Interplay between iron metabolism, inflammation, and EPO-ERFE-hepcidin axis in RDEB-associated chronic anemia by Lucía Quintana-Castanedo, Rocío Maseda, Isabel Pérez-Conde, Nora Butta, Elena Monzón-Manzano, Paula Acuña-Butta, María G. Crespo, Antonio Buño-Soto, Eva Jiménez, Jaris Valencia, María C. Arriba, Pilar Zuluaga, Raúl de Lucas, Marcela del Río, Ángeles Vicente, María J. Escámez, Rosa Sacedón

“…According to the reticulocyte production index, an inadequate bone marrow response was observed in 90% of patients with anemia, irrespective of EPO levels. Patients with functional or true iron deficiency had higher ERFE levels, although ERFE showed no consistent correlation with EPO and was elevated in both patients with anemia and those without anemia. …”
Get full text

¿Los pacientes octogenarios sometidos a reemplazo total de rodilla regresan a la actividad física? by J. Teves, F. Holc, A. García-Mansilla, S. Vildoza, R. Brandariz, L. Carbó, J. Costantini

“…Adjusted for confounders, patients >80 had less improvement than those < 80 (19 points). …”
Get full text

Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial by Patrick Stone, Ollie Minton, Alison Richardson, Peter Buckle, Zinat E Enayat, Louise Marston, Nick Freemantle

“…Primary outcome Fatigue at 6 (± 2) weeks measured using the Functional Assessment of Chronic Illness Therapy – Fatigue Scale score. …”
Get full text

[Translated article] Do octogenarian patients undergoing total knee replacement return to physical activity? by J. Teves, F. Holc, A. García-Mansilla, S. Vildoza, R. Brandariz, L. Carbó, J. Costantini

“…Background and objectives: It has been shown that total knee replacement improves functional capacity and physical activity; however, the influence of age remains unclear. …”
Get full text

Biomimetic design and integrated biofabrication of an in-vitro three-dimensional multi-scale multilayer cortical model by Ling Wang, Luge Bai, Sen Wang, Jiajia Zhou, Yingjie Liu, Chenrui Zhang, Siqi Yao, Jiankang He, Chaozong Liu, Dichen Li

“…This study provides a basis for the design and manufacture of accurate brain-like models for the functionalization of neuronal tissues.…”
Get full text

The KNAT3a1-WND2A/3A module positively regulates fiber secondary cell wall biosynthesis in Populus tomentosa by Kuan Sun, Di Fan, Yingying Peng, Chang Liu, Lingfei Kong, Ting Lan, Xianqiang Wang, Dan Li, Chaofeng Li, Keming Luo

“…PtoKNAT3a1 overexpression caused fiber SCW thickening and increased all measured SCW compositions by upregulating the expression of SCW -biosynthetic genes and -associated TFs, but had no effect on the vessels of SCW. The opposite phenotype was observed in the PtoKNAT3a1-knockout lines. …”
Get full text

16S rDNA sequencing combined with metabolomic probes to investigate the effects of Salmonella Pullorum on gut microbes and metabolites in broilers by Jiongwen Wu, Jiongwen Wu, Jiongwen Wu, Ruixiang Xue, Ruixiang Xue, Ruixiang Xue, Zhexia Fan, Zhexia Fan, Zhexia Fan, Ruina Li, Ruina Li, Ruina Li, Xiaomeng Wang, Xiaomeng Wang, Xiaomeng Wang, Chutian Ye, Chutian Ye, Chutian Ye, Shuya Chen, Shuya Chen, Shuya Chen, Cheng Fang, Cheng Fang, Cheng Fang, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang, Qingbin Luo, Qingbin Luo, Qingbin Luo

“…SP-infected broilers were classified into positive (P) and negative (N) groups using hematoxylin-and-eosin staining, metabolome sequencing, and 16S rDNA to investigate the effects of SP infection on the metabolites and microorganisms in the cecum of broilers. Groups had different degrees of inflammatory cell infiltration in the cecum, spleen, liver, and lung tissues. …”
Get full text

