COVID-19 on patients with immune-mediated rheumatic disease: a comparative study of disease activity, fatigue, and psychological distress over six months by Claudia Marques, Marcelo M. Pinheiro, Jennifer Lopes, Sandra Lúcia Euzébio Ribeiro, Mary Vânia Marinho de Castro, Lilian David de Azevedo Valadares, Aline Ranzolin, Nicole Pamplona Bueno de Andrade, Rafaela Cavalheiro do Espírito Santo, Nafice Costa Araújo, Cintya Martins Vieira, Valéria Valim, Flavia Patricia Sena Teixeira Santos, Laurindo Ferreira da Rocha, Adriana Maria Kakehasi, Ana Paula Monteiro Gomides Reis, Edgard Torres dos Reis-Neto, Gecilmara Salviato Pileggi, Gilda Aparecida Ferreira, Licia Maria Henrique da Mota, Odirlei Monticielo, Ricardo Machado Xavier

“…Diabetes mellitus showed a positive association (OR = 7.15), while TNF inhibitors had a protective effect (OR = 0.51). Fatigue, depression, anxiety, and stress were significantly greater in patients than in controls. …”
Get full text

Outcomes of transcatheter aortic valve replacement in younger low-risk patients: a comprehensive meta-analysis of efficacy and safety by António Rocha de Almeida, António Rocha de Almeida, António Rocha de Almeida, Maria Rita Lima, Maria Rita Lima, Daniel A. Gomes, Renato Fernandes, Eduardo Infante Oliveira, Eduardo Infante Oliveira, Pedro Araújo Gonçalves, Pedro Araújo Gonçalves, Rui Campante Teles, Rui Campante Teles, Manuel de Sousa Almeida, Manuel de Sousa Almeida, Lino Patrício

“…Secondary endpoints included all-cause mortality, disabling stroke, atrial fibrillation (AF), permanent pacemaker implantation (PPI), bleeding, functional class (NYHA), and quality-of-life (KCCQ score) improvements.ResultsFour RCTs were included with 4,252 patients (2,125 TAVI and 2,127 SAVR). …”
Get full text

Commensal microorganisms ameliorate the adverse effects of high wheat starch diet on the growth performance, glucose and lipid metabolisms in juvenile largemouth bass, Micropterus... by Bi-Yun Zhang, Hong-Ling Yang, Ze-Hui Yuan, Xiao-Ou Sun, Jia-Hao Yin, Jun-Ji Xu, Guo-He Cai, Yun-Zhang Sun

“…A 42-d feeding experiment was performed to study the functions of the seven microorganisms. A total of 810 fish (5.9 ± 0.01 g) were equally distributed into 9 groups. …”
Get full text

Molecular and genetic evidence for the role of AMBRA1 in suppressing S-phase entry and tumorigenesis by Hisako Akatsuka, Tomohiro Kashikawa, Kaori Masuhara, Mizuki Tokusanai, Chenyang Li, Yumi Iida, Chisa Okada-Yamaguchi, Yoshinori Okada, Masayuki Tanaka, Takahiro Suzuki, Norio Yamamoto, Katsuto Hozumi, Tomoaki Tanaka, Hirofumi Nakaoka, Kazuyoshi Hosomichi, Yu Hamaguchi, Michiaki Hamada, Yoshiki Shiraishi, Akihide Kamiya, Yoshihiko Nakamura, Kaito Harada, Abd Aziz Ibrahim, Takashi Yahata, Masato Ohtsuka, Naoya Nakamura, Hiroyuki Hosokawa, Minoru Kimura, Ituro Inoue, Takehito Sato

“…We had identified a missense mutation in AMBRA1 through exome analysis of a family with Cowden syndrome. …”
Get full text

Serum extracellular vesicle microRNAs as potential biomarkers to predict pembrolizumab response and prognosis in metastatic non-small cell lung cancer patients by Daniela Lamorte, Luciana De Luca, Alfredo Tartarone, Stefania Trino, Irene Giulivo, Angelo De Stradis, Maddalena Maietti, Antonella Caivano, Ilaria Laurenzana

“…This study aims to analyze cEVs microRNAs in serum of advanced stage NSCLC patients with PD-L1 expression ≥50% at diagnosis, before first-line pembrolizumab, to evaluate their possible role as potential biomarkers for immunotherapy response prediction and outcomes.MethodscEVs were isolated from serum of healthy subjects and NSCLC patients at diagnosis. All patients had tumor PD-L1≥50% and cEVs were extracted before first-line pembrolizumab treatment. cEVs were then characterized for morphology, integrity, concentration, size and protein contaminants. …”
Get full text

