EFFECT OF CYTOPROTECTION ON THE OXIDATIVE PROCESSES AND ENDOTHELIAL FUNCTION IN ELDERLY PATIENTS WITH ISCHEMIC HEART DISEASE by A. V. Shabalin, Yu. I. Ragino, S. A. Lyubimtseva, Ya. V. Polonskaya, M. V. Ivanova

“…To investigate the effects of cytoprotection with mildronate (Grindex, Latvia) on oxidative processes and endothelial function in elderly patients with ischemic heart disease (IHD). …”
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Modified pea apyrase has altered nuclear functions and enhances the growth of yeast and Arabidopsis by Manas K. Tripathy, Huan Wang, Robert D. Slocum, Han-Wei Jiang, Ji-Chul Nam, Tanya Sabharwal, Roopadarshini Veerappa, Katherine A. Brown, Katherine A. Brown, Xingbo Cai, Peter Allen Faull, Greg Clark, Stanley J. Roux

“…Apyrases (NTPDases) regulate growth and development in multiple eukaryotic organisms and function in multiple sub-cellular locales. An earlier report showed that the ectopic expression of psNTP9 (PS), a chromatin-associated pea (Pisum sativum) apyrase, enhanced the uptake of inorganic phosphate (Pi) and increased the growth of yeast and Arabidopsis. …”
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Physiological criteria of functional fitness and determinants of physical work capacity of highly skilled wrestlers by Oleksandr Pryimakov, Sergii Iermakov, Jerzy Eider, Stanislav Prysiazhniuk, Natalija Mazurok

“…The objective of the work is to study the key factors of highly skilled wrestler fitness structure determining the level of their functional state and physical work capacity at the stage of maximum realization of individual capacities. …”
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Simultaneous visualization of changes in perfusion and myocardial function of a transplanted heart in emergency cardiology by E. N. Ostroumov, E. V. Migunova, M. V. Vovchenko, G. A. Nefedova, A. A. Spasskiy, S. Yu. Shemakin, E. D. Kotina, K. S. Krupnova, L. T. Khamidova, A. A. Kanibolotskiy

“…To present the possibilities of perfusion myocardial single photon emission computed tomography synchronized with electrocardiography for a detailed assessment of the functional condition of both ventricles of the transplanted heartMaterial and methods. …”
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Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study by Yan Wang, XiaoLi Zhang, Qin Li, Qing Zhang, Jun Liu

“…BackgroundEvidence on the relationship between thyroid function and hepatic fibrosis/cirrhosis are still unclear, with inconsistent conclusions. …”
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Heart Failure Impairs Bone Marrow Hematopoietic Stem Cell Function and Responses to Injury by Tina B. Marvasti, Faisal J. Alibhai, Grace J. Yang, Shu‐Hong Li, Jun Wu, Terrence Yau, Ren‐Ke Li

“…Background Heart failure (HF) is a clinical syndrome associated with a progressive decline in myocardial function and low‐grade systemic inflammation. Chronic inflammation can have lasting effects on the bone marrow (BM) stem cell pool by impacting cell renewal and lineage differentiation. …”
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Resting-state functional near-infrared spectroscopy in neurodegenerative diseases – A systematic review by Franziska Albrecht, Alexander Kvist, Erika Franzén

“…Objective: To systematically review and summarize alterations found in resting-state activity as measured via functional near-infrared spectroscopy (fNIRS) in neurodegenerative diseases. …”
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GalNT2-mediated O-glycosylation affects pancreas development and function in mice by Baris Mercanoglu, Sissy-Alina Waschkowski, Elena Neuburg, Nina Schraps, Anastasios D. Giannou, Benjamin Dreyer, Sönke Harder, Markus Heine, Christian F. Krebs, Cenap Güngör, Hartmut Schlüter, Nathaniel Melling, Thilo Hackert, Maximilian Bockhorn, Christoph Wagener, Gerrit Wolters-Eisfeld

“…Abstract GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations in GALNT2 activity have been implicated in various diseases, such as cancer, metabolic disorders, and cardiovascular diseases, highlighting its importance in maintaining normal physiological functions. …”
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Possibility of evaluation of oxygen transport function in PAH patients on effective selexipag-based therapy by E. S. Allakhverdiev, E. A. Rezukhina, O. V. Slatinskaya, O. V. Rodnenkov, G. V. Maksimov, T. V. Martynyuk

“…In the complex pathogenesis of idiopathic  pulmonary  arterial hypertension (IPAH), which includes changes  in biochemical  and  biophysical  processes in various cell  types  as  the cause  of structural and  functional  impairment, inflammation and thrombosis  of the pulmonary vessels,  hypoxia also plays an important role due to conformational changes  in hemoglobin  molecules  with changes  in their structure and oxygen  transport function impairment.Aim: Using the method of Raman (Raman scattering) spectroscopy,  to study changes  in the conformation  and ability of hemoglobin  (Hb) to bind oxygen  in blood erythrocytes from the cubital vein in IPAH patients and healthy people. …”
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Cognitive functions in schizophrenia: the interplay between blood viscosity, serum osmolarity, and symptom severity by Ipek Özönder Ünal, Miray Pirincci Aytac, Derya Adalı Aker, Tomris Duymaz, Tonguc Demir Berkol