The value of intellectual structural imbalance in the differentiation of autism spectrum disorder and attention deficit hyperactivity disorder by Dan-Yang Zhang, Qiu-Hong Wei, Bin-Yue Hu, Dan Ai, Yu Zhang, Yuan Ding, Ting Yang, Jie Chen, Li Chen, Yuan Wu, Hong-Yu Chen, Xue-Li Xiang, Qiu-Hong Mou, Ting-Yu Li

“…Besides, we used SPSS 25.0 to assess the subtest scores and differences.ResultsThe comorbidity group had lower total IQ than the other two groups (p&lt;0.001). …”
Get full text

Dynamic SARS-CoV-2-specific B-cell and T-cell responses induced in people living with HIV after a full course of inactivated SARS-CoV-2 vaccine by Xiuwen Wang, Xiuwen Wang, Xiaodong Yang, Xin Zhang, Hongxia Yan, Junyan Jin, Zhenglai Ma, Junyi Duan, Guanghui Zhang, Tao Huang, Yongzheng Li, Hao Wu, Tong Zhang, Aiwei Zhu, Cong Jin, Xiangrong Song, Bin Su, Bin Su

“…Additionally, the percentages of activated T cells, exhausted T cells and SARS-CoV-2-specific T cells with enhanced functional activity were increased following the administration of inactivated SARS-CoV-2 vaccine. …”
Get full text

Geochemical and microbial factors driving crustacean assemblages in adjacent aquifer units within the same aquifer by T. Di Lorenzo, T. Di Lorenzo, T. Di Lorenzo, T. Di Lorenzo, S. Amalfitano, S. Amalfitano, D. M. P. Galassi, M. Melita, M. Melita, M. Melita, A. Zoppini, D. Parrone, S. Ghergo, D. Rossi, A. Tabilio Di Camillo, A. Tabilio Di Camillo, E. Preziosi

“…The K-rich and alkaline-earth AUs had different species; however, these species exhibited similar functions related to locomotion, diet, and feeding habit. …”
Get full text

Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China by Yongxiang Wang, Xiaolei Han, Xianda Zhang, Zhonglin Zhang, Lin Cong, Shi Tang, Tingting Hou, Cuicui Liu, Xiaojuan Han, Qinghua Zhang, Jianli Feng, Ling Yin, Lin Song, Yi Dong, Rui Liu, Yuanjing Li, Tiia Ngandu, Miia Kivipelto, Heather Snyder, Maria Carrillo, Jonas Persson, Laura Fratiglioni, Lenore J Launer, Jianping Jia, Yifeng Du, Chengxuan Qiu

“…Overall, 87.1% of the participants had at least two of the 15 chronic diseases (89.3% in women vs 84.2% in men, P < .001). …”
Get full text

Effects of antagonistic network-targeted tDCS on brain co-activation patterns depends on the networks’ electric field: a simultaneous tDCS-fMRI study by Hechun Li, Hongru Shi, Sisi Jiang, Changyue Hou, Haonan Pei, Hanxi Wu, María Luisa Bringas Vega, Gang Yao, Dezhong Yao, Cheng Luo

“…In contrast, the d-targeted tDCS had only a slight effect on brain dynamics, while sham tDCS showed no significant impact. …”
Get full text

Genetic evolution, epidemic trends, and recombination dynamics of PRRSV-1 in China by Chengzhen Weng, Chengzhen Weng, Chengzhen Weng, Xinxin Huang, Xinxin Huang, Xinxin Huang, Zhian Chen, Zhian Chen, Minjia He, Minjia He, Minjia He, Beiwen Zhang, Beiwen Zhang, Beiwen Zhang, Hongxi Li, Hongxi Li, Hongxi Li, Jingrui Xie, Jingrui Xie, Meichun Chen, Meichun Chen, Meichun Chen, Longxin Qiu, Longxin Qiu, Xiaobing Li, Xiaobing Li, Chong Cao, Chong Cao, Hongbo Chen, Hongbo Chen

“…The results indicated that mutations had occurred at amino acid sites within the antigenic epitopes and functional domains of GP5. …”
Get full text

