signaling mediates cellular immune function and promotes malaria parasite killing in the mosquito Anopheles gambiae. by George-Rafael Samantsidis, Hyeogsun Kwon, Megan Wendland, Catherine Fonder, Ryan C Smith

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Phosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzae. by Sarah E Clark, Julian Snow, Jianjun Li, Tracey A Zola, Jeffrey N Weiser

“…The human pathogen Haemophilus influenzae has the ability to quickly adapt to different host environments through phase variation of multiple structures on its lipooligosaccharide (LPS), including phosphorylcholine (ChoP). …”
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Molecular identification of a malaria merozoite surface sheddase. by Philippa K Harris, Sharon Yeoh, Anton R Dluzewski, Rebecca A O'Donnell, Chrislaine Withers-Martinez, Fiona Hackett, Lawrence H Bannister, Graham H Mitchell, Michael J Blackman

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A GDP-mannose-1-phosphate guanylyltransferase as a potential HIGS target against Sclerotinia sclerotiorum. by Cheng Zhang, Yan Xu, Lin Li, Mingsong Wu, Zheyi Fang, Jinyi Tan, Jeffrey A Rollins, Honghui Lin, Xinyi Huang, Shawn D Mansfield, Xin Li, Yuelin Zhang

“…It is caused by the necrotrophic ascomycete Sclerotinia (S.) sclerotiorum. Host-induced gene silencing (HIGS) has shown promise in disease control against insects and fungal pathogens, but effective HIGS target genes against S. sclerotiorum remain limited. …”
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Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunization in the pig lung. by Andrew Muir, Basudev Paudyal, Selma Schmidt, Ehsan Sedaghat-Rostami, Soumendu Chakravarti, Sonia Villanueva-Hernández, Katy Moffat, Noemi Polo, Nicos Angelopoulos, Anna Schmidt, Matthias Tenbusch, Graham Freimanis, Wilhelm Gerner, Arianne C Richard, Elma Tchilian

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EcoHIV infection of mice establishes latent viral reservoirs in T cells and active viral reservoirs in macrophages that are sufficient for induction of neurocognitive impairment. by Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E Gendelman, Mary Jane Potash, David J Volsky

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PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx. by Kei Miyakawa, Kiho Tanaka, Yoko Ino, Yayoi Kimura, Taichi Kameya, Fuminori Mizukoshi, Mayuko Nishi, Masaru Yokoyama, Jun Nakabayashi, Masako Nomaguchi, Hironori Sato, Hirokazu Kimura, Hirofumi Akari, Tomoyuki Miura, Akinori Takaoka, Hideki Hasegawa, Tetsuro Matano, Yoji Andrew Minamishima, Akihide Ryo

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Engineering, decoding and systems-level characterization of chimpanzee cytomegalovirus. by Quang Vinh Phan, Boris Bogdanow, Emanuel Wyler, Markus Landthaler, Fan Liu, Christian Hagemeier, Lüder Wiebusch

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