Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study by Joan B Soriano, Juan José Soler-Cataluña, Marc Miravitlles, Julio Ancochea, Elena García Castillo, Miguel Barrueco Ferrero, Begoña Gallego, Ramon Fernandez, Inmaculada Alfageme, Borja G Cosío, Cristina Represas, Pilar de Lucas, Ciro Casanova, Francisco García-Río, José Miguel Rodríguez González-Moro, María Guadalupe Sánchez Herrero, Claudia Valenzuela, Ana Pueyo Bastida, Lourdes Lázaro Asegurado, Luis Rodríguez Pascual, Mª José Mora, Luis Borderias Clau, Lourdes Arizón Mendoza, Sandra García, Juan AR Miranda, Julián Grande Gutiérrez, Jesús Agustín Manzano, Manuel González, Milagros Rosales, José AF Villar, Ana Priegue, Isabel Portela Ferreño, Cecilia Mouronte Roibás, Sara Fernández García, Rocío Cordova Díaz, Nuria Toledo Pons, Margalida Llabrés, José MM Trigo, Marta Forner, Pablo Cubero, Elisabet Vera, Mª BP Albero, Noelia González García, Agustín Valido Morales, Carolina Panadero, Cristina Benito Bernáldez, Maria Velarde, Antonio Santa Cruz Siminiani, Carlos Castillo Quintanilla, Rocío Ibáñez Meléndez, José JM Garcerán, Desirée Lozano Vicente, Pedro García Torres, Maria del Mar Valdivia, Juan PT Tajes, Montserrat Cizur Girones, Carmen Labiano Turrillas, Carlos Ruiz Martínez, Elena Hernando, Elvira Alfaro, José Manuel García, Jorge Lázaro, David Bravo, Laura Hidalgo, Silvia Francisco Terreros, Iñaki Zorrilla, Ainara Alonso Colmenero, Cristina Martínez González, Susana Margon, Rosirys Guzman Taveras, Alicia Álvarez, José RA Balbín, Juan Agüero Calvo, Jaume Ferrer Sancho, Esther Rodríguez González, Eduardo Loeb, José LI Alonso, Mª AR García, Juan Abreu González, Candelaria Martín García, Rebeca Muñoz, Haydée Martín García, Miguel AM Muñiz, Andrés AS Antuña, Jesús Allende González, Jose AG Blanco, Fernando JA Navascues, Manuel AV Montes, María Rodríguez Pericacho, Concepción Rodríguez García, Juan DA Mavárez

“…The objectives of this study were to describe the prevalence of reduced DLCO in a population-based sample of current and former smoker subjects without airflow limitation and to describe its morphological, functional and clinical implications.Methods A sample of 405 subjects aged 40 years or older with postbronchodilator forced expiratory volume in 1 s/forced vital capacity (FVC) >0.70 was obtained from a random population-based sample of 9092 subjects evaluated in the EPISCAN II study. …”
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Multi-omics analysis reveals the dominant intestinal microbial strains and metabolites related to the reproductive performance in pregnant sows by Qianhong Ye, Tingting Luo, Longshan Han, Yuwen Chen, Yifan Hu, Haoyi Jiang, Xiaojian Xu, Xianghua Yan

“…However, investigating the functional microbiota and metabolites to improve the reproductive performance and understanding the host–microbiota interaction are still arduous tasks. …”
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Time dependency of thrombectomy for large artery atherosclerosis versus cardioembolic stroke subtypes: evidence from the ANGEL-ACT registry by Yue Yin, Hanlin Chen, Anxin Wang, Anxin Wang, Anxin Wang, Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Miao Li, Ligang Song, Ligang Song, Ligang Song, Baixue Jia, Baixue Jia, Baixue Jia, Ning Ma, Ning Ma, Ning Ma, Dapeng Mo, Dapeng Mo, Dapeng Mo, Xuan Sun, Xuan Sun, Xuan Sun, Feng Gao, Feng Gao, Feng Gao, Yiming Deng, Yiming Deng, Yiming Deng, Zhongrong Miao, Zhongrong Miao, Zhongrong Miao