Complete sequencing of the mitochondrial genome of tea plant Camellia sinensis cv. ‘Baihaozao’: multichromosomal structure, phylogenetic relationships, and adaptive evolutionary an... by Zhiyin Chen, Zhiyin Chen, Zhiyin Chen, Zhiyin Chen, Zixu Wang, Zixu Wang, Zixu Wang, Zixu Wang, Wei Zhou, Wei Zhou, Wei Zhou, Wei Zhou, Sijie Liu, Sijie Liu, Sijie Liu, Sijie Liu, Yuxin Xiao, Yuxin Xiao, Yuxin Xiao, Yuxin Xiao, Yihui Gong, Yihui Gong, Yihui Gong, Yihui Gong

“…Overall, these findings systematically elucidate the adaptive evolutionary mechanisms and functional regulation of the tea plant mitochondrial genome.…”
Get full text

Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support by Christos P. Kyriakopoulos, Iosif Taleb, Eleni Tseliou, Konstantinos Sideris, Rana Hamouche, Eleni Maneta, Marisca Nelson, Ethan Krauspe, Sean Selko, Joseph R. Visker, Elizabeth Dranow, Matthew L. Goodwin, Rami Alharethi, Omar Wever‐Pinzon, James C. Fang, Josef Stehlik, Craig H. Selzman, Thomas C. Hanff, Stavros G. Drakos

“…We sought to investigate the effect of glycemia on functional cardiac improvement, morbidity, and mortality in durable left ventricular assist device (LVAD) recipients. …”
Get full text

Effects of previous steroid treatment on ischemic stroke outcomes: a propensity score-matched hospital analysis by Yasser Alatawi, Eman A. Alraddadi, Eman A. Alraddadi, Abdullah A. Alhifany, Faisal E. Alzahrani, Faisal E. Alzahrani, Saud M. Alknawy, Saud M. Alknawy, Nawaf M. Aljohani, Nawaf M. Aljohani, Husun K. Kecheck, Husun K. Kecheck, Alanoud K. Alaslab, Alanoud K. Alaslab, Aser F. Alamri, Aser F. Alamri, Ahmed Aljabri, Daniyah A. Almarghalani, Daniyah A. Almarghalani, Faisal F. Alamri, Faisal F. Alamri

“…Secondary outcomes included stroke severity and functional independence on admission and discharge, hemorrhagic transformation within 30 days, and mortality rate within 365 days of the index stroke.ResultsOut of 925 patients, 85 (9.19%) received steroids. …”
Get full text

Next-generation sequencing in early-stage multiple primary lung cancer: The prognostic significance of genomic accumulation status and BCL2L11del by Mu-Ting Wang, Chen-Hui Ni, Yan-Qi Lu, Wei Zheng, Shu-Liang Zhang, Mao-Hui Chen, Bin Zheng, Chun Chen

“…Additionally, the study sought to explore the biological functions and prognostic significance of PRMT8 in BCL2L11del lung cancer. …”
Get full text

Dietary mixtures of Bacillus spp. modulates intestinal morphology, resistance to Vibrio parahaemolyticus, response of immune-antioxidant genes, and growth of Dicentrarchus labrax by El-Sayed Hemdan Eissa, Afaf N. Abdel Rahman, Ragaa A. Ahmed, Basma M. Hendam, Yasmin M. Abd El-Aziz, Hagar Sedeek Dighiesh, Moaheda E.H. Eissa, Ekemini Moses Okon, Norhan H. Ahmed

“…Post-challenge with V. parahaemolyticus, the MBs3 and MBs4 groups had the highest survival rate (70.00 and 70.00 %), followed by the MBs2 group (60.00 %) and MBs1 group (50.00 %) compared to control (30.00 %). …”
Get full text

Overall Layout Method of Frame Structure Plane Based on Generative Adversarial Network by ZHONG Yan, LEI Xin, LONG Danbing, FANG Changjian, KANG Yongjun

“…The model’s generated frame columns met functional requirements, were well-placed, and had appropriate size and density. …”
Get full text

Specific features of axial involvement in psoriatic arthritis: data from real clinical practice by E. E. Gubar, E. Yu. Loginova, Yu. L. Kоrsakova, T. V. Korotayeva, S. I. Glukhova, M. V. Sedunova, I. N. Pristavsky, I. N. Bondareva, I. F. Umnova, E. L. Nasonov

“…Axial involvement was associated with more pronounced functional impairment. Median HAQ was 1,0 [0,6; 1,5] and 0 [0-2,2] (р=0,02). …”
Get full text