CLINICAL ASPECTS OF PATIENTS WITH NON-REMOVABLE PROSTHESIS RESULTS OF ZRO2 COATED PROSTHESES by O.M. Yakovyn, Z.R. Ozhohan

“…Patients of 2nd and 3rd groups satisfied patients in terms of aesthetic and functional requirements. Shade, smoothness, integrity structures were remained unchanged. …”
Get full text

基于樟树籽油和棕榈油硬脂结构脂的开发及其在人造奶油中的应用Development of structured lipids based on camphor seed oil and palm stearin and its application in margarine... by 高盼1,2， 张远鹏1， 王澍3， 周桐1， 殷娇娇1， 钟武1,2， 胡传荣1 GAO Pan 1,2, ZHANG Yuanpeng1, WANG Shu3, ZHOU Tong1, YIN Jiaojiao1, ZHONG Wu1,2, HU Chuanrong1

“…To develop a new type of margarine product with ehnanced nutritional and functional properties, camphor seed oil (CSO) and palm stearin (PST) were used as base oils, the structured lipids of CIE and EIE were prepared by chemical transesterification and enzymatic transesterification, respectively. …”
Get full text

Impacts of Chelated Iron Supplement with Organic Acid and Amino Acid on Growth Performance, Nutrient Digestibility, Feeding Behaviors, and Blood Parameters in Suckling Calves by Mahdi Ghavidel, Abdolhakim Toghdory, Taghi Ghoorchi, Mohammad Asadi

“…In the early stages of life, calves do not have a functional rumen, and it seems that they are more like monogastric animals that must obtain the nutrients they need. …”
Get full text

Hybrid azole-based conjugates as upcoming anticancer and antimicrobial agents by Luís M. T. Frija, Bruno E. C. Guerreiro, Inês C. C. Costa, Vera M. S. Isca, Lucília Saraiva, Beatriz G. Neves, Mariana Magalhães, Célia Cabral, Maria L. S. Cristiano, Patrícia Rijo

Get full text

Results of a 24-week open-label, non-interventional study on the efficacy and safety of olokizumab therapy in patients with rheumatoid arthritis after switching from anti-B-cell th... by A. V. Fedorova, N. E. Banshchikova, A. E. Sizikov, A. A. Mullagaliev, E. A. Letyagina, A. A. Akimova, N. A. Ilyina, Yu. D. Kurochkina, Yu. B. Ubshaeva, V. O. Omelchenko, O. A. Chumasova, N. S. Shkaruba, M. A. Korolev

“…The study included 19 patients with a confirmed diagnosis of RA who had received RTM at a dose of 500–1000 mg twice every 14 days at least 6 months ago. …”
Get full text

Headache: A potential sequela of posterior reversible encephalopathy syndrome by M. Rodrigo-Gisbert, E. Caronna, A. Alpuente, M. Torres-Ferrús, P. Pozo-Rosich

“…Seven patients completed validated questionnaires; on the Migraine Disability Assessment scale, 71.4% (5/7) had moderate–severe disability. The Short Form-36 Health Survey dimensions of general health, physical role, and vitality reflected a deterioration in the quality of life. …”
Get full text

THE REGENERATIVE POTENTIAL OF BONE TISSUE IN PATIENTS WITH GENERALIZED PERIODONTITIS STAGE II, II-III AND ANALYSIS OF IT`S ROLE DURING SURGICAL OPERATIONS ON PERIODONTAL TISSUES by G.F. Biloklytska, L.M. Panchenko, I.E. Braun

“…The date was comparwd with healthy patients who had indication for tooth extraction according to orthodontic or prosthodontic indications. …”
Get full text

PDGFRα promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India by Sameer Ahmad Guru, Rashid Mir, Musadiq Bhat, Imtiyaz Najar, Mariyam Zuberi, Mamta Sumi, Mirza Masroor, Naresh Gupta, Alpana Saxena

“…Moreover, patients with imatinib-induced thrombocytopenia had a significantly lower platelet-derived growth factor receptor-α messenger RNA expression, compared to patients without thrombocytopenia (p = 0.01). …”
Get full text