“…No significant difference was found in the 90-day clinical functional outcome between the LAA and CE patients when ORT was achieved within 240 min. …”
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Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Active groups experienced more mild adverse events compared to sham but had similar rates of severe adverse events and dropout. …”
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Pulmonary arterial hypertension with cardiopulmonary comorbidities: is it a unique phenotype? by Meng Zhang, Xueran Guo, Wei Guo, Yan Wang, Yao Xiao, Jiancheng Han, Ye Li, Tingting Man, Jie Li, Yong Chen, Shengchen Duan, Wenmei Zhang, Hui Li, Ao Yin, Jiafei Peng, Chunrong An, Wanmu Xie, Qian Gao, Shuai Zhang, Yunxia Zhang, Zhenguo Zhai, Jun Wan

“…According to whether they had cardiopulmonary diseases or not, they were classified into two groups: comorbidities group and non-comorbidities group. …”
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Geriatric Nutritional Risk Index Assessment in Patients Undergoing Transcatheter Edge-to-Edge Repair by Kenichi Shibata, PT, Masanori Yamamoto, MD, Ai Kagase, MD, Takahiro Tokuda, MD, Hiroshi Tsunamoto, MD, Testuro Shimura, MD, Azusa Kurita, MD, Ryo Yamaguchi, MD, Mike Saji, MD, Masahiko Asami, MD, Yusuke Enta, MD, Masaki Nakashima, MD, Shinichi Shirai, MD, Masaki Izumo, MD, Shingo Mizuno, MD, Yusuke Watanabe, MD, Makoto Amaki, MD, Kazuhisa Kodama, MD, Junichi Yamaguchi, MD, Toru Naganuma, MD, Hiroki Bota, MD, Yohei Ohno, MD, Masahiro Yamawaki, MD, Daisuke Hachinohe, MD, Hiroshi Ueno, MD, Kazuki Mizutani, MD, Toshiaki Otsuka, MD, Shunsuke Kubo, MD, Kentaro Hayashida, MD

“…Thirty-day mortality occurred in 51 patients (1.4%), and the GNRI <82 group had the highest 30-day mortality rate. Kaplan–Meier curves showed significantly better prognoses for the entire cohort, functional MR, and degenerative MR across the 4 groups (P < 0.001). …”
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Use of powdered immunized insects for inhibiting Pectobacterium carotovorum infestation and promoting growth in lettuce by Youngwoo CHO, Jun Ho LEE, Jangwoo PARK, Ki-Byung PARK, Mijeong KIM, Sung Su PARK, Sejung HWANG, Saeyoull CHO

“…However, the group treated with H. illucens powder had the least potato weight loss. When tested on lettuce, the H. illucens powder-treated group revealed an approximately 10% increase in the fresh weight of lettuce, with both the dry weight and leaf area of lettuce increasing in comparison with those in the control group. …”
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Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease by Jingyun Wu, Irene Santos-Garcia, Ivan Eiriz, Thomas Brüning, Aleš Kvasnička, David Friedecký, Tuula A. Nyman, Jens Pahnke

“…Histological analyses of the brain revealed delayed accumulation of activated astrocytes contributing to the preservation of the neural microenvironment by reducing neuroinflammation.The extent of FTY-related disease improvement was sex-dependent. Motor functions and body weight improved mostly in female mice with sustained estrogen levels, whereas males had to compensate for the ongoing, disease-related testis atrophy and the loss of androgen production.Our study underscores the beneficial therapeutic effects of FTY on HD involving endogenous steroid hormones and their important anabolic effects. …”
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Leveraging a disulfidptosis-based signature to characterize heterogeneity and optimize treatment in multiple myeloma by Bingxin Zhang, Dong Zheng, Shuxia Zhu, Xinyi Zhang, Quanqiang Wang, Zhili Lin, Ziwei Zheng, Shujuan Zhou, Zixing Chen, Sisi Zheng, Enqing Lan, Luning Cui, Hansen Ying, Yu Zhang, Xuanru Lin, Qiang Zhuang, Honglan Qian, Xudong Hu, Yan Zhuang, Qianying Zhang, Zhouxiang Jin, Songfu Jiang, Yongyong Ma, Yongyong Ma, Yongyong Ma

“…We further explored genetic mutation mapping, protein-protein interactions, functional enrichment, drug sensitivity, drug prediction, and immune infiltration analysis among subtypes and risk subgroups. …”
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New insight into Alzheimer's disease: Light reverses Aβ‐obstructed interstitial fluid flow and ameliorates memory decline in APP/PS1 mice by Xiangpei Yue, Yufei Mei, Yun Zhang, Zheng Tong, Dehua Cui, Jun Yang, Aibo Wang, Rui Wang, Xuechao Fei, Li Ai, Yalan Di, Hongjun Luo, Hui Li, Wenhong Luo, Yu Lu, Rui Li, Chunli Duan, Ge Gao, Hui Yang, Binggui Sun, Rongqiao He, Weihong Song, Hongbin Han, Zhiqian Tong