“…Abstract Objective Cognitive impairments—especially in executive function and attention—are core features of schizophrenia and major barriers to functional recovery. …”
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Spatiotemporal regulation by downstream genes of Prok2 in the olfactory system: from development to function by Bo-Ra Kim, Min-Seok Rha, Min-Seok Rha, Hyung-Ju Cho, Hyung-Ju Cho, Joo-Heon Yoon, Joo-Heon Yoon, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim

“…Mutations in PROK2, which encodes prokineticin-2, have been identified in approximately 9% of the KS patients with olfactory defects.MethodsWe examined olfactory function and analyzed the causes of olfactory dysfunction based on spatiotemporal development and gene expression changes in Prok2 knockout (KO) model mice with KS.ResultsThe ability of the OE to detect olfactory signals was diminished in adult Prok2 KO mice. …”
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Functional positioning in robotic medial unicompartmental knee arthroplasty: a step-by-step technique by Andriollo Luca, Mazzella Giovan Giuseppe, Koutserimpas Christos, Gregori Pietro, Servien Elvire, Batailler Cécile, Lustig Sébastien

“…Recent advances in robotic-assisted techniques have contributed to more personalized and reproducible procedures. …”
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Effects of low-dose furosemide combined with aminophylline on the renal function in septic shock patients by Zhenhua Mai, Yaying Tan, Yang Zhu, Zilong Yang, Hongpeng Chen, Shuting Cai, Wangwang Hu, Xiaoyan Wang, Fenghua Ding, Liehua Deng

“…Compared with the control group, the SOFA scores, ICU mortality, hospital mortality and 28-day mortality were significantly lower in the intervention group on days 3, 7, and 14, the CRRT time was shorter, and the cumulative fluid balance was lower on days 3 and 7 in the intervention group.Conclusions Although low-dose furosemide and aminophylline have fewer protective effects on the renal function in septic shock patients, they could reduce the CRRT time and improve the prognosis.…”
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A Review of Novel Antioxidant Ergothioneine: Biosynthesis Pathways, Production, Function and Food Applications by Haijing Zhang, Zheng Liu, Zhong Wang, Ziteng Lei, Yan Jia, Wei Chen, Ruoyu Shi, Chengtao Wang

“…Ergothioneine (EGT), a natural thiol compound with potent antioxidant properties, exhibits diverse biological functions, including anti-inflammatory, neuroprotective, and cardioprotective effects. …”
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Retinal Capillary Nonperfusion on OCT-Angiography and Its Relationship to Kidney Function in Patients with Diabetes by Elysse S. Tom, Steven S. Saraf, FuPeng Wang, Qinqin Zhang, Gautam Vangipuram, Christine P. Limonte, Ian H. de Boer, Ruikang K. Wang, Kasra A. Rezaei

“…Participants were excluded if they were known to have kidney disease from conditions other than diabetes. …”
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The development of functional opsonophagocytic assays to evaluate antibody responses to Klebsiella pneumoniae capsular antigens by Robert Lawrence, Emma Bownes, Marina Johnson, Heather Fox, Drew Huff, Ivan Olave, Anup Datta, David Goldblatt, Nathalie Karaky

“…Standardized assays to assess the immunogenicity of new vaccines are crucial for vaccine development and evaluation of other therapeutics. Therefore, we have developed assays that can assess the functionality of antibodies, which can be used to evaluate the potential of novel K. pneumoniae conjugate vaccines, and inform which antibodies are most effective for preventing disease.…”
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Recovery of left ventricular function after surgery for aortic and mitral regurgitation with heart failure by Wei-Tsung Lai, I-Chen Chen, Ming-Chon Hsiung, Ting-Chao Lin, Kuan-Chih Huang, Chung-Yi Chang, Jeng Wei

“…This study is sought to investigate the predictors of postoperative LV function recovery in left-sided regurgitant VHD with reduced left ventricular ejection fraction (LVEF), especially for mixed VHD. …”
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A cross-sectional investigation on the function of the female pelvic floor in the Sichuan Province, China by Ai-Ping Min, Die Zeng, Rui-Jin Zhang, Ting-Ting Pan, Xin Feng, Jia-Qi Luo

“…Methods A total of 368 married women were randomly recruited from the Obstetrics and Gynecology Department of Leshan People’s Hospital from May 2018 to December 2023 for pelvic floor function screening. Of these, 122 married women did not have children (group A), 122 married women had children before menopause (group B), and 124 women were postmenopausal (group C). …”
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FUNCTIONAL ACTIVITY OF ANTI-GD2 CAR-T CELLS WITH DIFFERENT ANTIGEN-RECOGNITION MODULE by Dzmitry Lutskovich, Hanna Klych, Maryia Maryia A. Keraz, Kate Lutskovich, Alexander Meleshko

“…Results of separate clinical trials have been published for CAR-T based on 14G2a and hu3F8, but there are no data on the use of the 8B6 antibody in CARs yet. …”
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Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy by Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao

“…Mutations and dysregulation of TETs have been associated with the pathogenesis of various diseases, including the nervous system, immune system, and metabolic diseases, as well as cancers. …”
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