Scaling and intermittent properties of oceanic and atmospheric <i>p</i>CO₂ time series and their difference in a turbulence framework by K. Robache, F. G. Schmitt, Y. Huang, Y. Huang

“…By using empirical mode decomposition of the time series, together with generalized Hilbert spectral analysis, the intermittency of the time series was considered in the multifractal framework. Concave moment functions were estimated, and Hurst indices <span class="inline-formula"><i>H</i></span> and intermittency parameters <span class="inline-formula"><i>μ</i></span> were determined in the framework of a lognormal multifractal fit. …”
Get full text

A Specific and Sensitive Immuno-Terahertz Method to Detect Pathogenic Microorganisms by Xuehao Wang, Ye Tian, Fenli Liu, Lintao Huang, Fulai Zhang, Xupeng Fu, Yu Li, Qingliang Feng, Wen Zeng, Junli Liang, Donghao Cheng, Yadong Xu, Jingyao Dai, Chaojun Song, Airong Qian

Get full text

The Mission of the Neocatechumenal Way in Times of Covid-19 by Bogumił Gacka

“…Long before the arrival of COVID-19, the lives of European and Americans had been disintegrating with deaths from suicide, drug overdose and alcoholic liver disease rising year on year. …”
Get full text

A peer-support lifestyle intervention for preventing type 2 diabetes in India: A cluster-randomized controlled trial of the Kerala Diabetes Prevention Program. by Kavumpurathu R Thankappan, Thirunavukkarasu Sathish, Robyn J Tapp, Jonathan E Shaw, Mojtaba Lotfaliany, Rory Wolfe, Pilvikki Absetz, Elezebeth Mathews, Zahra Aziz, Emily D Williams, Edwin B Fisher, Paul Z Zimmet, Ajay Mahal, Sajitha Balachandran, Fabrizio D'Esposito, Priyanka Sajeev, Emma Thomas, Brian Oldenburg

“…At 24 months, compared with the control group, intervention participants had a greater reduction in IDRS score (mean difference: -1.50 points, p = 0.022) and alcohol use (RR 0.77, p = 0.018) and a greater increase in fruit and vegetable intake (≥5 servings/day) (RR 1.83, p = 0.008) and physical functioning score of the HRQoL scale (mean difference: 3.9 score, p = 0.016). …”
Get full text

Nitrogen addition substantially affects plant phenology in terrestrial ecosystems: a meta-analysis by Yaqi He, Yaqi He, Yaqi He, Yaqi He, Tenglong Zhou, Tenglong Zhou, Tenglong Zhou, Tenglong Zhou, Jianing Mao, Jianing Mao, Jianing Mao, Jianing Mao, Mengke Li, Mengke Li, Mengke Li, Mengke Li, Ruomin Sun, Ruomin Sun, Ruomin Sun, Ruomin Sun, Chang Liu, Chang Liu, Chang Liu, Chang Liu, Wen Li, Wen Li, Wen Li, Wen Li, Lei Ma, Lei Ma, Lei Ma, Lei Ma, Shenglei Fu, Shenglei Fu, Shenglei Fu, Shenglei Fu

“…., flowering) in forest ecosystems, while temperature, precipitation, and nitrogen addition had little effect on the phenology of grassland and farmland plants.DiscussionThis is because different ecosystems have different functions, resource allocation, and climate adaptation strategies, resulting in different responses to different environmental factors. …”
Get full text

Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational... by Christopher E Brightling, Kamlesh Khunti, Naveed Sattar, Colin Berry, John P Greenwood, Gerry P McCann, Kelly S Parke, Joanne V Wormleighton, Stefan Neubauer, Betty Raman, Charalambos Antoniades, Elizabeth M Tunnicliffe, Alastair Moss, Jayanth Ranjit Arnold, Mark Toshner, Sue Francis, Sandeep S Hothi, Stephen M Smith, Mohamed Elshibly, Simran Shergill, Rachel J England, George J Hudson, James Wild

“…Introduction SARS-CoV-2 disease (COVID-19) has had an enormous health and economic impact globally. …”
Get full text

Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy by Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Jose C. Florez, Jose C. Florez, Jose C. Florez, Pierre-Étienne Jacques, Pierre-Étienne Jacques, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Camille E. Powe, Camille E. Powe, Camille E. Powe, Luigi Bouchard, Luigi Bouchard, Luigi Bouchard, Marie-France Hivert, Marie-France Hivert, Marie-France Hivert

Get full text