“…Then, the brains were sampled for biochemical analysis. Results RL at 630 nm had the least heating effects than other wavelengths associated with ~49% penetration ratio into the brains. …”
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Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis by Jing Yang, Jing Yang, Jing Yang, Wenyi Li, Wenyi Li, Wenyi Li, Mei Tian, Mei Tian, Mei Tian, Lei Zhang, Fengping Du, Fengping Du, Fengping Du, Xin Li, Xin Li, Xin Li, Qi Liu, Qi Liu, Qi Liu, Rui Li, Rui Li, Rui Li, Zhenzhong Li, Zhenzhong Li, Zhenzhong Li, Hui Dong, Hui Dong, Hui Dong, Yaling Liu, Yaling Liu, Yaling Liu

“…After controlling for age and sex, the ALS group had thinner cortexes in multiple clusters across the brain than the control group. …”
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Oral phenotype in SATB2-associated syndrome: cross-sectional study of the French cohort by Nancy Vegas, Marlène Rio, Pauline Adnot, Véronique Soupre, Florence Petit, Jamal Ghoumid, Annick Toutain, Klaus Dieterich, Isabelle Marey, Brigitte Gilbert-Dussardier, Gwenaël Le Guyader, Christine Francannet, Elise Schaefer, Laurence Perrin, Mathilde Nizon, Claire Beneteau, David Genevieve, Marjolaine Willems, Laurence Faivre, Marianne Grimaldi, Judith Melki, Radka Stoeva, Audrey Putoux, Linda Pons, Karelle Benistan, Jeanne Amiel, Véronique Abadie

“…A major language delay was described in all patients; 65% had a vocabulary of 10 words or less. An anomaly of RS spectrum was found in half the cases, and dental malformations were described in 90%. …”
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Patient Reported Outcome Measures in cancer care: a hybrid effectiveness-Implementation trial to optimise Symptom control and health service Experience (PROMISE)–protocol for a ran... by David Wyld, Afaf Girgis, Elizabeth Miller, Penelope M Webb, Gunter Hartel, Karen Martin, Rahul Ladwa, Melissa Eastgate, Suzanne O’Brien, Sabe Sabesan, Raymond J Chan, Amy Brown, Robert Mason, Mark B Pinkham, Bena Brown, Louisa G Collins, Fiona Crawford Williams, Kerrie Doupain, Vicki Fennelly, Peter McGuire, Rebecca Packer, Jasotha Sanmugarajah, Georgia Slapp, Doreen Tapsall, Jeanie White, Laurelie R Wishart

“…Studies have reported clear benefits in patient–clinician communication when PROMs are used and trials in the USA and France found patients randomised to complete regular ePROMs reported better health-related quality of life, had fewer unplanned hospital visits and, importantly, significantly better survival than those randomised to usual care. …”
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Integrated network pharmacology and in vivo experiments to reveal the anti-inflammatory mechanism of Qinghuo Rougan Formula in uveitis by Changying Jing, Changying Jing, Yaqi Sun, Yaqi Sun, Hongsheng Bi, Junguo Guo, Cong Ren, Jike Song, Beibei Wang, Qingmei Tian, Dadong Guo, Pengjuan He, Lijie Li, Xiaofeng Xie

“…The yellow module contained 120 genes had a strong correlation with uveitis using WGCNA. …”
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Right‐sided vagus nerve stimulation: Worldwide collection and perspectives by Marc Zanello, Berthold Voges, Ramesh Chelvarajah, Arjune Sen, Željka Petelin Gadže, Guillaume Penchet, Alessandro De Benedictis, Riccardo Fornaro, Masaki Iwasaki, Keiya Iijima, Elena Jiltsova, Goran Mrak, Sami Barrit, Alessandro Moiraghi, Andrea Landi, Marcus Neale, Shailendra Magdum, François Caire, Bertrand Godet, Philippe Domenech, Raphael Gaillard, Marc Guenot, Jason Labuschagne, Alexandre Rainha Campos, Herbert Rooijakkers, Riëm El Tahry, Tatiana Von Hertwig Fernandes De Oliveira, Amelia Alvarez‐Sala, Cristina V. Torres, Fernando Vale, Johan Pallud, Romain Carron

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FEATURES OF THE USE OF MOBILE COMMUNICATION IN THE STUDENT ENVIRONMENT / ОСОБЕННОСТИ ИСПОЛЬЗОВАНИЯ МОБИЛЬНОЙ СВЯЗИ В СТУДЕНЧЕСКОЙ СРЕДЕ... by SHARIKOV ALEXANDER V . / ШАРИКОВ А.В., EROFEEV SERGEI V. / ЕРОФЕЕВ С.В.

“…Among the respondents of GITR and HSE, 100% of the students had smartphones. The use of mobile communication by Russian students is characterized by wide functionality—the total number of identified functions amounted to more than 20, most of which are related to the Internet. …”
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On the added value of sequential deep learning for the upscaling of evapotranspiration by B. Kraft, B. Kraft, B. Kraft, J. A. Nelson, S. Walther, F. Gans, U. Weber, G. Duveiller, M. Reichstein, W. Zhang, M. Rußwurm, D. Tuia, M. Körner, Z. Hamdi, M. Jung

“…XGBoost showed a smaller ensemble spread compared to neural networks, in particular when conditions were poorly represented in the training data, but it was more sensitive to the covariate setup. Plant functional types were useful at the site level for the improved representation of spatial patterns but had a significant leverage on upscaling results – i.e., having a disproportionate impact on the spatial patterns, especially for XGBoost, but less for the LSTM model.…”
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Right-restricting measures implemented by Public Health Surveillance services during the COVID-19 pandemic: a systematic review protocol by Tiago Correia, Marcelo Dayrell Vivas, Larissa Bragagnolo, Igor Antônio Lourenço da Silva, Fernando Tureck, Reinaldo Santos, Samara Kielmann, Debora do Carmo, Camila Avarca, Franciele da Silva, Mariana Paes, Luis Fernando Nogueira Tofani, Arthur Chioro

“…The protocol of this systematic review aims to address a critical gap in the literature by analysing how Public Health Surveillance services worldwide implemented compulsory right-restricting measures during the COVID-19 pandemic, and what impacts these measures had on public health outcomes and individual rights.Methods and analysis This protocol focuses on studies about right-restricting measures enacted by Public Health Surveillance services during the COVID-19 pandemic. …”
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Effect of the Cervical Lesion Severity on Procedural and Clinical Outcomes after Endovascular Treatment of Acute Tandem Lesions: A Multicenter Study by Milagros Galecio‐Castillo, Mudassir Farooqui, Ameer E. Hassan, Mouhammad A. Jumaa, Afshin A. Divani, Marc Ribo, Michael Abraham, Nils H. Petersen, Johanna T. Fifi, Waldo R. Guerrero, Amer M. Malik, Thanh N. Nguyen, Sunil A. Sheth, Albert J. Yoo, Guillermo Linares, Nazli Janjua, Michael Dubinsky, Darko Quispe‐Orozco, Wondwossen Tekle, Syed F. Zaidi, Sara Y Sabbagh, Marta Olive‐Gadea, Tiffany Barkley, Reade A De Leacy, Mohamad Abdalkader, Sergio Salazar‐Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Leonardo Cruz‐Criollo, Piyush Kalakoti, Maxim Mokin, Dileep R. Yavagal, Tudor G Jovin, Santiago Ortega‐Gutierrez

“…Outcomes included successful and excellent recanalization, functional independence, symptomatic intracranial hemorrhage, and puncture‐to‐recanalization time. …”
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In-depth characterization of vaccine-induced neoantigen-specific T cells in patients with IDH1-mutant glioma undergoing personalized peptide vaccination by Martin Glas, Florian Battke, Dirk Hadaschik, Martin Schulze, Saskia Biskup, David Reardon, Christina Kyzirakos, Simone Kayser, Oliver Bartsch, Armin Rabsteyn, Henning Zelba, Borong Shao, Annekathrin Reinhardt, Carsten Greve, Lisa Oenning, Pauline Latzer, Tabea Riedlinger, Julian Wünsche, Johannes Harter, Magdalena Feldhahn, Yannick Bantel, Janina Johänning, Jiri Ködding, Olga Maksimovic, Veit Scheble, Alexandra M Miller, Michael Castro, Deborah T Blumenthal

“…We implemented an assay which allowed us to isolate functional antigen-specific CD4+T cells in an HLA-independent manner. …”
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